Codes in the cilia: New study maps how Cilk1 and Hedgehog levels sculpt tooth architecture
Changes in early tooth development can have surprisingly big effects on a person’s smile. Missing teeth, extra teeth, unusually small or large teeth, or teeth that fuse together can cause problems in appearance, chewing , and long-term oral and general health issues. Because these problems arise from intricate signaling networks that operate during tooth development, the underlying biological causes can be difficult to pinpoint, making diagnosis and prevention challenging. Scientists have uncovered many of the networks involved, but it remains challenging to fully explain how the body decides how many teeth to form—or where each ...
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