THE ORIGINAL COLLECTION · SINCE 2010

Science
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Science

Policy revision expands access to rotational atherectomy without compromising PCI outcomes

Percutaneous coronary intervention (PCI) is a standard treatment for significant coronary artery disease. Cardiologists use a catheter to place a stent that opens up the blockage and restores blood flow to the heart. However, dense, calcified atherosclerotic plaque can prevent proper placement or unfolding of stents, resulting in reduced blood flow to the heart even after PCI. Rotational atherectomy (RA) is a specialized technique used to modify heavily calcified plaque before stent placement. A conical burr ablates the calcified plaque, creating ...

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Science

Role of TGF-β1 signaling in spinal cord injury recovery

Spinal cord injury (SCI) often leads to long-term loss of motor and sensory function, with limited available treatment options to restore the lost function. A major challenge in recovery is the formation of scar tissue at the injury site that prevents damaged nerve fibers from regenerating. Glial scarring has been thoroughly investigated, while fibrotic scar formation has been less studied. Transforming growth factor -β1 (TGF-β1), a signaling molecule that regulates inflammation and tissue repair, has been known to play a critical role in fibrosis in many tissues. Understanding how fibrotic scars form could aid in the ...

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Science

Pythons’ feast-and-famine life hints at new weight-loss pathway

Pythons don’t nibble. They chomp, squeeze and swallow their prey whole in a meal that can approach 100% of their body weight. But even as they slither stealthily around the forest, months or even a year may pass between massive mouthfuls. This pattern of extreme feasting and fasting taxes their metabolism far beyond what humans experience on a day-to-day basis. Now researchers at Stanford Medicine and the University of Colorado, Boulder, have found that a metabolite that spikes a thousandfold in pythons after a large meal causes obese laboratory mice to shun their food pellets and lose ...

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Science

Caregiving without a net: Poll shows who needs help most

Nearly a third of Americans over age 50 provide regular care to an adult relative or friend with a health issue or disability, a new poll finds. But many of them don’t know about, or use, local resources that could help them with caregiving. And about 20% of these caregivers are like highwire acrobats working without a net, the poll reveals. They’re taking care of someone else with health needs, but without close friends or family members to pitch in if they needed help with their own health concerns. The new findings from the University of Michigan National Poll on Healthy Aging could inform caregiver-related policy discussions at state and ...

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Science

Myth defanged: baby rattlesnake bites aren’t more dangerous than bites from adult rattlesnakes

Baby rattlesnake bites are less dangerous than bites from adult rattlesnakes, according to a new study from Loma Linda University that summarizes the origin, transmission, and prevalence of the longstanding myth that baby rattlesnake bites are more dangerous. The myth that baby rattlesnakes can’t control the release of their venom and therefore release it all when biting is refuted by the study. This incorrect belief has led “to negative consequences, including misinformed risk‐taking by those encountering snakes, unwarranted fear among snakebite victims, ...

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Science

Cerebrovascular lesions in down syndrome do not follow a linear course

What has long been interpreted as permanent and irreversible vascular damage may not be exclusively so. In people with Down syndrome—one of the most robust populations for studying Alzheimer’s disease due to the near-universal presence of the characteristic proteinopathies of this dementia from the age of 40—some lesions visible on magnetic resonance imaging do not follow a linear course. A longitudinal study from the Institut de Recerca Sant Pau (IR Sant Pau), published in Alzheimer’s & Dementia, shows that these alterations can fluctuate and even decrease over time in the Down syndrome population. This is especially true once the clinical symptoms ...

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Science

Direct nervous system link promises more natural leg prostheses

A research team led by researchers at Chalmers University of Technology in Sweden, has, for the first time, successfully decoded leg movements directly from the remaining nerves in people with above-knee amputations. Using novel implantable neurotechnology and an AI method based on the nervous system’s own “language”, the researchers could do what was previously impossible and interpret detailed movements – even the will to wiggle toes. This technology opens the way to future leg prostheses that feel and act more like a natural part of the body. Helping amputees regain a functional and independent ...

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Science

John Dystel Prize for Multiple Sclerosis Research awarded to Dr. Ludwig Kappos for his transformative contributions to MS research

Ludwig Kappos, MD, a leading physician-scientist at the University Hospital Basel in Basel, Switzerland has been awarded the 2026 John Dystel Prize for Multiple Sclerosis Research – one of the field’s highest honors. Dr. Kappos serves as director of the Research Center for Clinical Neuroimmunology and Neuroscience Basel and has played a central role in advancing MS research and treatment over the past several decades. Dr. Kappos will deliver the Dystel Prize lecture and formally receive the award at the ...

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