High triglycerides drive life-threatening aortic aneurysms, study in mice finds
High levels of triglycerides, the most common type of fat in the body and the foods we eat, directly cause abdominal aortic aneurysms, according to a study in mouse models led by Michigan Medicine. Researchers identified triglyceride-rich lipoproteins and proteins that regulate triglyceride metabolism, including APOC3 and ANGPTL3, as causal drivers of abdominal aortic aneurysm. The study challenges the longstanding belief that triglycerides are merely biomarkers of vascular disease and instead demonstrates that they play a direct and pathogenic role in aneurysm development, ...
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