“One limitation [of Cre-LoxP], the focus of this editorial, is the potential loss of fidelity of Cre recombinase expression especially in the context of modeling cancer in mice.” BUFFALO, NY- December 1, 2023 – A new editorial paper was published in Oncoscience (Volume 10) on November 14, 2023, entitled, “Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research.” In this new editorial, researchers Piotr Czarnota and Jaroslaw Cisowski from Jagiellonian University discuss Cre-LoxP — a widely used system to conditionally modify gene expression in mouse models of cancer and other diseases.  “It ...

Philadelphia, December 1, 2023 – Chimeric Antigen Receptors (CARs) have opened up an exciting new field of therapeutic advancements for rare and difficult-to-treat cancers, as they have the ability to deliver targeted therapies that can kill tumor cells. Peptide-centric CARs (PC-CARs) rely on specific peptide “barcodes,” which are derived from proteins within the cell created by potentially cancer-causing oncogenes, are designed to find and target cancer cells. These “barcodes” are displayed by human leukocyte antigens (HLAs), which help the immune system distinguish its own proteins from foreign invaders, ...

NEWS RELEASE EMBARGOED UNTIL FRI, DEC. 1 -- 2:00 P.M. EASTERN   Contact Colleen McDonald - Sr. Consultant, Earned Media 414.801.3146 | cmcdonald@mcw.edu     Milwaukee, Wis. – Dec. 1, 2023 – Preeclampsia is a mysterious condition that occurs in about one of 10 pregnancies without any early warning signs. After 20 weeks or more of normal blood pressure during the pregnancy, patients with preeclampsia will begin to experience elevated blood pressure and may also have increased levels of protein in their urine due to hypertension reducing the filtering power of the kidneys. Prolonged hypertension due ...

Following an 18-month meditation programme can improve the wellbeing of older adults, finds a new randomised controlled trial by an international team co-led by UCL. The findings, published in PLOS ONE, show that meditation can improve people’s awareness, connection to others, and insight. While the meditation training did not confer significant benefits on two commonly used measures of psychological wellbeing and quality of life, the researchers say their findings may reveal limitations in existing methods of tracking wellbeing. Lead author Marco Schlosser (UCL Psychiatry and University of Geneva) said: “As the global population ...

What happens in the human brain when we learn from positive and negative experiences? To help answer that question and better understand decision-making and human behavior, scientists are studying dopamine. Dopamine is a neurotransmitter produced in the brain that serves as a chemical messenger, facilitating communication between nerve cells in the brain and the body. It is involved in functions such as movement, cognition and learning. While dopamine is most known for its association with positive emotions, scientists are also exploring ...

Upon infection or immunization, all jawed vertebrate species generate proteins called antibodies that bind and neutralize pathogens. Strong and long-lasting antibody responses in warm-blooded species such as mammals are produced in secondary lymphoid microstructures (SLMs) among which germinal centers (GCs) are the centerpiece. Despite the apparent absence of GCs or similar SLMs in cold-blooded vertebrates (e.g., fish), these species can mount significant antibody responses that can persist for several months. Thus, for decades, the outstanding question has remained as to how and where ...

  Babies and children need vitamins, including vitamin B-12, to help their brains and bodies develop and grow. Babies get B-12 from their mothers and can have low levels of B-12 if their mothers had low vitamin levels during pregnancy and breastfeeding. The vitamin B-12 levels of infants strongly depend on maternal levels. Adequacy of vitamin B-12 in breast milk is particularly important for infants during the first six months of life when breastfeeding is highly recommended. Even after the first six months of life, breast milk may continue ...

  Children must be taught more about the importance of plants if education about climate change and sustainability is to be effective, experts have warned. Botany should feature more heavily in the school curriculum, and be a greater focus of educational policy, the study says. It warns neither the importance of plants for sustainability or the threats facing many of them are adequately represented in science education. While the problem has been identified for some time, attempts to address it have often struggled to gain a foothold in science education practice. Dr Bethan Stagg from the University of Exeter and Professor Justin Dillon ...

Cambridge, MA - Want to avoid a root canal? In the future, you might be able to opt for tissue regeneration instead. ADA Forsyth scientists are testing a novel technology to treat endodontic diseases (diseases of the soft tissue or pulp in your teeth) more effectively. The study, “RvE1 Promotes Axin2+Cell Regeneration and Reduces Bacterial Invasion,” which appeared in The Journal of Dental Research, demonstrates regenerative properties of resolvins, specifically Resolvin E1 (RvE1), when applied to dental pulp. Resolvins ...

Plastics are firmly entrenched in today’s world thanks to their cheap, light and versatile nature, but the downside is that plastic waste continues piling up. Earlier this year, United Nations Secretary-General Antonio Guterres said that every day, the equivalent of over 2,000 garbage trucks full of plastics is dumped into our oceans, rivers and lakes. According to the World Economic Forum, the United States only recycled about 6% of the 40 million tons of plastic waste it generated in 2021. Around the world, about 400 million tons of plastic waste is produced each year. Much of it ends up in landfills, oceans and natural ...

Auburn University's Department of Physics is hosting a special meeting targeting college students passionate about pursuing a PhD in Physics. This engaging event is set for December 8 at 2 PM Central Time. Interested individuals can join the session virtually via Zoom at https://aub.ie/faKH5W. Studying Physics at Auburn University is an immersive journey into the universe's fundamental principles. Our PhD program offers a robust foundation in physics and promotes groundbreaking research and discovery. Known for small class sizes and personalized ...

UNIVERSITY PARK, Pa. — If Thanksgiving dinner conversations have turned into heated political arguments over the past two decades, social media may be to blame. Popular social media figures — or influencers — who create or share distorted political messages may cause political parties to moderate their policies to win over independent voters in general elections but tend to polarize the rest of society, according to researchers who created a model to study how social media may affect election ...

More older Americans use cannabis now than before the pandemic, with 12% saying they’ve consumed a THC-containing substance in the past year and 4% saying they do so multiple times a week, according to a new study of people aged 50 to 80. Those who drink alcohol at risky levels have a much higher rate of cannabis use. The new findings, published in the journal Cannabis and Cannabinoids Research by a team from the University of Michigan’s Institute for Healthcare Policy and Innovation, suggest a need for more education and screening of older adults for cannabis-related ...

(Boston)—Alcohol is the most common addictive substance in the world. Every year in the U.S. excessive alcohol use costs $249 billion and causes approximately 88,000 deaths, as well as various chronic diseases and social issues. Alcohol use disorder, a highly prevalent, chronic, relapsing disorder, affects more than 14 million people in the U.S. alone, in addition to being severely under-treated, with only three modestly effective pharmacological therapies available.   Chronic exposure to alcohol has been shown to produce profound neuroadaptations in specific brain regions, including the recruitment of key stress neurotransmitters, ultimately ...

If you mix cornstarch and water in the right proportions, you get something that seems not-quite-liquid but also not-quite-solid. Oobleck flows and settles like a liquid when untouched, but stiffens when you try to pick it up or stir it with a spoon. The properties of oobleck and other non-Newtonian fluids — including Silly Putty, quicksand, paint, and yogurt — change under stress or pressure and scientists have long struggled to prove exactly why. Now, researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) have used piezoelectric nanoparticles, which themselves change in response to pressure, to investigate the fundamental physics of non-Newtonian ...

A researcher has just finished writing a scientific paper. She knows her work could benefit from another perspective. Did she overlook something? Or perhaps there's an application of her research she hadn't thought of. A second set of eyes would be great, but even the friendliest of collaborators might not be able to spare the time to read all the required background publications to catch up. Kevin Yager—leader of the electronic nanomaterials group at the Center for Functional Nanomaterials (CFN), a U.S. Department of Energy (DOE) Office of Science User Facility ...

Hip hop dancing can be used to spread awareness of disability rights and help those with sight problems to participate in performance equally, a new study says.   Breakin’ – which is commonly referred to as breakdancing - is good for mobility and helps promote balance and stability as well as wellbeing.   It also offers an important opportunity for people to slow down and to connect with their inner selves, their feelings, their bodies, and their peers, according to researchers. It has been used to treat symptoms of depression, anxiety and PTSD.   Nathan Geering, ...

Millions of people are suffering from digital health inequality because of poverty, experts have warned. A new study says urgent work is needed to ensure those from deprived areas can access healthcare as the NHS increasingly turns to the use of apps and online health portals for the provision of healthcare. A team of doctors and academics found a “significant association” between increased poverty and reduced use of digital services. Their modelling estimates that this association accounts for 4.27million patients across England who have not downloaded the NHS app. In October 2022 it was estimated more than 37million patients had activated ...

How do you create strong, yet quick-release connections between living and non-living tissues? This is a question that continues to puzzle bioengineers who aim to create materials that bond together for advanced biomedical applications. Looking to nature for inspiration, the McGill-led research zeroed in on the marine mussel byssus, a fibrous holdfast, which these bivalve mollusks use to anchor themselves in seashore habitats. The byssus attaches to rocky surfaces using an underwater glue, but the other end (the byssus stem root) is firmly anchored within the mussel’s soft living tissue. This area of contact between the living ...

In a groundbreaking study published in Science Advances, researchers from the Federal University of Rio de Janeiro (UFRJ) and the German Center for Neurodegenerative Diseases (DZNE-Berlin) shed light on the intricate dance between the prion protein and copper ions in the physiopathology of live cells. The research paves the way for potential treatments addressing copper-bound prion protein clusters to prevent abnormal solid formation and mitigate neurodegenerative outcomes. Like oil droplets in water, cells harbor membrane-bound organelles that ...

Communities can prosper by providing attentive education and social services to their youngest residents — but the challenge is for leaders to work together. That is the message of Craig Ramey and Sharon Ramey, Virginia Tech distinguished research professors of the Fralin Biomedical Research Institute at VTC, who today (Dec. 1, 2023) presented details of a decades-long study that focuses on early childhood education and development. In a research article in the journal Medical Research Archives, the official journal of the European Society of Medicine, the scientists discuss lessons ...

Toronto, ON – A new study published in Clinical Social Work Journal found that adolescents and young adults who experienced adverse childhood experiences (ACEs) before the age of 18 were significantly more likely to experience symptoms of muscle dysmorphia. With previous research showing that more than half of North American children and adolescents experience at least one adverse childhood experience in their lifetime, these new findings highlight the need for greater awareness of how adverse experiences in childhood (such as domestic violence, emotional abuse, and sexual abuse) and muscle dysmorphia (the pathological ...

New research from the Texas A&M University School of Public Health suggests that those who live with ongoing poverty and poor housing conditions are more likely to develop new mobility issues following a COVID-19 infection. This study, published in Preventive Medicine, is the first to examine the relationship between social vulnerability and persistent COVID-19 symptoms. In it, researchers analyzed data about socially vulnerable Michigan residents who experienced new difficulty in walking or climbing stairs after ...

The Global Alliance for Genomics and Health (GA4GH) and the International Neuroinformatics Coordinating Facility (INCF) launched a new group to lay the groundwork for connecting global neuroscience and genomic data.  Answering data-driven questions in neuroscience means dealing with complexity: in types of data, data management systems, the number and variety of conditions, ethical and legal requirements, and the genetic and biological conditions themselves. Even just aligning industry standards for neuroimaging and genomics can be a struggle. To improve life for people with neurological conditions, we need to tackle the complexity together. The new GA4GH & INCF Neuroscience ...

Key takeaways  A new mental health screening tool accurately predicts mental health outcomes for hospitalized trauma patients.   To be sustainable, mental health screening and recovery programs should be tailored to each trauma center, with the engagement of all stakeholders, a related study finds.  Studies shed light on the need for trauma centers to provide injured patients with mental health resources, such as online education, support, and referrals to mental healthcare providers when needed.  CHICAGO (December 1, 2023): A novel screening ...