A novel antibacterial lipopeptide produced by the bacterium Serratia marcescens has been shown to be highly effective in killing Staphylococcus aureus – one of the most important pathogens occurring in humans. Staphylococcus aureus is one of the five most common causes of hospital-acquired infections and is often the cause of life-threatening infections following surgery. Since the introduction of antibiotics in the early 1940s, S. aureus has by now developed resistance against most classes of antibiotics, ...

The genus of Harposporium belongs to the Ascomycota of the Fungi kingdom, the class Sortariomycetes, the order Hypocreales, and the family Ophiocordyceiaceae, is a common genus of soil fungi. The species of Harposporium are pathogens of nematodes, with some also infecting rotifers or tardigrades, and has significant ecological value. In recent years, studies have shown that a few species of the genus Harposporium can also parasitize insects or other invertebrates, such as H. janus, which can infect beetles in the Coleoptera family. However, so far, it has not been found that the same species in this genus can parasitize different invertebrates in both sexual and asexual stages. Is there a ...

Bile acids are essential molecules the liver produces that play a critical role in digestion. They help us absorb fat-soluble vitamins and cholesterol from our food. However, bile acids can become a double-edged sword. While they are necessary for proper digestion, high concentrations can also be toxic to the liver. Recent research is shedding light on the complex relationship between bile acids and liver health. Scientists have identified new ways in which bile acids interact with cellular stress responses, impacting how the liver functions in diseases ...

June 6, 2024, Cleveland: Cleveland Clinic researchers found higher amounts of the sugar alcohol xylitol are associated with increased risk of cardiovascular events like heart attack and stroke.     The team, led by Stanley Hazen, M.D., Ph.D., confirmed the association in a large-scale patient analysis, preclinical research models and a clinical intervention study. Findings were published today in the European Heart Journal.     Xylitol is a common sugar substitute used in sugar-free candy, gums, baked ...

WINSTON-SALEM, N.C. – June 6, 2024 – People with high blood pressure have a higher risk of cognitive impairment, including dementia, but a new study from researchers at Wake Forest University School of Medicine suggests that engaging in vigorous physical activity more than once a week can lower that risk. The findings appear online today in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. “We know that physical exercise offers many benefits, including lowering blood pressure, improving heart health and potentially delaying cognitive decline,” said Richard Kazibwe, ...

LEXINGTON, Ky. — Researchers at the University of Kentucky Sanders-Brown Center on Aging are working to develop a pre-symptomatic disease diagnostic tool for Alzheimer’s disease. “While the need for better treatments is clear, such treatments will not be very meaningful if they are administered after symptoms have onset. By then, Alzheimer’s disease has been ravaging the brain for decades to the point the brain can no longer compensate for the extreme cellular death,” said Mark ...

Research Highlights: Women with excess weight at age 14 or 31 may have increased ischemic (clot caused) stroke risk before age 55. The same ischemic stroke risk was not found in men. Losing excess weight after adolescence may not eliminate the stroke risk. These findings are according to a study conducted in Finland that followed more than 10,000 people from birth into their 50s. Researchers suggest health care professionals pay attention to overweight and obesity in young people and work with them to promote healthy eating and physical activity from an early age. Embargoed ...

·  Major advance for treatment of deadly brain cancer ·  Clinical trial launched at Northwestern to test treatment ·  Ultrasound microbubbles open blood-brain barrier to admit chemotherapy and immunotherapy cocktail   CHICAGO --- In a major advance for the treatment of the deadly brain cancer glioblastoma, Northwestern Medicine scientists used ultrasound technology to penetrate the blood-brain barrier and provide a small dose of a chemotherapy and immunotherapy drug cocktail. The study found that this treatment ...

New research led by Lia Siegelman, a physical oceanographer at UC San Diego’s Scripps Institution of Oceanography, shows that the roiling storms at the planet Jupiter’s polar regions are powered by processes known to physicists studying Earth’s oceans and atmosphere. The geophysical commonalities spanning the 452 million miles between the two planets could even help facilitate an improved understanding of those processes on Earth.  Siegelman first made the connection between our planet and the gas giant in 2018 when she noticed a striking similarity between images of Jupiter’s huge cyclones and the ocean turbulence she was studying. ...

COLUMBUS, Ohio – A searchable database is now ready to help study Alzheimer’s disease. Neuroscience and biomedical informatics researchers at The Ohio State University Wexner Medical Center and College of Medicine created the comprehensive, user-friendly repository. The free database – known as ssREAD – is outlined in a manuscript published online in Nature Communications.   Alzheimer’s disease is the most common cause of dementia, accounting for up to 80% of cases. An estimated 6.7 million Americans who are age 65 and older are living with Alzheimer's dementia today, according ...

Economic analysis of the E-MOTIVE trial finds that average cost per patient of drape and treatment to save women’s lives incurs minimal additional cost compared with usual care, while significantly improving health outcomes. The additional cost to achieve the improved outcome could be as little as 30 US cents extra- on average, compared to usual care. Post-partum haemorrhage currently affects 14m women around the world and leads to 70,000 deaths a year which is equivalent to one woman dying every 6 minutes   A lifesaving package including early detection and bundled treatment for ...

The hidden challenges faced by people with tooth loss and dentures has been identified by new research from the University of Sheffield.   Improvements in dental care, more people living longer and the social value placed on having a healthy smile has led to people keeping their own teeth longer, but it has also led to an increasing number of people needing some kind of restoration work including crowns, bridges and implants.    Many of these treatments remain unobtainable for most people due to the availability of NHS dentists and the high cost of private dental work. Removable dentures are often the only viable option for anyone experiencing tooth loss with an estimated ...

Nano-agriculture: Sustainable solutions for global food security PITTSBURGH—Researchers in the Department of Civil and Environmental Engineering at Carnegie Mellon University are using findings from nanomedicine and digital twin technologies to understand the new field of Plant Nanobiotechnology, address unsustainable agricultural practices, and meet increasing global food demands. Currently, agriculture accounts for 14-28% of global greenhouse gas emissions and 70% of all freshwater withdraws. This, in addition to a range of other factors from extreme weather ...

WORLD-FIRST STUDY INTO PRECISION MEDICINE FOR HIGH-RISK CHILDHOOD CANCER YIELDS EXTRAORDINARY RESULTS VIDEO - https://www.youtube.com/watch?v=bwyugwVwNzc In a world-first, Australian researchers and clinicians have shown that precision medicine – where treatment is tailored to an individual child’s cancer – leads to significantly improved outcomes in children with high risk cancer. In a study published this week in the leading international journal Nature Medicine, the researchers found that precision medicine (also called personalised medicine) was shown to be superior to standard or non-guided therapy, both in terms of clinical response and survival. A staggering ...

Advanced technologies enable the controlled release of medicine to specific cells in the body. Scientists argue these same technologies must be applied to agriculture if growers are to meet increasing global food demands.  In a new Nature Nanotechnology journal review paper, scientists from UC Riverside and Carnegie Mellon University highlight some of the best-known strategies for improving agriculture with nanotechnology. Nanotechnology is an umbrella term for the study and design of microscopically small things. How small? A nanometer is one billionth of a meter, or about 100,000 times smaller ...

Peer Reviewed | Observational study | People  Researchers at Queen Mary University of London have developed a new method for predicting dementia with over 80% accuracy and up to nine years before a diagnosis. The new method provides a more accurate way to predict dementia than memory tests or measurements of brain shrinkage, two commonly used methods for diagnosing dementia.  The team, led by Professor Charles Marshall, developed the predictive test by analysing functional MRI (fMRI) scans to detect changes in the brain’s ‘default mode network’ (DMN). The DMN connects regions of the brain ...

With the European Parliament elections now underway, millions of EU citizens are finalizing their decisions about which political party best represents their views. But anyone using LlamaChat, one of the major new AI chatbots, is very likely to be confronted with biased answers. It turns out that the large language model developed by Meta, upon which LlamaChat is based, has clear political leanings. This has been demonstrated in a new study from the University of Copenhagen in which Department of Computer Science researchers examined the language model's knowledge of political groups in the European Parliament. Moreover, they tested LlamaChat’s ...

Philadelphia, June 6, 2024 – A new study in Heart Rhythm, the official journal of the Heart Rhythm Society, the Cardiac Electrophysiology Society, and the Pediatric & Congenital Electrophysiology Society, published by Elsevier, examined the potential dangers of consuming energy drinks for patients with genetic heart diseases. A cohort of 144 sudden cardiac arrest survivors was examined at Mayo Clinic, of which seven patients (5%) had consumed one or more energy drinks in close proximity to their cardiac ...

A review of research to-date reveals the complex nature of revealing a diagnosis of a sexually transmitted infection (STI) to a partner ahead of engaging in sexual activity. With individuals experiencing a variety of feelings and emotions related to the prospect of disclosure, the research shows that only around half or fewer individuals felt able to disclose their diagnosis to a partner before sexual engagement. Peer-reviewed results, published today in The Journal of Sex Research, also show a similar number of people believed they should have to disclose having a STI to a partner prior to engaging in sexual intercourse. In order ...

Australia’s ski industry is at risk of major disruptions and shorter seasons if the current level of climate pollution continues, according to new modelling from Protect Our Winters Australia (POW) and The Australian National University (ANU).  The report found the average ski season across all resorts in Australia will be 44 days shorter by 2050 under a mid-greenhouse gas emissions scenario and 55 days shorter under a high-emissions scenario.   It also shows that despite a dramatic decline in snowfall under mid- and high-emissions scenarios, the ...

CORVALLIS, Ore. – The early worm gets the arachnid, fossil research by an Oregon State University scientist has shown. In a parasitic first, a Baltic amber specimen has revealed that millions of years ago tiny worms known as nematodes were living inside of and feeding on the outer protective layer of pseudoscorpions. “This is very strange,” said George Poinar Jr., who has a courtesy appointment in the OSU College of Science. “No other invertebrate-associated nematodes are known to have this detailed habit.” Findings were published in Historical Biology. Pseudoscorpions are a highly diverse lineage of arachnid, said Poinar, an international expert in ...

Drugs like Ozempic, Wegovy and Mounjaro have been around for years, but they’ve recently been making headlines due to a rise in popularity as weight loss agents. They all belong to a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1RAs), which mimic a hormone (GLP-1) in the body that helps control insulin and blood glucose levels and promotes feelings of satiety. These drugs are extremely effective for blood glucose control and weight management, which, combined with their relatively limited side effect profile, makes them ...

Nuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical cellular functions, such as gene expression, chromatin organization and RNA processes that influence cell survival, proliferation, and differentiation. In recent years, new studies, including work by Maximiliano D’Angelo, Ph.D., associate professor in the Cancer Metabolism and Microenvironment Program at Sanford Burnham Prebys, have noted that NPCs in cancer cells are different, but how ...

A drug approved to treat eczema provided significant improvement in the symptoms of patients with severe itching diseases that currently have no targeted treatments, according to a new study published in JAMA Dermatology. The drug, abrocitinib, was found to cause minimal side effects during a small 12-week study led by University of Maryland School of Medicine (UMSOM) researchers. It was beneficial for those with an itching disease called prurigo nodularis as well as for those with chronic pruritus of unknown origin, a condition that causes chronic unexplainable itching symptoms. “Very ...

“Approximately one in seventy working people in the United States are employed by either the police or departments of corrections.” In recent years, and in particular, in the aftermath of the Black Lives Matter protests of 2020, activists have focused renewed attention on the role of prisons in the United States. Thinkers like Angela Davis have articulated the ways in which the prison-industrial complex serves the interest of an oppressive state by reinforcing race and class hierarchies and extracting value from its incarcerated population. But despite this surge of interest ...