SAN ANTONIO — May 22, 2024 — Southwest Research Institute will share the latest developments from its ongoing NEXTCAR Phase II project at the 2024 ARPA-E Energy Innovation Summit in Dallas (May 22-24). The Institute’s NEXTCAR Program aims to reduce vehicular energy consumption by more than 30% using next generation connected and automated vehicle (CAV) technology. “We are demonstrating real-world next-generation automated driving technology that puts SwRI’s ongoing NEXTCAR energy efficiency research into practice,” said SwRI’s Scott R. Hotz, P.E., director of the Powertrain ...

Background and Aims Three-dimensional power Doppler (3DPD) ultrasound has been used for assessing adnexal masses, and in this study, we aimed to perform a meta-analysis to evaluate its role in the differential diagnosis of adnexal masses.   Methods A search for primary studies assessing the diagnostic performance of 3DPD in discriminating benign from malignant masses carried out between January 1990 and May 2023 was performed in Medline (PubMed), Scopus, and Web of Science databases with study quality evaluated ...

EMBARGOED UNTIL 12:01 a.m. EST Wednesday, May 22, 2024 Contact: Jillian McKoy, jpmckoy@bu.edu Michael Saunders, msaunder@bu.edu ## During extreme rain or rapid snowmelt, the high volume of water that enters sewer systems can cause untreated sewage to flow into waterways in US cities that have combined wastewater and stormwater sewer systems, including the Merrimack River in Massachusetts. A new study led by Boston University School of Public Health (BUSPH) researchers has found that residents living in the downstream communities that ...

Scientists have uncovered the properties of a rare earth element that was first discovered 80 years ago at the very same laboratory, opening a new pathway for the exploration of elements critical in modern technology, from medicine to space travel. Promethium was discovered in 1945 at Clinton Laboratories, now the Department of Energy’s Oak Ridge National Laboratory, and continues to be produced at ORNL in minute quantities. Some of its properties have remained elusive despite the rare earth element’s ...

We’ve been told, “The eyes are the window to the soul.” Well, windows work two ways. Our eyes are also our windows to the world. What we see and how we see it help determine how we move through the world. In other words, our vision helps guide our actions, including social behaviors. Now, a young Cold Spring Harbor Laboratory (CSHL) scientist has uncovered a major clue into how this works. He did it by building a special AI model of the common fruit fly brain. CSHL Assistant Professor Benjamin Cowley and his team honed their AI model through a technique they developed called “knockout training.” ...

Metals get softer when they are heated, which is how blacksmiths can form iron into complex shapes by heating it red hot. And anyone who compares a copper wire with a steel coat hanger will quickly discern that copper is much more pliable than steel.  But scientists at MIT have discovered that when metal is struck by an object moving at a super high velocity, the opposite happens: The hotter the metal, the stronger it is. Under those conditions, which put extreme stress on the metal, copper can actually be just ...

About The Study: In this study, death by firearm homicide was concentrated among Black individuals ages 15 to 24 before, during, and subsequent to the COVID-19 pandemic, implying that there are likely to be social and structural conditions that contribute to these racial disparities.  Corresponding Author: To contact the corresponding author, Alex R. Piquero, Ph.D., email axp1954@miami.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.12946) Editor’s ...

About The Study: The findings of this study suggest that mental disorders might be transmitted within adolescent peer networks. More research is required to elucidate the mechanisms underlying the possible transmission of mental disorders.  Corresponding Author: To contact the corresponding author, Jussi Alho, Ph.D., email jussi.alho@helsinki.fi. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (10.1001/jamapsychiatry.2024.1126) Editor’s Note: Please see the article ...

A landmark longitudinal study of LGBTQ+ youths has found that transitioning gender identities is not associated with depression and that about 1 in 3 gender-minority youths change their gender identity more than once. In fact, the study found higher rates of depression among transgender youths are more closely associated with bullying and victimization. The findings from a team of researchers at The University of Texas at Austin and in Brazil are outlined in a paper in JAMA Network Open. The study followed 366 LGBTQ+ young people ages 15-21 in two U.S. cities from 2011 to 2015 and measured depressive symptoms ...

BOSTON--In new research, investigators at Massachusetts General Hospital (MGH) show that the 100-year-old Bacillus Calmette-Guérin (BCG) vaccine, originally developed to prevent tuberculosis, protects individuals with type 1 diabetes from severe COVID-19 disease and other infectious diseases. Two back-to-back randomized double-blinded placebo-controlled trials found that the BCG vaccine provided continuous protection for nearly the entire COVID-19 pandemic in the US, regardless of the viral variant. “Individuals with type 1 diabetes are highly susceptible to infectious diseases and had worse outcomes when they were infected with the SARS-CoV-2 virus,” ...

Cell division is fundamental to life, enabling growth, reproduction, and survival across all organisms, from single-celled bacteria to complex multicellular animals. While animals and fungi share a common eukaryotic ancestry, their mechanisms of cell division, particularly mitosis, have diverged significantly, raising intriguing evolutionary questions. Animals typically undergo open mitosis, where the nuclear envelope disassembles during cell division, while fungi exhibit closed mitosis, maintaining an intact nuclear envelope. The evolutionary reasons behind these divergent strategies ...

The inflorescence architecture of crop plants like barley is predominantly regulated by meristem activity and fate, which play a critical role in determining the number of floral structures for grain production. Spikelets are the basic reproductive unit of grass inflorescences. The identity and determinacy of many grass meristems are partially determined by a group of genes expressed specifically at organ boundaries, which can form local signalling centres that regulate adjacent meristem fate and activity. These genes are critical for establishing and ...

According to a study published in Current Biology on May 22, the genetic components of the ancient populations in the western Tibetan Plateau are closest to ancient populations in the southern Tibetan Plateau, and their major genetic components have been maintained over the past 3,500 years. In addition, these ancient populations in the western Tibetan Plateau had complex and frequent interactions with ancient populations inside and outside the plateau. The study was conducted by Prof. FU Qiaomei's team from the Institute of Vertebrate Paleontology and Paleoanthropology ...

Cell division is one of the most fundamental processes of life. From bacteria to blue whales, every living being on Earth relies on cell division for growth, reproduction, and species survival. Yet, there is remarkable diversity in the way different organisms carry out this universal process. A new study from EMBL Heidelberg’s Dey group and their collaborators, recently published in Nature, explores how different modes of cell division evolved in close relatives of fungi and animals, demonstrating, for the first time, the link between an organism’s ...

Researchers from Tokyo Medical and Dental University (TMDU) and Osaka University find that a newly developed modified sugar increases the efficacy and safety of antisense oligonucleotides designed to treat central nervous system disease   Tokyo, Japan – Diseases that affect the brain and spinal cord can be particularly devastating, and finding new and more effective ways to treat these conditions is an important goal for researchers and clinicians alike. Now, a research group from Japan reports that slightly modifying an existing treatment for central nervous system (CNS) disease dramatically increases its ...

Hepatocellular carcinoma (HCC), a prevalent form of cancer, profoundly influences the progression and prognosis of the disease through immune response mechanisms. The tumor microenvironment plays a pivotal role in fostering immune suppression and maintaining self-tolerance, which are crucial in developing and refining immunotherapy approaches. In our comprehensive review, we initially delve into the characteristics of the tumor microenvironment in HCC, elucidating the predominant immunosuppressive mechanisms at play and the biomarkers pivotal for tracking the disease progression and therapeutic ...

Boulder, Colo., USA: Chevron, a leading energy corporation committed to supporting educational initiatives in the geosciences, has announced a partnership with the Geological Society of America (GSA) to provide field trip grants, beginning with the organization’s annual meeting, GSA Connects 2024. This year’s meeting will take place in Anaheim, California, USA, 22–25 September. The GSA/Chevron Field Trip Grant aims to support students or early career professionals in attending field trips during GSA Connects. GSA’s field trips provide valuable hands-on learning experiences, networking opportunities, ...

Since cannabidiol (CBD), the non-intoxicating component of cannabis, was legalized in the United States by the 2018 Farm Bill, products containing the compound have flooded the consumer health sector. While there is a single FDA-approved medication containing CBD which can be used to treat rare forms of epilepsy, evidence for the efficacy of commercial CBD products, which generally contain low doses of CBD, is limited. However, this has not stopped their widespread and growing use. Now, a new study published in Cannabis ...

No parent wants to risk their child having a serious infection, least of all while still in the womb, but did you know that the immune response to a viral infection during pregnancy could also affect the development of the unborn offspring? Scientists from Harvard University in Cambridge, USA, have shown that immune reactions in pregnant mice are detected by a specific type of brain cell in the developing embryo and alter how genes are regulated in the brain – a change that persists in juvenile mice. Published today in the journal Development, this study provides ...

Many countries around the world are considering revising cannabis policies. A new study by a researcher at Carnegie Mellon University assessed cannabis use in the United States between 1979 and 2022, finding that a growing share of cannabis consumers report daily or near-daily use and that their numbers now exceed those of daily and near-daily alcohol drinkers. The study concludes that long-term trends in cannabis use parallel corresponding changes in policy over the same period. The study appears in Addiction. “The data come from survey self-reports, but the enormous changes in ...

New York, NY – The American Federation for Aging Research (AFAR), a national non-profit organization whose mission is to support and advance healthy aging through biomedical research, is pleased to recognize the exemplary contributions of Bérénice Benayoun, PhD, to the field of aging research through the 2024 Vincent Cristofalo Rising Star Award in Aging Research.  This award is named in honor of the late Dr. Cristofalo, who dedicated his career to aging research and encouraged young scientists to investigate important issues in the biology of aging. Established in 2008, the award ...

A research team has demonstrated for the first time a proof-of-concept tandem solar cell using antimony selenide as the bottom cell material and a wide-bandgap organic–inorganic hybrid perovskite material as the top cell material. The device achieved a power conversion efficiency of over 20 percent. This study shows that antimony selenide has great potential for bottom cell applications.   The research is published in the journal Energy Materials and Devices on March 4, 2024.   Photovoltaic technology, that harnesses sunlight and converts it into electricity, is popular because it provides a clean, renewable energy source. Scientists ...

This study is led by Professor Yan Wang (School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai, China). Her team found that the lack of MIR1 gene, which encodes mitochondrial phosphate carrier, can lead to severe virulence defects in Candida albicans.   In the Caenorhabditis elegans candidiasis model, the survival rate of the wild-type strain infected group dropped to about 20% at 120 h, while the survival rate of the mir1Δ/Δ-infected group remained about 90% at 120 h. Similar results were obtained in the murine model. None of the mice infected with mir1Δ/Δ mutant died during 21 days of ...

Spontaneous coagulation casting (SCC), a new type of colloidal forming process, has garnered significant attention since 2011 due to various advantages of a high bulk density and non-toxicity, as well as the ability to achieve dispersion and coagulation with very low additions (< 1 wt%) of copolymers of isobutylene and maleic anhydride (PIBM). Further research has revealed that the green bodies formed by this method are brittle, and the smaller the powder particle size used the more brittle the green bodies are. This paper reports ...

Background and Aims Olaparib is a selective poly (ADP-ribose) polymerase inhibitor. However, its clinical application is hindered by low solubility and undesired pharmacokinetic profiles (e.g., relatively short circulation). Therefore, the present study aims to exploit polymeric micelles as a safe solubilizer and nanocarrier of olaparib, in order to improve its solubility and pharmacokinetics.   Methods Poly (ε-caprolactone)-co-poly (benzyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate), i.e., benzyl-functionalized trimethylene carbonate)-b-poly (ethylene glycol) (P(CL-co-TMC-Bz)-PEG), was synthesized by ring-opening polymerization, ...