Oak Brook, IL – The June 2023 issue of SLAS Discovery contains one review article, five full-length articles and two technical briefs covering spheroid models, 3D cell high-throughput screening (HTS) applications for treating Alzheimer’s and other drug discovery research. In drug discovery, 3D cell models have emerged as more physiologically relevant than traditional 2D cell cultures in ex vivo models. As the complexity of patient-derived primary 3D cell cultures increases, so does the need for a supportive matrix for facilitating their formation. Featured in this month’s issue is the article “Comparison of two supporting matrices for patient-derived cancer ...

Oak Brook, IL – Ideas that were once inconceivable, such as generating human tissue for organ transplants, are quickly becoming a reality as bioprinting technology is rapidly advancing. The June special issue of SLAS Technology showcases the latest developments in the field of biotechnology with its collection of seven research articles. “With the continuous development of novel materials, fabrication techniques and bio-ink compositions, bioprinting is poised to revolutionize many aspects of medicine, from drug development to organ transplantation,” says SLAS Technology Editor-in-Chief Edward Kai-Hua Chow, Ph.D. (National University ...

INDIANAPOLIS – Mild cognitive impairment, which occurs in about one in six individuals in the U.S., age 65 and older, remains substantially underdiagnosed, especially in disadvantaged populations. Convened by the non-profit UsAgainstAlzheimer’s, The Brief Cognitive Assessment Work Group, is composed of 15 clinicians, researchers and health systems administrators from across the U.S. The group advocates for early detection of cognitive impairment to benefit both patients and caregivers by providing time to plan for future care, allowing preventive steps to potentially delay some symptoms as well as recognizing cognitive impairment due to a currently treatable condition. The ...

A review paper by researchers at the Beijing Institute of Technology summarized recent advancements and challenges in the use of cross-frequency coupling (CFC) for neuroscience and cyborg and bionic systems (CBS). The new review paper, published on May 31 in the journal Cyborg and Bionic Systems, provided an overview of the latest developments in CFC research, with emphasis on methodologies, neural mechanisms, and applications in CBS, especially clinical interventions. “CFC has gained great interest as an ...

Sports are a way in for people who want to build contacts with other people. Sports give you an opportunity to integrate and interact with people on an equal footing. For immigrants, sports can be the key that allows them to fit into a society. But how easy is it for people with strange names to join in the fun? That depends on how foreign sounding a person’s name is, and perhaps where the person lives. Because the results from the experiment were not the same throughout Scandinavia. Some are more similar than others. The rigged football experiment actually shows encouraging ...

The Vidalia onion is a trademarked variety of sweet onion that can only be grown in several counties in Georgia by law. These prized vegetables are currently threatened by the bacterial pathogen Pantoea ananatis, which severely damages the plant by rotting the onion bulbs and leaves. This results in substantial losses for onion growers in Georgia, as there are no disease resistant cultivars available. The plant toxin pantaphos, produced by the P. ananatis pathogen, causes the rotting symptoms in onion. More specifically, the eleven genes responsible ...

Nearly 4 million infants are born in the United States each year. Despite improvements in obstetric and perinatal care, infant mortality in the U.S. is of ongoing concern. The nation ranks No. 23 in the world for infant mortality rates with 5.4 deaths per 1,000 live births, with worse outcomes observed in Black infants compared to white infants. Now, new original research from Florida Atlantic University’s Schmidt College of Medicine and collaborators indicates that infant mortality alone may be insufficient as a health indicator. For the study, researchers explored time trends and racial inequities ...

(Toronto, June 28, 2023) With the release of the 2023 Journal Citation Reports™ (JCR) today, we first want to thank everyone who has contributed to our continued mission toward a more open world. Of our 34 open access journals, 14 now have a Journal Impact Factor (JIF)—that’s a 133% increase since last year, and we still have more journals launched in the last 2 years that won’t yet be relevant for metrics such as the JIF and CiteScore.   Eight of our journals now have a JIF: Interactive Journal of Medical Research - 2 JMIR ...

The UN’s International Maritime Organization (IMO) is actively contributing to the shipping industry being far off course from ever reaching its climate goals. In large part, this is because the organization lacks funding and expertise. Without strengthening the IMO, any transition of the enormous industry is hazily imaginable. This, according to the Copenhagen and Lund university researchers behind a new study of the organization. Three percent of the world's total greenhouse gas emissions is attributable to the shipping industry. And things remain headed in the wrong direction – with CO2 emissions from ships continuing to rise year after year. This has increased ...

Ikoma, Japan – The gastric corpus, which is a major component of the glandular stomach, is composed of parietal, chief, pit, and neck cells. Each of these specialized epithelial cells play an important role in digestion, and they are continuously replenished by new ones which are formed via the differentiation of stem cells. Defects in this process lead to gastric diseases such as intestinal metaplasia and gastric cancer. However, the underlying mechanisms responsible for the renewal and differentiation of stem cells, and ...

TORONTO, ON – American adults 65 years old and older living in warmer regions are more likely to have serious vision impairment than their peers living in cooler regions, according to a recent study published in the journal Ophthalmic Epidemiology.   Compared to those who lived in counties with average temperature of less than 50°F (< 10 °C), the odds of severe vision impairment were 14% higher for those who lived in counties with average temperature between 50-54.99°F, 24% higher for those between ...

Pregnant women may be better supported by trained dietitians to control weight gain during pregnancy, a new analysis of almost 100 studies shows.   The meta-analysis of almost 35,000 participants across 99 studies published in JAMA Network Open found that interventions from allied health professionals such as dietitians were the most beneficial for controlling gestational weight gain (GWG).   Spanning 30 years of international evidence, the research team including maternal health expert Professor Shakila Thangaratinam from the University of Birmingham identified that between 6 and 20 sessions on a one-to-one ...

A new meta-analysis (an analysis of past research) published by the scientific journal Addiction presents important findings that shed light on the effectiveness of psychological treatments for gambling problems. The analysis provides both positive and negative insights, including uncovering potential overstatements of the benefits associated with using cognitive-behavioural techniques (CBTs). Significantly more funds are essential to increase the rigor of studies and to improve understanding of treatment impact among individuals experiencing gambling problems. The analysis pooled the results of 29 randomised controlled trials of CBTs on reducing ...

In Politics, Lies and Conspiracy Theories, released today, Marcel Danesi Ph.D., a professor of semiotics and linguistic anthropology at the University of Toronto, Canada, analyzes the speeches of dictators including Mussolini, Stalin, Putin and Hitler, as well as prominent hate groups. His research finds there is one thing they all have in common: they all use dehumanizing metaphors to instill and propagate hatred of others. “The intent of such speech is to attack those who do not belong to the mainstream, such as racial minorities, or people of different sexual orientations,” says Danesi. Powerful language For example words like ‘pests’, ...

Children do better at maths when music is a key part of their lessons, an analysis of almost 50 years of research on the topic has revealed.    It is thought that music can make maths more enjoyable, keep students engaged and help any ease fear or anxiety they have about maths.  Motivation may be increased and pupils may appreciate maths more, the peer-reviewed article in Educational Studies details.     Techniques for integrating music into maths lessons range from clapping to pieces with different rhythms when learning numbers and fractions, to using ...

Kyoto, Japan -- Animal experimentation may not be a thing of the past just yet, but work on human iPS cell technology may someday grant emancipation for lab mice and other species. Renal proximal tubules are an essential part of our kidneys' ability to reabsorb vital substances into the bloodstream, such as albumin, before the conversion to urine. However, in order to pursue accurate testing and other applications, researchers have needed a quantitative evaluation system that simulates the function of ...

A technology for the three-dimensional integration of processing units and memory, as reported by researchers from Tokyo Tech, has achieved the highest attainable performance in the whole world, paving the way to faster and more efficient computing. Named "BBCube 3D," this innovative stacked architecture achieves higher data bandwidths than state-of-the-art memory technologies, while also minimizing the energy needed for bit access. In the present digital age, engineers and researchers keep coming up with new computer-assisted technologies that require higher data bandwidths between the processing units (or PUs, such as GPUs and CPUs) and memory chips. Some examples ...

Scientists are reporting the first evidence that our Earth and the universe around us are awash in a background of spacetime undulations called gravitational waves. The waves oscillate very slowly over years and even decades and are thought to originate primarily from pairs of supermassive black holes leisurely spiraling together before they merge.   The findings, reported in a series of papers in The Astrophysical Journal Letters, come from 15 years’ worth of observations made ...

University of Cambridge psychologists have developed the first validated “misinformation susceptibility test”: a quick two-minute quiz that gives a solid indication of how vulnerable a person is to being duped by the kind of fabricated news that floods online spaces.  The test, proven to work through a series of experiments involving over 8,000 participants taking place over two years, has been deployed by polling organisation YouGov to determine how susceptible Americans are to fake headlines.  The first survey to use the new 20-point test, called ‘MIST’ ...

Following 15 years of data collection in a galaxy-sized experiment, scientists have “heard” the perpetual chorus of gravitational waves rippling through our universe for the first time — and it’s louder than expected. The groundbreaking discovery was made by scientists with the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) who closely observed stars called pulsars that act as celestial metronomes. The newly detected gravitational waves — ripples in the fabric of space-time — are by far the most powerful ever measured: They carry roughly a million times as much energy as ...

You can't see or feel it, but everything around you — including your own body — is slowly shrinking and expanding. It's the weird, spacetime-warping effect of gravitational waves passing through our galaxy, according to a new study by a team of researchers with the U.S. National Science Foundation's NANOGrav Physics Frontiers Center. The findings published today in The Astrophysical Journal Letters are from the North American Nanohertz Observatory for Gravitational Waves (NANOGrav), a collaborative team of researchers from more than 50 institutions in the U.S. and abroad. The team ...

Astrophysicists using large radio telescopes to observe a collection of cosmic clocks in our Galaxy have found evidence for gravitational waves that oscillate with periods of years to decades, according to a set of papers published today in The Astrophysical Journal Letters. The gravitational-wave signal was observed in 15 years of data acquired by the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) Physics Frontiers Center (PFC), a collaboration of more than 190 scientists from the US and Canada who use pulsars ...

Astronomers using data collected by CSIRO’s Parkes radio telescope, Murriyang, have found their strongest evidence yet for low-frequency gravitational waves. For nearly 20 years the Parkes Pulsar Timing Array collaboration has monitored a set of rapidly spinning stars that pulse like a lighthouse, called pulsars. They are looking for nanosecond pulse delays caused by gravitational waves to provide further evidence for Einstein’s general theory of relativity and build on our understanding of the Universe. By ...

CORVALLIS, Ore. – Gravitational waves, ripples in the fabric of time-space predicted by Albert Einstein more than a century ago, are permeating the universe at low frequencies, according to a multiyear National Science Foundation project led by Oregon State University scientists. The findings appear in a collection of five papers authored by researchers from the NANOGrav Physics Frontier Center co-directed by Xavier Siemens, professor of physics in the OSU College of Science. Evidence of the gravitational waves, whose oscillations are ...

It’s a dilemma that many a regular bettor probably faces often -- deciding when to place a sports bet. In a study entitled “A statistical theory of optimal decision-making in sports betting,” Jacek Dmochowski, Associate Professor in the Grove School of Engineering at The City College of New York, provides the answer. His original finding appears in the journal PLOS One.  “The central finding of the work is that the objective in sports betting is to estimate the median outcome. Importantly, this is not the same as the average outcome,” said Dmochowski, whose expertise ...