Osteoarthritis (OA) is a debilitating joint disease which affects over 500 million people worldwide, with trends increasing as populations age. OA is caused by progressive, irreversible degeneration of joint cartilage, leading to pain, swelling and immobility in the affected joint. Current therapies focus on symptom relief but cannot restore degenerated cartilage. A potentially alternative treatment is the regeneration of cartilage from stem cells. Importantly, not all types of stem cells can make cartilage and earlier clinical trials with mesenchymal stem or stromal cells (MSCs) obtained did not convincingly show that MSCs make new cartilage when given to OA patients. In search for the ...

Writing a commentary in the 50th anniversary issue of Cell, FU Qiaomei and E. Andrew Bennett, both of the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) of the Chinese Academy of Sciences, explored the contribution of paleogenomics to our understanding of the evolution of modern humans. Given her numerous contributions to the field of human evolution through the analysis of both archaic and early modern human genomes, Prof. FU was invited by the journal Cell to write a commentary reviewing what we have learned about the evolution ...

Climate change is increasing the frequency and intensity of severe weather events, which may particularly endanger vulnerable populations such as the elderly. Researchers from Mass General Brigham and colleagues examined how weather disasters between 2011 and 2016 influenced healthcare delivery and mortality among Medicare beneficiaries in affected counties, finding that one week after major weather events, emergency department (ED) use and mortality remained elevated by 1.22% and 1.4%, respectively, from pre-disaster ...

For more than a decade, invasive Asian honeybees have defied evolutionary expectations and established a thriving population in North Queensland, much to the annoyance of the honey industry and biosecurity officials. Research published today in Current Biology has shown the species, Apis cerana, has overcome what is known as a genetic bottleneck to grow from a single swarm into a population of more than 10,000 colonies over a 10,000 square kilometre area – which is about the size of Greater Sydney. Co-lead author Dr Rosalyn Gloag from the University of Sydney School of Life and Environmental Sciences said: “Our study of this bee population shows that some species can ...

Several areas of the globe — including the Bay of Bengal, the Philippines, and the Caribbean Sea — are likely to experience record-breaking average surface air temperatures in the year period up to June 2024 as a result of the ongoing El Niño phenomenon. The modelling results, published in Scientific Reports, also suggest that there is an estimated 90 percent chance of record-breaking global mean surface temperatures occurring over the same period under a moderate or strong El Niño scenario. The El Niño-Southern Oscillation, centred ...

About The Study: This study of 536 participants identified changes in patient portal use over time and highlighted populations that had lower access to health information. The COVID-19 pandemic was associated with an increase in portal use. Sociodemographic disparities by sex and age were reduced, although disparities by health literacy widened. A brief validated health literacy measure may serve as a useful digital literacy screening tool to identify patients who need further support.  Authors: Esther Yoon, Ph.D., M.P.H., M.S., of Northwestern University in Chicago, is the corresponding ...

About The Study: The findings of this study of 34,500 patients suggest that racial and ethnic disparities in locally advanced rectal cancer treatment outcomes may be multifactorial, with an independent association with non-Hispanic Black race, suggesting unidentified biological variables or social determinants of health that warrant exploration.  Authors: Sanjeevani Arora, Ph.D., and Shannon M. Lynch, Ph.D., M.P.H., of the Fox Chase Cancer Center in Philadelphia, are the corresponding authors.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamanetworkopen.2024.0044) Editor’s ...

Today, the Chan Zuckerberg Initiative (CZI) announced four multi-year grants that will bring together regional labs in California, the Mid-Atlantic, and the Research Triangle in North Carolina to explore the frontiers of genomics, cell biology, and synthetic biology by developing new measurement technologies. These projects will focus on developing technologies to engineer cell and tissue models, exploring cellular responses to genetic and environmental stressors, understanding RNA's role in metabolism, and more.  “To unravel the mysteries of the cell, we need new technologies, and the Exploratory Cell Networks grants support early-stage ...

Diabetes accelerates the development of atherosclerosis, increasing the incidence of cardiovascular events. In atherosclerosis, immune cells called macrophages release molecules such as chemokines and cytokines, causing inflammation and leading to arterial plaque formation. However, significant gaps persist in understanding the exact molecular mechanisms controlling this increased inflammatory response in individuals with diabetes. In a new, preclinical study, researchers from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, identified a long non-coding RNA (lncRNA) sequence that could help them unravel the ...

LA JOLLA, CA—Roughly 4 billion years ago, Earth was developing conditions suitable for life. Origin-of-life scientists often wonder if the type of chemistry found on the early Earth was similar to what life requires today. They know that spherical collections of fats, called protocells, were the precursor to cells during this emergence of life. But how did simple protocells first arise and diversify to eventually lead to life on Earth? Now, Scripps Research scientists have discovered one plausible pathway for how protocells may have first formed and chemically ...

– By Will Ferguson A greater understanding of how plants and microbes work together to store vast amounts of atmospheric carbon in the soil will help in the design of better bioenergy crops for the fight against climate change.  Deciphering the mechanics of this mutually beneficial relationship is challenging, however, as conditions in nature are extremely difficult for scientists to replicate in the laboratory. To address this challenge, researchers at Lawrence Berkeley National Laboratory (Berkeley Lab) created fabricated ecosystems or EcoFABs.  In a new paper in Science Advances, they ...

Digital Science has awarded two new Catalyst Grants of £25,000 each to innovative AI-based technology ideas aimed at advancing global research. The winners will use the funding to develop their ideas, which include using AI to alleviate the burden on researchers of applying for research funding, and to predict research impact. The winning applications from Digital Science’s 2023 Catalyst Grant round announced today are: Atom – Tomer du Sautoy (co-founder and CEO) and Hamilton Evans (co-founder and ...

Fonio (Digitaria exilis), a type of millet, is the oldest indigenous crop in West Africa and one of the fastest maturing cereals. Despite its low yield, the combination of quick maturation and drought tolerance and its ability to thrive in poor soils make it a useful model for understanding how cereals can adapt to future climate change conditions. Nutritionally, fonio is comparable to other millets, says KAUST researcher Naheed Tabassum, but yields are much lower than the major cereal crops rice, maize and wheat. Tabassum believes fonio could complement staple crops amid climate change and desertification ...

An international team of astronomers — including Clemson University astrophysicist Dieter Hartmann — obtained observational evidence for the creation of rare heavy elements in the aftermath of a cataclysmic explosion triggered by the merger of two neutron stars. The massive explosion unleashed a gamma-ray burst, GRB230307A, the second brightest in 50 years of observations and about 1,000 times brighter than a typical gamma-ray burst. GRB230307A was first detected by NASA’s Fermi Gamma-Ray Space Telescope on March 7, 2023. Using multiple space- and ground-based ...

The metabolic process of bilirubin has been a focus in medical research since the abnormal accumulation of bilirubin has been found to be associated with a variety of diseases. Bilirubin is a substance produced by the breakdown of aging or damaged red blood cells, and its effective removal is essential for human health.  A research team led by Prof. CHEN Yuxing and Prof. ZHOU Congzhao from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences has revealed the three-dimensional structure and working mechanism of the human bilirubin transporter ABCC2. The study was published ...

The metabolic process of bilirubin has been a focus in medical research since the abnormal accumulation of bilirubin has been found to be associated with a variety of diseases. Bilirubin is a substance produced by the breakdown of aging or damaged red blood cells, and its effective removal is essential for human health.  A research team led by Prof. CHEN Yuxing and Prof. ZHOU Congzhao from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences has revealed ...

A new species and genus of fairy lantern, tiny glass-like white plants that feed on fungi, has been discovered in Japan. In the country renowned for its extensive flora research, the discovery of a new plant genus is extremely rare and has not occurred in almost 100 years. Fairy lanterns, or Thismiaceae as they are known to botany, are very unusual plants found mainly in tropical but also in subtropical and temperate regions. First of all, they are not green and do not engage in photosynthesis, but rather feed on fungal mycelia in the ground. As a consequence, they are often hidden under fallen leaves and only for a brief period produce above-ground flowers that look like glasswork. The ...

PHOENIX, February 29, 2024 — Research on patient-centered treatment of head and neck cancers will be presented at the 2024 Multidisciplinary Head and Neck Cancers Symposium, which takes place in Phoenix and online today through March 2. Media registration is available via our press kit, and general registration is available via the meeting website. Seven high-impact studies recommended by symposium leadership for media are noted below. All abstracts are available online. Experts are available to provide outside commentary and perspective on research at the meeting; ...

Over the past two decades, the immune system has attracted increasing attention for its role in fighting cancer. As researchers have learned more and more about the cancer-immune system interplay, several antitumor immunotherapies have become FDA-approved and are now regularly used to treat multiple cancer types. Yet despite these advances, much remains unknown about how the immune system fights cancer — and about immunity in general, said Martin LaFleur, a postdoctoral fellow in the laboratory of Arlene ...

In a first-of-its-kind development, UBC Okanagan researchers, in collaboration with Drexel University, have created a new compound that can be used to 3D print telecommunication antennas and other connectivity devices. These 3D printed products, created by combining a two-dimensional compound called MXenes with a polymer, can be used as an alternative for metallic counterparts and can make a vast improvement in communication technology including elements such as antennas, waveguides and filters. Waveguides are everywhere, yet most people don’t know what they are, says Dr. Mohammad Zarifi, a researcher in UBC Okanagan’s Microelectronics and Gigahertz ...

An estimated 4 to 8 million older adults with mild cognitive impairment are currently driving in the United States, and one-third of them will develop dementia within five years. Individuals with progressive dementias are eventually unable to drive safely, yet many remain unaware of their cognitive decline. Currently, screening and evaluation services for driving can only test a small number of individuals with cognitive concerns, missing many who need to know if they require treatment. Nursing, engineering and neuropsychology researchers at Florida Atlantic University are testing and evaluating a readily and rapidly available, unobtrusive in-vehicle sensing ...

(LOS ANGELES) – February 29, 2024 - The Terasaki Institute for Biomedical Innovation (TIBI) is pleased to announce their selection of Professor Nicholas A. Peppas of The University of Texas at Austin as the recipient of the 2024 Paul Terasaki Distinguished Scientist Innovation Award. The award will be presented at TIBI’s 2nd annual Terasaki Innovation Summit, to be held March 27-29, 2024, at the UCLA Meyer & Renee Luskin Conference Center. The award was created in memory of Dr. Paul I. Terasaki, a pioneer in organ transplant research and innovation. It recognizes outstanding achievement in the field of biomedical ...

(LOS ANGELES) – February 29, 2024 - The Terasaki Institute for Biomedical Innovation (TIBI) is pleased to announce their selections of Assistant Professors Amir Manbachi of Johns Hopkins University and Ritu Raman of the Massachusetts Institute of Technology (MIT) as the recipients of the 2024 Hisako Terasaki Young Innovator Awards. The awards will be presented at TIBI’s 2nd annual Terasaki Innovation Summit, to be held March 27-29, 2024, at the UCLA Meyer & Renee Luskin Conference Center. The award was created in memory of Hisako Terasaki, philanthropist, accomplished artist, and wife ...

The latest Canada’s Food Guide presents a paradigm shift in nutrition advice, nixing traditional food groups, including meat and dairy, and stressing the importance of plant-based proteins. Yet, the full implications of replacing animal with plant protein foods in Canadians’ diets are unknown. New research at McGill University in collaboration with the London School of Hygiene & Tropical Medicine provides compelling evidence that partially substituting animal with plant protein foods can increase life expectancy and decrease greenhouse gas emissions. Importantly, ...

More than ever before, there is a growing interest in dedicating resources to stop the loss of biodiversity, as recently exemplified by the Kunming-Montreal Global Biodiversity Framework (GBF) decided at COP15 in December 2022. The GBF focuses on understanding why biodiversity is declining and what actions are needed to reverse this trend. However, according to researchers at McGill University, implementing the plan is challenging because information about biodiversity changes is not evenly available everywhere, and is uncertain in many places. With the available data, can the ...