The ongoing COVID-19 pandemic caused by SARS-CoV-2 has caused serious damage to public health and the global economy, and one strategy to combat COVID-19 has been the development of broadly neutralizing antibodies for prophylactic and therapeutic use. The most emergency-use authorized (EUA) therapeutic monoclonal antibodies, are more likely to lose their neutralizing activities as the viral epitopes (e.g. the receptor-binding domain, RBD) within spike protein of SARS-CoV-2 they target are more prone to mutate. By contrast, the S2 subunit of spike protein, has a much lower frequency of mutation than ...

Researchers have discovered how “leaky” mitochondria – the powerhouses of our cells – can drive harmful inflammation responsible for diseases such as lupus and rheumatoid arthritis. Scientists may be able to leverage the findings to develop better treatments for those diseases, improve our ability to fight off viruses and even slow aging. The new discovery reveals how genetic material can escape from our cellular batteries, known as mitochondria, and prompt the body to launch a damaging immune response. By developing therapies to target this process, doctors may one day be able to stop the harmful inflammation ...

To find out how planetary systems such as our Solar System form, an international research team including scientists from the University of Cologne studied a stellar nursery, the Orion Nebula, using the James Webb Space Telescope (JWST). By observing a protoplanetary disc named d203-506, they discovered the key role massive stars play in the formation of planetary systems that are less than a million years old. The study, led by Dr Olivier Berné from the National Centre for Scientific Research (CNRS) ...

A research paper by scientists at Bournemouth University proposed a randomized pilot trial, which aimed to determine the effect of an intervention where outdoor walking distance is used as a goal to increase daily activity of older adults using a commercial activity monitor at 3 to 6 months post total hip replacement (THR). The new research paper, published on Nov. 30 in the journal Cyborg and Bionic Systems, indicated the participants in the intervention group had higher activity levels after THR, compared to those in the control group. The Cohen’s effect ...

Zinc-air batteries are an inexpensive, powerful battery alternative that can be used on the small scale to power electronics or on the large scale for electric vehicles or energy storage. These batteries work when oxygen from the air oxidizes zinc, but the difficulty in oxygen activation which degrades battery performance has prevented their wide commercial adoption. Information presented in a paper published in Carbon Future on 19 January shows how fullerene- metalloporphyrin derived carbon materials as catalysts can improve the performance and stability of zinc-air batteries. “The sluggish kinetic characteristics caused by the difficulty ...

Highlights: A chemical called Bisphenol A (BPA) is used to make many durable plastics and resins. Previous studies suggest high BPA exposure can increase health risks and change gut microbiome structure. Researchers investigated links between BPA exposure, obesity and the gut microbiome. The study found that normal-weight children had more unique bacteria taxa, which may help degrade BPA. The findings may help point to microbial strains that neutralize BPA in the gut. Washington, D.C. — March 1, 2024 — A synthetic chemical called Bisphenol A, or BPA, is widely used in the production of durable plastic products including eyewear, ...

Community leaders and administrators now have a more powerful tool for understanding their communities’ economic strengths and vulnerabilities, thanks to the newly enhanced and cleverly monikered National Economic Resilience Data Explorer (NERDE). The online data portal’s enhanced second edition makes it easier for users to create economic development plans, improve resilience and apply for economic assistance and grants. NERDE first launched as a partnership between the U.S. Department of Energy’s (DOE) Argonne National ...

The most recent COVID-19 booster shot reduces adults’ risk of moderate or severe COVID by more than half, according to a new nationwide data study from September 2023 through January 2024, a period of JN.1 variant dominance. The new study is one of the first to evaluate protection provided by the updated shot against COVID-19-associated emergency department and urgent care visits (markers for moderate disease) and against hospitalizations (a marker for severe disease), in individuals 18 and older, due to JN.1, the most ...

Mendelian randomization, a powerful tool in medical research, helps us understand whether certain factors truly cause disease. This technique uses genetic variations as "natural experiments" to reveal cause-and-effect relationships. However, choosing the proper genetic variations is crucial for accurate results. Think of a train network where the genetic variation is the starting point, the exposure is a station, and the disease is the destination. The train must pass through the exposure station en route to the disease. This represents the critical assumption of Mendelian randomization: ...

Penn Engineers have developed a new means of targeting the lungs with lipid nanoparticles (LNPs), the miniscule capsules used by the Moderna and Pfizer-BioNTech COVID-19 vaccines to deliver mRNA, opening the door to novel treatments for pulmonary diseases like cystic fibrosis.  In a paper in Nature Communications, Michael J. Mitchell, Associate Professor in the Department of Bioengineering, demonstrates a new method for efficiently determining which LNPs are likely to bind to the lungs, rather than the liver. “The way the liver is designed,” says Mitchell, “LNPs tend to filter into hepatic cells, and struggle ...

The question of where the boundary between classical and quantum physics lies is one of the longest-standing pursuits of modern scientific research and in new research published today, scientists demonstrate a novel platform that could help us find an answer.   The laws of quantum physics govern the behaviour of particles at miniscule scales, leading to phenomena such as quantum entanglement, where the properties of entangled particles become inextricably linked in ways that cannot be explained by classical physics. Research in quantum physics ...

New findings reveal that the body undergoes significant, systematic changes across multiple organs during prolonged periods of fasting. The results demonstrate evidence of health benefits beyond weight loss, but also show that any potentially health-altering changes appear to occur only after three days without food.  The study, published today in Nature Metabolism, advances our understanding of what’s happening across the body after prolonged periods without food.   By identifying the potential health benefits from fasting ...

The microbiome can identify those who benefit from combination immunotherapy across multiple different cancers, including rare gynaecological cancers, biliary tract cancers and melanoma. Researchers from the Wellcome Sanger Institute, the Olivia Newton-John Cancer Research Institute in Australia, and collaborators, have identified specific strains of bacteria that are linked with a positive response to combination immunotherapy in the largest study of its kind. The study, published today (1 March) in Nature Medicine, details a signature collection of microorganisms in an individual’s gut bacteria that may help identify those who would benefit from combination immunotherapy and ...

A study published today in Nature Nanotechnology shows that similarly charged particles can sometimes attract, rather than repel. The team found that like-charged particles suspended in liquids can attract one another at long-range, depending on the solvent and the sign of the charge. The study has immediate implications for processes that involve interactions in solution across various length-scales, including self-assembly, crystallisation, and phase separation. ‘Opposites charges attract; like charges repel’ is a fundamental principle of basic physics. But a new study from Oxford University, published today in Nature Nanotechnology, has demonstrated that similarly ...

In this study, we determined nine genomes of Japanese wolves and 11 genomes of modern Japanese dogs at high coverage and analyzed with one hundred dog and wolf genomes in the public database. The analyses showed that 1) the Japanese wolf was a unique subspecies of the gray wolf that is genetically distinct from both extant and ancient gray wolves known to date, 2) the Japanese wolf is most closely related to the monophyletic group of dogs. Furthermore, 3) Japanese wolf ancestry has introgressed into the ancestor of East Eurasian dogs at an early stage of the dog’s history ...

Brown bears foraging for food in the Shiretoko Peninsula of Hokkaido, Japan, have been disrupting tree growth in artificial conifer forests, according to a new study. Researchers compared soil and tree samples from human-forested plots with samples from natural forests. They found that the bears’ digging for cicada nymphs damaged tree roots and altered the nitrogen content of the soil, which in turn limited the diameter growth of trees. The phenomena of bears digging for cicadas, an unusual food source, appears to be restricted to human-planted conifer forest; diversely vegetated natural forest ...

Reconstructing a 3D face from visuals is crucial for digital face modeling and manipulation. Traditional methods predominantly depend on RGB images, which are susceptible to lighting variations and offer only 2D information. In contrast, depth images, resistant to lighting changes, directly capture 3D data, offering a potential solution for robust reconstructions. Recent studies have turned to deep learning for more robust reconstruction from depth data; however, the scarcity of real depth images with accurate 3D facial labels has hindered the training process. Attempts to use auto-synthesized data for training have met limitations ...

Assistant Professor Takahiro Kosugi of Institute for Molecular Science, assistant Professor Yoshiaki Kamada at National Institute for Basic Biology, and colleagues have developed an advanced molecular cell biology approach by integrating computational redesigning of protein complexes based on the predicted three-dimensional structure into yeast genetics. They revealed that two types of protein complexes in yeast, which were thought to have the same function, play distinct roles in cellular environmental response and lifespan. Furthermore, ...

Fiber, as the wearable material with the longest application in the history of humankind, is currently an ideal substrate for wearable devices due to its excellent breathability, flexibility, and ability to adapt perfectly to the 3D irregular shape of the human body. As a means of visualization in the field of functional fibers, light-emitting fiber breaks the rigidity of the traditional display interface and is expected to become an emerging interaction interface. The current commercial light-emitting fibers are polymer optical fibers and Corning® Fibrance® light-diffusing fibers. These fibers ...

The General Medical Council (GMC) should revise its terminology regarding international medical graduates (IMGs) in the UK, argues a new commentary published in the Journal of the Royal Society of Medicine (JRSM). The existing terminology used by the GMC fails to encompass the full spectrum of doctors facing challenges in the UK medical workforce, according to the paper’s author, Professor Mo Al-Haddad of Queen Elizabeth University Hospital, Glasgow. Notably, he says, the GMC's definition of IMGs overlooks ...

A new study from experts at the University of Exeter has found that a widely used test for prostate cancer may leave black men at increased risk of overdiagnosis. Prostate-specific antigen (PSA) testing is routinely used as the first step in the UK to investigate men with urinary symptoms such as blood in urine or urinating very frequently. Men aged over 50 years without symptoms are also able to request the blood test from their GP. The new study, published in BMC Medicine, sought to investigate the performance of the PSA test in identifying prostate cancer among men ...

Niigata, Japan –Dialysis patients often develop dialysis-related amyloidosis and exhibit bone and joint disorders that impair their activity of daily living (Figure 1). Blood purification devices consisting of hexadecyl-immobilized cellulose beads aimed at removing the precursor protein, β2- microglobulin (β2-m), are used in the treatment of dialysis-related amyloidosis. Dr. Yamamoto et al. investigated that comprehensive analysis of proteins adsorbed onto blood purification devices revealed the identification of 200 types of proteins, including β2-m. ...

Magnetite, a tiny particle found in air pollution, can induce signs and symptoms of Alzheimer’s disease, new research suggests. Alzheimer’s disease, a type of dementia, leads to memory loss, cognitive decline, and a marked reduction in quality of life. It impacts millions globally and is a leading cause of death in older individuals. The study, Neurodegenerative effects of air pollutant particles: Biological mechanisms implicated for early-onset Alzheimer’s disease, led by Associate Professor Cindy Gunawan and Associate Professor Kristine McGrath from the University of Technology Sydney (UTS) was recently published in Environment ...

A patient with gastrointestinal problems pays his doctor a visit. The doctor orders a stool test that will measure fecal bile acids, compounds made by the liver that can also be modified by the intestinal microbiome and are known for facilitating digestion and absorption of lipids or fats in the small intestine. Bile acid profiles are altered in several gastrointestinal conditions, including irritable bowel syndrome, Crohn’s disease, and several forms of diarrhea, colitis and some bacterial ...

The loneliness often experienced by older people in our society has a negative effect on their physical health, according to researchers from Amsterdam UMC and the University of Glasgow. Emiel Hoogendijk, epidemiologist at Amsterdam Public Health, analysed research results from more than 130 studies and found that loneliness led to an increase in physical frailty, which in turn increases the risk of adverse health outcomes such as depression, falls and cognitive decline. These results are published today in The Lancet Healthy Longevity.   "Recently, ...