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Hepatic hydrogen sulfide levels are reduced in mouse model of progeria

Hepatic hydrogen sulfide levels are reduced in mouse model of progeria
2023-07-11
“To date, no studies have directly measured [hydrogen sulfide] production in Hutchinson-Gilford Progeria Syndrome [...]” BUFFALO, NY- July 11, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 12, entitled, “Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndrome.” Hutchinson-Gilford progeria syndrome (HGPS) is a rare ...

Missing a rare cause of hereditary cancer

Missing a rare cause of hereditary cancer
2023-07-11
New research from Cedars-Sinai Cancer investigators could warrant reconsideration of current screening guidelines to include a poorly recognized cause of Lynch syndrome, the most common cause of hereditary colorectal and endometrial cancers. Their study, published today in the JNCCN—Journal of the National Comprehensive Cancer Network, concluded that the guidelines leave a significant number of patients undiagnosed. “When patients with Lynch syndrome—whose first cancers generally appear at an early age—aren’t diagnosed promptly, they don’t get appropriate follow-up or surveillance,” said Megan Hitchins, ...

U of M Medical School receives DARPA award to develop detection tools for early symptoms of depression, psychosis and suicidality

2023-07-11
MINNEAPOLIS/ST. PAUL (07/11/2023) — Researchers at the University of Minnesota Medical School recently received a four-year award from the Defense Advanced Research Projects Agency’s (DARPA’s) Neural Evidence Aggregation Tool program. The goal of their project— titled Fast, Reliable Electrical Unconscious Detection (FREUD)—is to develop tools to better detect early symptoms of depression, psychosis and suicidality, with the intent that treatment can be started as early in a condition’s trajectory as possible. “It’s exactly those early moments when getting someone therapy or mental health services could save their life or ...

Research aims to identify better COPD diagnosis in African American patients

2023-07-11
DENVER — Recently published research suggests that despite showing clear symptoms of chronic obstructive pulmonary disease (COPD), many African Americans are not officially diagnosed with the disease due to flaws in diagnosis methods.  The Research was led by National Jewish Health and recently published in the Journal of General Internal Medicine from the COPDGene study.  Fixed-ratio spirometry, a standard method of measuring respiratory capacity, has long been used as a method of detecting COPD. ...

With a comfort promise, new clinic aims to eliminate pain in kids

2023-07-11
Each year, too many kids in the East Bay suffer needlessly from pain related to long-term serious illness, including migraines, joint and abdominal pain, sickle cell anemia and more. A new UCSF Health pain clinic in Walnut Creek is opening to provide relief. The new clinic extends the reach of the Stad Center for Pediatric Pain, Palliative & Integrative Medicine beyond UCSF Benioff Children’s Hospitals in San Francisco and Oakland. The Center is one of the nation’s most innovative and comprehensive integrative ...

Potential targets to delay motor aging revealed by C. elegans genome-wide screen

Potential targets to delay motor aging revealed by C. elegans genome-wide screen
2023-07-11
Genome-wide screen in the nematode Caenorhabditis elegans reveals potential targets to delay motor aging, including the phosphatidylinositol 3-kinase VPS-34; genetic and pharmacological partial inhibition of VPS-34 improves neurotransmission and muscle integrity through increased PI(3)P-PI-PI(4)P conversion, ameliorating motor aging in both worms and mice. ##### In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology:   http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002165 Article ...

Scientists build a healthy dietary pattern using ultra-processed foods

2023-07-11
GRAND FORKS, N.D., July 11, 2023   ̶  Scientists at the USDA Agricultural Research Service’s (ARS) Grand Forks Human Nutrition Research Center led a study that demonstrates it is possible to build a healthy diet with 91 percent of the calories coming from ultra-processed foods (as classified using the NOVA scale) while still following the recommendations from the 2020-2025 Dietary Guidelines for Americans (DGA). The study highlights the versatility of using DGA recommendations in constructing healthy menus. “The study is a proof-of-concept that shows a more balanced view of healthy ...

Low-glucose sensor in the brain promotes blood glucose balance

2023-07-11
The body’s blood glucose level needs to be maintained in a relatively narrow range. It cannot be too high, as it can lead to diabetes, and it cannot be too low because it can cause fainting or even death. “There are many glucose-sensing neurons in the brain that are thought to actively participate in detecting small changes of glucose levels in the body and then trigger responses accordingly to return the level to a healthy range,” said Dr. Yong Xu, professor of pediatrics – nutrition, ...

New study is first to find exposure to neurotoxic rodenticide bromethalin in birds of prey

2023-07-11
In 2020, Tufts Wildlife Clinic Director Maureen Murray, V03, published a study that showed 100% of red-tailed hawks tested at the clinic were positive for exposure to anticoagulant rodenticides (ARs). Such exposure occurs when these chemicals are used to kill mice or rats, which eat the poison, and the birds eat the poisoned prey. Now, Murray is expanding that research with a new study published recently in the journal Environmental Pollution, which found that another type of rodenticide—a neurotoxicant called bromethalin—also ...

Changing the way we deliver immune-based cancer drugs could reduce costs by 14%

Changing the way we deliver immune-based cancer drugs could reduce costs by 14%
2023-07-11
ANN ARBOR, Michigan — A new analysis finds that up to millions of dollars could be saved annually on cancer immunotherapy treatments across the Veterans Health Administration by reconsidering how those drugs are delivered.   It’s a concept that could be applied to all cancer centers nationwide. Immune checkpoint inhibitors were initially tested and approved at weight-based dosages but then moved to one-size-fits-all flat doses, in part to reduce drug waste. But researchers from the University of Michigan Rogel Cancer Center found that if vials intended for a single ...

Damage to gut bacteria linked with chemo-induced weight gain in breast cancer patients

2023-07-11
EDMONTON — Researchers have found a link between chemotherapy-induced changes to gut bacteria and the unhealthy weight gain seen in breast cancer patients, pointing the way to potentially help survivors avoid obesity-related illness later in their lives.  In newly published research, a team at the University of Alberta found that the patients treated with chemotherapy lost muscle mass and gained abdominal fat, which has been linked to heart disease, diabetes and even cancer recurrence. The chemo patients also exhibited signs of inflammation and significant changes to the number and variety of bacteria in their guts. “Changes in the bacterial populations ...

Nurse researcher casts new light on bruise detection in patients with darker skin tones

2023-07-11
July 11, 2023 – A leading forensic nurse researcher has developed new approaches to detecting bruises in patients with darker skin tones – thus helping to overcome barriers to diagnosing injuries in patients of color, according to a special article on nurse innovators in the July issue  of the American Journal of Nursing (AJN). The journal is published in the Lippincott portfolio by Wolters Kluwer. The article highlights the work of Katherine Scafide, PhD, RN, of George Mason University, Fairfax, Va., whose "nonconventional program ...

Warmer weather makes venomous snake bites more likely, especially in spring

Warmer weather makes venomous snake bites more likely, especially in spring
2023-07-11
American Geophysical Union Press Release No. 23-27 For Immediate Release 11 July 2023 This press release is available online at: https://news.agu.org/press-release/warmer-weather-makes-venomous-snake-bites-more-likely-especially-in-spring AGU press contact: Rebecca Dzombak, news@agu.org, +1 (202) 777-7492 (UTC-4 hours) Emory University press contact: Rob Spahr, rob.spahr@emory.edu (UTC-4 hours) Interview requests should be sent to Rob. WASHINGTON — Climate change is not only making Georgia hotter but also increasing the likelihood of snake bite, according to a new study. Every degree Celsius of daily temperature increase corresponds with about ...

Aston University researcher turns one of the basic rules of construction upside down

Aston University researcher turns one of the basic rules of construction upside down
2023-07-11
1675 theory states a hanging chain mirrors shape of an upstanding rigid arch Research from Aston University shows that this common-held belief is incorrect Explained using transition from Newtonian to Lagrangian mechanics and mathematical rigour.     Monday 10 July 2023 | Birmingham, UK   An Aston University researcher has turned one of the basic rules of construction on its head.   For centuries a hanging chain has been used as an example to explain how masonry arches stand.   Structural engineers are familiar ...

Software creates entirely new views from existing video

2023-07-11
ITHACA, N.Y. -- Filmmakers may soon be able to stabilize shaky video, change viewpoints and create freeze-frame, zoom and slow-motion effects – without shooting any new footage – thanks to an algorithm developed by researchers at Cornell University and Google Research. The software, called DynIBar, synthesizes new views using pixel information from the original video, and even works with moving objects and unstable camerawork. The work is a major advance over previous efforts, which ...

Working to make steel greener, cleaner

Working to make steel greener, cleaner
2023-07-11
CLEVELAND–Case Western Reserve University chemical engineer Rohan Akolkar is leading a research team working to develop a new zero-carbon, electrochemical process to produce iron metal from ore.   If successful, the project could be a first step toward eliminating harmful greenhouse gas emissions by eventually replacing century-old, blast-furnace ironmaking with a new electrolytic-iron production process.   Reducing iron ore to metal is carbon- and energy-intensive, leading to significant carbon-dioxide emissions that drive global warming.   “We don’t use carbon at all in our process, so ...

Crawford Lake chosen as the primary marker to identify the start of the Anthropocene epoch

Crawford Lake chosen as the primary marker to identify the start of the Anthropocene epoch
2023-07-11
EMBARGOED: Not for Release Until 18:00 BST 11 July 2023. Crawford Lake chosen as the primary marker to identify the start of the Anthropocene epoch Anthropocene proposes human activity has become a dominant influence on the planet, especially since the mid-twentieth century Nuclear bomb tests have left a ‘stark plutonium fingerprint’ of this change in human activity Evidence from Crawford Lake in Canada and 12 secondary locations will be assessed by International Commission on Stratigraphy to decide if we have entered a new geological era Today [11 July 2023] an international team of researchers has chosen the location ...

New study finds U.S. military veterans living in discriminatory ‘redlined’ areas suffered higher rates of cardiovascular disease

2023-07-11
CLEVELAND—U.S. military veterans who lived in what were once known as “redlined” areas had a higher risk for heart attacks and other cardiovascular issues, according to a new study by researchers at Case Western Reserve University, University Hospitals and the Cleveland VA Medical Center. In the 1930s, the federal government-sponsored Homeowners’ Loan Corp. (HOLC) established maps of U.S. neighborhoods that identified levels of mortgage risk. This practice led to disinvestments and segregation in “redlined” neighborhoods. Judicial rulings--and, later, federal legislation--prohibited such government practices, but research has shown their ...

$1.5 million donation supports research on effects of psychedelic DMT on the brain

$1.5 million donation supports research on effects of psychedelic DMT on the brain
2023-07-11
One of the most powerful psychedelics known, N,N-dimethyltryptamine (DMT) has been described as causing imaginative visuals akin to the dream state. It is typically consumed on its own or in ayahuasca, a ceremonial brew that has been used for spiritual and visionary purposes by indigenous cultures for centuries. Some have expressed that DMT helped address psychological ailments such as depression and addiction, promoting emotional well-being. However, the way that DMT impacts the brain, body and health is largely unknown. A ...

Carbon taxes that focus on luxury consumption are fairer than those that tax all emissions equally

Carbon taxes that focus on luxury consumption are fairer than those that tax all emissions equally
2023-07-11
Not all carbon emissions are made for the same reason—they range from more essential purposes like heating a home to nonessential “luxury” activities like leisure travel. However, proposals for the implementations of carbon taxes tend to apply to all emissions at an equal rate. This can give rise to and exacerbate inequalities. A new analysis published on July 11 in the journal One Earth suggests taxing luxury carbon emissions at a higher rate instead; if all 88 countries analyzed in this study adopted the luxury-focused policy, this would achieve 75% of the emissions reduction needed to reach the Paris Agreement’s goal of limiting climate change ...

Thermal cloak passively keeps electric vehicles cool in the summer and warm in the winter

Thermal cloak passively keeps electric vehicles cool in the summer and warm in the winter
2023-07-11
When an electric vehicle is parked outside, its temperature can swing wildly from day to night and season to season, which can lead to deterioration of the battery. To dampen these fluctuations and extend the battery’s lifespan, researchers have designed an all-season thermal cloak that can cool an electric vehicle by 8°C on a hot day and warm it by 6.8°C at night. The cloak, made predominantly of silica and aluminum, can do so passively without outside energy input and operates without any modification between hot or cold weather. This prototype is described July 11 in the newly launched Device, an application-oriented sister journal ...

Breaking into tears with microrheology to design custom eye drops

Breaking into tears with microrheology to design custom eye drops
2023-07-11
WASHINGTON, July 11, 2023 – Compared to artificial tears, or eye drops, human tears are significantly more complex liquids, with a wide range of components including lipids, carbohydrates, proteins, water, and salt. It is this complex mixture that gives tears the perfect thickness and ability to moisturize the eye, a design that is hard to replicate with fewer ingredients. In Physics of Fluids, from AIP Publishing, Vega et al. researched human tears at the micron level to reveal new ways of customizing artificial tears to address individual symptoms of dry eye disease. The detailed insights they gained about the composition and behavior ...

Unborn babies use ‘greedy’ gene from dads to ‘remote-control’ mums into feeding them extra food

Unborn babies use ‘greedy’ gene from dads to ‘remote-control’ mums into feeding them extra food
2023-07-11
Unborn babies use ‘greedy’ gene from dads to ‘remote-control’ mums into feeding them extra food Fetuses use a copy of a gene inherited from their dad to force their mum to release as much nutrients as possible during pregnancy, Cambridge scientists have discovered. The unborn baby ‘remote controls’ its mother’s metabolism so the two are in a nutritional tug of war. The mother’s body wants the baby to survive but needs to keep enough glucose and fats circulating in her system for her own health, to be able to deliver ...

The science behind skipping stones

The science behind skipping stones
2023-07-11
WASHINGTON, July 11, 2023 – Inspired by the need to safeguard marine animals and promote sustainable solutions within marine environments, an interdisciplinary team of researchers from King Abdullah University of Science and Technology in Saudi Arabia and Sofia University in Bulgaria are delving into the hydrodynamics of buoyant objects at the air-water interface. By studying these dynamics, their goal is to expand the understanding of fluid hydrodynamics and complex surface interactions – and advance fields such as the design and performance of marine engineering systems, buoy systems, and ...

Association of racial discrimination with obesity in children and adolescents

2023-07-11
About The Study: The findings of this study suggest that personally mediated racial discrimination may be a risk factor for developing obesity in children and adolescents, above and beyond socioeconomic status. The results highlight the need for a multifaceted approach to address racial discrimination and its impact on the health of children and adolescents. Authors: Adolfo G. Cuevas, Ph.D., of the New York University School of Global Public Health in New York, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2023.22839) Editor’s Note: Please ...
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