PCB2DG, a polyphenol with anti-inflammatory properties, works by targeting and directly interacting with the major glutamine transporter protein, alanine serine cysteine transporter 2 (ASCT2), to inhibit the uptake of glutamine, an important amino acid found in the blood. This reduction of intracellular glutamine accumulation in CD4+ T cells also reduces the production of interferon-gamma, or IFN-γ showing promise in the future of dietary polyphenol treatment for those suffering from autoimmune diseases. Additionally, the identification of ASCT2 as the target protein of PCB2DG is one ...

Unlike humans and other mammals, which become less fertile with age, naked mole-rats can reproduce throughout their remarkably long lifespans. A new study, published today in Nature Communications, sheds light on unique processes that bestow the rodents with what seems like eternal fertility, findings that could eventually point to new therapies for people. “Naked mole-rats are the weirdest mammals,” said lead author Miguel Brieño-Enríquez, M.D., Ph.D., assistant professor at Magee-Womens Research Institute and the University of Pittsburgh School of Medicine’s Department of Obstetrics, Gynecology and Reproductive Sciences. “They’re ...

Infants outperform artificial intelligence in detecting what motivates other people’s actions, finds a new study by a team of psychology and data science researchers. Its results, which highlight fundamental differences between cognition and computation, point to shortcomings in today’s technologies and where improvements are needed for AI to more fully replicate human behavior.  “Adults and even infants can easily make reliable inferences about what drives other people’s ...

The cell membrane has numerous channels for the transport of various substances, including ions, between the cell and its environment. Ion transport determines the ion exchange rate (or the transmembrane transport coefficient), which, in turn, controls biological functions, such as nerve excitation, heartbeat, muscle contraction, and hormone secretion. It can also be anisotropic, wherein a non-uniform distribution of ions causes different ion exchange rates in different directions. This effect is quite pronounced in heterogeneous tissues. Therefore, the boundaries and overlap of tissues can be detected by measuring the associated anisotropic transmembrane transport. Fluorescence ...

Land subsidence is a phenomenon wherein the Earth’s surface sinks downwards. It occurs mainly due to human activities, such as excessive groundwater extraction. It is a major global concern, affecting 19% of the world’s population. In Japan, some parts of the Tokyo metropolitan region are already sinking. This process can accelerate the flooding of coastal areas and cause damage to buildings and infrastructure. Therefore, monitoring land subsidence is crucial. In Japan, observation wells are utilized to measure changes in the land surface and groundwater levels every few months. Additionally, the global navigation satellite system (GNSS) is also popular. However, ...

PROVIDENCE, R.I. [Brown University] — Three years into the COVID-19 pandemic, new variant outbreaks continue to fuel economic disruptions and hospitalizations across the globe. Effective therapies remain unavailable in much of the world, and circulating variants have rendered monoclonal antibody treatments ineffective. But a new analysis shows how convalescent plasma can be used as an effective and low-cost treatment both during the COVID-19 pandemic and in the inevitable pandemics of the future. In a study published in Clinical Infectious Diseases, an international ...

New York, NY | February 21, 2023 — The National Institutes of Health (NIH) will award $3,906,026 over five years to researchers from the Institute for Implementation Science in Population Health (ISPH) at the CUNY Graduate School of Public Health and Health Policy (CUNY SPH) to test the efficacy of a new socialization and sex education curriculum for young people with intellectual and developmental disabilities. CUNY SPH Professor Suzanne McDermott and Associate Professor Heidi Jones will test the curriculum in a randomized controlled trial among 856 adolescents ...

Sixty-one organisations in the UK committed to a 20% reduction in working hours for all staff, with no fall in wages, for a six-month period starting in June 2022. The vast majority of companies also retained full-time productivity targets. Now, results from the world’s largest trial of a four-day working week reveal significantly reduced rates of stress and illness in the workforce – with 71% of employees self-reporting lower levels of “burnout”, and 39% saying they were less ...

The UK Prisons and Probation Ombudsman (PPO) must improve transparency when investigating prisoner deaths, according to a new report and policy brief by prison safety experts at the University of Nottingham. The report, written by Dr Sharon Shalev, draws on research led by Dr Philippa Tomczak in the Faculty of Social Sciences, which offers recommendations to the PPO and policymakers for improving prisoner death investigations and promoting change. Every year, hundreds of prisoners die in England and Wales — in the 12 months to September 2022, there were 307 deaths in prison custody1. These deaths will almost always be ...

For parents, the decision to vaccinate their kids against SARS-CoV-2 is complex, influenced by scientific evidence, political and social pressures, and views about individual versus collective benefits of vaccination, according to a new study published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.221401. Researchers conducted a qualitative study with in-depth interviews of 20 parents to understand their views about SARS-CoV-2 vaccination, with a goal to support future vaccination initiatives. “Given the ...

Advocacy by student-led Gender-Sexuality Alliance (GSA) clubs could help to reduce school-wide disparities in depressive symptoms between LGBTQ+ and heterosexual students, according to a new study.    The findings, published today in the Journal of Clinical Child and Adolescent Psychology, suggest that schools with GSAs (also known as Gay-Straight Alliances) that engage in more advocacy to highlight issues affecting LGBTQ+ students can help to promote well-being among LGBTQ+ youth across the wider school population.    “Discrimination ...

Residing in border regions was linked with a higher risk of dying within five years among children with acute lymphoblastic leukemia, the most common type of pediatric cancer. In an analysis of cancer registry data from Texas, children with acute lymphoblastic leukemia (ALL) who lived along the border with Mexico were more likely to die within five years than those living in other areas of the state. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society. The ...

The Korea Institute of Civil Engineering and Building Technology (KICT, President Kim Byung-Suk) announced that it has developed the D.N.A. (Data, Network, and AI) technologies to predict the levels of damage and aging of bridges for preventive maintenance.   As of 2021, the percentage of Korean bridges aged 30 years or more stands at a relatively low 12.5%. However, this ratio is expected to increase in the next decade to 39.3% by 2031 and rapidly spike up to 76.1% in 20 years. For the preemptive management of these aging bridges, the ...

Despite the fact that we all start out as an egg cell in one of our mother’s ovaries, these human reproductive organs are surprisingly under-studied. Scientists have been working on creating in vitro models of human ovaries so that we can learn more about them and develop treatments for ovarian conditions, but most existing models use a combination of human and mouse cells, which do not faithfully replicate human ovary functions and take a long time to grow in the lab. Now, researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard Medical School (HMS) and Duke University in collaboration with ...

Engineering researchers at the University of Waterloo are successfully using a robot to help keep children with learning disabilities focused on their work.  This was one of the key results in a new study that also found both the youngsters and their instructors valued the positive classroom contributions made by the robot. “There is definitely a great potential for using robots in the public education system,” said Dr. Kerstin Dautenhahn, a professor of electrical and computer engineering. “Overall, the findings imply ...

Most babies born to mothers with COVID-19 were separated after birth resulting in low breastfeeding and skin-to-skin contact rates during the height of the pandemic, according to a new global study. The international research, led by Murdoch Children’s Research Institute in collaboration with the the European Society of Paediatric and Neonatal Intensive Care (ESPNIC), found that transmission of COVID-19 from mother to baby was rare and generally mild when it occurred. But despite this, almost half of all babies did not receive any breast milk, with ...

Social cohesion and connection decline in an ageing population, according to a new study of one of humanity’s closest relatives. For decades, researchers have been observing the rhesus macaques on Cayo Santiago (known as “Monkey Island”) in Puerto Rico. Recent research showed that female macaques “actively reduce” the size of their social networks and prioritise existing connections as they age – something also seen in humans. The new study, by an international team led by the University of Exeter, examines how this affects the overall cohesion and connection of the groups older monkeys live in. While ...

The Internet of Things (IoT) requires the installation free of time and space, therefore, needs independent power sources that are not restricted by batteries or power lines. Energy harvesting technology harvests wasted energy such as vibration, heat, light, and electromagnetic waves from everyday settings, such as automobiles, buildings, and home appliances, and converts it into electrical energy. Energy harvesters can generate sufficient electricity to run small electronic devices by harvesting ambient energy sources without an external power supply. The Korea Institute of Science and Technology (KIST, President Seok Jin Yoon) announced ...

For many children, winter season comes with regular exposure to circulating viruses at school or daycare. And a warm forehead is often one of the first clear signs a child has caught a bug. But some parents may not be properly measuring or responding to elevated temperatures in children, a new national poll suggests. While most parents recognize that a low-grade fever helps a child’s body fight off infection, one in three would give fever-reducing medication for spiked temperatures below 100.4 – which isn’t recommended – according to the C.S. Mott Children’s Hospital National Poll on Children’s Health at University of Michigan Health. Half of parents ...

Correspondence shows troubling interactions between U.S. officials and the alcohol industry By Kimberly Flynn PISCATAWAY, NJ — Growing evidence exists that the alcohol industry uses a variety of strategies to influence public policy in a way that is advantageous to its own corporate interests, rather than the interest of public health. Recent communication between employees of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and alcohol industry groups shows extensive interaction on policy-relevant scientific issues, according to a new study in the Journal of Studies on Alcohol and Drugs. Researchers at the University ...

New York, NY [February 20, 2023] – Analyzing the most extensive datasets in the United States, researchers from the Icahn School of Medicine at Mount Sinai have revealed that vaccination against COVID-19 is associated with fewer heart attacks, strokes, and other cardiovascular issues among people who were infected with SARS-CoV-2, the virus that causes COVID-19. The research letter, “Impact of Vaccination on Major Adverse Cardiovascular Events in Patients with COVID-19 Infection,” was published in the Journal of the American College ...

Contact: Chip Colwell chip@sapiens.org 212.683.5000 New York, NY – SAPIENS magazine is excited to share news of its 2023 poet-in-residence: Toiba Naseema. Through this position, Naseema will use poetry, film, and music to reflect on memory, occupation, and resilience in Indian-occupied Kashmir.  Naseema earned a master’s degree in mass communication, specializing in documentary filmmaking, and she is currently pursuing a master’s in anthropology at the University of Kashmir. She has been involved as an international ...

A vaginal ring containing the antiretroviral drug dapivirine posed no safety concerns when used in the third trimester of pregnancy, according to results to date from the first study of the dapivirine ring during pregnancy and one of only a few studies of an HIV prevention product in pregnant cisgender women. The ongoing Phase IIIb study, known as DELIVER, or MTN-042, was designed to evaluate the safety and acceptability of the monthly dapivirine vaginal ring, a new HIV prevention method approved in several African countries and recommended by the World Health Organization (WHO), as well as ...

February 20, 2023 – Researchers from the University of Washington (UW), Kenya Medical Research Institute (KEMRI), and Hennepin Healthcare Research Institute (HHRI) announced results at CROI from a clinical trial demonstrating that doxycycline taken after sex does not prevent bacterial sexually transmitted infections (STIs) – chlamydia or gonorrhea – among cisgender women. The dPEP Kenya Trial was conducted in Kisumu, Kenya, to evaluate the effectiveness of doxycycline postexposure prophylaxis (PEP) to prevent bacterial STIs. The results of the study have been highly anticipated, as this is the first study of doxycycline PEP among cisgender ...

Geckos can use their tongue to differentiate their own odor from that of other members of their species, as researchers from the University of Bern have shown in a new experimental study. The findings show that geckos are able to communicate socially, meaning that they are more intelligent than was previously assumed. Self-recognition is the ability to detect stimuli which come from oneself. We as people, and also some animals, can identify ourselves visually when we look in the mirror. However, not all animals rely on their sense of sight, first and foremost. Geckos, and also other lizards ...