Sight loss in certain inherited eye diseases may be caused by gut bacteria, and is potentially treatable by antimicrobials, finds a new study in mice co-led by a UCL and Moorfields researcher. The international study observed that in eyes with sight loss caused by a particular genetic mutation, known to cause eye diseases that lead to blindness, gut bacteria were found within the damaged areas of the eye. The authors of the new paper, published in Cell and jointly led by researchers in China, say their findings suggest that the genetic mutation may relax the body’s defences, thus allowing harmful bacteria to reach the eye and cause blindness. The gut contains trillions ...

DCM is the leading cause of heart failure in patients with chronic diabetes. However, the underlying mechanisms of DCM are poorly understood, and treatment options are limited. Another mystery is the regulation of cytochrome P450 enzymes (CYPs) in the central nervous system. Moreover, the link between the gut microbiome, microbiota-derived metabolites, and the progression of AD remains unknown. In the December issue of JPA, three articles provide insights into the pathologies of DCM, hippocampal neurotoxicity, and AD, providing a comprehensive ...

Electrogenerated chemiluminescence (ECL) cells, characterized by their self-emissive nature, have gathered significant interest for prospective display applications due to their uncomplicated structure and straightforward fabrication process. These cells are created by sandwiching a solution-based emitting layer between two transparent electrodes. Nevertheless, when compared to other self-emissive devices like light-emitting diodes (LED) and organic LEDs, the luminescent performance of ECL cells ...

Human herpesviruses comprise the alpha, beta, and gamma subfamilies and are a widely prevalent group of DNA-enveloped viruses, capable of establishing lifelong latent infections in humans and causing various diseases. Among them, herpes simplex virus (HSV) belongs to the alpha herpesvirus group and infects a wide population, causing symptoms like oral or genital herpes. As an enveloped virus, HSV possesses a series of glycoproteins involved in virus recognition, adhesion, and infection processes. Among these, gB serves as the viral fusion protein, mediating the fusion between the virus and host cell membranes, and ...

As Canada’s flu season collides with record strep A cases and ongoing COVID-19 concerns, a new study is shedding light on our understanding of respiratory immune responses. Scholars from the Research Institute of the McGill University Health Centre (RI-MUHC) have discovered a surprising facet about a century-old vaccine for tuberculosis, Bacillus Calmette Guérin (BCG). The study, published in the journal Nature Immunology, uncovered a previously unknown mechanism that extends the vaccine’s shield to combat influenza A virus—the most prevalent flu strain. “The immune interactions ...

Fungi are frequently found both around and within plant tissues (especially in roots) and are involved in both plant nutrient acquisition and resistance to pathogens. Thus, characterizing the diversity and composition of plant-associated fungal communities has been a growing interest in recent years.   High-throughput sequencing (HTS), also called metabarcoding, has become a prominent tool to assess complex microbial communities from environmental samples. However, HTS applied to plant-associated ...

World hunger is growing at an alarming rate, with prolonged conflicts, climate change, and COVID-19 exacerbating the problem. In 2022, the World Food Programme helped a record 158 million people. On this trajectory, the United Nations’ goal to eradicate hunger by 2030 appears increasingly unattainable. New research at McGill University shines the spotlight on a significant piece of the puzzle: international food assistance. With no global treaty in place, food aid is guided by a patchwork of international agreements and institutions. Using the concept of a “regime ...

Ultraviolet-laser processing is a promising technique for developing intricate microstructures, enabling complex alignment of muscle cells, required for building life-like biohybrid actuators, as shown by Tokyo Tech researchers. Compared to traditional complex methods, this innovative technique enables easy and quick fabrication of microstructures with intricate patterns for achieving different muscle cell arrangements, paving the way for biohybrid actuators capable of complex, flexible movements. Biomimetic robots, which mimic the movements and biological functions of living organisms, are a fascinating area of research that ...

[Vienna, Feb 26 2024] — Leptospirosis is a globally distributed infectious disease that affects both animals and humans. While the infection is endemic in tropical regions, its incidence seems to increase in temperate regions. The serological diagnostic test used in routine to detect antibodies against the bacteria responsible for the disease performs better when local variants are used. In Austria, however, no locally circulating strain has been available to date. A new study, published in the latest issue of Scientific Reports, has now been able to close this research gap.  "In our study, ...

Bethesda, MD (Feb. 26, 2024) — The AGA Research Foundation has announced a $1.4 million endowment grant from The Bern Schwartz Family Foundation. The AGA Institute will provide matching support, resulting in a $2.8 million endowment dedicated to advancing basic research in pancreatic cancer, the third leading cause of cancer deaths in the U.S.   The endowment will fund a second AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer. The first award, created in 2013, will also continue. Both awards provide selected early career-investigators with $100,000 per year for three years ...

Calls to U.S. poison centers involving psilocybin, or “magic mushrooms,” among adolescents and young adults rose sharply after several U.S. cities and states began decriminalizing the hallucinogen, University of Virginia School of Medicine researchers have found.  Psilocybin-related calls more than tripled among teens ages 13-19 from 152 to 464 and more than doubled among adults ages 20-25 from 125 to 294 between 2018 and 2022, according to anonymized data gathered from the National Poison Data System. Local and state efforts to decriminalize the possession, use and cultivation of psilocybin began in May 2019. Oregon and Colorado have decriminalized psilocybin, as ...

The average researcher thinks they are better than their colleagues at following good research practice. They also think that their own research field is better than other research fields at following good research practice. This is shown in a new study by researchers at Linköping University, Sweden. The results point to a risk of becoming blind to one’s own shortcomings, according to the Linköping researchers. “The starting point for the project is that there’s a bit of a crisis in the research world. Research misconduct or difficulties to replicate research results have been discovered in many studies. Credibility has been called into question,” ...

When you get a tattoo, do you know what you’re putting under your skin? According to new Binghamton University research, the ingredient labels on tattoo ink don’t match the actual substances in the bottle. Produced by the lab of Binghamton Univerity Assistant Professor of Chemistry John Swierk, “What’s in my ink: An analysis of commercial tattoo ink on the U.S. market” was recently published in the journal Analytical Chemistry. Swierk’s lab explores the potential impact of light on tattoos and their chemical breakdown. Early on, doctoral student Kelli Moseman ...

As we get older, we may start to notice it takes us longer to find the right words. This can lead to concerns about cognitive decline and dementia. However, a new study by Baycrest and the University of Toronto suggests that talking speed is a more important indicator of brain health than difficulty finding words, which appears to be a normal part of aging. This is one of the first studies to look at both differences in natural speech and brain health among healthy adults. “Our results indicate that changes in general talking speed may reflect changes in the brain,” says Dr. Jed Meltzer, ...

Deforestation, a critical consequence of human activity, has garnered significant attention due to its impact on environmental sustainability, biodiversity and climate change. However, an equally pressing yet less explored aspect is the relationship between deforestation and human health, especially in impoverished regions. Scientists have increasingly recognized the detrimental effects of deforestation on various aspects of human health, particularly among children. Studies reveal that children residing in areas with high deforestation rates are at an elevated risk of malaria, ...

In 2023, Rhode Island, Massachusetts and Minnesota joined a growing list of states that allow undocumented immigrants to obtain driver’s licenses if an applicant can provide certain documentation, such as a foreign birth certificate or passport and evidence of current residency in the state. Altogether, 19 states and the District of Columbia have similar legislation in place. And lawmakers in other states, such as Michigan and Oklahoma, have introduced similar legislation. In many cases, these laws were passed ...

In a study in today’s (Monday Feb. 26) Nature Human Behavior, scientists delve into the world of chemical neuromodulators in the human brain, specifically dopamine and serotonin, to reveal their role in social behavior.  The research, conducted in Parkinson's disease patients undergoing brain surgery while awake, homed in on the brain’s substantia nigra, a crucial area associated with motor control and reward processing.  Led by Virginia Tech computational neuroscientist Read Montague, the international team revealed ...

BOSTON – About eight million people live with Type 1 diabetes (T1D) worldwide, a chronic autoimmune condition in which the body attacks and destroys its own insulin-producing β-cells (pronounced “beta”) in the pancreas, leading to a lack of insulin and inability to regulate blood sugar. It’s not known why the body suddenly perceives its own β-cells as the enemy; some lines of evidence suggest environmental factors such as viral infections may trigger the onset of T1D, others suggest genetics may also play some role.   Groundbreaking ...

She studies the giant explosions of dying stars and dreams of experiencing and extracting data from a supernova close to Earth. Professor Irene Tamborra from the Niels Bohr Institute also tirelessly promotes equity and inclusion in research. Today she receives the prestigious Elite Research Prize and DKK 1.2 million in honor of her research in astrophysics.   "I am fascinated by anything that explodes in the sky," Professor Irene Tamborra says as she begins to describe her research. The professor from the University of Copenhagen’s ...

In an early phase clinical trial, a combination of antibody-based medications targeting the immune system generated promising safety data and anti-tumor activity in individuals with various types of advanced cancer. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society. Both medications tested in the trial support immune responses against tumor cells. CS1002 increases the activation and proliferation of T immune cells by binding to a T cell receptor called CTLA-4. CS1003, also called nofazinlimab, ...

Eight new Pacific bee species and new insights into Fijian bird behaviour on Viti Levu Island have been described in new scientific studies led by Flinders University.  The studies, both funded by field work supported by the Australian Government’s New Colombo Mobility Plan Program, highlight the potential for species discovery, ecological and conservation knowledge and cultural engagement from Asia-Pacific research collaborations. In the past 10 years, Australian Government-funded Flinders University field trips have worked closely ...

ANN ARBOR, Mich. –  While it’s not surprising to spot teens wearing headphones and earbuds, it’s also becoming a widespread trend among younger children, a national poll suggests. Two in three parents say their child ages 5-12 uses personal audio devices, with half of parents of children ages 5-8 reporting elementary-aged kids use a device. Among parents whose children use headphones and earbuds, half say kids spend at least an hour a day using them while one in six say a typical ...

In 1934, American entomologist Elwood Zimmerman, then an undergraduate student at Berkeley, participated in the ‘Mangarevan expedition’ to Polynesia. Among the samples he collected were three tiny (4 mm long), orange-brown solitary bees found on tahetahe flowers in the Tuamotu Archipelago. The specimens rested undisturbed in the Bernice P Bishop Museum of Honolulu until 1965, when the famous bee specialist Prof Charles Michener examined them. He described them as a species new to science: Hylaeus tuamotuensis, or Tuamotu’s masked bee, in the family ...

Many older adults receiving home care do not receive any palliative home care before death, suggesting we need better methods to identify people who need this support, according to new research in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.221513. "Palliative care is an essential component of a holistic, comprehensive and patient-centred approach to care for all people with a life-limiting illness from the time of diagnosis with the disease," said Dr. Amy Hsu, investigator at the Bruyère Research Institute and faculty in the Department of Family Medicine at the ...

Forests have a critical role to play in capturing and storing carbon from the Earth’s atmosphere – but some models exaggerate their carbon removal potential by almost three-fold, according to a leading professor of forest economics. Global Forest Carbon: Policy, Economics and Finance by Runsheng Yin from Michigan State University emphasizes the value of nature-based solutions to the climate crisis but calls for significant changes to the way carbon credits from reforestation, afforestation, and improved forest management are calculated. He has found that current modeling of local ...