In an effort to expedite its life-saving work, the Colorectal Cancer Alliance (Alliance) Project Cure CRC initiative is excited to open its Request for Proposals (RFP). Tens of millions of dollars will be available to researchers from around the world whose work aims to expedite colorectal cancer (CRC) research to a curable science. Beginning March 1, the program is accepting applications for one to three-year projects from qualifying professionals at research-based institutions and private companies. Priority will be given to proposals that focus on high-risk/high-reward projects to accelerate new CRC therapies and technologies from bench to bedside.   The ...

First-of-its-kind study suggests increasing the percentage of youth in the United States who participate in sports to meet a Healthy People 2030 goal could improve children’s physical and mental health and save $80 billion. Achieving the Healthy People 2030 youth sports participation goal could save the United States $80 billion in direct medical costs and productivity losses and deliver over 1.8 million more quality years of life to Americans, according to a study that will be published on Feb. 27 in the American Journal of Preventive Medicine. Every decade since 1980, Healthy People has provided science-based, 10-year national objectives and ...

Current lithium-ion battery technology does not have the energy density necessary to meet the demands for renewable energy. In theory, lithium-sulfur batteries could be a viable alternative with a higher specific capacity and energy density. However, sulfur has disadvantages that currently limit its practical adoption. A comprehensive review published in Nano Research on February 8 outlines how metal organic frameworks-based cathode materials could improve the performance of lithium-sulfur batteries, making them a practical alternative to lithium-ion batteries.  “The ...

Imagine technology as a race car speeding down a track – it can only go as fast as its engine allows. But just when it seemed like organic solar cells hit a roadblock, along comes 3PNIN, a game-changing molecule shaped like a propeller, ready to turbocharge their progress and break through barriers.   Organic solar cells (OSCs) represent the pinnacle of renewable energy, yet certain components have fallen significantly behind the trajectory of ongoing development. Particularly, cathode interfacial materials (CIMs) have failed to sustain ...

BINGHAMTON, N.Y. -- Binghamton University, State University of New York researcher Karin Sauer is among 65 scientists elected as Fellows of the American Academy of Microbiology this year. Fellows are elected by their peers based on their scientific achievements and original contributions to the field of microbiology. Sauer’s lab aims to find ways to control communities of bacteria called biofilms and to curb their extraordinary resistance to antimicrobial agents. The team’s findings could have an impact on a wide range of healthcare practices, from ear infections to wound care. “I’m honored and ...

Archeologists have long used the shapes and styles of pottery as a proxy for ancient cultures. But how does the cultural alignment of ceramic forms arise? To explore this question, Tetsushi Nonaka and colleagues asked 21 potters in three different communities—one in France in Bourgogne and two in India in Bulandshahar district, Uttar Pradesh—to throw pots with the same unfamiliar shapes. One of the Indian pottery workshops was Hindu, the other was Muslim. In each community, several different potters tried the shapes. Through careful measurement, the authors were able to determine ...

A study quantifies the emission of extremely tiny particles by gas stoves and finds that the particles could harm human health. Airborne nanoparticles between 1–3 nm, referred to as nanocluster aerosol or NCA, are known to be bioactive and toxic, but measuring such minute particles has been a challenge. Brandon E. Boor and colleagues measured indoor NCA during propane gas cooking in the Purdue zero Energy Design Guidance for Engineers (zEDGE) test house using a novel instrument. Combining measurement data with the general dynamic equation for aerosols, the authors were able to characterize the production and behavior ...

Continuous research is being conducted globally on using the Moon as an advanced base for deep space exploration, and Korea is no exception in these efforts. The Korea Institute of Civil Engineering and Building Technology (KICT, President Kim, Byung-suk) successfully implemented an electrostatic environment that simulates the Moon's surface conditions, not in space but on Earth. The researchers also assessed its performance and effectiveness. Among the most serious threats in executing lunar missions is the Moon's surface environment, which is electrostatically charged. Due to its extremely thin atmosphere, the Moon is directly exposed to solar ultraviolet rays, X-rays, ...

In an editorial, Sandro Galea and Gillian Buckley summarize the findings of a National Academies of Sciences, Engineering, and Medicine consensus study report on social media and adolescent mental health. Social media has to some extent been treated as a monolith, but the report finds that different types of engagements with different digital platforms may have very different effects on mental health. In some situations, social media may benefit adolescent mental health, as when LGBTQ+ adolescents in isolating circumstances are able to form supportive ...

Thousands of satellites take pictures, gather information and relay internet traffic from high above the Earth. Now, the challenge is making satellites that operate closer to home, in what is called a very low earth orbit (VLEO), where there is ample space for additional satellites, and the pictures taken would be clearer. Working at an altitude with air would mean more force would be needed to propel the satellite forward, but many scientists believe there is also an advantage: the air could be used as the propellant. They say charged particles of air-breathing plasma – the fourth state of matter – could be used to propel the thrusters, potentially ...

Research Highlights Closer proximity to and a higher number of ready-to-eat food outlets — particularly pubs, bars and fast-food restaurants — may be associated with a greater risk of developing heart failure, according to a study of half a million adults in the UK Biobank. The association between food environments and increased heart failure risk was stronger among people who did not have a college degree and those living in urban areas without access to facilities for physical activity such as gyms or fitness centers. Embargoed until 4 a.m. CT/5 a.m. ET Tuesday, Feb. 27, 2024 DALLAS, Feb. 27, 2024 — Living close to pubs, bars and fast-food restaurats may ...

Research Highlights: Women’s heart disease and stroke risks and outcomes differ throughout life in comparison to men. A special Journal of the American Heart Association “spotlight” issue features a collection of the latest research about sex differences in cardiovascular disease and their implications for gender-specific care. Among the topics in this issue: the impact of sedentary behavior on heart disease risk in older women; sex differences in the relationship between schizophrenia and the development ...

Cells actively rely on maintaining an appropriate acid-base balance to support optimal function. Under normal physiological settings, the pH inside cells remains within a controlled range. However, disruptions in this equilibrium have been linked to a wide range of health conditions, both minor and catastrophic. Changes in the extracellular environment are monitored by “membrane receptors,” of which the G protein-coupled receptors (GPCRs) are a large family of membrane proteins that mediate multiple cellular responses. However, the role of GPR30, also known as G protein-coupled estrogen ...

Researchers have developed a “self-driving” lab that uses artificial intelligence (AI) and automated systems to provide in-depth analyses of catalytic reactions used in chemical research and manufacturing. The new tool, called Fast-Cat, can provide more information in five days than is possible in six months of conventional testing. At issue are the yield and selectivity of chemical reactions in the presence of molecules called ligands. Yield refers to how efficiently a chemical reaction produces a desired product from the chemicals you started with. Selectivity refers ...

Are museums, theaters, and opera houses truly walking the talk when it comes to social and environmental sustainability? The University of Lausanne (UNIL) delved into this pressing question, conducting an international survey with over 200 major cultural organizations. The verdict? While there's significant room for improvement across the spectrum, Anglophone countries lead the charge. Cultural organizations, with their wide-reaching influence and power to shape narratives and imaginations, are poised to ...

Tomato (Solanum lycopersicum L.) is the most widely cultivated and consumed horticultural crop. At present, saline–alkali is an important abiotic stress source that affects tomato production. Exogenous methyl jasmonate (MeJA) can enhance the resistance of tomatoes to various stress, but its exact mechanism is still unclear. In January 2024, Horticulture Research published a research entitled by “SlWRKY80-mediated jasmonic acid pathway positively regulates tomato resistance to saline-alkali stress by enhancing spermidine content and stabilizing ...

The impact of abdominal fat on brain health and cognition is generally more pronounced in middle-aged men at high risk of Alzheimer’s disease as opposed to women, according to researchers at Rutgers Health.   In middle-aged individuals with a family history of Alzheimer’s disease, the amount of fat in their abdominal organs (pancreas, liver, and belly fat) is related to their brain volumes and cognitive function, according to the study published in the journal Obesity. The study was written by Sapir Golan Shekhtman, a Ph.D. student at the Joseph Sagol Neuroscience Center at the Sheba Medical Center in Israel and led by ...

ROCKVILLE, Md.— High-fat diets cause obesity in male mice. The underlying mechanism, however, remains controversial. After assessing three contrasting ideas, researchers have determined that the hedonic overdrive model provides the best fit, according to a new study published in the journal Obesity, The Obesity Society’s (TOS) flagship journal. “Our work provides some direction as to why high-fat/high-carb macronutrient combinations stimulate overconsumption. The study is in mice so we ...

The tone and tuning of musical instruments has the power to manipulate our appreciation of harmony, new research shows. The findings challenge centuries of Western music theory and encourage greater experimentation with instruments from different cultures.     According to the Ancient Greek philosopher Pythagoras, ‘consonance’ – a pleasant-sounding combination of notes – is produced by special relationships between simple numbers such as 3 and 4. More recently, scholars have tried to find psychological explanations, but these ‘integer ratios’ are still credited with making a chord sound beautiful, and deviation from them ...

A new paper in Genome Biology and Evolution, published by Oxford University Press, finds that the link between paternal age and rare congenital disorders is more complex than scientists had previously thought. While researchers have long realized that older fathers are more likely to have children with bone and heart malformations, such as Achondroplasia, Apert, or Noonan syndrome or neurodevelopmental disorders, schizophrenia, and autism, new examination indicates that while the link between some pathogenic mutations increases with paternal age, others do not and may even occur in the father’s testis before sexual maturity. Delayed fatherhood results in a higher ...

A study into parental smoking and childhood obesity has challenged previous notions by revealing that the links between the two are not confined to a specific socio-economic group.  The data shows a strong correlation between parents who smoke and their children’s consumption of high calorie unhealthy foods and drinks, across social classes.  Using longitudinal data on 5,000 Australian children collected over a 10-year period, the research found those living with parents who smoke, on average, eat less healthy, higher calorie food such as fruit juice, sausages, fries, snacks, full fat milk products, ...

Professor Jian HE, from the Department of Chemistry at The University of Hong Kong (HKU), has spearheaded a research endeavour aimed at revolutionising organic synthesis. His research team has successfully developed a novel heterogeneous copper photocatalyst that enables the efficient formation of cyclobutane rings, a crucial structural element in a vast array of bioactive molecules. Cyclobutane rings are prominently featured in pharmaceuticals, natural products, and various biologically active compounds. By enabling researchers to construct these rings easily and selectively, ...

The success of a deep learning-based network intrusion detection systems (NIDS) relies on large-scale, labeled, realistic traffic. However, automated labeling of realistic traffic, such as by sand-box and rule-based approaches, is prone to errors, which in turn affects deep learning-based NIDS. To solve the problems, a research team led by Yuefei ZHU published their new research on 15 Feb 2024 in Frontiers of Computer Science co-published by Higher Education Press and Springer Nature. The team ...

Researchers at the Centre for Genomic Regulation (CRG) reveal that the Snhg11 gene is critical for the function and formation of neurons in the hippocampus. Experiments with mice and human tissues revealed the gene is less active in brains with Down syndrome, potentially contributing to the memory deficits observed in people living with the condition. The findings are published today in the journal Molecular Psychiatry.   Traditionally, much of the focus in genomics has been on protein-coding genes, which in humans constitutes around just 2% of the entire genome. The rest is "dark ...

In The BMJ today, Keisha Bentley-Edwards at Duke University, North Carolina, and colleagues argue that systemic racism and economic inequality are at the root of disparity in covid-19 outcomes and suggest how to distribute resources more equitably.  The article is part of a series that highlights the lessons that can be learned from the US’s covid-19 experience and the actions that are needed to prevent the loss of another million citizens in the next pandemic and improve and protect population health. "Rather than waiting for the next pandemic to address systemic failures, the ...