BIRMINGHAM, Ala. – A United States Food and Drug Administration mandate to limit the dosage of acetaminophen in pills that combine acetaminophen and opioid medications is significantly associated with subsequent reductions in serious liver injury, researchers report in the medical journal JAMA. The federal mandate was announced in 2011 and implemented in 2014. “The FDA mandate that limits acetaminophen dosage to 325 milligrams per tablet in combination acetaminophen-opioid medications was associated with a significant and persistent decline in the yearly rate of hospitalizations and proportion per year of acute liver failure ...

WASHINGTON, March 7, 2023 – Proxy data – indirect records of the Earth’s climate found in unlikely places like coral, pollen, trees, and sediments – show interesting oscillations approximately every 100,000 years starting about 1 million years ago. Strong changes in global ice volume, sea level, carbon dioxide concentration, and surface temperature indicate cycles of a long, slow transition to a glacial period and an abrupt switch to a warm and short interglacial period. Milutin Milankovitch hypothesized that the timing of these cycles was controlled by the orbital parameters of the Earth, including the shape of its path around ...

A hormone called fibroblast growth factor 21 (FGF21) protects mice against ethanol-induced loss of balance and righting reflex, according to a study publishing on March 7 in the journal Cell Metabolism. “We’ve discovered that the liver is not only involved in metabolizing alcohol but that it also sends a hormonal signal to the brain to protect against the harmful effects of intoxication, including both loss of consciousness and coordination,” says co-senior study author Steven Kliewer of the University of Texas Southwestern Medical Center. “We’ve further shown that by increasing FGF21 concentrations even higher by injection, we can dramatically ...

At a glance: New research suggests female mice show more stable exploratory behavior than male mice, despite hormone cycles The results challenge a long-held assumption that hormones have a broad effect on behavior in female mice, making them less suitable for research The findings make a strong scientific case for increasing the inclusion of female mice in neuroscience and other experiments Mice have long been a central part of neuroscience research, providing a flexible model that scientists ...

About The Study: This study of 24,000 participants age 45 or older found an independent association between perceived stress and both prevalent and incident cognitive impairment. The findings suggest the need for regular screening and targeted interventions for stress among older adults.  Authors: Ambar Kulshreshtha, M.D., Ph.D., of the Emory University School of Medicine in Atlanta, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamanetworkopen.2023.1860) Editor’s ...

About The Study: The findings of this study suggest that despite initial telemedicine gains at rural Veterans Affairs (VA) health care sites, the pandemic was associated with an increase in the rural-urban telemedicine divide across the VA health care system. To ensure equitable access to care, the VA health care system’s coordinated telemedicine response may benefit from addressing rural disparities in structural capacity (e.g., internet bandwidth) and from tailoring technology to encourage adoption among rural users.  Authors: Lucinda B. Leung, M.D., Ph.D., M.P.H., of the Veterans Affairs Greater Los Angeles Healthcare System in Los Angeles, is the corresponding ...

A United States Food and Drug Administration mandate to limit the dosage of acetaminophen in pills that combine acetaminophen and opioid medications is significantly associated with subsequent reductions in serious liver injury, according to a study led by investigators at the University of Alabama and Weill Cornell Medicine. The federal mandate was announced in 2011 and implemented in 2014. The results were reported March 7 in the medical journal JAMA. “After researchers found that more than 40 percent of acetaminophen-induced acute liver failure cases involved combination acetaminophen and opioid medications, and an FDA advisory ...

The selective breeding of grain crops is one of the main reasons why domesticated plants produce such excellent yields. Selecting the best candidates for breeding is, however, a remarkably complex task. On one hand, it requires a skilled breeder with trained eyes to assess plant resistance to disease and pests, crop growth, and other factors. On the other hand, it also requires precise tool-assisted measurements such as grain size, mass, and quality. Although all these standard measures are useful, none of them takes into account the number ...

Safe live microorganisms are found in a variety of foods we eat every day, from yogurt and other fermented foods, to raw fruits and vegetables. Despite the widespread idea that these mixtures of live microbes contribute to health, convincing evidence linking live dietary microbes to health benefits has been lacking. A new study provides some of the first real-world evidence that higher consumption of live microbes may promote health. A group of scientists led by the International Scientific Association for Probiotics and Prebiotics (ISAPP) classified over 9,000 individual ...

The International Vaccine Institute (IVI), an international organization with a mission to discover, develop, and deliver safe, effective, and affordable vaccines for global health, announced the start of a multi-country study to better understand the burden of Human papillomavirus (HPV) among girls and women in low- and lower middle-income countries. This study received $14.99 million USD in funding from the Bill & Melinda Gates Foundation with $1 million USD co-funding from the Swedish government and will help inform intervention implementation and prioritization of research and development efforts that have the greatest potential public health ...

Sustainable energy solutions cannot be pulled out of thin air. However, combining air with metal and other frameworks may pave the way for environmentally friendly energy conversion and storage, according to a research team based in China.   They published their review of novel porous materials — called metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) — and their potential to advance metal-air batteries on 03 March in Nano Research Energy.   The porous crystal material frameworks comprise various arrangements of bonded materials that can induce desired properties, including the ability to accelerate reactions between oxygen and metals ...

Macrophages are highly specialized cells of the immune system that help the body detect and fight deadly pathogens. In particular, M1-like macrophages detect and destroy tumor cells, and release protective chemokines such as interleukin (IL)-6 and tumor-necrosis factor α (TNF α), thus shielding the body from life-threatening pathologies like cancer. However, not all macrophages show anti-tumor potential. Certain types of macrophages, i.e., M2-like macrophages, promote tumor growth. Luckily, the desired macrophage phenotype—a set of traits resulting from the genetic makeup of the macrophage—can be activated by modulating the ...

OAK BROOK, Ill. – An artificial intelligence (AI) tool can accurately identify normal and abnormal chest X-rays in a clinical setting, according to a study published in Radiology, a journal of the Radiological Society of North America (RSNA). Chest X-rays are used to diagnose a wide variety of conditions to do with the heart and lungs. An abnormal chest X-ray can be an indication of a range of conditions, including cancer and chronic lung diseases. An AI tool that can accurately differentiate between normal and abnormal chest X-rays would greatly alleviate the heavy workload experienced by radiologists globally. “There is an exponentially growing demand for medical ...

A study at Hospital for Special Surgery (HSS) found that intraoperative three-dimensional (3D) imaging was superior to two-dimensional radiographs in confirming the accuracy of pedicle screw placement during spine surgery. The research was presented today at the American Academy of Orthopaedic Surgeons (AAOS) Annual Meeting in Las Vegas.   Many spinal surgeries require the use of implants called pedicle screws to stabilize the spine. Precise positioning of these screws is critical for a successful outcome. “Two-dimensional biplanar radiographs [BPR] ...

Recently, a research team from Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, proposed a bionic quadruped soft thin-film microrobot actuated by magnetic fields with a mass of only 41 mg, which promises to be applied to stomach examination and treatment. Researchers realized the multimodal locomotion control of the soft microrobot in magnetic fields and the grasping and transportation of micro-objects by the soft microrobot.   The new paper, published in Cyborg and Bionic System, details the process ...

Starting with the emergence of quantum mechanics, the world of physics has been divided between classical and quantum physics. Classical physics deals with the motions of objects we typically see every day in the macroscopic world, while quantum physics explains the exotic behaviors of elementary particles in the microscopic world. Many solids or liquids are composed of particles interacting with one another at close distances, which sometimes results in the rise of “quasiparticles.” Quasiparticles are long-lived excitations that behave effectively as weakly interacting particles. The idea of quasiparticles was introduced by the Soviet physicist Lev Landau in 1941, and ...

Network-assisted full-duplex (NAFD) systems enable uplink and downlink communications within the same time-frequency resources, so as to avoid the overhead of switching uplink/downlink modes. However, as the number of users and access points (APs) proliferated, mass access brings significant overhead in mode selection. In addition, the differentiated service demands among users also makes the effective utilization of resources difficult. Combined with network slicing technology, a slicing capacity-centered mode selection and resource optimization scheme is proposed. This scheme adopts a double-layer deep reinforcement ...

“As a Black woman, I’m invisible. They just erase your humanity. You don’t exist in front of them.” (Tessa, 33-year-old Black research assistant) “It wasn’t about disliking what I did or being judgmental of what I did. It was a different kind of problem, to not be acknowledged. They didn’t care. There was no curiosity. They didn’t give a f***. We were invisible.” (Brinda, 30-year-old South Asian consultant) Invisibility is a salient and recurring experience of mistreatment for women of colour working in traditionally white and male professions, two ...

Love muffins? We’re talking about a tasty, fluffy muffin that has no artificial additives and that simultaneously contains lots of beneficial nutrients. As remarkable as it might sound, a recently published study led describes the development of just such a new muffin in the journal Foods. From muffins to functional food The new super muffin has been named Roselle, because it contains calyx extract from the tropical plant Hibiscus sabdariffa, which is often referred to by the same name. [caption id="attachment_79738" align="aligncenter" width="559"] Here's a look at the different formulations that researchers tested. Photo: Screenshot from Food ...

Will AI drive the next biomedical revolution? Why is RNA so powerful? What can we learn from studying bias? You’ll get the answers to these questions and more at Discover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology, to be held March 25–28 in Seattle. Reporters are invited to register for a complimentary press pass to attend #DiscoverBMB in Seattle or to access press materials electronically. This year’s #DiscoverBMB program features leading ...

Color plays a huge role in our lives — the hues we wear and decorate with are a way for us to signal who we are, where we’re from, and what we care about. And it’s been that way for a long time. In a new study in the Journal of Archaeological Science: Reports, archaeologists compared the colors on pieces of ancient Peruvian pottery. They found that potters across the Wari empire all used the same rich black pigment to make ceramics used in rituals: a sign of the empire’s influence. The Wari empire spread over Peru’s highlands and coastal areas from 600-1050 ...

According to NOAA Fisheries, more than 80 percent of marine aquaculture production in the United States consists of bivalve mollusks such as oysters, clams and mussels. However, it’s not just humans who enjoy eating these shellfish, so do marine rays. They like to “crunch” on clams, which can sometimes take a big bite out of clammers’ profits. Part of the process of culturing hard clams (Mercenaria mercenaria) involves deploying them in submerged bottom leases in the marine environment where clams can grow to market size. When deployed onto the clam lease, clammers incorporate a variety of anti-predator ...

AMES, IA — With the youngest baby boomers sliding into retirement, adults aged 65 and older are expected to outnumber children by 2030. The demographic shift will be a first in U.S. history. But many rural areas, especially in the Midwest and Great Plains, are already experiencing this. Researchers are looking to small towns in Iowa to understand how some support aging in place better than others. Their findings, published in Journal of Rural Studies, could help communities plan for the ...

Bipolar disorder (BD) is a debilitating condition characterized by alternating states of depression (known as depressive episodes) and abnormal excitement or irritability (known as manic episodes). Large-scale genome-wide association studies (GWASs) have revealed that variations in the genes present on the fatty acid desaturase (FADS) locus are linked to an increased risk of BD. Enzymes coded by FADS genes—FADS1 and FADS2—convert or "biosynthesize" omega-3 fatty acids into the different forms required by the human body. Omega-3 fatty acids like ...

Researchers have achieved a breakthrough to enable ‘perfectly secure’ hidden communications for the first time. The method uses new advances in information theory methods to conceal one piece of content inside another in a way that cannot be detected. This may have strong implications for information security, besides further applications in data compression and storage. A group of researchers has achieved a breakthrough in secure communications by developing an algorithm that conceals sensitive information so effectively that it is impossible to detect that anything has been hidden. The team, led by ...