There is substantial geographic variation across the U.S. health care system to diagnose and treat early-stage Alzheimer’s disease with disease-modifying therapies, and engaging primary care providers in the effort may be a key to accelerating delivery of emerging new treatments, according to a new RAND report.   Enabling primary care practitioners to diagnose and evaluate patients for treatment eligibility would make the biggest impact on reducing wait times for specialists and increase the number of people treated with disease-modifying therapies from 2025 through 2044.   While primary care providers are technically capable of performing cognitive assessments, ...

A new causal link has been found between the presence of oncofoetal ecosystems and recurrence and response to immunotherapy in primary liver cancer, hepatocellular carcinoma (HCC) The findings will pave the way to use the presence of oncofoetal ecosystems as a biomarker to treat HCC, a disease with a poor prognosis that is typically diagnosed late Singapore, 30 January 2024 - A team of clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS), Agency for Science, Technology and Research (A*STAR), the Harry Perkins Institute of Medical Research and global research partners, has found a causal link between the presence of oncofoetal ...

Hf-based carbides are highly desirable candidates for thermal protection applications above 2000 ℃ due to their extremely high melting point and favorable mechanical properties. However, as a crucial indicator for composition design and performance assessment, the static oxidation behavior of Hf-based carbides at their potential service temperatures has been rarely studied. In a study published in the KeAi journal Advanced Powder Materials, a group of researchers from Central South University and China Academy of Launch Vehicle Technology revealed the static oxidation mechanism ...

Laser sources operating at the 1.2 μm wavelength band have some unique applications in photodynamic therapy, biomedical diagnosis and oxygen sensing. Additionally, they can be adopted as pump sources for mid-infrared optical parametric generation as well as visible light generation by frequency doubling. Laser generation at 1.2 μm waveband has been achieved with different solid-state lasers including semiconductor laser, diamond Raman laser, and fiber laser. Among these three types, fiber laser thanks to its simple structure, good beam quality, and operation flexibility, is a great choice for 1.2 μm waveband laser generation.   Researchers ...

We know that our climate is changing. Extreme weather events are becoming more common, sea levels are rising and overall, our planet is getting warmer. Monitoring these changes is critical. One of the best indicators of climate change is the Ocean Heat Content (OHC) estimate, a measurement of overall oceanic temperature calculated by gathering water temperature data in oceans around the world in differing locations, at varying depths and across time. The data necessary to calculate the OHC over such a wide-spread area is gathered by the Global Ocean Observing System (GOOS), an integrated network of platforms ...

Soil microbiome has far-reaching significance, particularly for rice production, which can be better explained with a Japanese proverb: “Rice grows with soil fertility, while upland crops depend on fertilization”. Therefore, understanding the paddy field microbiome is crucial for sustainable soil fertility and rice production. This would also lead us to overcome the global food shortage problem as rice is the primary food source for nearly half of the world's population.  Among the paddy field microbes, bacteria, fungi, and archaea are well-studied, while protists, the vast majority of eukaryotes, are largely unknown. Protists are the most diverse eukaryotic microorganisms ...

Ahead of the 2024 US presidential election, The BMJ today launches a forward-looking series that highlights the lessons that can be learned from the US’s covid-19 experience and the actions that are needed to prevent the loss of another million citizens in the next pandemic and improve and protect population health. The articles, written by leading clinicians and researchers across the US, explore topics such as how systemic racism and economic inequality contributed to covid-19 disparities; mass incarceration and poor prison health as a driver of the pandemic; ...

An analysis published today in the The BMJ examines the risks faced by frontline workers in the United States during the pandemic and suggests reforms that could protect population health and save lives. Lead author Professor David Michaels at the George Washington University and his colleagues note that from the onset laws and regulations in the United States inadequately protected frontline workers. The gaps allowed a rapid spread of disease in US workplaces like meat packing plants. At the same time, these essential workers were rarely seen as a population that needed special attention ...

Results of a large-scale innovative Citizen Science experiment called Project M which involved over 1000 scientists, 800 samples and 110 UK secondary schools in a huge experiment will be published in the prestigious RSC (Royal Society of Chemistry) journal CrystEngComm on 29 January 2024. The paper is titled: “Project M: Investigating the effect of additives on calcium carbonate crystallisation through a school citizen science program”. The paper shares a giant set of results from the school citizen scientists who collaborated with a team at Diamond to find out how different additives affect the different forms of calcium carbonate produced. These additives affect the ...

Washington, D.C.—Researchers have identified 2 strains of probiotics that can be used to reduce weight in obese dogs. The research is published this week in Microbiology Spectrum, a journal of the American Society for Microbiology. In the new study, the research team investigated metabolic diseases in companion animals and set out to identify probiotics suitable for long-term and safe treatment. “The initial challenge involved selecting specific metabolic diseases for examination, leading us to focus on the prevalent issue of 'obesity in pets,’” said study principal investigator Younghoon Kim, Ph.D., professor in the ...

CAMBRIDGE, MA – An intricate, honeycomb-like structure of struts and beams could withstand a supersonic impact better than a solid slab of the same material. What’s more, the specific structure matters, with some being more resilient to impacts than others. That’s what MIT engineers are finding in experiments with microscopic metamaterials — materials that are intentionally printed, assembled, or otherwise engineered with microscopic architectures that give the overall material exceptional properties. In a study appearing today in the Proceedings of the National Academy of Sciences, the engineers report on a new way ...

Global tree-planting campaigns have reached fad-like proportions over the past decade, and it’s easy to understand their appeal. Healthy forests help in the fight against climate change by absorbing some of our excess carbon dioxide emissions, and they can provide wildlife habitat and quality-of-life benefits for local human communities too. So why not plant more trees? It seems like an easy win.  But the problem is, there’s a huge difference between simply planting a tree and making sure that trees survive and grow over the long-term. And without the necessary ecological understanding or long-term planning and ...

Embargoed for release until 5:00 p.m. ET on Monday 29 January 2024   Annals of Internal Medicine Tip Sheet    @Annalsofim   Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.   ----------------------------   1. ...

HERSHEY, Pa. — Prenatal exposure to air pollution increases the risk of severe respiratory distress in newborn babies, according to new research conducted at the Penn State College of Medicine in collaboration with the Maternal-Infant Research on Environmental Chemicals (MIREC) Study led by Health Canada. The risk increases with exposure specifically to fine particulate matter (PM2.5) and nitrogen dioxide (NO2), which occur in wildfire and cigarette smoke and vehicle emissions, among other sources. The findings, which published on Jan. 25 in the journal Environmental Health Perspectives, reveal a better understanding of ...

New research from University of Utah psychology researchers is helping prove what American authors John Muir and Henry David Thoreau tried to teach more than 150 years ago: Time spent in nature is good for the heart and soul. Amy McDonnell and David Strayer are showing it is good for your brain, too. Their latest research, conducted at the university’s Red Butte Garden, uses electroencephalography (EEG), which records electrical activity in the brain with small discs attached to the scalp, to measure participants’ attentional capacity. “A walk in nature enhances certain executive control processes in the brain above and beyond the benefits associated with exercise,” ...

A new guideline to help define the emerging field of Medical Extended Reality. Which seeks to standardize terminology, categorize existing work, and provide a structured framework for future research development in MXR.   END ...

Statement Highlights: Despite significant advances in research, education, clinical practice and community-based programs, survival from cardiac arrest remains low. Significant disparities also exist in cardiac arrest outcomes. This scientific statement specifically identifies impact goals to achieve or exceed by 2030 to improve cardiac arrest for all people. DALLAS, January 22, 2024 — Only 10% of people who experience a cardiac arrest survive.[1] In new challenge goals outlined in the American Heart Association Emergency Cardiovascular Care 2030 Impact Goals and Call to Action to Improve Cardiac Arrest Outcomes, the American Heart Association’s volunteer ...

“An improved understanding of the molecular basis of thyroid cancer has led to the development of new targeted agents.” BUFFALO, NY- January 29, 2024 – A new research perspective was published in Oncotarget's Volume 15 on January 24, 2024, entitled, “Genetic alterations in thyroid cancer mediating both resistance to BRAF inhibition and anaplastic transformation.” In this new paper, researchers Mark Lee and Luc GT Morris from New York Presbyterian Hospital and Memorial Sloan Kettering Cancer Center discuss thyroid cancer. A subset of thyroid cancers present at advanced stage or with dedifferentiated histology and have limited response to standard therapy. ...

Previous studies focused on cocaine use have found that women are more likely than men to develop an addiction, try cocaine at a younger age, use larger amounts of the drug, and suffer from overdose. Now, a new study from researchers at The University of Texas at Arlington in the journal Pharmacology Biochemistry and Behavior finally validates what scientists have long suspected: The female sex hormone estradiol (a synthetic version of the naturally occurring estrogen) is responsible for why women are more susceptible to cocaine addiction than men. “For the first time, we have shown that estradiol enhances the cocaine-conditioned reward,” said Linda Perrotti, ...

By Ileana Wachtel January 29, 2024 Chinese citizens who rarely voice open criticism of their government reveal stronger negative views when they can answer questions anonymously, according to a new study published in The China Quarterly. The study by researchers at the USC Dornsife College of Letters, Arts and Sciences shows an enormous drop in citizen support for the Chinese Communist Party (CCP) and government policies when citizens are surveyed using a method that hides their identities and makes them feel more anonymous than a typical survey. Why ...

COLUMBIA, Mo. -- School nurses are more than just health care heroes. They also play a key role in identifying students who are at risk for chronic absenteeism — a growing problem that diminishes academic success and can hurt students’ health and lead to a variety of negative long-term life outcomes. A recent study by a University of Missouri researcher found that school nurses are often well-positioned to identify students at-risk for chronic school absenteeism. The finding could help schools implement assessments and interventions to ultimately better support students ...

LA JOLLA, CA — Nerve cells in the brain demand an enormous amount of energy to survive and maintain their connections for communicating with other nerve cells. In Alzheimer’s disease, the ability to make energy is compromised, and the connections between nerve cells (called synapses) eventually come apart and wither, causing new memories to fade and fail. A Scripps Research team, reporting in the journal Advanced Science on January 18, 2024, has now identified the energetic reactions in brain cells that malfunction and lead to neurodegeneration. By using a small molecule ...

HOUSTON – (Jan. 29, 2023) – Rice University scientists have discovered a first-of-its-kind material, a 3D crystalline metal in which quantum correlations and the geometry of the crystal structure combine to frustrate the movement of electrons and lock them in place. The find is detailed in a study published in Nature Physics. The paper also describes the theoretical design principle and experimental methodology that guided the research team to the material. One part copper, two parts vanadium and four parts sulfur, the alloy features a 3D pyrochlore lattice consisting ...

It has long been known that agricultural pesticides are one of the greatest threats to bees and other essential pollinators. What farmers have lacked is an understanding of how different pesticides, applied at various times on a variety of crops, affect the risk of exposure to bees living near the fields. Researchers have drawn from real-world data to try to address this gap, developing and testing a spatial model for predicting pesticide exposure in bumblebees. The journal Science of the Total Environment published the work, based on the interactions of the yellow-faced bumblebee (Bombus vosnesenskii) ...

EMBARGOED UNTIL MONDAY, 29 JANUARY 2024, 21:00 CET (20:00 LONDON TIME, 15:00 U.S. EASTERN TIME) Have you ever seen a hummingbird hawk moth? When people encounter this moth for the first time, they are usually intrigued: Looking like a cross between a butterfly and a bird – hence the name – this animal has the amazing ability to hover like a helicopter for long periods. On closer inspection, another feature of the hummingbird hawk moth quickly catches the eye: the spiralling curled proboscis, which is as long as the entire animal. The moth uses its proboscis ...