FOR IMMEDIATE RELEASE A combination of two cancer drugs could be effective against malignant peripheral nerve sheath tumors (MPNSTs) — soft tissue tumors that are stubbornly resistant to chemotherapy and radiation — according to a laboratory study led by researchers at the Johns Hopkins Kimmel Cancer Center.  Both drugs interfere with cell growth and replication but have different mechanisms of action. Used together, they suppressed the growth of MPNSTs in mouse models of human disease, the researchers found. The findings were published ...

Harmful emissions from the industrial sector could be reduced by up to 85% across the world, according to new research.  The sector, which includes iron and steel, chemicals, cement, and food and drink, emits around a quarter of global greenhouse gas (GHG) emissions - planet-warming gases that result in climate change and extreme weather.   This new study, led by the University of Leeds as part of its contribution to the UK Energy Research Centre (UKERC), found that decarbonising the sector is technically possible with a mix of “high and low-maturity” technologies - those that are tried and tested, along with upcoming tech that is not yet ready to be used in industry.   Lead ...

In a rare but serious complication of cancer, the body’s own immune system can start attacking the brain, causing rapid-onset memory loss and cognitive deficits. What triggers this sudden biological civil war was largely unknown. Now, researchers at University of Utah Health have found that some tumors can release a protein that looks like a virus, kickstarting an out-of-control immune reaction that may damage brain cells. Their findings published in Cell on Jan. 31, 2024. A rapid immune attack Jason Shepherd, Ph.D., associate ...

"Only exercise can remove all kinds of doubts," Goethe said. Physical exercise is the lubricant between the body and the mind. Alleviation of anxiety by motor activity forms an integral part of our daily life; whether going for a walk to refresh our mind or running excessively in the park to recuperate from a stressful event, we are all well aware of the beneficial impact. In fact, the plain view that exercise can prevent anxiety and depression has been supported by accumulating prospective cohort studies in recent years. Yet, apart from some general interactions between the periphery of our body and our ...

Nuclear facilities, particularly during decommissioning, face significant challenges due to hazardous materials and environments. Traditional methods often rely heavily on human intervention, posing risks and inefficiencies. A groundbreaking research introduces a symbiotic autonomous robot ecosystem, designed to transform nuclear facility decommissioning. This innovative approach leverages a Cyber-Physical System (CPS) coordinated through a digital twin interface, significantly enhancing safety, efficiency, and operational awareness ...

Intensive agricultural cultivation and the resulting changes in soil structure cause low humidity in the near-surface air during heat waves in really dry years. As a result, summer cold fronts roar across the Plain without the usual thunderstorms and precipitation, researchers at the Institute of Geography and Earth Sciences at Eötvös Loránd University explain in a review of articles on topics ranging from geodynamics to soil science to meteorology what made the summer of 2022 so severe in the eastern part of the country. In 2022, the 7-week period starting in mid-June was disastrous for eastern Hungary. Almost no rain fell for weeks, and in the eastern part of the country, ...

Research in recent years displays that several chemical modifications (binders, composite materials, and electrolytes) provide superior stability and enhance electrochemical performance in Si-based anodes in lithium-ion batteries (LIBs). Thus far, several different chemical interactions on structural alterations to Si-based anode materials have been tried to enhance Li+ kinetics, structural stability, and volume development control throughout the delithiation/lithiation process. Despite significant advancements, Si and Si-based electrodes are still in their infancy and are still far from finding widespread practical use. Si-based anodes face some difficulties, including substantial ...

Angiotensin-converting enzyme inhibitors - ACE inhibitors for short - are effective antihypertensive drugs. They block the formation of the hormone angiotensin II, which plays a central role in the development of high blood pressure. On the other hand, these drugs increase the concentration of the vasoactive signaling substance bradykinin. Among other things, this can lead to acute swelling of the skin or mucous membranes. In general, such swellings are not life-threatening. However, if they affect the tongue, throat or larynx, angioedema can be life-threatening for the patient due to the potential risk of suffocation. Research to date suggests that susceptibility to such drug-induced angioedema ...

Space solar power satellite (SSPS) is a tremendous energy system that collects and converts solar power to electric power in space, and then transmits the electric power to earth, spacecraft, or moving targets via microwave. It is regarded as one of the most potential ways to solve the problem of energy crisis. In 2022, a team of researchers from Xidian University in China has completed a full-link and full-system ground demonstration and verification system for an SSPS, named the Sun-Chasing Project. Their study, recently published in Engineering, introduces the design concept of OMEGA 2.0 SSPS, the related key technologies, and the development of ground demonstration ...

WASHINGTON—Coronary artery calcification is increasing in prevalence, leading to greater risks both during procedures such as percutaneous coronary intervention (PCI) and adverse events in the short and long term. Along with these challenges, treatment options are expanding, increasingly including calcium modification prior to stent implantation. A newly published SCAI Expert Consensus Statement on the Management of Calcified Coronary Lesions outlines methods for interventional cardiologists to identify various types of calcified coronary lesions ...

Brain function depends on the swift movement of electrical signals along axons, the long extensions of nerve cells that connect billions of brain cells. The nerve fibers are insulated by a fatty layer called myelin, which is produced by specialized cells called oligodendrocytes. These cells wrap around and insulate nerve fibers ensuring the rapid and efficient transmission of signals that is essential for brain function. Oligodendrocytes sense and respond to the electrical signals Now, a team of neuroscientists led by Aiman Saab at the Institute of Pharmacology and Toxicology at the University ...

Northwestern University researchers have successfully coaxed a deadly pathogen to destroy itself from the inside out. In the new study, researchers modified DNA from a bacteriophage or “phage,” a type of virus that infects and replicates inside of bacteria. Then, the research team put the DNA inside Pseudomonas aeruginosa (P. aeruginosa), a deadly bacterium that is also highly resistant to antibiotics. Once inside the bacterium, the DNA bypassed the pathogen’s defense mechanisms ...

NIH study shows higher mortality rates for patients on respiratory support in rural intermediate care units Findings highlight the importance of providing ICU-level care to rural patients with respiratory failure A new National Institutes of Health-supported study finds that patients receiving ventilator life support in the intermediate care units – a potentially less costly alternative for people not sick enough for the intensive care units (ICUs) but too ill for the general ward – of rural hospitals had significantly higher death rates than patients in the same type of ...

A researcher from the New Jersey Institute of Technology has published a perspective paper that examines sentience and its application to artificial intelligence (AI) and robotics. Sentience describes the ability to sense and feel, drawing its meaning from the Latin word sentire which means “to feel.” The paper addresses a set of ideological commitments at stake in debates over sentient machines. The author proposes that artificial sentience is both necessary and impossible.   The perspective paper is published in the Journal of Social Computing on December 31, 2023.   “I argue ...

Medicare is sporadically compromised by fraudulent insurance claims. These illicit activities often go undetected, allowing full-time criminals and unscrupulous health providers to exploit weaknesses in the system. Last year, the estimated annual fraud topped $100 billion according to the National Health Care Anti-Fraud Association, but it is likely much higher. Traditionally, to detect Medicare fraud, a limited number of auditors, or investigators, are responsible for manually inspecting thousands of claims, but only have enough time to look for very specific patterns indicating suspicious behaviors. Moreover, there are not enough ...

Green roofs have become increasingly popular thanks to their benefits related to climate adaptation, mitigation, and urban biodiversity management. These vegetated surfaces on the rooftops of buildings absorb excess storm water, reduce energy use by insulating buildings, and cool neighborhoods, tempering urban heat islands, while also creating urban habitats for plants, pollinators, and wildlife. But, in the U.S., green roofs are typically planted with non-native plants in sterile soils, and their effectiveness declines over time. A Dartmouth-led research team set out to determine ...

SEATTLE – For many aspiring mothers with autoimmune disease, pregnancy can be daunting and full of unknowns. In some cases, those suffering from specific autoimmune conditions have chosen to forego pregnancy altogether due to concerns about their disease treatments and adverse pregnancy outcomes. In a just-published study in the journal Lancet eClinical Health, researchers at the Institute for Systems Biology (ISB) and Providence showed nuanced pregnancy outcomes for pregnant individuals with autoimmune disease. The ...

The world of online dating can be overwhelming with the dizzying array of options for attracting a partner but new research from Washington University in St. Louis shows that those looking for love may have more success if they also seek a sense of purpose in life. Researcher Isabella D’Ottone, in the lab of Patrick Hill, associate professor of psychological and brain sciences in Arts & Sciences, published a study about how that sense of purpose can affect how others may rate dating app profiles. Those whose profiles show a sense of purpose were rated higher on various scales for attractiveness compared ...

COLUMBUS, Ohio – A new study has found that the brain system enabling us to inhibit our own pain changes with age, and that gender-based differences in those changes may lead females to be more sensitive to moderate pain than males as older adults. Researchers used fMRI scans to examine brain responses in men and women who had rated the intensity and unpleasantness of pain during exposure to increasing levels of heat. The results suggested that established gender differences in pain perception could likely be traced at least ...

Photoluminescent molecules, capable of absorbing and re-emitting light, play an important role in the development of technologies such as light-emitting diodes, sensors, and displays. Among them, ordered arrangements of π-electronic molecules such as crystals of organoplatinum(II) complexes, where a platinum(II) ion is coordinated by organic ligands in a square-planar arrangement, stand out for their applications in energy-efficient flexible displays. However, their luminescence in the solid state is short-lived due to the interaction between excitons (bound electron-hole pairs) of neighboring molecules. To address this ...

A new system that brings together real-world sensing and virtual reality would make it easier for building maintenance personnel to identify and fix issues in commercial buildings that are in operation. The system was developed by computer scientists at the University of California San Diego and Carnegie Mellon University.  The system, dubbed BRICK, consists of a handheld device equipped with a suite of sensors to monitor temperature, CO2 and airflow. It is also equipped with a virtual reality environment that has access to the sensor data and metadata in a specific building while being ...

PULLMAN, Wash. – A snippet of hair can reveal a pregnant person’s stress level and may one day help warn of unexpected birth problems, a study indicates. Washington State University researchers measured the stress hormone cortisol in hair samples of 53 women in their third trimester. Of that group, 13 women who had elevated cortisol levels later experienced unpredicted birth complications, such as an early birth or hemorrhaging. While more research is needed with larger groups, this preliminary finding could eventually lead to a non-invasive way to identify those ...

Palliative care is the interdisciplinary medical specialty of caring for people with serious and often terminal illnesses. Its aim is to improve quality of life for such patients and their families, by relieving symptoms and stress. Palliative care is widely considered to be a human right, even if the World Health Organization estimates that only 14% of the approximately 56.8 million people who need it each year worldwide actually receive it. Since seriously ill patients often experience stress, psychological interventions such as relaxation therapy play an important role in palliative care. Now, researchers have shown in a ground-breaking clinical trial ...

Since the onset of COVID-19, we've become accustomed to seeing antiviral films attached to elevator buttons and public transportation handles. However, conventional antiviral films are made by mixing antiviral metal particles with polymers. Due to the manufacturing process, only a very small fraction of these metal particles is exposed on the surface. As a result, contrary to the belief that these films will protect us from viruses, the actual antiviral effect upon contact with the film surface is not ...

LiDAR sensors are indispensable for the realization of advanced technologies such as advanced driver assistance systems (ADAS), autonomous driving, and AR/VR. In particular, short- and mid-range LiDAR used in AR/VR devices and smartphones requires better distance (depth) resolution to detect the shape of a person or object more accurately, and so a single-photon detector with better timing jitter performance is required. LiDAR measures distance and creates a 3D image by calculating the time it takes for a photon emitted by the transmitter to strike an object, reflect, and arrive back at the ...