January 31, 2024—Using Emergency Medical Services (EMS) data, researchers at Columbia University Mailman School of Public Health compared the national burden of pedestrian injuries from motor vehicles to that of pedestrian falls occurring on streets and sidewalks and found that the probability of a pedestrian suffering a severe injury is higher for motor vehicle collisions as compared to falls.   Yet, the public health burden of the number of pedestrians injured from a fall – severe or otherwise - is significantly higher compared to the number of pedestrians injured by a motor ...

A protein found abundantly in breast cancers that are refractory to conventional treatments is thought to cause the development of metastasis. Targeting it would prevent metastatic spread and therefore increase patients survival. These are the findings of a study conducted by a French-American team and led by a biologist at CNRS1. The study, the results of which appear on 31st January in Cell Discovery, aims to better understand the mechanisms at play in the development of primary tumours in aggressive ...

About The Study: In this analysis using data from the 2019 Global Burden of Disease study, there was a high prevalence of mental disorders affecting children and youths, indicating that more than 1 of 10 (or 293 million) individuals ages 5 to 24 globally live with a diagnosable mental disorder. In terms of burden, around one-fifth of all disease-related disability (considering all causes) was attributable to mental disorders among this population. Additionally, this age period encompasses about one-fourth of the mental disorder burden across the entire life course.  Authors: Christian Kieling, M.D., Ph.D., of the Universidade ...

RICHMOND, Va. (Jan. 31, 2024) – As many as 10% of older U.S. veterans diagnosed with dementia may suffer instead from reversible cognitive decline caused by advanced liver disease, according to an analysis from the Virginia Commonwealth University’s School of Medicine and the Richmond VA Medical Center.  It can be difficult for physicians to differentiate dementia from the cognitive decline caused by cirrhosis, called hepatic encephalopathy. If undetected, patients may not receive appropriate treatment that can reverse or halt the impairment. ...

About The Study: Participation in leisure-time physical activity at the recommended level or above was associated with lower odds of both non-injurious and injurious falls in this study of 7,100 older women. Brisk walking and both moderate and moderate-vigorous leisure-time physical activity were associated with lower odds of non-injurious falls. Authors: Wing S. Kwok, B.App.Sc., of the University of Sydney in Sydney, Australia, is the corresponding author.  To access the embargoed study: Visit our For The Media website ...

Researchers from the Oxford Martin Programme on the Future of Plastics, University of Oxford, have outlined ambitious targets to help deliver a sustainable and net zero plastic economy.  In a paper published in Nature, the authors argue for a rethinking of the technical, economic, and policy paradigms that have entrenched the status-quo, one of rising carbon emissions and uncontrolled pollution. Currently the global plastics system results in over 1 gigatonnes per annum (Gt/annum) of carbon dioxide equivalent emissions which is the same as the total combined emissions ...

New Haven, Conn. — Treatment with a molecule known as A485 can quickly and temporarily increase levels of white blood cells, a critical part of the body’s immune system, an effect that is difficult to deliver with currently available pharmaceuticals, a new Yale study finds.  In an experiment, the researchers found that exposure to the molecule in mice caused white blood cells to mobilize from the bone marrow, a response that could inform future treatment for patients who need a boost in immune activity, the researchers say. The findings were reported Jan. 31 in the journal ...

Unexpected findings have emerged about how and when certain infection-killing white blood cells decide to form memories about their encounters with a pathogen. It has been known for decades that these cells can turn themselves into durable memory cells that can survive a long time after an initial infection is cleared. They are prepared to quickly recognize and eliminate future intrusions by the same kind of pathogen. That is one reason people are resistant to some infectious diseases after exposure to or recovery from the illness.  Vaccinations also work this ...

(Boston)—Significant bleeding due to traumatic injury is the number one cause of preventable deaths in the U.S., with the majority of deaths occurring within six hours. Emerging evidence suggests that the transfusion of whole blood (blood that is not separated into parts) is associated with a survival benefit compared to the traditional use of blood component transfusion (red blood cells, plasma, and platelets) in these patients. A new study from researchers from Boston University Chobanian & Avedisian School of ...

FOR IMMEDIATE RELEASE A combination of two cancer drugs could be effective against malignant peripheral nerve sheath tumors (MPNSTs) — soft tissue tumors that are stubbornly resistant to chemotherapy and radiation — according to a laboratory study led by researchers at the Johns Hopkins Kimmel Cancer Center.  Both drugs interfere with cell growth and replication but have different mechanisms of action. Used together, they suppressed the growth of MPNSTs in mouse models of human disease, the researchers found. The findings were published ...

Harmful emissions from the industrial sector could be reduced by up to 85% across the world, according to new research.  The sector, which includes iron and steel, chemicals, cement, and food and drink, emits around a quarter of global greenhouse gas (GHG) emissions - planet-warming gases that result in climate change and extreme weather.   This new study, led by the University of Leeds as part of its contribution to the UK Energy Research Centre (UKERC), found that decarbonising the sector is technically possible with a mix of “high and low-maturity” technologies - those that are tried and tested, along with upcoming tech that is not yet ready to be used in industry.   Lead ...

In a rare but serious complication of cancer, the body’s own immune system can start attacking the brain, causing rapid-onset memory loss and cognitive deficits. What triggers this sudden biological civil war was largely unknown. Now, researchers at University of Utah Health have found that some tumors can release a protein that looks like a virus, kickstarting an out-of-control immune reaction that may damage brain cells. Their findings published in Cell on Jan. 31, 2024. A rapid immune attack Jason Shepherd, Ph.D., associate ...

"Only exercise can remove all kinds of doubts," Goethe said. Physical exercise is the lubricant between the body and the mind. Alleviation of anxiety by motor activity forms an integral part of our daily life; whether going for a walk to refresh our mind or running excessively in the park to recuperate from a stressful event, we are all well aware of the beneficial impact. In fact, the plain view that exercise can prevent anxiety and depression has been supported by accumulating prospective cohort studies in recent years. Yet, apart from some general interactions between the periphery of our body and our ...

Nuclear facilities, particularly during decommissioning, face significant challenges due to hazardous materials and environments. Traditional methods often rely heavily on human intervention, posing risks and inefficiencies. A groundbreaking research introduces a symbiotic autonomous robot ecosystem, designed to transform nuclear facility decommissioning. This innovative approach leverages a Cyber-Physical System (CPS) coordinated through a digital twin interface, significantly enhancing safety, efficiency, and operational awareness ...

Intensive agricultural cultivation and the resulting changes in soil structure cause low humidity in the near-surface air during heat waves in really dry years. As a result, summer cold fronts roar across the Plain without the usual thunderstorms and precipitation, researchers at the Institute of Geography and Earth Sciences at Eötvös Loránd University explain in a review of articles on topics ranging from geodynamics to soil science to meteorology what made the summer of 2022 so severe in the eastern part of the country. In 2022, the 7-week period starting in mid-June was disastrous for eastern Hungary. Almost no rain fell for weeks, and in the eastern part of the country, ...

Research in recent years displays that several chemical modifications (binders, composite materials, and electrolytes) provide superior stability and enhance electrochemical performance in Si-based anodes in lithium-ion batteries (LIBs). Thus far, several different chemical interactions on structural alterations to Si-based anode materials have been tried to enhance Li+ kinetics, structural stability, and volume development control throughout the delithiation/lithiation process. Despite significant advancements, Si and Si-based electrodes are still in their infancy and are still far from finding widespread practical use. Si-based anodes face some difficulties, including substantial ...

Angiotensin-converting enzyme inhibitors - ACE inhibitors for short - are effective antihypertensive drugs. They block the formation of the hormone angiotensin II, which plays a central role in the development of high blood pressure. On the other hand, these drugs increase the concentration of the vasoactive signaling substance bradykinin. Among other things, this can lead to acute swelling of the skin or mucous membranes. In general, such swellings are not life-threatening. However, if they affect the tongue, throat or larynx, angioedema can be life-threatening for the patient due to the potential risk of suffocation. Research to date suggests that susceptibility to such drug-induced angioedema ...

Space solar power satellite (SSPS) is a tremendous energy system that collects and converts solar power to electric power in space, and then transmits the electric power to earth, spacecraft, or moving targets via microwave. It is regarded as one of the most potential ways to solve the problem of energy crisis. In 2022, a team of researchers from Xidian University in China has completed a full-link and full-system ground demonstration and verification system for an SSPS, named the Sun-Chasing Project. Their study, recently published in Engineering, introduces the design concept of OMEGA 2.0 SSPS, the related key technologies, and the development of ground demonstration ...

WASHINGTON—Coronary artery calcification is increasing in prevalence, leading to greater risks both during procedures such as percutaneous coronary intervention (PCI) and adverse events in the short and long term. Along with these challenges, treatment options are expanding, increasingly including calcium modification prior to stent implantation. A newly published SCAI Expert Consensus Statement on the Management of Calcified Coronary Lesions outlines methods for interventional cardiologists to identify various types of calcified coronary lesions ...

Brain function depends on the swift movement of electrical signals along axons, the long extensions of nerve cells that connect billions of brain cells. The nerve fibers are insulated by a fatty layer called myelin, which is produced by specialized cells called oligodendrocytes. These cells wrap around and insulate nerve fibers ensuring the rapid and efficient transmission of signals that is essential for brain function. Oligodendrocytes sense and respond to the electrical signals Now, a team of neuroscientists led by Aiman Saab at the Institute of Pharmacology and Toxicology at the University ...

Northwestern University researchers have successfully coaxed a deadly pathogen to destroy itself from the inside out. In the new study, researchers modified DNA from a bacteriophage or “phage,” a type of virus that infects and replicates inside of bacteria. Then, the research team put the DNA inside Pseudomonas aeruginosa (P. aeruginosa), a deadly bacterium that is also highly resistant to antibiotics. Once inside the bacterium, the DNA bypassed the pathogen’s defense mechanisms ...

NIH study shows higher mortality rates for patients on respiratory support in rural intermediate care units Findings highlight the importance of providing ICU-level care to rural patients with respiratory failure A new National Institutes of Health-supported study finds that patients receiving ventilator life support in the intermediate care units – a potentially less costly alternative for people not sick enough for the intensive care units (ICUs) but too ill for the general ward – of rural hospitals had significantly higher death rates than patients in the same type of ...

A researcher from the New Jersey Institute of Technology has published a perspective paper that examines sentience and its application to artificial intelligence (AI) and robotics. Sentience describes the ability to sense and feel, drawing its meaning from the Latin word sentire which means “to feel.” The paper addresses a set of ideological commitments at stake in debates over sentient machines. The author proposes that artificial sentience is both necessary and impossible.   The perspective paper is published in the Journal of Social Computing on December 31, 2023.   “I argue ...

Medicare is sporadically compromised by fraudulent insurance claims. These illicit activities often go undetected, allowing full-time criminals and unscrupulous health providers to exploit weaknesses in the system. Last year, the estimated annual fraud topped $100 billion according to the National Health Care Anti-Fraud Association, but it is likely much higher. Traditionally, to detect Medicare fraud, a limited number of auditors, or investigators, are responsible for manually inspecting thousands of claims, but only have enough time to look for very specific patterns indicating suspicious behaviors. Moreover, there are not enough ...

Green roofs have become increasingly popular thanks to their benefits related to climate adaptation, mitigation, and urban biodiversity management. These vegetated surfaces on the rooftops of buildings absorb excess storm water, reduce energy use by insulating buildings, and cool neighborhoods, tempering urban heat islands, while also creating urban habitats for plants, pollinators, and wildlife. But, in the U.S., green roofs are typically planted with non-native plants in sterile soils, and their effectiveness declines over time. A Dartmouth-led research team set out to determine ...