Research conducted at Cruzeiro do Sul University in São Paulo, Brazil, can contribute to earlier diagnosis of diabetic neuropathy, a disorder characterized by damage to peripheral nerves, with symptoms such as pain and paresthesia (pricking, burning and numbness), mainly in the legs and feet. In the study, a group led by Professor Paulo Barbosa de Freitas Júnior measured grip force in diabetic patients while they were holding and handling objects. The results were compared with data for healthy subjects and patients with other neurological diseases, such as multiple sclerosis, Parkinson’s, and carpal tunnel syndrome (pain, numbness and tingling in the hand and arm caused by a pinched nerve in the wrist). Freitas and his ...

July 7, 2021 - The murders of George Floyd and other Black Americans have prompted a national outcry against structural racism and police brutality. How are leading nursing organizations and schools of nursing defining their positions on racism? That's the topic of a special article in the July/August issue of The Journal of the Association of Nurses in AIDS Care (JANAC). The official journal of the Association of Nurses in AIDS Care, JANAC is published in the Lippincott portfolio by Wolters Kluwer. Three major national nursing organizations and many top-ranked schools ...

Colorado researchers have published new findings in Emerging Infectious Diseases that take a first look at the use of SARS-CoV-2 mathematical modeling to inform early statewide policies enacted to reduce the spread of the Coronavirus pandemic in Colorado. Among other findings, the authors estimate that 97 percent of potential hospitalizations across the state in the early months of the pandemic were avoided as a result of social distancing and other transmission-reducing activities such as mask wearing and social isolation of symptomatic individuals. The modeling team was led by faculty and researchers in the Colorado School of Public Health and involved experts from the University of Colorado Anschutz Medical Campus, University of Colorado Denver, University of Colorado ...

Immunologists at St. Jude Children's Research Hospital have identified a biological pathway that selectively controls how key immune cells, called T follicular helper cells, mature into functional components of the immune system. The finding offers the promise of developing drugs to activate the metabolic pathway to enhance the effectiveness of vaccines, including those that protect against COVID-19. Such medications could stimulate the immune system to respond more vigorously following immunization to produce more antibodies against a virus or bacterium. The work also lays the foundation for drugs that dial down the pathway to alleviate autoimmune diseases such as lupus. In such disorders, an overactive immune system produces antibodies that attack the body's own tissues. Led by ...

URBANA, Ill. ¬- Bioenergy from crops is a sustainable alternative to fossil fuels. New crops such as energycane can produce several times more fuel per acre than soybeans. Yet, challenges remain in processing the crops to extract fuel efficiently. Four new studies from the University of Illinois explore chemical-free pretreatment methods, development of high-throughput phenotyping methods, and commercial-scale techno-economic feasibility of producing fuel from energycane in various scenarios. The studies are part of the ROGUE (Renewable Oil Generated with Ultra-productive Energycane) project at U of I. ROGUE focuses on bioengineering ...

What The Study Did: Wearable sensor data were used to examine the duration and variation of recovery among COVID-19-positive and COVID-19-negative participants. Authors: Jennifer M. Radin, Ph.D., M.P.H., of the Scripps Research Translational Institute in La Jolla, California, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.15959) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please ...

What The Study Did: The characteristics and factors associated with deaths among individuals detained in U.S. Immigration and Customs Enforcement (ICE) facilities from 2011 to 2018 were examined in this study. Authors: Parveen Parmar, M.D., M.P.H., of the Keck School of Medicine of the University of Southern California in Los Angeles, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.16019) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding ...

Diversification in the sourcing of food into cities can go a long way to tempering "food shock" -- a sudden drop in food supply due to unforeseen events, according to a team of researchers from Penn State and Northern Arizona University, who developed a statistical risk model linking supply chain diversity to the probability of a city experiencing food shocks. "The model is simple, operationally useful and hazard-agnostic," the researchers report today (July 8) in Nature. "Using this method cities can improve their resistance to food supply shocks with policies that increase the food supply chain diversity." The researchers investigated four types of food -- crops, live animals, feed and meat -- over a four-year period from ...

A massive explosion from a previously unknown source - 10 times more energetic than a supernova - could be the answer to a 13-billion-year-old Milky Way mystery. Astronomers led by David Yong, Gary Da Costa and Chiaki Kobayashi from Australia's ARC Centre of Excellence in All Sky Astrophysics in 3 Dimensions (ASTRO 3D) based at the Australian National University (ANU) have potentially discovered the first evidence of the destruction of a collapsed rapidly spinning star - a phenomenon they describe as a "magneto-rotational hypernova". The previously unknown type of cataclysm - which occurred barely a billion years after the Big Bang - is the most likely explanation ...

Our cells fight microbial invaders by engulfing them into membrane sacs - hostile environments in which pathogens are rapidly destroyed. However, the pathogen Salmonella enterica, which grows and reproduces inside our cells, has evolved ways to detoxify such hostile compartments, turning them into a comfortable home where Salmonella can survive and thrive. A team of scientists led by EMBL group leader Nassos Typas has uncovered new details of Salmonella´s survival strategies. The researchers analysed protein interactions in Salmonella-infected cells to identify the diverse biological processes of the host cell that the bacterium uses. Salmonella targets and modifies cellular protein machineries and pathways, ...

Scientists from Trinity College Dublin are homing in on a recipe that would enable the future production of entirely renewable, clean energy from which water would be the only waste product. Using their expertise in chemistry, theoretical physics and artificial intelligence, the team is now fine-tuning the recipe with the genuine belief that the seemingly impossible will one day be reality. Initial work in this area, reported just under two years ago, yielded promise. That promise has now been amplified significantly in the exciting work just published in leading journal, Cell Reports Physical Science. Energy ...

Researchers from North Carolina State University have developed a patch that plants can "wear" to monitor continuously for plant diseases or other stresses, such as crop damage or extreme heat. "We've created a wearable sensor that monitors plant stress and disease in a noninvasive way by measuring the volatile organic compounds (VOCs) emitted by plants," says Qingshan Wei, co-corresponding author of a paper on the work. Wei is an assistant professor of chemical and biomolecular engineering at NC State. Current methods of testing for plant stress or disease involve taking plant tissue samples and conducting an assay in a lab. However, this ...

The Hikurangi Margin, located off the east coast of the North Island of New Zealand, is where the Pacific tectonic plate dives underneath the Australian tectonic plate, in what scientists call a subduction zone. This interface of tectonic plates is partly responsible for the more than 15,000 earthquakes the region experiences each year. Most are too small to be noticed, but between 150 and 200 are large enough to be felt. Geological evidence suggests that large earthquakes happened in the southern part of the margin before human record-keeping began. Geophysicists, geologists, and geochemists from throughout the world have been working together to understand why this plate boundary behaves as it does, producing both imperceptible silent earthquakes, but also potentially major ...

Reston, VA--For patients with pancreatic ductal adenocarcinomas (PDAC), molecular imaging can improve staging and clinical management of the disease, according to research published in the June issue of The Journal of Nuclear Medicine. In a retrospective study of PDAC patients, the addition of PET/CT imaging with 68Ga-FAPI led to restaging of disease in more than half of the patients, most notably in those with local recurrence. PDAC is a highly lethal cancer, with a five-year survival rate of less than 10 percent. Optimal imaging of PDAC is crucial for accurate initial TNM (tumor, node, metastases) staging and selection ...

Dancing with music can halt most debilitating symptoms of Parkinson's disease First-of-its-kind York U study shows participating in weekly dance training improves daily living and motor function for those with mild-to-moderate Parkinson's TORONTO, July 7, 2021 - A new study published in Brain Sciences today, shows patients with mild-to-moderate Parkinson's disease (PD) can slow the progress of the disease by participating in dance training with music for one-and-a-quarter hours per week. Over the course of three years, this activity was found to reduce daily motor issues such as those related to balance and speech, ...

When a head of state or government official travels to another country to meet with his/her counterpart, the high-level visit often entails a range of public diplomacy activities, which aim to increase public support in the host country. These activities often include events such as hosting a joint press conference, attending a reception or dinner, visiting a historic site, or attending a social or sports event. A new study finds that public diplomacy accompanying a high-level visit by a national leader increases public approval in the host country. The findings are published in the American Political ...

The Arctic is warming at approximately twice the global rate. A new study led by researchers from McGill University finds that cold-adapted Arctic species, like the thick-billed murre, are especially vulnerable to heat stress caused by climate change. "We discovered that murres have the lowest cooling efficiency ever reported in birds, which means they have an extremely poor ability to dissipate or lose heat," says lead author Emily Choy, a Postdoctoral Fellow in the Natural Resource Sciences Department at McGill University. Following reports of the seabirds dying in their nests on sunny days, the researchers trekked the cliffs ...

Data from nine cities in Mexico confirms that identifying dengue fever “hot spots” can provide a predictive map for future outbreaks of Zika and chikungunya. All three of these viral diseases are spread by the Aedes aegypti mosquito. Lancet Planetary Health published the research, led by Gonzalo Vazquez-Prokopec, associate professor in Emory University’s Department of Environmental Sciences. The study provides a risk-stratification method to more effectively guide the control of diseases spread by Aedes aegypti. “Our results can help public health officials to do targeted, proactive interventions ...

Prostate cancer is the most diagnosed cancer and a leading cause of death by cancer in Australian men. Early detection is key to successful treatment but men often dodge the doctor, avoiding diagnosis tests until it's too late. Now an artificial intelligence (AI) program developed at RMIT University could catch the disease earlier, allowing for incidental detection through routine computed tomography (CT) scans. The tech, developed in collaboration with clinicians at St Vincent's Hospital Melbourne, works by analysing CT scans for tell-tale signs of prostate ...

Phosphinoylazidation of alkenes is a direct method to build nitrogen- and phosphorus-containing compounds from feedstock chemicals. Notwithstanding the advances in other phosphinyl radical related difunctionalization of alkenes, catalytic phosphinoylazidation of alkenes has not yet been reported. Thus, efficient access to organic nitrogen and phosphorus compounds, and making the azido group transfer more feasible to further render this step more competitive remain challenging. Recently, a research team led by Prof. Hongli Bao from Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences (CAS) reported the first iron-catalyzed phosphinoylazidation of alkenes under ...

The growing rate of ice melt in the Arctic due to rising global temperatures has opened up the Northwest Passage (NWP) to more ship traffic, increasing the potential risk of an oil spill and other environmental disasters. A new study published in the journal Risk Analysis suggests that an oil spill in the Canadian Arctic could be devastating--especially for vulnerable indigenous communities. "Infrastructure along the NWP in Canada's Arctic is almost non-existent. This presents major challenges to any response efforts in the case of a natural disaster," says Mawuli Afenyo, lead author, University of Manitoba researcher, and expert on the risks of Arctic shipping. Afenyo and his colleagues have developed a new ...

(Boston)--High-risk neuroblastoma is an aggressive childhood cancer with poor treatment outcomes. Despite intensive chemotherapy and radiotherapy, less than 50 percent of these children survive for five years. While the genetics of human neuroblastoma have been extensively studied, actionable therapeutics are limited. Now researchers in the Feng lab at Boston University School of Medicine (BUSM), in collaboration with scientists in the Simon lab at the Perelman School of Medicine at the University of Pennsylvania (Penn), have not only discovered why this cancer is so aggressive but also reveal a promising therapeutic approach to treat these patients. These findings appear online in the journal Cancer Research, a journal ...

An international research team has found that despite being the world's leading cause of pain, disability and healthcare expenditure, the prevention and management of musculoskeletal health, including conditions such as low back pain, fractures, arthritis and osteoporosis, is globally under-prioritised and have devised an action plan to address this gap. Project lead, Professor Andrew Briggs from Curtin University said more than 1.5 billion people lived with a musculoskeletal condition in 2019, which was 84 per cent more than in 1990, and despite many 'calls to action' and an ever-increasing ageing population, health systems continue to ...

Screens may be larger on smartphones now, but nearly every other component is designed to be thinner, flatter and tinier than ever before. The engineering requires a shift from shapely, and bulky lenses to the development of miniaturized, two-dimensional metalenses. They might look better, but do they work better? A team of Japan-based researchers says yes, thanks to a solution they published on July 7th in Applied Physics Express, a journal of the Japan Society of Applied Physics. The researchers previously developed a low-reflection metasurface -- an ultra-thin interface that can manipulate electromagnetic ...

Researchers from IDIBELL and the University of Barcelona (UB) have described that neurons derived from Parkinson's patients show impairments in their transmission before neurodegeneration. For this study, it has been used dopaminergic neurons differentiated from patient stem cells as a model. Parkinson's is a neurodegenerative disease characterized by the death of dopaminergic neurons. This neuronal death leads to a series of motor manifestations characteristic of the disease, such as tremors, rigidity, slowness of movement, or postural instability. In most cases, the cause of the disease is unknown, however, mutations in the LRRK2 gene are responsible for 5% of cases. Current therapies against Parkinson's are focus on alleviating the symptoms but do not stop its progression. It ...