INDIANAPOLIS - A new study from U.S. Department of Veterans Affairs, Regenstrief Institute, IUPUI and Icahn School of Medicine at Mount Sinai researchers reports that primary care physicians recognize the need for better coordination and welcome health information exchange (HIE) event notifications as a means of improving the flow of information to enable provision of better patient care. Individuals often receive medical care from more than one healthcare system. Care coordination among providers, for example after discharge from an emergency department or hospital in one system, with the patient's primary care physician in another, is ...

Should we delay covid-19 vaccination in children? The net benefit of vaccinating children is unclear, and vulnerable people worldwide should be prioritised instead, say experts in The BMJ today. But others argue that covid-19 vaccines have been approved for some children and that children should not be disadvantaged because of policy choices that impede global vaccination. Dominic Wilkinson, Ilora Finlay, and Andrew Pollard say for a health system to offer any vaccine to a child, two key ethical questions must be asked. First, do the benefits outweigh the risks? Second, if the vaccine is in short supply, does someone else need it more? "Careful attention ...

*Note: this paper is being presented at the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) and is being published in The Lancet Rheumatology. Please credit both the congress and the journal in your stories* A new study presented at this year's European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) and published in The Lancet Rheumatology, shows that the antibody - but not the T-cell - response to the first dose of the Pfizer COVID-19 vaccine is weakened in patients taking the immunosuppressant methotrexate. In contrast, antibody and T cell responses are preserved in patients taking biological drugs such as tumour necrosis factor (TNF) inhibitors. Around 3% to 7% of people in Europe and North America have ...

*Note: this paper is being presented at the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) and is being published in The Lancet Microbe. Please credit both the congress and the journal in your stories* A new study presented at this year's European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) and published in The Lancet Microbe, shows that antibodies generated by CoronaVac, an inactivated COVID-19 vaccine, work less well against the P.1 Brazil (Gamma) variant. It also suggests that the P.1 variant may be able to reinfect individuals who previously had COVID-19. ...

Interim data from a phase 3 trial of a COVID-19 vaccine developed in China (CoronaVac) suggests that two doses offer 83.5% protection against symptomatic COVID-19. The preliminary findings, published in The Lancet and presented at this year's European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), indicate that CoronaVac induces a robust antibody response. No severe adverse events or deaths were reported among the more than 10,000 trial participants in Turkey, with most adverse events mild and occurring within 7 days of an injection. However, more research is needed to confirm vaccine efficacy in the long term, in a more diverse group of participants, and against emerging variants of concern. CoronaVac uses an inactivated whole virus. When people receive the vaccine, ...

Led by the London School of Hygiene & Tropical Medicine (LSHTM), in partnership with the World Health Organization (WHO) and Avenir Health, the research team carried out a systematic review and meta-analysis of syphilis prevalence among MSM between 2000 to 2020, drawing on data from 275 studies involving more than 600,000 study participants across 77 countries. The worldwide prevalence of syphilis among MSM was 15x higher than most recent estimates for men in the general population (7.5% versus 0.5%). Researchers further estimated the prevalence across eight regions of the Sustainable Development Goals (SDG) and six regions of the WHO. Latin America and the Caribbean region had the highest prevalence of syphilis (10.6%), whereas Australia and New Zealand had the lowest (1.9%). ...

A new paper in Nature lays out the way natural ecosystems parallel U.S. supply chains and how American cities can use these tools to strengthen their supply chains. The paper, "Supply chain diversity buffers cities against food shocks," is co-authored by Benjamin Ruddell, director of the FEWSION Project and the School of Informatics, Computing, and Cyber Systems at Northern Arizona University, and Richard Rushforth, an assistant research professor in SICCS, in collaboration with FEWSION project researchers at Penn State. FEWSION is an NSF-funded collaboration that uses comprehensive data mapping to monitor domestic supply chains for food, water and energy down to the county level. This research looks at the importance of diversity within the ...

Remember Napster? The peer-to-peer file sharing company, popular in the late 1990s and early 2000s, depended on users sharing their music files. To promote cooperation, such software "could mislead its users," says Bryce Morsky, a postdoc in Penn's School of Arts & Sciences. Some file-sharing companies falsely asserted that all of their users were sharing. Or, they displayed the mean number of files shared per user, hiding the fact that some users were sharing a great deal and many others were not. Related online forums promoted the idea that sharing was both ethical and the norm. ...

As light detection and ranging (lidar) technology evolves, forest ecology and ecological restoration researchers have been using these tools in a wide range of applications. "We needed an accounting of relative accuracy and errors among lidar platforms within a range of forest types and structural configurations," said associate professor Andrew Sánchez Meador, executive director of NAU's Ecological Restoration Institute (ERI). Sánchez Meador led a study recently published in Remote Sensing, "Adjudicating Perspectives on Forest Structure: How Do Airborne, ...

Hundreds of millions of years ago, in the middle of what would eventually become Canada's Yukon Territory, an ocean swirled with armored trilobites, clam-like brachiopods and soft, squishy creatures akin to slugs and squid. A trove of fossils and rock layers formed on that ancient ocean floor have now been unearthed by an international team of scientists along the banks of the Peel River a few hundred miles south of the Arctic's Beaufort Sea. The discovery reveals oxygen changes at the seafloor across nearly 120 million years of the early Paleozoic era, a time that fostered the most rapid development and diversification of complex, multi-cellular life in Earth's history. "It's unheard of to have that much of Earth's history in one place," said Stanford University geological ...

Our gut microbiome -- the ever-changing "rainforest" of bacteria living in our intestines -- is primarily affected by our lifestyle, including what we eat or the medications we take, most studies show. But a University of Notre Dame study has found a much greater genetic component at play than was once known. In the study, published recently in END ...

Nonprofits and companies planting trees in the tropics may often pick species for their commercial rather than ecological value, researchers found in a new analysis of organizations' publicly available data. They also found many may not have tracked the trees' survival. Tree planting is a promising, but controversial, restoration strategy for fighting climate change. A new study in the journal Biological Conservation provides a detailed look at what restoration organizations across the tropics are actually doing on the ground. "We found some organizations placed an emphasis on biological diversity and forest restoration in their mission statements. When we looked at the species they reported ...

Major ecosystem changes like sea-level rise, desertification and lake warming are fueling uncertainty about the future. Many initiatives - such as those fighting to fully eradicate non-native species, or to combat wildfires - focus on actively resisting change to preserve a slice of the past. However, resisting ecosystem transformation is not always a feasible approach. According to a new paper published today in the Ecological Society of America's journal Frontiers in Ecology and the Environment, accepting and directing ecosystem change are also viable responses, and should not necessarily be viewed as fallback options or as last resorts. The paper presents a set of guiding principles for applying a "RAD" strategy - a framework that involves ...

BENGALURU, India (July 8, 2021) - A new study led by WCS-India documents how a big cat deity worshipped by Indigenous Peoples facilitates coexistence between humans and leopards. The study, published in a special issue of the journal Frontiers in Conservation Science: Human-Wildlife Dynamics called Understanding Coexistence with Wildlife documents how the Indigenous Warli people of Maharashtra, India, worship Waghoba, a leopard/tiger deity to gain protection from leopards, and how they have lived side-by-side with them for centuries (formerly tigers, too). The researchers have identified over 150 shrines dedicated ...

Researchers at Johns Hopkins Medicine have shown that a type of echocardiogram, a common test to evaluate whether a person's heart is pumping properly, may be useful in predicting which patients with COVID-19 are most at risk of developing atrial fibrillation -- an irregular heartbeat that can increase a person's risk for heart failure and stroke, among other heart issues. The new findings, END ...

Ever since the 1986 discovery that copper oxide materials, or cuprates, could carry electrical current with no loss at unexpectedly high temperatures, scientists have been looking for other unconventional superconductors that could operate even closer to room temperature. This would allow for a host of everyday applications that could transform society by making energy transmission more efficient, for instance. Nickel oxides, or nickelates, seemed like a promising candidate. They're based on nickel, which sits next to copper on the periodic table, and the two elements have some common characteristics. It ...

Conditions in the tropical ocean affect weather patterns worldwide. The most well-known examples are El Niño or La Niña events, but scientists believe other key elements of the tropical climate remain undiscovered. In a study recently published in Geophysical Research Letters, scientists from the University of Washington and NOAA's Pacific Marine Environmental Laboratory use remotely-piloted sailboats to gather data on cold air pools, or pockets of cooler air that form below tropical storm clouds. "Atmospheric cold pools are cold air masses that flow outward beneath intense thunderstorms and alter the surrounding environment," ...

In a critical next step toward room-temperature superconductivity at ambient pressure, Paul Chu, Founding Director and Chief Scientist at the Texas Center for Superconductivity at the University of Houston (TcSUH), Liangzi Deng, research assistant professor of physics at TcSUH, and their colleagues at TcSUH conceived and developed a pressure-quench (PQ) technique that retains the pressure-enhanced and/or -induced high transition temperature (Tc) phase even after the removal of the applied pressure that generates this phase. Pengcheng Dai, professor of physics and astronomy at Rice University and his group, and Yanming Ma, Dean of the College of Physics ...

The Large High Altitude Air Shower Observatory (LHAASO), one of China's key national science and technology infrastructure facilities, has accurately measured the brightness over 3.5 orders of magnitude of the standard candle in high-energy astronomy, thus calibrating a new standard for ultra-high-energy (UHE) gamma-ray sources. The standard candle is the famous Crab Nebula, which evolved from the "guest star" recorded by the imperial astronomers of China's Song Dynasty. LHAASO has also discovered a photon with an energy of 1.1 PeV (1 PeV = one quadrillion electronvolts), indicating the presence of an extremely powerful electron accelerator--about one-tenth the size of the solar system--located in the core ...

As tectonic plates slip past each other, the rivers that cross fault lines change shape. The shifting ground stretches the river channels until the water breaks its course and flows onto new paths. In a study published July 9 in Science, researchers at UC Santa Cruz created a model that helps predict this process. It provides broad context to how rivers and faults interact to shape the nearby topography. The group originally planned to use the San Andreas fault in the Carrizo Plain of California to study how fault movement shapes the landscapes near rivers. But after spending hours pouring over aerial imagery and remote topographic data, their understanding of how the terrain evolves began to change. They realized that rivers play a more active ...

For the first time, Princess Margaret researchers have mapped out where and how leukemia begins and develops in infants with Down syndrome in preclinical models, paving the way to potentially prevent this cancer in the future. Children with Down syndrome have a 150-fold increased risk of developing myeloid leukemia within the first five years of their life. Yet the mechanism by which the extra copy of chromosome 21 predisposes to leukemia remains unclear. Down syndrome is a genetic disorder caused by a random error in cell division in early human development that results in an extra copy of chromosome 21. This extra copy is what causes the developmental changes and physical ...

Proactive, frequent rapid testing of all students for COVID-19 is more effective at preventing large transmission clusters in schools than measures that are only initiated when someone develops symptoms and then tests positive, Simon Fraser University researchers have found. Professors Caroline Colijn and Paul Tupper used a mathematical model to simulate COVID-19's spread in the classroom and published their research results today in the journal PLOS Computational Biology. The simulations showed that, in a classroom with 25 students, anywhere from zero to 20 students might be infected after exposure, depending on even small adjustments ...

(BOSTON) -- Current clinical interventions for infectious diseases are facing increasing challenges due to the ever-rising number of drug-resistant microbial infections, epidemic outbreaks of pathogenic bacteria, and the continued possibility of new biothreats that might emerge in the future. Effective vaccines could act as a bulwark to prevent many bacterial infections and some of their most severe consequences, including sepsis. According to the END ...

Feeling anxious about health, family or money is normal for most people--especially during the COVID-19 pandemic. But for those with anxiety disorders, these everyday worries tend to heighten even when there is little or no reason to be concerned. Researchers from Indiana University School of Medicine recently studied the behaviors associated with anxiety--published in Psychopharmacology--examining how biological factors impact anxiety disorders, specifically in females. They found that anxiety in females intensifies when there's a specific, life-relevant condition. The team, led by Thatiane De Oliveira Sergio, PhD, postdoctoral fellow in the laboratory of Woody Hopf, PhD, professor of ...

Lesbian, gay, and bisexual Veterans from the Vietnam era report PTSD and poorer mental health more often than their heterosexual counterparts, according to an analysis of data from the Vietnam Era Health Retrospective Observational Study (VE-HEROeS). A greater burden of potentially traumatic events among LGB Veterans, such as childhood physical abuse, adult physical assault, and sexual assault, was associated with the differences. "This study is the first to document sexual orientation differences in trauma experiences, probable PTSD, and health-related quality of life in LGB Veterans using a nationally representative sample," said Dr. John Blosnich, ...