A global team of researchers has created an algorithmic tool that can identify existing drugs in order to combat future pandemics. The work, reported in the Cell Press journal Heliyon, offers the possibility of responding more quickly to public-health crises. “There is no silver bullet to defeat the Covid pandemic as it takes us over a public-health roller-coaster of deaths and devastation,” explains Naomi Maria, an immunologist, a visiting scientist at New York University’s Courant Institute of Mathematical Sciences, and the paper’s lead author. “However, using this AI tool, coupled with in vitro data and other resources, we’ve ...

Study’s findings may lead to more personalized follow-up care for patients. New research indicates that for patients with breast cancer, the cancer’s stage and receptor status can help clinicians predict whether and when cancer might recur after initial treatment. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society. For the study, Heather Neuman, MD, MS, of the University of Wisconsin, and her colleagues analyzed data on 8,007 patients with stage I–III breast cancer who participated in nine clinical trials from 1997–2013 ...

In the earliest days of human flight, before the invention of the first radio beacons and ground-based electronic systems, and modern GPS, pilots commonly navigated by following roads and railways – striking linear landscape elements at ground level that guide towards a destination of interest. Enter the honeybee. A century of research has shown that honeybees are navigators par excellence. They can navigate by their sense of smell, the sun, the sky’s pattern of polarized light, vertical landmarks that stand out from the panorama, and possibly the Earth’s magnetic field. They are also clever learners, able to recognize associations between disparate ...

PITTSBURGH, March 6, 2023 — The monthly opioid overdose death (ODD) rate fell by 30% in Pennsylvania counties that implemented a novel community-focused strategy developed by University of Pittsburgh researchers, according to a new study published today in the Journal of Studies on Alcohol and Drugs. By analyzing counties that did or didn’t implement the Pennsylvania Opioid Overdose Reduction Technical Assistance Center (ORTAC) strategy over time, the researchers estimate that this cost-effective, community-led approach prevented 1,818 opioid-related deaths over two years. “I ...

Conifers are generally better than broadleaved trees at purifying air from pollutants. But deciduous tree may be better at capturing particle-bound pollution. A new study led by the University of Gothenburg shows that the best trees for air purification depend on the type of pollutant involved. Trees and other greenery in cities provide many benefits that are important for the well-being of residents. Leaves and needles on trees filter air pollutants and reduce exposure to hazardous substances in the air. But which trees purify the air most effectively? Researchers from the University ...

Scientists in Japan have revealed a chemical compound that could be used for the treatment of various autoimmune diseases like multiple sclerosis and rheumatoid arthritis. These diseases occur when the body’s immune response goes wiry. The immune system, which normally attacks pathogens and infections, instead attacks healthy cells and tissues. For the millions of people who suffer from autoimmune diseases worldwide, the result can be debilitating—rheumatoid arthritis causes excessive joint pain, while multiple sclerosis can disable one’s brain and spinal cord function. “The key to the development of autoimmune ...

Promoting physical activity and other behavioural support can help people wanting to reduce their smoking to quit in the short-term. However, after nine months, physical activity delivers no noticeable benefits – compared with offering no additional support – in the rates of people stopping smoking, according to the findings of a major national study. The Trial of physical Activity and Reduction of Smoking (TARS) study, led by the University of Plymouth with funding from the National Institute for Health and Care Research, took place across four cities – Plymouth, Nottingham, Oxford and ...

A total of 1,261,990 people will die from cancer in 2023 in the EU (EU-27). A further 172,314 people will die from the disease in the UK, according to new research published in the leading cancer journal Annals of Oncology [1] today (Monday).   Researchers led by Carlo La Vecchia (MD), a professor at the University of Milan (Italy), estimate there will be a 6.5% fall in cancer death rates in men and a 3.7% fall in women between 2018 and 2023.   They predict that death rates from the ten most common cancers will continue to fall in most European countries in 2023, although the numbers of people dying will go up ...

Globally, activated sludge treats the majority of urban wastewaters; yet it is one of the most complex biological processes used. It is a sophisticated microbial process fraught with operational problems leading to occasional failures in achieving required effluent quality standards. With the increasing problem of partially treated and raw sewage entering rivers and estuaries, the pressure on the process to cope with ever increasing volumes of wastewater has never been so great. With increasing volumes of dilute wastewater entering treatment plants the high variability in hydraulic and organic ...

Cell membranes are barriers that maintain cellular homeostasis, and the intracellular delivery of biologically functional molecules, including peptides, proteins, and nucleic acids to manipulate cellular functions. Conventional intracellular uptake processes require high concentrations of biofunctional molecules with low permeability to pass through the cell membrane. This results in low drug activity because the probability of the biofunctional molecules entering target cells and their organelles is low. In addition, many drugs damage healthy cells as well as the cells that are supposed to target due to poor selectivity, making ...

Why are Canadians having problems accessing physicians despite historic highs in physician numbers? Factoring in changing demographics and physician work trends can help with physician workforce planning, according to a new analysis in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.221239. "[T]he increasing [health care] needs of an aging population have been empirically important since around 2005, while the supply of physician service hours has simultaneously declined in a manner that is largely unrelated to the evolving age–sex composition of the physician workforce," writes Dr. Arthur Sweetman, ...

Pregnant and postpartum people with schizophrenia have a more than threefold increase in the risk of an emergency department visit for interpersonal violence, compared with those without schizophrenia, according to a new study in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.220689. Interpersonal violence can include physical, sexual and psychological abuse by a family member, intimate partner, acquaintance or stranger. "Though we found a threefold increased risk for individuals with schizophrenia, we also found that ...

Getting tested for levels of HDL (the good) and LDL (the bad) cholesterol is part of the annual physical exam. But emerging research is showing that these standard tests may not be the most accurate way to test for heart disease risk. Instead, emerging data suggest that testing for levels of Apolipoprotein B-100 (ApoB), a protein that carries fat molecules, including LDL cholesterol – the so-called “bad cholesterol” – around the body, may be a more accurate risk predictor of atherosclerotic cardiovascular disease, which occurs ...

An automated system that flags which patients could most benefit from an underused yet life-saving cardiology drug more than doubled new prescriptions, according to a pilot program test by researchers at NYU Grossman School of Medicine. “Our findings suggest that tailored electronic notifications can boost the prescription of life-saving drugs,” said study lead author and cardiologist Amrita Mukhopadhyay, MD, a clinical instructor in the Department of Medicine at NYU Langone Health. “By compiling key information in one place, the system may help providers to spend less time searching through medical records during a visit ...

About The Study: In this study of nearly 13,000 U.S. adults ages 20 to 44, diabetes and obesity increased from 2009 to March 2020, while hypertension did not change and hyperlipidemia declined. The data from this study show a high and rising burden of most cardiovascular risk factors in young U.S. adults, especially for Black, Hispanic, and Mexican American individuals. Authors: Rishi K. Wadhera, M.D., M.P.P., M.Phil., of the Beth Israel Deaconess Medical Center in Boston, is the corresponding author. To access the embargoed study: Visit ...

Transcatheter mitral valve repair for heart failure patients with mitral regurgitation can reduce the long-term rate of hospitalizations by almost 50 percent, and death by nearly 30 percent, compared with heart failure patients who don’t undergo the minimally invasive procedure. These are the breakthrough findings from a new study led by a researcher from the Icahn School of Medicine at Mount Sinai. This multi-center trial is the largest trial to examine the safety and effectiveness of transcatheter mitral-valve repair in a heart failure population using Abbott’s ...

Even patients with mild COVID-19 infections can suffer from health complications for months, even years, post infection. Nearly 19% of U.S. adults who had previously tested positive for COVID-19 report having “Long COVID,” where they experience signs and symptoms for four weeks or more after the initial phase of infection. In an effort to quantify what Long COVID means now, and could mean in the future for these patients, researchers from Intermountain Health in Salt Lake City studied nearly 150,000 ...

“We are living in an extraordinary moment in history,” says Didier Queloz, who directs ETH Zurich’s Centre for Origin and Prevalence of Life and the Leverhulme Centre for Life in the Universe at Cambridge. While still a doctoral student Queloz was the first to discover an exoplanet - a planet orbiting a solar-type star outside of Earth’s solar system. A discovery for which he would later receive a Nobel Prize in physics. Within a generation, scientists have now discovered more than 5,000 exoplanets and predict the potential existence of trillions more in the Milky Way galaxy alone. Each ...

The COVID-19 pandemic impacted just about every part of people’s lives. Quarantining, social distancing, societal disruptions and an ever-shifting, uncertain landscape of rules and restrictions and variants created stress and isolation that impacted the mental health of millions of Americans. Now, in a new study of nearly 136,000 patients from Intermountain Health in Salt Lake City, researchers found that depressive symptoms and severity of depression was significant among all patients in the study, regardless ...

University of Houston researchers are developing a program to teach small-scale, underserved and limited resources (SULR) farmers how to improve their crop production by reducing greenhouse gas emissions and increasing carbon removal. The work is supported by a nearly $5 million grant from the US Department of Agriculture (USDA) Natural Resources Conservation Service. Researchers will partner with colleagues from Prairie View A&M University, Texas A&M University and Michigan Aerospace Corp. to study how best to implement a Climate-Smart ...

On Mar. 2, the first evening of the Our Ocean Conference in Panama City, Panama, a distinguished group hosted by the Smithsonian Tropical Research Institute (STRI), the Bezos Earth Fund, Re:wild and Pew Bertarelli Ocean Legacy gathered at Panama’s BioMuseo to celebrate their commitment to conserve a sustainable and resilient Eastern Tropical Pacific Ocean (ETP).    The event recognized significant contributions by the public sector—especially the governments of Panama, Colombia, Costa Rica, and Ecuador; the private sector; civil society, the scientific sector; together with generous philanthropists, ...

Sea level rise this century may disproportionately affect certain Asian megacities as well as western tropical Pacific islands and the western Indian Ocean, according to new research that looks at the effects of natural sea level fluctuations on the projected rise due to climate change. The study, led by scientists at the French National Center for Scientific Research (CNRS) and University of La Rochelle in France and co-authored by a scientist at the National Center for Atmospheric Research (NCAR), mapped sea level hotspots around the globe. The research team identified several ...

BIRMINGHAM, Ala. – Obese fruit flies are the experimental subjects in a Nature Communications study of the causes of muscle function decline due to obesity. In humans, skeletal muscle plays a crucial role in metabolism, and muscle dysfunction due to human obesity can lead to insulin resistance and reduced energy levels. Interestingly, studies in various animal models have shown that time-restricted feeding — a natural non-pharmaceutical intervention — protects against obesity, aging and circadian disruption in peripheral tissues such as skeletal muscle. However, the mechanisms underlying those ...

A ball, a saddle, or a flat plate. The curvature of biomaterials inhibits or stimulates bone cells to make new tissue. This is what TU Delft engineers show in research published on Friday, 3rd of March in Nature Communications. This study of geometries could be an important step in research into repairing damaged tissues. Living cells can perceive and respond to the geometry of their environment. ‘Cells sense and respond to the geometry of the surfaces they are exposed to. Depending on their curvature, surfaces can either encourage cells to create new tissue or prevent them from doing so,’ says Amir Zadpoor, ...

Human papillomavirus (HPV) vaccination rates among eligible veterans and active-duty military are half that of their civilian peers, putting them at greater risk of HPV-related cancers. That’s according to a new study published today in JAMA Oncology that provides the first national estimate of HPV vaccination rates in this population. “Our findings should serve as a call to action to the Department of Defense and the Veterans Health Administration to advocate that their service members get vaccinated,” said senior author José P. Zevallos, ...