Researchers from Cleveland Clinic and IBM have published a strategy for identifying new targets for immunotherapy through artificial intelligence (AI). This is the first peer-reviewed publication from the two organizations’ Discovery Accelerator partnership, designed to advance research in healthcare and life sciences. The team worked together to develop supervised and unsupervised AI to reveal the molecular characteristics of peptide antigens, small pieces of protein molecules immune cells use to recognize threats. Project members ...

Everyone ruminates about the bad things that happen to them. Whether it’s a nasty breakup, an embarrassing failure or simply when someone is mean, it can be hard to stop thinking about what happened and why. For people who ruminate too much, this negative thought pattern can cause lasting problems with mental health. A research team led from the University of California, Davis, Center for Mind and Brain found that adolescent girls who have a stronger tendency to ruminate show different patterns of brain activity when faced with social rejection. The study was ...

Neurons intricately communicate and respond to stimuli within a vast network, orchestrating essential functions from basic bodily processes to complex thoughts. Traditional neuroscience methods, relying on in vivo electrophysiology (within a living organism), often have difficulty addressing the complexity of the brain as a whole. An alternative approach involves extracting cells from the organism and conducting studies on a culture dish instead (in vitro), providing researchers with enhanced control and precision in measuring neural processes. In a new study featured in Advanced Science, researchers unveil a cost-effective, open-source in vitro system ...

While recent therapies have the potential to stall or delay the progression of multiple sclerosis, a new study shows that young Black and Hispanic women fare worse than young white women.  Minority women were more likely to have more advanced disease and faced greater challenges in pregnancy, the researchers reported in their study, publishing in the journal Neurology on Jan. 23, 2024.  Researchers tracked medical records at nine MS centers throughout the country for 294 women whose pregnancies resulted in live births. Approximately half of the patients ...

Combining testosterone-blocking drugs in patients with prostate cancer relapse prevents the spread of cancer better than treatment with a single drug, a multi-institution, Phase 3 clinical trial led by UC San Francisco researchers has found.  The approach can extend the time between debilitating drug treatments without prolonging the time it takes to recover from each treatment.   Prostate cancer affects 1 in 8 men and causes 34,000 deaths each year in the United States. It is usually treated with one of several testosterone-lowering drugs for a set period of ...

MEDIA CONTACT: Cate Douglass; cdouglass@gwu.edu   More than 50 countries are set to hold national elections this year and analysts have long sounded the alarm on the threat of bad actors using artificial intelligence (AI) to disseminate and amplify disinformation during the election season across the globe. Now, a new study led by researchers at the George Washington University predicts that daily, bad-actor AI activity is going to escalate by mid-2024, increasing the threat that it could affect election results. The research, published today in the journal PNAS Nexus, is the first quantitative scientific ...

First study to examine the impact of tissue contamination on AI models ‘If it’s paying attention to the tissue contaminants, it’s paying less attention to the patient’s tissue that is being examined’ ‘Pathologists fear — and AI companies hope — that the computers are coming for our jobs. Not yet.’   Human pathologists are extensively trained to detect when tissue samples from one patient mistakenly end up on another patient’s microscope slides ...

“[...] we identified LTBR as a potential target for cancer immunotherapy and a marker of immune infiltration and poor prognosis.”   A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 1, entitled, “Systematic analysis of the prognostic value and immunological function of LTBR in human cancer.” Lymphotoxin beta receptor (LTBR) is a positive T cell proliferation regulator gene. It is closely associated with the tumor immune microenvironment. However, its role in cancer and ...

The CUNY Graduate School of Public Health and Health Policy (CUNY SPH) has announced an expansion and endowment of the Molina Health Equity Scholarship Fund as a groundbreaking and permanent source of support for students dedicated to advancing health equity in underserved Hispanic and Latino communities. Established by Dr. Marilyn Aguirre-Molina, CUNY SPH professor emerita and CUNY SPH Foundation Board member, and distinguished academician Dr. Carlos W. Molina, the Molina Health Equity Scholarship Fund now becomes the first named and endowed master’s degree scholarship in the school’s ...

A recent study from researchers at University Hospitals (UH) Connor Whole Health examined variables associated with engagement in (1) integrative health and medicine (IHM) and (2) nonpharmacologic modalities rather than opioids among United States adults with chronic pain. The study, published in the Journal of Pain Research, uncovered disparities in access to these modalities, particularly among older adults, Black/African American individuals, and those with higher depressive symptoms and lower education and income levels, who are more likely to have chronic pain. The researchers used data ...

CHAMPAIGN, Ill. — More than 25% of the young adults surveyed in a recent study mistakenly believed that sexual activity increases older adults’ risk of heart attack and that disinterest in sex is a normal and inevitable part of aging. While most of those in the study had permissive views about sexual activity in later life, the findings also shed light on the misconceptions and ageist views that can infringe on older adults’ rights to sexual expression. More than 270 young adults ages 18-35 participated in the study, which assessed their level of knowledge about sexuality in older adulthood, their general attitudes toward ...

Marine heat waves appear to trigger earlier reproduction, high mortality in early life stages and fewer surviving juvenile Pacific cod in the Gulf of Alaska, a new study shows. These changes in the hatch cycle and early growth patterns persisted in years following the marine heat waves, which could have implications for the future of Gulf of Alaska Pacific cod, an economically and culturally significant species,     END ...

The Seismological Society of America (SSA) will present its highest honor, the 2024 Harry Fielding Reid Medal, to Norman A. Abrahamson, adjunct professor of civil and environmental engineering at the University of California, Berkeley and University of California, Davis, and former engineering seismologist at Pacific Gas & Electric Co. Abrahamson, who will receive the Reid Medal at the 2024 SSA Annual Meeting, is recognized as a global leader in the field of probabilistic seismic hazard assessment (PSHA). Within the seismic hazard community, he is known for developing new methodologies as well as refining state-of-the-art practices ...

Doyeon Kim (DK) has been honored with the Seismological Society of America’s (SSA) 2024 Charles F. Richter Early Career Award for his scientific productivity across a variety of topics, including recent work on Martian seismology and his pioneering approaches to seismic imaging. Kim, a lecturer in planetary science in the Faculty of Engineering at Imperial College London, will receive the Richter Award at the 2024 SSA Annual Meeting. “I am sincerely grateful for this award, which I humbly attribute to the collective efforts of those who have played a pivotal role in shaping my academic career. This recognition fuels my dedication to furthering ...

For his work leading to profound improvements in how earthquake science is communicated to students, the media and decision makers, the Seismological Society of America (SSA) honors Harley M. Benz with the 2024 Frank Press Public Service Award. Benz, a former U.S. Geological Survey technical coordinator for the Advanced National Seismic System (ANSS) and the director of the USGS National Earthquake Information Center (NEIC), will receive the Press Award at the 2024 SSA Annual Meeting. In his nomination of Benz for the award, Gavin Hayes, senior science advisor for earthquake ...

For his outstanding contributions as chair of the SSA Publications Committee, the Seismological Society of America (SSA) will present Douglas Scott Dreger with its 2024 Distinguished Service Award (DSA). Dreger will receive the award at the 2024 SSA Annual Meeting. Dreger, a professor of geophysics at the University of California, Berkeley, served as Publications Committee chair between 2016 and 2022. Dreger “instigated a broad range of initiatives intended to reinforce the reputation and financial performance ...

A new camera system allows ecologists and filmmakers to produce videos that accurately replicate the colors that different animals see in natural settings, Vera Vasas at the University of Sussex, UK, and colleagues from the Hanley Color Lab at George Mason University, US, report in the open access journal PLOS Biology, publishing January 23rd. Different animals perceive the world differently because of the capabilities of the photoreceptors in their eyes. For example, animals like honeybees and some birds can see UV light, which are outside the range of human perception. Reconstructing the colors that animals ...

In a new study, two species of bacteria grown in a lab reversed their predator-prey relationship after one species was grown at a lower temperature. Marie Vasse of MIVEGEC, France, and colleagues publish these findings January 23rd in the open access journal PLOS Biology. Prior research has shown that ecological context can influence predator-prey relationships. For instance, similarity or contrast between background color and coloration of a prey species can influence how easily it is detected by predators. In addition, predator-prey relationships can sometimes switch, as is the case for two crustacean species that mutually prey on each other, where a change in surrounding salinity ...

Author Interview: Why did you create this reporting guideline? We created this reporting guideline because consensus methods are widely used to produce recommendations in research and patient care, and so it is important to be able to judge how well they were conducted and how relevant these results might be. How did you go about this? We assembled an international steering committee of clinicians, journal editors, guideline and consensus experts, publication professionals and patients to look at how ...

A new study finds that very few patients diagnosed with type 2 diabetes are able to achieve normal blood glucose levels through weight loss alone. A team led by Andrea Luk of the Chinese University of Hong Kong, report these findings January 23rd in the open access journal PLOS Medicine. Clinical trials suggest that people with type 2 diabetes can control their blood glucose levels without medication if they lose weight and keep it off. However, it is unknown how many patients can achieve remission through weight loss alone under real-world conditions. In the new study, researchers looked at 37,326 people in Hong Kong who were newly diagnosed with type 2 diabetes to see ...

The Louis-Jeantet Foundation honors the Director at the Max Planck Institute (MPI) for Multidisciplinary Sciences for discovering a new kind of biological matter that acts as a highly selective barrier to control central transport pathways in the cell. He has made groundbreaking contributions to our understanding of the processes by which macromolecules are transported into and out of the cell nucleus, the foundation said. The prestigious award is endowed with 500,000 Swiss francs (around 537,000 euros). Görlich studies how cells solve the logistical challenge of getting their ...

CORVALLIS, Ore. – Ecologists have long known that standing dead trees, commonly referred to as snags, are an important habitat element for forest dwellers and act as a driver of biodiversity. They’re so important that in some managed forests, snag creation is part of the conservation tool kit – i.e., crews sometimes convert a percentage of live trees into dead ones through techniques ranging from sawing off their tops to wounding their trunks to injecting them with disease-causing fungi. Until now, however, key questions had remained unanswered: How well do any of those techniques actually work over the long term? ...

NEW ORLEANS – Ochsner Health has been named the winner of five awards from Press Ganey, a globally recognized analytics company offering healthcare experience solutions and services. These awards are part of Press Ganey’s annual ranking of the top hospitals and health systems in the country, according to performance in patient experience, employee experience, physician experience, clinical quality performance and consumer experience. “We’re honored to be recognized by Press Ganey for our excellence and compassion in caring for ...

Ozempic and other GLP1 agonists are associated with a reduced risk of developing cirrhosis and liver cancer in people with type 2 diabetes and chronic liver disease, according to a nationwide study from Karolinska Institutet in Sweden published in the journal Gut. GLP1 agonists like Ozempic reduce blood sugar levels and are mainly used to treat type 2 diabetes. However, as the drug also reduces appetite, it is now increasingly used to treat obesity and has become a popular weight-loss drug. Reduced risk of liver damage Results from early clinical trials also suggest that GLP1 agonists may reduce the risk of liver damage. Therefore, researchers at ...

DENVER/Jan. 23, 2024 – Morris Animal Foundation-funded researchers have delved into various cat species' entire DNA sequence (genome), uncovering novel perspectives on domestic and wild cat evolution. This new work highlights distinct genetic changes and will be a critical tool for researchers investigating feline diseases and characteristics. This study, which led to the findings published in Nature Genetics, used cutting-edge genome sequencing and assembly technologies to generate a more comprehensive and complete cat genome assembly, providing fundamental information on the feline blueprint and aiding in advancements in feline medicine. "This ...