Public health initiatives to understand and tackle these inequalities should be prioritised, say the researchers. The aortic valve keeps blood flowing from the heart's lower left chamber (left ventricle) to the aorta—the main artery bringing blood from the heart to the body. Aortic stenosis occurs when the aortic valve narrows as a result of calcium build-up, impeding normal blood flow. This causes shortness of breath, light headedness, and chest pain (angina). Aortic valve replacement (AVR) not only relieves these symptoms, but increases life expectancy, and improves quality of life, say the researchers, adding that up to 1 in 4 of those with severe or very severe aortic stenosis ...

Information on clinical complications is often missing, while key information on the factors behind medical decision-making, the effectiveness of the lethal drugs used, and the extent of palliative care support isn’t even collected, reveals the review. Physician assisted suicide as it’s formally known has been legal in the US state of Oregon since 1997 under the Death with Dignity Act.  The legislation allows terminally ill residents over the age of 18 to hasten their death by taking lethal drugs prescribed by a doctor, providing they are capable of making and communicating healthcare ...

A device has been created that could carry out Clinical Breast Examinations (CBE). The manipulator, designed by a team at the University of Bristol and based at the Bristol Robotics Laboratory, is able to apply very specific forces over a range similar to forces used by human examiners and can detect lumps using sensor technology at larger depths than before. This could revolutionise how women monitor their breast health by giving them access to safe electronic CBEs, located in easily accessible places, such as pharmacies and health centres, which provide accurate results.     Precision, repeatability and ...

Agriculture in Syria started with a bang 12,800 years ago as a fragmented comet slammed into the Earth’s atmosphere. The explosion and subsequent environmental changes forced hunter-gatherers in the prehistoric settlement of Abu Hureyra to adopt agricultural practices to boost their chances for survival. That’s the assertion made by an international group of scientists in one of four related research papers, all appearing in the journal Science Open: Airbursts and Cratering Impacts. The papers ...

The the latest data on  universal screening for type 1 diabetes (T1D) is reveiwed in a session at this year’s Annual Meeting of the European Association for the Study of Diabetes (EASD) in Hamburg, Germany (2-6 October). The talk will be given by Dr Emily K. Sims, Associate Professor of Pediatrics, Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA. Research by various groups has established that individuals with multiple islet autoantibodies (biomarkers showing that the body is attacking and killing its own insulin producing beta cells in ...

New research being presented at this year’s Annual Meeting of The European Association for the Study of Diabetes (EASD), Hamburg (2-6 Oct) finds that cigarette smoking increases the risk of developing type 2 diabetes in part by affecting a variety of metabolites—small chemicals produced in the processes of metabolism—that circulate in the bloodstream. The influence of these metabolic changes on diabetes risk appears to be amplified in individuals with genetic susceptibility to type 2 diabetes or insulin resistance. The analysis of over 93,000 UK Biobank participants also identified a metabolic ...

A session at this year’s Annual Meeting of the European Association for the Study of Diabetes will explore the latest data on the concept of metabolically healthy obesity (MHO) – more commonly known by the public as ‘fat but fit’. Professor Matthias Blüher, University of Leipzig, Leipzig and Helmholtz Center Munich, Germany  will explain how we define MHO and ask if it can really be described as healthy. “Some 15-20% of people living with obesity have none ...

The introduction of screening for type 2 diabetes in Accident and Emergency (A&E) departments could uncover thousands of previously undiagnosed cases every year, suggests new research being presented at this year’s Annual Meeting of The European Association for the Study of Diabetes (EASD), Hamburg (2-6 Oct). “Early diagnosis is the best way to avoid the devastating complications of type 2 diabetes, and offers the best chance of living a long and healthy life”, says Professor Edward Jude, Tameside and Glossop Integrated Care NHS Foundation Trust, UK. “Symptoms of type 2 diabetes may be absent and can be tricky ...

Six adults with type 1 diabetes (T1D) treated with stem cell-derived islet cells (VX-880) have shown improved blood sugar control with three participants achieving insulin independence, according to new research being presented at this year’s Annual Meeting of The European Association for the Study of Diabetes (EASD), Hamburg (2-6 Oct). All patients treated with VX-880 have demonstrated improved glycaemic control, as evidenced by elimination of severe hypoglycaemia (low blood sugar), improvements in HbA1c (a measure of long-term sugar levels) and the amount of time their ...

In a breakthrough for environmentally friendly chemical production, researchers at the Center for Advanced Bioenergy and Bioproducts Innovation (CABBI) have developed an economical way to make succinic acid, an important industrial chemical, from sugarcane. The team of University of Illinois and Princeton University researchers created a cost-effective, end-to-end pipeline for this valuable organic acid by engineering a tough, acid-tolerant yeast as the fermenting agent, avoiding costly steps in downstream processing. Succinic acid is a widely ...

To discover new treatments for genetic disorders, scientists need a thorough knowledge of prior literature to determine the best gene/protein targets and the most promising drugs to test. However, biomedical literature is growing at an explosive rate and often contains conflicting information, making it increasingly time-consuming for researchers to conduct a complete and thorough review.   To address this challenge, Cole Deisseroth, a graduate student enrolled in the M.D./Ph.D. program and mentored by Drs. Huda Zoghbi and Zhandong Liu at the Jan and Duncan ...

Lessening the effects of climate change will require a variety of innovations and a lot of ingenuity. Now, a new center led by the U.S. Department of Energy’s (DOE) Princeton Plasma Physics Laboratory (PPPL) will help these efforts by advancing the understanding of plasma-based clean hydrogen production. PPPL was selected to lead a DOE Energy Earthshot Research Center (EERC) as part of the Hydrogen Shot™, which aims to reduce the cost of hydrogen by 80%. With funding from the DOE’s Office of Science, the EERCs support fundamental ...

As a source of protein and biodiesel for cleaner renewable energy, soybean is an important crop worldwide. But is it performing to its full potential? An ambitious effort led by the University of Illinois Urbana-Champaign and the U.S. Department of Energy Joint Genome Institute (JGI) will sequence 400 soybean genomes to develop a “pangenome” — an attempt to characterize all the useful diversity in the genome to create an even more robust and resilient crop. The soybean pangenome project will sequence and analyze at least 50 soybean genomes from cultivated lines and wild relatives at reference quality, the gold standard of modern sequencing. A further ...

“DISE is effective against all cancers we tested.”  A new editorial paper was published in Oncotarget's Volume 14 on September 25, 2023, entitled, “DISE, an ancient anti-cancer mechanism that senses mutational load in cancerous cells?” In their new editorial, researchers Monal Patel and Marcus E. Peter from Northwestern University discuss a recent breakthrough in cancer therapy. Despite the multiple advances in therapy, cancer remains one of the most common causes of death globally. ...

A multi-institutional project led by a Penn State researcher is focused on developing an all-in-one semiconductor device that can both store data and perform computations. The project recently received $2 million in funding over three years as part of the new National Science Foundation Future of Semiconductors (FuSe) program, a $45.6 million investment to advance semiconductor technologies and manufacturing through 24 research and education projects across the United States. “The goal of ...

Nemours Children’s Health will host the first-ever dedicated pediatric session at HLTH, the leading platform bringing together the entire health ecosystem focused on health innovation and transformation. This invited program, “Elevating Kids Health Well Beyond Medicine,” will extend HLTH’s 2023 theme, “Elevating Humanity,” to focus on health in childhood and why it is the only way to build good health across the lifespan. “The child health perspective is an essential viewpoint for the attendees of HLTH to consider and we are proud to offer ...

University of Oklahoma engineering researcher Reza Foudazi, Ph.D., has been selected to receive a $600,000 grant from the U.S. Department of Defense under the Defense Established Program to Stimulate Competitive Research, or DEPSCoR. The highly competitive grant was awarded to only 28 academic teams nationwide.  An associate professor in the School of Sustainable Chemical, Biological and Materials Engineering, Foudazi’s research centers on the exploration of electrochemical energy storage systems that incorporate multivalent ions. ...

Messenger RNA (mRNA) technology has become popular in the last few years due to its use in COVID-19 vaccines. This technology has been so groundbreaking that it recently won the 2023 Nobel Prize in medicine “for discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.” This isn’t new technology, however— modified mRNAs have been studied for decades and show significant potential for therapeutic applications. Compared to unmodified mRNAs, modified ...

Abdolhossein Haji-Sheikh, a retired professor in the Mechanical and Aerospace Engineering Department at The University of Texas at Arlington, has made a $500,000 gift to support his former department. The gift creates an endowed professorship in heat transfer, one of Haji-Sheikh’s areas of expertise during his decades of teaching at UTA. The professorship will be awarded in 2026. Haji-Sheikh began his career at what was then Arlington State College in 1966. He said he wants to give back to ...

Inventor of xenobots unveils new advance toward artificial life New AI algorithm compresses billions of years of evolution into seconds The evolved robot has three legs and rear fins, something a human engineer would never devise Researcher: ‘Now anyone can watch evolution in action as AI generates better and better robot bodies in real time.’ A team led by Northwestern University researchers has developed the first artificial intelligence (AI) to date that can intelligently design robots from ...

Two Rice University bioengineers received the National Institutes of Health (NIH) Director’s New Innovator Award (NIA) for creative research projects demonstrating broad impact potential. Part of the High-Risk, High-Reward Research program, NIA awards support early-career investigators with ambitious, unconventional project proposals “in any area of biomedical, behavioral or social science research relevant to the NIH mission,” according to the agency’s website. Rice’s ...

Cancer-related fatigue (CRF) is a debilitating yet all-too-common condition, which can severely affect quality of life for patients undergoing treatment. For those struggling with CRF, there have been no effective pharmaceutical treatments for the constellation of symptoms that together define the syndrome. In a new study led by Yale Cancer Center researchers at Yale School of Medicine, the team found that a metabolism-targeting drug called dichloroacetate (DCA) helped alleviate CRF in mice, without interfering with cancer ...

Effective September 26, 2023, NRG Oncology-RTOG 1308, a phase III randomized trial comparing overall survival after photon versus proton chemoradiotherapy for patients with inoperable stage II-IIIB non-small cell lung cancer (NSCLC) has met its accrual target. The trial, one of several NRG Oncology ongoing clinical trials across various malignancies within the National Clinical Trials Network (NCTN) that compare photon versus proton radiation therapy techniques, is the first phase III head-to-head comparison of these ...

Even as the world slowly begins to decarbonize industrial processes, achieving lower concentrations of atmospheric carbon requires technologies that remove existing carbon dioxide from the atmosphere — rather than just prevent the creation of it. Typical carbon capture catches CO2 directly from the source of a carbon-intensive process. Ambient carbon capture, or “direct air capture” (DAC) on the other hand, can take carbon out of typical environmental conditions and serves as one weapon in the battle against climate change, particularly as reliance ...

Dr. Tanya Stoyanova, associate professor of molecular and medical pharmacology and urology at the David Geffen School of Medicine at UCLA, was awarded a $350,000 Idea Development Award from the Department of Defense. The award will help Stoyanova, a member of the UCLA Jonsson Comprehensive Cancer Center, to identify new cancer detection and treatment strategies for small cell lung cancer, a highly aggressive form of the disease that accounts for approximately 15% of lung cancers. Known for spreading quickly, most people diagnosed with the disease face low chances of survival beyond five years. The award ...