New research by Joseph Wu, Edgar Engelman, and colleagues at Stanford University, US has advanced an old concept to develop a new strategy to train the immune system of mice to recognize cancer cells. This work is based on the recent understanding that induced pluripotent stem cells (iPSCs), which are stem cells generated from skin or blood cells through a method called reprogramming, produce a large set of antigens that have overlap to a specific type of pancreatic cancer and that these similarities can be used for potential clinical benefit. It is well known that vaccines can be highly effective ...

In spintronics, the magnetic moment of electrons (spin) is used to transfer and manipulate information. An ultra-compact 2D spin-logic circuitry could be built from 2D materials that can transport the spin information over long distances and also provide strong spin-polarization of charge current. Experiments by physicists at the University of Groningen (The Netherlands) and Colombia University (USA) suggest that magnetic graphene can be the ultimate choice for these 2D spin-logic devices as it efficiently converts charge to spin current and can transfer this strong spin-polarization ...

At extremely low temperatures, matter often behaves differently than in normal conditions. At temperatures only a few degrees above absolute zero (-273 degrees Celsius), physical particles may give up their independence and merge for a short time into a single object in which all the particles share the same properties. Such structures are known as Bose-Einstein Condensates, and they represent a special aggregate state of matter. An international team of researchers led by physicists Dr Carlos Anton-Solanas and Professor Christian Schneider from the UNiversity of Oldenburg has now succeeded for the first time in generating this unusual quantum state in charge carrier complexes that are closely linked ...

Hydrogen-based fuels should primarily be used in sectors such as aviation or industrial processes that cannot be electrified, finds a team of researchers. Producing these fuels is too inefficient, costly and their availability too uncertain, to broadly replace fossil fuels for instance in cars or heating houses. For most sectors, directly using electricity for instance in battery electric cars or heat pumps makes more economic sense. Universally relying on hydrogen-based fuels instead and keeping combustion technologies threatens to lock in a further fossil fuel dependency ...

ROCHESTER, Minn. ? Heart disease can take a number of forms, but some types of heart disease, such as asymptomatic low ejection fraction, can be hard to recognize, especially in the early stages when treatment would be most effective. The ECG AI-Guided Screening for Low Ejection Fraction, or EAGLE, trial set out to determine whether an artificial intelligence (AI) screening tool developed to detect low ejection fraction using data from an EKG could improve the diagnosis of this condition in routine practice. Study findings are published in Nature Medicine. Systolic low ejection fraction is defined as the heart's inability to contract strongly enough with each beat to pump at least 50% of the blood from ...

What The Editorial Says: JAMA Health Forum debuts this week as a peer-reviewed, open-access, online journal focused on health policy, health care systems, and global and public health. The journal has transitioned from an online health policy channel and is the newest member of the family of JAMA Network specialty journals. The editor of JAMA Health Forum is John Z. Ayanian, M.D., M.P.P., of the University of Michigan in Ann Arbor, and the deputy editor is Melinda B. Buntin, Ph.D., of the Vanderbilt University School of Medicine in Nashville, Tennessee. Authors: John Z. Ayanian, M.D., M.P.P., of the University of Michigan in Ann Arbor, is the corresponding author. To access the embargoed study: Visit our For The Media website at ...

What The Study Did: Researchers compared health care use among patients with COVID-19 who were enrolled in a home monitoring program with similar patients who were not enrolled. Authors: Anita D. Misra-Hebert, M.D., M.P.H., of the Cleveland Clinic, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamahealthforum.2021.0333) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: The full study and editor's ...

New York, NY (May 6, 2021) -- Researchers have finally cracked the code of a bewildering pediatric disease that sets off a characteristic cytokine storm--a harmful immune system overaction resembling one that arises in COVID-19 cases--and can lead to catastrophic multisystem organ failure or neurodegeneration. Their study, which identifies the cause of the cytokine storm and possible treatments, was published in Nature Medicine in May. The mystery of this disease, Langerhans-cell histiocytosis (LCH), runs deep. Its symptoms vary widely, and LCH has the ability to infiltrate almost any organ system, leaving most patients with long-term ...

A team of researchers from UCLA, Cedars-Sinai and the Cystic Fibrosis Foundation has developed a first-of-its-kind molecular catalog of cells in healthy lungs and the lungs of people with cystic fibrosis. The catalog, described today in the journal Nature Medicine, reveals new subtypes of cells and illustrates how the disease changes the cellular makeup of the airways. The findings could help scientists in their search for specific cell types that represent prime targets for genetic and cell therapies for cystic fibrosis. "This new research has provided us with valuable insights into the cellular makeup of both healthy and diseased airways," said Dr. Brigitte Gomperts, a co-senior author of the study and a member of the Eli and Edythe Broad Center of Regenerative ...

Obesity may be a stronger risk factor for death, severe pneumonia and the need for intubation in men than in women with COVID-19, according to a study published in the European Journal of Clinical Microbiology & Infectious Diseases. An analysis of a cohort of 3530 COVID-19 patients showed that both moderate (BMI of 35/m2 or higher) and severe obesity (BMI of 40kg/m2 and higher) in men but only severe obesity in women (BMI of 40kg/m2 and higher) was associated greater risk of developing severe disease, needing intubation and dying from COVID-19 in hospital. Previous research demonstrated that obesity is a risk factor for hospitalization, severe disease, and death in patients with COVID-19. ...

Bacteria contain symmetry in their DNA signals that enable them to be read either forwards or backwards, according to new findings at the University of Birmingham which challenge existing knowledge about gene transcription. In all living organisms, DNA code is divided into sections which provide information about a specific process. These must be read before the information can be used. Cells identify the start of each section using 'signposts', which scientists first identified in the 1960s. It has always been assumed that these signposts enable genetic sequences ...

The origins of a pretty smile have long been sought in the fearsome jaws of living sharks which have been considered living fossils reflecting the ancestral condition for vertebrate tooth development and inference of its evolution. However, this view ignores real fossils which more accurately reflect the nature of ancient ancestors. New research led by the University of Bristol and the Naturalis Biodiversity Center published in Nature Ecology and Evolution reveals that the dentitions of living shark relatives are entirely unrepresentative of the last shared ancestor of jawed vertebrates. The study reveals ...

What The Study Did: This study estimates the association between Pfizer-BioNTech BNT162b2 vaccination and symptomatic and asymptomatic SARS-CoV-2 infections among health care workers more than seven days after getting a second vaccine dose. Authors: Ronen Ben-Ami, M.D., of the Tel Aviv Sourasky Medical Center in Israel, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2021.7152) Editor's Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: The full study ...

What The Study Did: This study describes an association between the Pfizer-BioNTech BNT162b2 vaccine and decreased risk of symptomatic and asymptomatic infections with SARS-CoV-2 in hospital employees. Authors: Li Tang, Ph.D., of the St. Jude Children's Research Hospital in Memphis, Tennessee, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2021.6564) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest ...

The bulging, equator-belted midsection of Earth currently teems with a greater diversity of life than anywhere else -- a biodiversity that generally wanes when moving from the tropics to the mid-latitudes and the mid-latitudes to the poles. As well-accepted as that gradient is, though, ecologists continue to grapple with the primary reasons for it. New research from the University of Nebraska-Lincoln, Yale University and Stanford University suggests that temperature can largely explain why the greatest variety of aquatic life resides in the tropics -- but also why it has not ...

A key driver of patients' well-being and clinical trials for Parkinson's disease (PD) is the course the disease takes over time. However, nearly all that is known about the genetics of PD is related to susceptibility -- a person's risk for developing the disease in the future. A new study by investigators from Brigham and Women's Hospital published in Nature Genetics uncovers the genetic architecture of progression and prognosis, identifying five genetic locations (loci) associated with progression. The team also developed the first risk score for predicting ...

Pulsars - another name for fast-spinning neutron stars - originate from the imploded cores of massive dying stars through supernova explosion. Now, more than 50 years after the discovery of pulsars and confirmation of their association with supernova explosions, the origin of the initial spin and velocity of pulsars is finally beginning to be understood. Based on observations from the Five-hundred-meter Aperture Spherical radio Telescope (FAST), Dr. YAO Jumei, member of a team led by Dr. LI Di from National Astronomical Observatories of Chinese Academy of Sciences (NAOC), found the first evidence for three-dimensional (3D) spin-velocity alignment in pulsars. The study was published in Nature Astronomy on May 6. It also marks the beginning of in-depth pulsar research with FAST. For decades, ...

While other medical systems across the country failed to maintain HIV screening volumes throughout the COVID-19 pandemic, the University of Chicago Medicine maintained screening volumes by including universal HIV screening alongside COVID-19 testing in its busy emergency department, according to a new report published April 12 in JAMA Internal Medicine. Through targeted efforts to maintain infrastructure and enthusiasm for HIV screening, the number of HIV tests remained at pre-pandemic levels while the rate of acute HIV diagnoses actually increased. Widespread screening to diagnose individuals newly infected with HIV is a key part of Centers for Disease Control and Prevention's (CDC) plan to ...

Early in human development, during the first trimester of gestation, a fetus may have XX or XY chromosomes that indicate its sex. Yet at this stage a mass of cells known as the bipotential gonad that ultimately develops into either ovaries or testes has yet to commit to its final destiny. While researchers had studied the steps that go into the later stages of this process, little has been known about the precursors of the bipotential gonad. In a new study published in Cell Reports and co-led by Kotaro Sasaki of Penn's School of Veterinary Medicine, an international team lays ...

Although the fairy tale of the wicked stepmother is a tale as old as time, the effects of blending children with their new stepfamilies may not be as grim as once thought. In fact, new research shows that stepparents are not at a disadvantage compared to their peers from single-parent households and actually experience better outcomes than their halfsiblings -- good news for the more than 113 million Americans that are part of a steprelationship. Led by East Carolina University anthropologist Ryan Schacht and researchers from the University of Utah, the study, "Was Cinderella just a fairy tale? Survival differences between stepchildren and their half-siblings," is available in the May edition of the Philosophical Transactions ...

The European Alps is certainly one of the most scrutinized mountain range in the world, as it forms a true open-air laboratory showing how climate change affects biodiversity. Although many studies have independently demonstrated the impact of climate change in the Alps on either the seasonal activity (i.e. phenology) or the migration of plants and animals, no systematic analysis has been carried out on both consequences simultaneously. A European team of ecologists1, including Jonathan Lenoir, CNRS Researcher in the research unit Écologie et Dynamique des Systèmes Anthropisés (CNRS/University of Picardie Jules Verne), has just published a review that ...

Cells of all life forms are surrounded by a membrane that is made of phospholipids. One of these are the cardiolipins, which form a separate class due to their unique structure. When studying the enzyme that is responsible for producing cardiolipins in archaea (single-cell organisms that constitute a separate domain of life), biochemists at the University of Groningen made a surprising discovery. A single archaeal enzyme can produce a spectacular range of natural and non-natural cardiolipins, as well as other phospholipids. The results, which show potential for biotechnological applications, ...

Lessons Learned from India's Polio Vaccination Program Provide Valuable Insights for Future Mass Vaccination Initiatives. Toronto - As India urgently scales up its vaccination campaign for the COVID-19 virus, a new study which examined the country's successful program to eliminate polio provides guidance on how this and future mass immunization campaigns can be successful, especially in vaccinating hard to reach groups. The study, conducted by students and faculty with the Reach Alliance, a research initiative based at the University of Toronto's Munk School of Global Affairs & Public Policy, says that medicine alone is insufficient for the elimination of disease. The World Health Organization declared India polio-free in 2014. ...

AMHERST, Mass. - A team of researchers at the Center for Bioactive Delivery at the University of Massachusetts Amherst's Institute for Applied Life Sciences has engineered a nanoparticle that has the potential to revolutionize disease treatment, including for cancer. This new research, which appears today in Angewandte Chemie, combines two different approaches to more precisely and effectively deliver treatment to the specific cells affected by cancer. Two of the most promising new treatments involve delivery of cancer-fighting drugs via biologics or antibody-drug conjugates (ADCs). Each has its own advantages and limitations. Biologics, such as protein-based ...

May 6, 2021 -- A significant level of symptoms of depression, anxiety and post-traumatic stress may follow COVID-19 independent of any previous psychiatric diagnoses, according to new research by Columbia University Mailman School of Public Health with colleagues at Universidade Municipal de São Caetano do Sul in Brazil. Exposure to increased symptomatic levels of COVID-19 may be associated with psychiatric symptoms after the acute phase of the disease. This is the largest study to evaluate depressive, anxiety, and post-traumatic stress symptoms in tandem among patients who had mild COVID-19 ...