A study led by research groups of Prof. FU Qiaomei from the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) of the Chinese Academy of Sciences and Prof. ZHANG Hucai from Yunnan University covers the largest temporal transect of population dynamics in East Asia so far and offers a clearer picture of the deep population history of northern East Asia. The study was published in Cell on May 27. Northern East Asia falls within a similar latitude range as central and southern Europe, where human population movements and size were influenced by Ice Age climatic fluctuations. Did these climatic fluctuations have an impact on the population history of northern East Asia? Stories uncovered by ancient DNA in East Asia remain relatively underexplored. The population ...

BOSTON - Although everyone can benefit from exercise, the mechanistic links between physical fitness and overall health are not fully understood, nor are the reasons why the same exercise can have different effects in different people. Now a study published in Nature Metabolism led by investigators at Beth Israel Deaconess Medical Center (BIDMC) provides insights related to these unanswered questions. The results could be helpful for determining the specific types of exercise most likely to benefit a particular individual and for identifying new therapeutic targets for diseases related to metabolism. "While groups as a whole benefit from exercise, the variability in responses between any two individuals undergoing the very ...

Geneva, 27 May 2021 - A total investment in nature of USD 8.1 trillion is required between now and 2050 - while annual investment should reach USD 536 billion annually by 2050 - in order to successfully tackle the interlinked climate, biodiversity, and land degradation crises, according to the State of Finance for Nature report released today. The report finds that annual investments in nature-based solutions will have to triple by 2030 and increase four-fold by 2050 from the current investments into nature-based solutions of USD 133 billion (using 2020 as base year). The authors of the report - produced by ...

UNIVERSITY PARK, Pa. -- A Penn State scientist studying crystal structures has developed a new mathematical formula that may solve a decades-old problem in understanding spacetime, the fabric of the universe proposed in Einstein's theories of relativity. "Relativity tells us space and time can mix to form a single entity called spacetime, which is four-dimensional: three space-axes and one time-axis," said Venkatraman Gopalan, professor of materials science and engineering and physics at Penn State. "However, something about the time-axis sticks out like sore thumb." For ...

The way the human brain works remains, to a great extent, a topic of controversy. One reason is our limited ability to study neuronal processes at the level of single cells and capillaries across the entire living brain without employing highly invasive surgical methods. This limitation is now on the brink of change. Researchers led by Daniel Razansky, Professor of Biomedical Imaging at ETH Zurich and the University of Zurich, have developed a fluorescence microscopy technique that facilitates high-resolution images of microcirculation without the ...

Bethesda, MD (May 27, 2021) -- Crohn's disease, a type of inflammatory bowel disease (IBD) that causes inflammation (pain and swelling) in the gastrointestinal tract, can cause daily health problems, frequent hospitalizations and surgery when not adequately controlled. While there is no cure for Crohn's disease, there are treatments that can help patients live a symptom-free life. After a detailed review of available literature, the American Gastroenterological Association (AGA) has released new clinical guidelines outlining the benefits and risks of each drug currently available to Crohn's patients. Based on this research, AGA recommends the early introduction of biologics for patients experiencing luminal and fistulizing Crohn's disease rather than waiting ...

Signals can be amplified by an optimum amount of noise, but this so-called stochastic resonance is a rather fragile phenomenon. Researchers at AMOLF were the first to investigate the role of memory for this phenomenon in an oil-filled optical microcavity. The effects of slow non-linearity (i.e. memory) on stochastic resonance were never considered before, but these experiments suggest that stochastic resonance becomes robust to variations in the signal frequency when systems have memory. This has implications in many fields of physics and energy technology. In particular, the scientists numerically show that introducing slow non-linearity in a mechanical oscillator harvesting energy from noise can increase its efficiency by tenfold. They publish their findings in ...

Ant workers that are infected with a tapeworm live much longer than their uninfected nest-mates. Parasitic infections are usually harmful to their hosts, but there are some exceptions. According to the results of a multi-year scientific study, ants of the species Temnothorax nylanderi show exceptionally high survival rates when infected with a tapeworm. "The lifespan of the infected ants is significantly prolonged. According to our observations, such workers have a survival rate similar to that of queens," said Professor Susanne Foitzik of Johannes Gutenberg University ...

A new discovery by University of Guelph researchers may ultimately help in devising new therapies and improving quality of life for people with Parkinson's disease. By showing how entangled proteins in brain cells enable the neurodegenerative disease to spread, the researchers hope their findings will lead to drugs that halt its progression, said PhD candidate Morgan Stykel, first author of a paper published this month in Cell Reports. Parkinson's disease is the world's fastest-growing neurodegenerative disease and Canada has some of the world's highest rates, according to Parkinson Canada. Its exact cause is unknown. Current therapies only treat symptoms rather than halting the disease, said Dr. Scott Ryan, a professor ...

In the largest genetic analysis of depression to date, Veterans Affairs researchers identified many new gene variants that increase the risk for depression. The groundbreaking study helps researchers better understand the biological basis of depression and could lead to better drug treatments. The study involved genetic data on more than 300,000 participants of VA's Million Veteran Program (MVP), along with more than a million subjects from other biobanks, including 23andMe. With such a large participant pool, the researchers were able to spot trends in genetic risk of depression not previously known. Co-primary investigator Dr. Joel Gelernter, a researcher with the VA Connecticut Healthcare System and Yale University School of Medicine, explained ...

Researchers at the University of Illinois Chicago are a step closer to discovering why it is so difficult for people to withdraw from some antidepressant medications. The paper "Antidepressants produce persistent Gαs associated signaling changes in lipid rafts following drug withdrawal," published in the journal Molecular Pharmacology, addresses the molecular and cellular mechanisms that cause antidepressant withdrawal syndrome. The study's authors, Mark Rasenick, distinguished professor of physiology and biophysics and psychiatry at UIC and research career scientist at the Jesse Brown VA Medical Center, and Nicholas ...

Higher percentage of patients treated with nivolumab and ipilimumab in clinical trial reach the six-and-a-half-year survival mark than those treated with either drug alone. BOSTON - In the longest follow-up results from a clinical trial of combination immunotherapy for metastatic melanoma, investigators report that nearly half the patients who received the drugs nivolumab and ipilimumab were alive a median of six and a half years after treatment. The results, stemming from the CheckMate 067 clinical trial, represent a new landmark in survival rates for patients with melanoma treated with immune checkpoint inhibitor drugs. F. ...

URBANA, Ill. - As the owner of a human body, you're carrying trillions of microbes with you everywhere you go. These microscopic organisms aren't just hitching a ride; many of them perform essential chemical reactions that regulate everything from our digestion to our immune system to our moods. One important set of reactions relates to fat absorption via bile acids. Our livers make these acids to help digest fats and fat-soluble vitamins as they travel through the small intestine. Near the end of the small intestine, microbes convert the acids into new forms, which can either be beneficial or ...

Over the past 20 years, first-principles simulations have become powerful, widely used tools in many, diverse fields of science and engineering. From nanotechnology to planetary science, from metallurgy to quantum materials, they have accelerated the identification, characterization, and optimization of materials enormously. They have led to astonishing predictions--from ultrafast thermal transport to electron-phonon mediated superconductivity in hydrides to the emergence of flat bands in twisted-bilayer graphene-- that have gone on to inspire remarkable experiments. The current push to complement ...

WASHINGTON -- Researchers have developed a new technique that allows microscopic fluorescence imaging at four times the depth limit imposed by light diffusion. Fluorescence microscopy is often used to image molecular and cellular details of the brain in animal models of various diseases but, until now, has been limited to small volumes and highly invasive procedures due to intense light scattering by the skin and skull. "Visualization of biological dynamics in an unperturbed environment, deep in a living organism, is essential for understanding the complex biology of living organisms ...

Five years on from the first discovery of gravitational waves, an international team of scientists, including from the ARC Centre of Excellence for Gravitational Wave Discovery (OzGrav), are continuing the hunt for new discoveries and insights into the Universe. Using the super-sensitive, kilometre-sized LIGO detectors in the United States, and the Virgo detector in Europe, the team have witnessed the explosive collisions of black holes and neutron stars. Recent studies, however, have been looking for something quite different: the elusive signal from a solitary, rapidly-spinning neutron star. Take a star similar in size to the Sun, squash it down to a ball about ...

The hunt for the never before heard "hum" of gravitational waves caused by mysterious neutron stars has just got a lot easier, thanks to an international team of researchers. Gravitational waves have only been detected from black holes and neutron stars colliding, major cosmic events that cause huge bursts that ripple through space and time. The research team, involving scientists from the LIGO Scientific Collaboration (LSC), Virgo Collaboration and the Centre for Gravitational Astrophysics (CGA) at The Australian National University (ANU), are now turning their eagle eye to spinning neutron stars to detect the waves. Unlike the massive bursts caused by black holes or neutron stars colliding, the researchers ...

AMHERST, Mass. - New research by University of Massachusetts Amherst astronomer Daniel Wang reveals, with unprecedented clarity, details of violent phenomena in the center of our galaxy. The images, published recently in Monthly Notices of the Royal Astronomical Society, document an X-ray thread, G0.17-0.41, which hints at a previously unknown interstellar mechanism that may govern the energy flow and potentially the evolution of the Milky Way. "The galaxy is like an ecosystem," says Wang, a professor in UMass Amherst's astronomy department, whose findings are a result of more than two decades of research. "We know the centers of galaxies are where the action is and play an enormous role in their evolution." And yet, whatever has ...

Individuals with genetic high cholesterol, heart disease or both, who were infected with COVID-19 had more heart attacks according to new research by the FH Foundation. While previous studies have speculated about poorer outcomes if a person with genetic high cholesterol - called familial hypercholesterolemia (FH) contracts COVID-19, this study from the FH Foundation's national healthcare database is the first to demonstrate higher heart attack rates in the real world. Published online in the American Journal of Preventive Cardiology, the study also importantly confirms that COVID-19 increases heart attack rates in individuals with established atherosclerotic cardiovascular disease (ASCVD). The FH Foundation performed an analysis of 55,412,462 individuals, separating groups into six ...

Leesburg, VA, May 27, 2021--According to an open-access Editor's Choice article in ARRS' American Journal of Roentgenology (AJR), accurate prenatal diagnosis of severe placental accreta spectrum (PAS) disorder by imaging could help guide maternal counseling and selection between hysterectomy and uterine-preserving surgery. "The findings suggest strong performance of placental bulge in diagnosing severe PAS on both ultrasound and MRI, with potentially relatively stronger performance on MRI," wrote corresponding author Manjiri Dighe from the department of radiology at the University of Washington School of Medicine. "Nonetheless, interobserver agreement remains suboptimal on both modalities." On ultrasound and MRI alike, the placental bulge sign represents ...

A small Japanese fishing community devastated by the Great East Japan Earthquake and Tsunami of 2011 managed to recover from the disaster through cooperative community activity despite the propensity for individualist-competitive behavior within fisheries - cooperative activity that continued many years later. A social scientist who spent years interviewing fishers in the fishing hamlet of Isohama has discovered a long-standing continuum of competitive and collective endeavor amongst fishers, with potential ramifications for how government policy can better promote resilience in the wake of natural disasters and other calamities. The findings appear in the journal of Disaster ...

Using the circular vibration of surface acoustic waves, a collaborative research group have successfully controlled the magnetization of a ferromagnetic thin film. Their research was published in the journal Nature Communications on May 10, 2021. Essentially, acoustic waves are waves of atomic vibrations in a substance. When the waves propagate across the surface of a material, the vibration becomes circular. This circular motion, known as angular momentum, can help measure rotational motion. Surface acoustic waves are utilized in bandpass filters in cell phones. The bandpass allows certain frequencies ...

New Orleans, LA - A review study led by Maria D. Sanchez-Pino, PhD, an assistant research professor in the departments of Interdisciplinary Oncology and Genetics at LSU Health New Orleans' School of Medicine and Stanley S. Scott Cancer Center, advances knowledge about the connection between obesity-associated inflammation and cancer. The researchers suggest that inflammatory cells with immunosuppressive properties may act as a critical biological link between obesity and cancer risk, progression, and metastasis. The paper is published in the June 2021 issue of Obesity, available here. Despite evidence showing that ...

The study, which is published in the journal PLOS Biology, represents the most comprehensive mapping performed to date between neural activity recoded in vivo and identified neuron types. This major breakthrough may enable biologically meaningful computer modeling of the full neuronal circuit of the hippocampus, a region of the brain involved in memory function. Circuits of the mammalian cerebral cortex are made up of two types of neurons: excitatory neurons, which release a neurotransmitter called glutamate, and inhibitory neurons, which release GABA (gamma-aminobutanoic acid), the main inhibitor of the central nervous system. "A balanced dialogue between the 'excitatory' and 'inhibitory' activities is critical for brain function. ...

Exploiting the unusual metal-reducing ability of the iron-breathing bacterium Geobacter sulfurreducens, KAUST researchers have demonstrated a cheap and reliable way to synthesize highly active single-atom catalysts. The innovation, which could dramatically improve the efficiency and cost of hydrogen production from water, highlights the role nature can play in the search for new energy systems. Many chemical reactions require a catalyst as a reactive surface where atoms or molecules are brought together with the right amount of energy to spark a chemical change. Water, for example, can be split into hydrogen and oxygen atoms by reacting on a pair of electrodes made of platinum and iridium oxide. The efficiency of the reaction, however, depends largely ...