May 04, 2021 - In its latest clinical practice guideline on community-acquired pneumonia the American Thoracic Society's guidelines panel addresses the use of nucleic acid-based testing for non-influenza viral pathogens. The guideline was published online in the May 1 issue of the American Journal of Respiratory and Critical Care Medicine. An explainer video may be viewed here. Community-acquired pneumonia is caused by a wide range of respiratory pathogens, prominently including viruses. However, the only viral pathogen addressed by the 2019 clinical practice guideline was influenza. The panel determined that, given the increasing recognition of non-influenza viral causes ...

DAVIS, CA, May 4, 2021 - In a randomized, controlled study* published online in the journal, Nutrients, researchers found that including mixed tree nuts in a weight management program resulted in significant weight loss and improved satiety. Researchers at UCLA compared 95 overweight/obese men and women (BMI 27.0-35.0 kg/m2) ages 30-68 years who consumed either 1.5 ounces of mixed tree nuts or a pretzel snack. Both snacks provided the same number of calories, as part of a hypocaloric weight loss diet (500 calories less than resting metabolic rate) over 12 weeks. This was followed by an isocaloric weight maintenance program for an additional ...

Cancer of the colon and rectum is one of the deadliest forms of cancer, and has in recent years affected growing numbers of young people. In the largest registry study to date, researchers at Karolinska Institutet in Sweden and Harvard University in the USA demonstrate a possible connection between colorectal polyps in close relatives and the risk of developing colorectal cancer. The study, which is published in the British Medical Journal, is of potential consequence for different countries' screening procedures. Colorectal cancer is the second deadliest form of cancer in the world, according to the World Health ...

Nearly one in five older adults say their mental health has gotten worse since the pandemic began in March 2020, and an equal percentage say their sleep has suffered in that time too. More than one in four say they're more anxious or worried than before the COVID-19 era, according to a new poll of people age 50 to 80. Women, people in their 50s and early 60s, and older adults who have a college degree or higher were more likely than others to report worse mental health than before the pandemic, according to the END ...

DALLAS, May 4, 2021 -- A meta-analysis of 14 air pollution studies from around the world found that exposure to high levels of air pollutants during childhood increases the likelihood of high blood pressure in children and adolescents, and their risk for high blood pressure as adults. The study is published in a special issue on air pollution in the Journal of the American Heart Association, an open access journal of the American Heart Association. Other studies look at: the effects of diesel exhaust on the muscle sympathetic nerve; the impact of pollutants on high blood pressure; rates of hospital readmission for heart failure among those exposed ...

Osaka, Japan --Straight-line constant-speed propagation in free space is a basic characteristic of light. In a recent study published in Communications Physics, researchers from Osaka University discovered the phenomenon of reciprocating propagation of laser pulse intensity in free space. Spatiotemporal couplings have been recently used to produce light with tunable group-velocity, direction, and trajectory in free space. For example, the flying focus (a moving laser pulse intensity in the extended Rayleigh length), where longitudinal chromatism and temporal chirp are combined to control the spectrum-dependent focus-separation ...

Scientists have revealed how an antibiotic of 'last resort' kills bacteria. The findings, from Imperial College London and the University of Texas, may also reveal a potential way to make the antibiotic more powerful. The antibiotic colistin has become a last resort treatment for infections caused by some of the world's nastiest superbugs. However, despite being discovered over 70 years ago, the process by which this antibiotic kills bacteria has, until now, been something of a mystery. Now, researchers have revealed that colistin punches holes in bacteria, causing them to pop like balloons. The work, funded by the Medical Research Council and Wellcome Trust, and published in the journal eLife, also identified a way of making the antibiotic more effective at killing bacteria. Colistin ...

New Edith Cowan University (ECU) research has found that by eating just one cup of nitrate-rich vegetables each day people can significantly reduce their risk of heart disease. The study investigated whether people who regularly ate higher quantities of nitrate-rich vegetables, such as leafy greens and beetroot, had lower blood pressure, and it also examined whether these same people were less likely to be diagnosed with heart disease many years later. Cardiovascular diseases are the number one cause of death globally, taking around 17.9 million lives each year. Researchers examined data from over 50,000 people residing in Denmark taking part in the Danish Diet, ...

In a recent article in Sustainability, scientists from Reykjavik University (RU), the University of Gothenburg, and the Icelandic Meteorological Office describe their finding of microplastic in a remote and pristine area of Vatnajokull glacier in Iceland, Europe's largest ice cap. Microplastics may affect the melting and rheological behaviour of glaciers, thus influencing the future meltwater contribution to the oceans and rising sea levels. This is the first time that the finding of microplastic in the Vatnajökull glacier is described. The group visualised and identified microplastic particles of various sizes and materials by optical microscopy and μ-Raman spectroscopy. The discussion about microplastics has mainly been focused on the contamination ...

Over the coming decades, our economy and society will need to dramatically reduce greenhouse gas emissions as called for in the Paris Agreement. But even a future low-carbon economy will emit some greenhouse gases, such as in the manufacture of cement, steel, in livestock and crop farming, and in the chemical and pharmaceutical industries. To meet climate targets, these emissions need to be offset. Doing so requires "negative emissions" technologies, by means of which CO2 is removed from the atmosphere and permanently stored in underground repositories. Researchers at ETH Zurich have now calculated the potential of one of these technologies for Europe: the combination of energy extraction from biomass with the capture and ...

Small changes in the structure of DNA have been implicated in breast cancer and other diseases, but they've been extremely difficult to detect -- until now. Using what they describe as a "chemical nose," UC Riverside chemists are able to "smell" when bits of DNA are folded in unusual ways. Their work designing and demonstrating this system has been published in the journal Nature Chemistry. "If a DNA sequence is folded, it could prevent the transcription of a gene linked to that particular piece of DNA," said study author and UCR chemistry professor Wenwan Zhong. "In other words, this could have a positive effect by silencing a gene with the potential to cause cancer or promote tumors." Conversely, DNA folding ...

Talking about your bad day at work could lead to great solutions. Cold Spring Harbor Laboratory (CSHL) Associate Professor Saket Navlakha and his wife, Dr. Sejal Morjaria, an infectious disease physician at Memorial Sloan Kettering Cancer Center (MSK), found a way to predict COVID-19 severity in cancer patients. The computational tool they developed prevents unnecessary expensive testing and improves patient care. Morjaria says, "Generally, I have good intuition for how patients will progress." However, that intuition failed her when confronted with COVID-19. She says: "When the pandemic ...

Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent. 1. Increased use of minimally invasive non-endoscopic tests for Barrett's esophagus screening could impact detection and prevention of esophageal cancer Abstract: https://www.acpjournals.org/doi/10.7326/M20-7164 URL ...

Throughout the history of the West, human actions have often rushed the desert -- and their actions backfired. In the 1920s, the Colorado River Compact notoriously overallocated water still used today by several western states because water measurements were taken during a wet period. More currently, operators of the massive Ivanpah Solar Electric Generating System in the Mojave Desert are spending around $45 million on desert tortoise mitigation after initial numbers of the endangered animals were undercounted before its construction. A study published in the journal Ecological Applications from the University of California, Davis, and UC Santa Cruz warns against another potential desert timing mismatch amid the race against climate change and toward rapid renewable ...

The importance of pollinators to ensure successful harvests and thus global food security is widely acknowledged. However, the specific pollinators for even major crops - such as cocoa - haven't yet been identified and there remain many questions about sustainability, conservation and plantation management to enhance their populations and, thereby, pollination services. Now an international research team based in Central Sulawesi, Indonesia and led by the University of Göttingen has found that in fact ants and flies - but not ceratopogonid midges as was previously thought - appear to have a crucial role to play. In addition, they found ...

Today, the Sumatran rhinoceros (Dicerorhinus sumatrensis) is critically endangered, with fewer than 100 individuals surviving in Indonesia on the islands of Sumatra and Borneo. To ensure survival of the threatened species, accurate censusing is necessary to determine the genetic diversity of remaining populations for conservation and management plans. A new study reported in BMC Research Notes characterized 29 novel polymorphic microsatellite markers -- repetitive DNA sequences -- that serve as a reliable censusing method for wild Sumatran rhinos. The study was a collaborative effort involving the University ...

Boulder, Colo., USA: A new focus article in the May issue of Geology summarizes research on plastic waste in marine and sedimentary environments. Authors I.A. Kane of the Univ. of Manchester and A. Fildani of the Deep Time Institute write that "Environmental pollution caused by uncontrolled human activity is occurring on a vast and unprecedented scale around the globe. Of the diverse forms of anthropogenic pollution, the release of plastic into nature, and particularly the oceans, is one of the most recent and visible effects." The authors cite multiple studies, including one in the May issue by Guangfa Zhong and Xiaotong ...

UNIVERSITY PARK, Pa. -- As more people go online for shopping, understanding how they rely on e-commerce recommendation systems to make purchases is increasingly important. Penn State researchers now suggest that it's not just what is recommended, but how and why it's recommended, that helps to shape consumers' opinions. In a study, the researchers investigated how people reacted to two product recommendation systems. The first system generated recommendations based on the user's earlier purchases -- often referred to as content-based recommendation systems. ...

EL PASO, Texas -- For more than a year, researchers at The University of Texas at El Paso's Stanley E. Fulton Gait Research & Movement Analysis Lab in the College of Health Sciences have been using real-time 3D animation to investigate motor impairments in children who have autism spectrum disorder (ASD). Their aim is to understand how children with autism can learn motor skills, so that they can receive effective therapies. The results of their study, titled "Children With Autism Exhibit More Individualized Responses to Live Animation Biofeedback Than Do Typically Developing Children," were recently published in the journal of Perceptual and Motor Skills. The paper's release coincides with National Autism Awareness Month in April. "The greatest takeaway from this study is that when teaching ...

UNIVERSITY PARK, Pa. -- Tweaking the look of a social media profile may subtly alter a person's reaction to the health messages that appear on that site, according to researchers. They add that these reactions could influence whether the users heed the advice of those messages. In a study, the researchers found that people who gained a feeling of control when they customized an online website were more likely to perceive the health message as a threat to their freedom, lowering the chance that they will adopt the message's advice. On the other hand, when customization bolstered the users' sense of identity, they did not resent the message as much and were more willing to consider the ads' recommended behavioral changes, according to the researchers. "In ...

Ensuring that veterans have stable housing not only reduces homelessness but also slashes the cost of providing them with publicly funded health care, according to a national study led by University of Utah Health scientists. The researchers found that veterans who received temporary financial assistance (TFA) from the Department of Veterans Affairs (VA) to acquire or retain housing had fewer hospital visits and an average reduction in health care costs of $2,800 over a two-year period than veterans who did not receive this benefit. The researchers say this model could help non-profit organizations and other federal, state, and local governments better serve homeless Americans who are not veterans. "Getting ...

Black and Latino neighborhoods in the 30 most populous U.S. cities had fewer pharmacies than white or diverse neighborhoods in 2007-2015, USC research shows, suggesting that 'pharmacy deserts'- like so-called food deserts-may be an overlooked contributor to persistent racial and ethnic health disparities. Pharmacies are increasingly vital points of care for essential health services. In addition to filling prescriptions to treat chronic health conditions, pharmacists dispense emergency doses of naloxone to reverse opioid overdoses, contraceptives to prevent unplanned pregnancy and COVID-19 testing and vaccinations. But ...

More than 25% of the world's population (greater than 1.5 billion people) face the burden of soil-transmitted helminth (STH) infections, a species of intestinal parasite whose eggs develop in the soil before finding a new host. The main cause of this high infection rate is lack of access to adequate sanitation facilities (toilets) and the consequent contamination of the environment with human feaces. While universal access to adequate sanitation is one of the sustainable development goals, parasite burdens are still causing harm. Fortunately, deworming medicines are highly effective and safe. Researchers from Syracuse University, the World Health Organization, ...

A year into the COVID-19 pandemic, mass vaccinations have begun to raise the tantalizing prospect of herd immunity that eventually curtails or halts the spread of SARS-CoV-2. But what if herd immunity is never fully achieved - or if the mutating virus gives rise to hyper-virulent variants that diminish the benefits of vaccination? Those questions underscore the need for effective treatments for people who continue to fall ill with the coronavirus. While a few existing drugs show some benefit, there's a pressing need to find new therapeutics. Led by The University of New Mexico's Tudor Oprea, MD, PhD, scientists ...

An abnormal build up of carbohydrates -- sugars and starches -- in the kernels and leaves of a mutant line of corn can be traced to one misregulated gene, and that discovery offers clues about how the plant deals with stress. That is the conclusion of Penn State researchers whose previous study discovered the Maize ufo1 gene responsible for creating the mutant corn line. They now are assessing its effects and potential for inclusion in breeding new lines of corn better able to thrive in a warming world. The finding of higher sugar levels in plant tissues in their latest study is just ...