A high-throughput single-cell single-mitochondrial genome sequencing technology known as iMiGseq has provided new insights into mutations of mitochondrial DNA (mtDNA) and offers a platform for assessing mtDNA editing strategies and genetic diagnosis of embryos prior to their implantation. An international team of researchers, led by KAUST stem cell biologist Mo Li, has now quantitatively depicted the genetic maps of mtDNA in single human oocytes (immature eggs) and blastoids (stem cell-based synthetic embryos)[1]. This has revealed molecular features of rare mtDNA mutations that cause maternally inherited diseases. Mitochondria, the ...

A multi-state study from the Centers for Disease Control and Prevention’s (CDC’s) VISION Network confirms that the Pfizer-BioNTech mRNA COVID-19 vaccine has provided children and adolescents, ages 5-17, with protection against both moderate and severe COVID-19 outcomes. The study found that for 12-17 year olds, vaccine effectiveness was high against the Delta variant but lower during Omicron dominance, including BA.4 and BA.5. Due to the youngest age (5-11) group’s ineligibility for vaccination during Delta predominance, vaccine effectiveness could be estimated for these children only during the Omicron predominant ...

PLYMOUTH MEETING, PA [April 13, 2023] — The National Comprehensive Cancer Network® (NCCN®) and the NCCN Foundation® today announced four winners for the 2023 NCCN Foundation Young Investigator Awards. These annual awards honor up-and-coming leaders in oncology research working to investigate and advance cancer care. The honorees will each receive up to $150,000 in funding for projects that will run over two years. The selection process is overseen by the NCCN Oncology Research Program (ORP) which will also provide oversight. “It is a privilege to support these emerging innovators ...

We are often attracted to others with whom we share an interest, but that attraction may be based on an erroneous belief that such shared interests reflect a deeper and more fundamental similarity—we share an essence—according to research published by the American Psychological Association. “Our attraction to people who share our attributes is aided by the belief that those shared attributes are driven by something deep within us: one’s essence,” said lead author Charles Chu, PhD, an assistant professor at the Boston University Questrom School of Business. “To put it concretely, we like someone who agrees with us on a political issue, shares our music ...

Today the Biophysical Journal is launching a new initiative, the Postdoctoral Reviewer Program. The program provides postdoctoral researchers in biophysics the opportunity to partner with Associate Editors and complete reviews that will be used in deciding whether articles will be accepted for publication. Candidates for this program must be in a postdoctoral position during the 2023–2024 academic year and a member of BPS in good standing. Applications for the new program will be accepted through July 1 for a single-year term beginning in September 2023. Interested candidates can find more information about the program and application process online. “I am extremely ...

Newcastle University researchers have created environmentally-friendly, high-efficiency photovoltaic cells that harness ambient light to power internet of Things (IoT) devices. Led by Dr Marina Freitag, the research group from the from School of Natural and Environmental Sciences (SNES) created dye-sensitized photovoltaic cells based on a copper(II/I) electrolyte, achieving an unprecedented power conversion efficiency of 38% and 1.0V open-circuit voltage at 1,000 lux (fluorescent lamp). The cells are non-toxic and environmentally friendly, setting a new standard for sustainable ...

The iconic image of the supermassive black hole at the center of M87—sometimes referred to as the “fuzzy, orange donut”—has gotten its first official makeover with the help of machine learning. The new image further exposes a central region that is larger and darker, surrounded by the bright accreting gas shaped like a “skinny donut.” The team used the data obtained by the Event Horizon Telescope (EHT) collaboration in 2017 and achieved, for the first time, the full resolution of the array. In 2017, the EHT collaboration used a network of seven pre-existing telescopes ...

By using a new method, precious metals can be efficiently recovered from thin-film solar cells. This is shown by new research from Chalmers University of Technology, Sweden. The method is also more environmentally friendly than previous methods of recycling and paves the way for more flexible and highly efficient solar cells. Today there are two mainstream types of solar cells. The most common is silicon-based and accounts for 90 percent of the market. The other type is called thin-film solar cells which in turn uses three main sub-technologies, one of which is known as CIGS ...

Many infant formulas promise a lot. Several products claim that they help develop the brain, increase immunity and promote children's growth and development, among other things. Now a research group led by Imperial College London has looked at whether these promises have any substance to them. The article has recently been published in BMJ. “Most of the claims about the health-giving and nutritional properties of breast milk substitutes seem to be based on little or no evidence,” the research group says. Claims surrounding these replacement milk products are controversial. They can give the impression ...

Milan (Italy), 13 April 2023 – The Center for Ethics in Science and Science Journalism (CESJ, www.cesj.eu) is among the partners of the FRONTIERS consortium that was selected by the European Research Council for a grant of 1.5 million euro to establish a residency program for science journalists in research institutions across Europe, and measure its impact on the lifelong professional development of science journalism in Europe. The consortium also includes the NOVA University of Lisbon (Portugal), ...

People who experience periods of high inflation are more likely to buy a home, according to a new study from the University of California San Diego’s Rady School of Management. The paper, to be published in The Journal of Finance, uses various sources of data which reveal households that have been exposed to high inflation are more likely to invest in real estate. The study suggests many homeowners buy because they are motivated to protect themselves from possible future price hikes. The study is the first to reveal that personal ...

A new paper in Molecular Biology and Evolution, published by Oxford University Press, provides interesting new evidence about the evolution of North American wolves, which has been a subject of debate among conservationists and taxonomists. Southeastern Canada is home to populations of wolves and coyotes whose origins and genetic relationships have long puzzled scientists. In particular, eastern wolves have been the subject of great dispute, and it remains unknown whether these canids represent ...

Helium usually has two protons and two neutrons strongly bound to each other, often forming a substructure within the nucleus. A nucleus composed of several such substructures is called a cluster structure. In the standard picture, nuclei are difficult to understand in terms of so-called shell structure; because there was no way to clearly distinguish whether each nucleus has a cluster or a shell structure. Associate Professor Wataru Horiuchi and Professor Naoyuki Itagaki from the Osaka Metropolitan University Graduate School of Science, have developed an ...

Cross-sectional study of 1,123 participants confirms α-synuclein seed amplification assay (αSyn-SAA) technique is highly accurate at identifying people with Parkinson’s disease.  The technique detects at-risk individuals and those with early, non-motor symptoms of Parkinson’s disease prior to diagnosis, suggesting that a positive result on αSyn-SAA may be an early indicator of disease onset.  Differences in the frequency of a positive αSyn-SAA result were detected based on age and sex, and if people ...

The UK’s decision to join one of the world’s largest free trade agreements, known as the Comprehensive and Progressive Agreement on Trans-Pacific Partnership (CPTPP), poses a major threat to UK public health, warn experts in The BMJ today. In acceding to the CPTPP, the government hopes to boost trade, improve economic growth, and strengthen the UK’s strategic position as a global rule setter.  But Courtney McNamara and colleagues argue that free trade deals have serious and wide ranging implications for public health and ...

Women working in healthcare who are regularly exposed to radiation from x-rays and other imaging procedures need better ionising radiation protection to help minimise their risk of developing breast cancer, argue doctors in The BMJ today. Ionising radiation is a known human carcinogen and breast tissue is highly radiation sensitive. As such, there are concerns that regular exposure to ionising radiation during image guided procedures may be linked to a higher risk of breast cancer in female healthcare workers. Personal protective equipment (PPE) such as lead gowns are used to shield the body from harmful radiation during these ...

*Note: this is a joint press release from the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) and The Lancet.  Please credit both the congress and the journal in your stories* A new study to be presented at this year’s European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2023, Copenhagen 15-18 April), and published in The Lancet, shows that, compared with standard care that included low dose corticosteroid use, treating hypoxic COVID-19 patients needing ...

Paper available at: https://drive.google.com/drive/folders/1y9GfgYkRdUtwyq6nBhySePTUHZYP6iAj?usp=share_link Landmark study finds no difference in psychological wellbeing or quality of family relationships between children born by assisted reproduction (egg or sperm donation or surrogacy) and those born naturally at age 20. However, findings suggest that telling children about their biological origins early – before they start school – can be advantageous for family relationships and healthy adjustment. The study, by University of Cambridge researchers, is the first to examine the long-term ...

Nitrogen dioxide is one of the criteria air pollutants that plays an important role as a precursor gas of fine particulate matter and ozone. NO2 emissions are known to be primarily generated by industrial facilities or vehicle exhausts. Recently, a research team from POSTECH analyzed satellite remote sensing data from the European Space Agency (ESA) and released results showing that food processing facilities and high-rise apartments that are 10 stories or higher are significant sources of NO2 emissions. Their findings have drawn attention from NASA.   A ...

Niigata, Japan - A new Japanese study reveals significant birth cohort effects on the incidence trend of ESKD requiring RRT. “Different birth cohorts may have different levels of exposure to a particular risk factor, which may produce a change in disease incidence for individuals born at a particular time, i.e. a cohort effect,” said Dr. Wakasugi, the corresponding author of the study. “Age-Period-Cohort (APC) analysis, a statistical method to distinguish between age, period, and ...

As a four-day work week is trialled in countries across the globe, health researchers at the University of South Australia say they’re ‘all in’ when it comes to a long weekend, especially as new empirical research shows that the extra time off is good for our health.   Assessing changes in daily movements before, during and after holidays, researchers found that people displayed more active, healthy behaviours when they were on holiday, even when they only had a three-day break.   Across the 13-month study period, people generally took an average two to three holidays, each being around 12 days. The most common holiday type was ‘outdoor ...

Anthocyanins are compounds related to the color of plants. They also have beneficial effects on human health and are used as a supplement. Various species of anthocyanins, divided by their molecular shape, are present in plants. Therefore, simple, and rapid, analytical techniques that can distinguish among these species in crops are necessary for breeding and quality assessment. A team of Nagoya University researchers in Japan has used a technique called probe electrospray ionization tandem mass spectrometry (PESI/MS/MS) to analyze anthocyanins in crops. ...

A research team led by Dr Chaogu ZHENG from the School of Biological Sciences at The University of Hong Kong (HKU) has recently made a significant discovery about the evolutionary age of different type of cells in a small animal called Caenorhabditis elegans (C. elegans). By using single-cell transcriptomic data and refined phylostratigraphy, the team determines the transcriptomic age of individual cells, which means they are able to estimate the evolutionary origin of different cells based on the age of the genes expressed in the ...

Until recently, fish that eat coral — corallivores — were thought to weaken reef structures, while fish that consume algae and detritus — grazers — were thought to keep reefs healthy. But scientists have discovered that feces from grazers leave large lesions on coral, possibly because they contain coral pathogens. By contrast, feces from corallivores may provide a source of beneficial microbes that help coral thrive. “Corallivorous fish are generally regarded as harmful because they bite the corals,” said Dr Carsten Grupstra of Rice University, ...

Arlington, Va., April 13, 2023 – New data published today in the American Journal of Infection Control (AJIC) provide the first published evidence that a positive safety climate and adherence to standard precautions predict key healthcare-associated infection (HAI) and occupational health outcomes among patients and health care workers, respectively. The findings highlight features within hospitals’ organizations and safety climates that could be modified to improve these outcomes. “Despite the infection prevention and safety benefits associated with standard precautions, generating consistent adherence in the healthcare setting has been ...