Researchers have established the protein p53 as critical for regulating sociability, repetitive behavior, and hippocampus-related learning and memory in mice, illuminating the relationship between the protein-coding gene TP53 and neurodevelopmental and psychiatric disorders like autism spectrum disorder. “This study shows for the first time that p53 is linked directly to autism-like behavior,” said Nien-Pei Tsai, an associate professor of molecular and integrative biology at the University of Illinois Urbana-Champaign and a researcher at the Beckman Institute for Advanced Science and Technology. In living systems, ...

Accessing stable employment with fair pay and predictable hours is harder for workers in the North and Midlands, which can severely affect their living standards, health, and future job prospects.   A new report published by the Work Foundation at Lancaster University reveals the regions with the highest and lowest levels of ‘severely insecure’ work (employment that is involuntarily temporary or part-time, or when multiple forms of insecurity come together, such as casual or zero-hours contracts, or low or unpredictable ...

Increased consumption of carbohydrate from refined grains, starchy vegetables, and sugary drinks is associated with greater weight gain throughout midlife, while increased fibre and carbohydrate from whole grains, fruit, and non-starchy vegetables is linked to less weight gain, finds a large US study published by The BMJ today. Most of these associations were stronger for people with excessive body weight, highlighting the potential importance of carbohydrate quality and source for long term weight management, say the researchers. The role of carbohydrates in weight gain and obesity remains controversial, and few studies have evaluated ...

Patients in some of the most deprived areas of England, where respiratory conditions including chronic lung disease (COPD) and asthma are most prevalent, have limited or no access to vital diagnostic tests to confirm their diagnosis, reveals a survey by The BMJ today. Despite NHS England’s promise of access via Community Diagnostic Centres (CDCs), journalist Sally Howard speaks to GPs in some of the worst affected areas who say having no means of referring patients for lung function tests is “troubling” and “a silent scandal.” And last month, a report by the charity Asthma + Lung UK ...

A project mapping medieval England’s known murder cases has now added Oxford and York to its street plan of London’s 14th century slayings, and found that Oxford’s student population was by far the most lethally violent of all social or professional groups in any of the three cities. The team behind the Medieval Murder Maps – a digital resource that plots crime scenes based on translated investigations from 700-year-old coroners’ inquests – estimate the per capita homicide ...

Cambridge researchers have found that women who smoke during pregnancy are 2.6 times more likely to give birth prematurely compared to non-smokers – more than double the previous estimate. The study, published today in the International Journal of Epidemiology, also found that smoking meant that the baby was four times more likely to be small for its gestational age, putting it at risk of potentially serious complications including breathing difficulties and infections. But the team found no evidence that caffeine intake was linked to adverse outcomes. Women are currently recommended to stop smoking and limit their caffeine intake during pregnancy because of the risk of complications ...

CHAMPAIGN, Ill. — Having a chronic illness is a great deal of work, communication researchers have long known. But having an illness that is stigmatized, not well understood or not perceived as a priority by clinicians is uniquely burdensome for many women, who find themselves struggling to establish both the legitimacy of their medical problems and their credibility with clinicians, family members and friends, a recent study suggests. Sasha, a 25-year-old woman interviewed for the project, told the researchers she has a binder 3 inches thick containing all her medical records that she lugs to every doctor’s appointment to provide documentation ...

The results of the Chi-Nu physics experiment at Los Alamos National Laboratory have contributed essential, never-before-observed data for enhancing nuclear security applications, understanding criticality safety and designing fast-neutron energy reactors. The Chi-Nu project, a years-long experiment measuring the energy spectrum of neutrons emitted from neutron-induced fission, recently concluded the most detailed and extensive uncertainty analysis of the three major actinide elements — uranium-238, uranium-235 and plutonium-239.   “Nuclear fission and related nuclear chain ...

The friction on a graphene surface can be dynamically tuned using external electric fields, according to researchers at the University of Illinois Urbana-Champaign led by Professor Rosa Espinosa-Marzal of the Department of Civil and Environmental Engineering. The work is detailed in the paper, “Dynamically tuning friction at the graphene interface using the field effect,” published September 19, 2023, in the journal Nature Communications. Friction plays a key role in both natural and engineered systems, dictating the behavior of sliding contacts, affecting ...

Using an innovative new approach to sampling corals, researchers at the University of Hawai‘i (UH) at Mānoa are now able to create maps of coral biochemistry that reveal with unprecedented detail the distribution of compounds that are integral to the healthy functioning of reefs. Their study was published today in Communications Biology. “This work is a major step in understanding the coral holobiont [the coral animal and all of its associated microorganisms], which is critical for reef restoration and management,” said lead author Ty Roach, who conducted this study as a postdoctoral researcher at the Hawai‘i Institute of Marine Biology (HIMB) in the UH ...

September 27, 2023, NEW YORK – A Ludwig Cancer Research study has for the first time exhaustively analyzed immune cells known as neutrophils that reside in brain tumors, including gliomas, which develop in the brain itself, and cancers that spread there from the lung, breast and skin. Led by Ludwig Lausanne’s Johanna Joyce and Roeltje Maas, an MD-PhD student in her laboratory, the study also details the key role neutrophils play in ensuring the survival of brain cancers and exposes the mechanisms by which the tumor microenvironment (TME) tweaks their biology to turn them into enablers of malignant growth. Its findings suggest new approaches ...

CHAMPAIGN, Ill. — As much of the U.S. broils under record-setting temperatures, battles wildfires and is rocked by fierce storms, a new study suggests that the science learning standards for many public schools are not preparing young people to understand and respond to problems such as climate change that will dramatically impact their lives and those of millions of people around the globe. Published in the Proceedings of the Royal Society B: Biological Science, the findings raise troubling questions about political bias shaping if and what the nation’s ...

The scientists who received the 2017 Nobel Prize in chemistry were honored for their development of a technique called cryo-electron microscopy, or cryo-EM. The technology was revolutionary because it enabled scientists to see the atomic structure of biological molecules in high resolution. But cryo-EM still had a catch: It was only effective for imaging large molecules. Now, UCLA biochemists, working with pharmaceutical industry scientists, have developed a solution that will make it possible for cryo-EM to acquire high-quality images of smaller protein molecules, too. The scientists engineered a 20 nanometer, cube-shaped ...

EL PASO, Texas (Sept. 27, 2023) — The University of Texas at El Paso has been chosen to become a center of thought leadership for Hispanic Serving Institutions (HSIs) across the country, thanks to a new $7 million grant from the National Science Foundation (NSF). The new grant, known as NODE (Network Opportunities for Developing Equitable and Effective Evaluation at HSIs), is a six-year investment that will position UTEP to provide the first full portrait of the effectiveness of all grants funded by the NSF HSI program. Anne-Marie Núñez, Ph.D., executive director of the Diana Natalicio Institute ...

    Image In a solar system called TRAPPIST-1, 40 light years from the sun, seven Earth-sized planets revolve around a cold star.    Astronomers obtained new data from the James Webb Space Telescope (JWST) on TRAPPIST-1 b, the planet in the TRAPPIST-1 solar system closest to its star. These new observations offer insights into how its star can affect observations of exoplanets in the habitable zone of cool stars. In the habitable zone, liquid water can still exist on the orbiting planet's surface.   The ...

New York, September 27, 2023 – Individual innovation is considered one sign of intelligence within species, and elephants are among the animals that researchers have long taken an interest in because of their sophisticated approach to problem solving. A newly published study in the journal Animal Behaviour details findings from a six-month-long study documenting the abilities of individual wild Asian elephants to access food by solving puzzles that unlocked storage boxes. “This is the first research study to show that individual wild elephants have different willingness and abilities to problem solve in ...

In eastern Africa, malaria parasites have developed resistance to artemisinins, the backbone of current treatment regimens, a development that could dramatically worsen malaria’s impact if partner drugs fail in the future.  The finding from studies in Eritrea was reported Sept. 28 in the New England Journal of Medicine by a team of researchers led by Didier Ménard, PhD, of the Université de Strasbourg/Institut Pasteur in France and including Columbia University microbiologist David Fidock, PhD, the C.S. Hamish Young Professor of Microbiology & Immunology and professor of medical sciences in the Vagelos College of Physicians and Surgeons.    Treatment ...

BUFFALO, N.Y. – Industry has long relied upon energy-intensive processes, such as distillation and crystallization, to separate molecules that ultimately serve as ingredients in medicine, chemicals and other products. In recent decades, there has been a push to supplant these processes with membranes, which are potentially a lower-cost and eco-friendly alternative. Unfortunately, most membranes are made from polymers that degrade during use, making them impractical. To solve this problem, a University at Buffalo-led research team ...

EAST LANSING, Mich. – Providing safe drinking water was a great public health achievement in the 20th century, yet problems persist. According to the Centers for Disease Control and Prevention, about 7.15 million waterborne illnesses occur in the United States annually resulting in 601,000 emergency room visits, 6,630 deaths and $3.33 billion in direct health care costs. Michigan State University, a world leader in water research, is working to make our drinking water safer. MSU has been awarded a $2.1 million grant from the U.S. Environmental Protection ...

When people have to make a tough decision, their first instinct is usually to gather as much information as possible. Just one problem: according to research published this week in Cognitive Research: Principles and Implications, most people’s decision-making actually gets worse, not better, when you give them additional facts and details. “It’s counterintuitive, because we all like to think we use information wisely to make smart decisions,” said Farber Chair Associate Professor ...

At a glance: Johan Paulsson, HMS professor of systems biology, will lead project studying bacterial behavior and antibiotic resistance. Efforts will focus on developing technology to improve diagnosis, speed discovery of new antibiotics, and illuminate basic mechanisms of bacterial behavior. Harvard Medical School researcher Johan Paulsson will lead a multi-institutional $104 million effort to study bacteria and antibiotic resistance, the U.S. Department of Health and Human Services announced today. The work is funded by the newly established Advanced Research Projects Agency for Health (ARPA-H) in an ...

BOSTON - Researchers at Boston Medical Center and Dana-Farber Cancer Institute conducted one of the first-ever analyses of neuroendocrine tumors (NETs) at single cell resolution, unlocking new insights into this rare and often hard-to-treat cancer. The findings represent a tremendous leap forward in understanding why these tumors are largely resistant to immunotherapy and provide key insights that could lead to future treatments. “This study was a tour-de-force that catalyzed the efforts and innovations of researchers across Boston – including Boston Medical Center and Dana-Farber Cancer Institute - and has resulted in a better understanding ...

“With the majority of lung cancer patients being older than 65, it is imperative that actions are taken to encourage and facilitate clinical trials among older patients.” BUFFALO, NY- September 27, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 17, entitled, “Promising trends in lung cancer care, but are we overlooking the majority?” In their new editorial, ...

“The balance between appropriate precautions and the harm of social isolation always requires a thorough appraisal.”  BUFFALO, NY- September 27, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on September 22, 2023, entitled, “Reassessing the risks and benefits of COVID-19 precautions in 2023.” The COVID-19 pandemic has killed over one million Americans with many dying during the Omicron wave. By now most Americans have either had COVID-19 and/or been vaccinated against it. Despite the availability of updated immunizations, only 16.7% of Americans are now up-to-date on bivalent ...

EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, SEPTEMBER 27, 2023   MINNEAPOLIS – People with a higher cumulative estrogen exposure throughout their life may have a lower risk of cerebral small vessel disease, according to a new study published in the September 27, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. Cerebral small vessel disease, a form of cerebrovascular disease, results from damage to small blood vessels in the brain. It raises the risk of cognitive impairment and dementia.   “Previous research has shown that rates of cerebrovascular disease increase after menopause, which is often attributed ...