About The Study: The results of this study of 220,000 American Indian and Alaska Native patients with Medicare insurance suggest a significant burden of cardiovascular disease and cardiometabolic risk factors. These findings highlight the critical need for future efforts to prioritize the cardiovascular health of this population.  Authors: Lauren A. Eberly, M.D., M.P.H., of the Indian Health Service in Gallup, New Mexico, is the corresponding author.  To access the embargoed study: Visit ...

https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2023-0031 Announcing a new article publication for Zoonoses journal.  Monkey B virus (BV) infection in humans and other macaque species has a mortality rate of approximately 80%. Because BV infects humans through bites, scratches, and other injuries inflicted by macaques, the simple and rapid diagnosis of BV in field laboratories is of great importance to protect veterinarians, laboratory researchers, and support personnels from the threat of infection. Two recombinase polymerase amplification (RPA) assays with a closed vertical flow (VF) visualization strip (RPA-VF-UL27 and RPA-VF-US6) were developed that target ...

A research group at the University of Helsinki and its partners have found a promising drug candidate for the treatment of amyotrophic lateral sclerosis (ALS). Cerebral dopamine neurotrophic factor CDNF prolongs the lifespan of and alleviates disease symptoms in rats and mice in animal studies. Amyotrophic lateral sclerosis (ALS) is a rapidly progressing fatal neurodegenerative disease that affects the nerve cells in the brain and spinal cord. Specifically, a selective degeneration of motoneurons occurs in the spinal cord, leading to muscle atrophy and paralysis. Most patients with ...

Researchers have made a significant finding in determining the genetic background of dilated cardiomyopathy in Dobermanns. This research helps us understand the genetic risk factors related to fatal diseases of the heart muscle and the mechanisms underlying the disease, and offers new tools for their prevention. Researchers from the University of Helsinki and the Folkhälsan Research Center, together with their international partners, have identified the genetic background of dilated cardiomyopathy, a disease that enlarges the heart muscle, in dogs and humans. Based ...

Proton exchange membrane fuel cells (PEMFCs) hold promise as a replacement for fossil fueled engines in heavy-duty vehicles. Reducing the platinum content in catalysts is pivotal for scaling up in such applications. Yet, the degradation patterns of low platinum content catalysts remain poorly understood. A team of scientists conducted experiments to shed light on the degradation mechanisms associated with varying catalyst content, offering valuable insights. Their work is published in the journal Industrial Chemistry & Materials on 11 Aug 2023. In ...

Palm oil is the world's most produced and consumed vegetable oil and everyone knows that its production can damage the environment. But do consumers have the full picture? In fact, replacing palm oil with rapeseed oil would require a four to five-fold increase in the amount of land needed. Research led by the University of Göttingen investigated the attitudes, beliefs and understanding about palm oil of the general public in Germany, and how this links to land use. The researchers show that people find it hard to know the consequences of their buying choices, even when extra information is supplied. The results were published in Sustainable ...

CHAPEL HILL, N.C. – Scientists studying Alzheimer’s disease (AD) have identified thousands of genetic variants in the genome in the development of this progressive neurodegenerative disease. These variants are predominantly located in genomic regions that do not code for proteins, making it difficult to understand which variants confer individuals’ risk of AD. Non-coding variants were once thought to be “junk DNA” by scientists. In recent years, these variants have been appreciated for playing crucial roles in controlling gene expression across tissues and cell types. However, linking these non-coding variants to the genes they regulate and effects ...

A groundbreaking study conducted by Jun Sun’s research team at the University of Illinois Chicago has revealed a new and critical role of Axin1 in regulating intestinal epithelial development and microbial homeostasis. The research, published in the journal Engineering, highlights the potential therapeutic strategies for human inflammatory bowel disease (IBD). IBD, a chronic inflammatory disorder affecting the gastrointestinal tract, has been a significant health concern worldwide. The study focused on understanding the role of Axin1, a negative regulator of Wnt/β-catenin ...

Tsukuba, Japan—Fuel cells are attracting attention as a clean energy source technology because the cells do not produce carbon dioxide and emit only water during power generation. However, two contradictory phenomena can hamper their performance: flooding, wherein water remains inside the fuel cell and interferes with power generation, and dry-out, wherein an excess of water is removed and the polymer membrane, through which hydrogen ions permeate, dries out. To detect such issues, various devices and sensors have been used in analyses based on substantial amounts of data. This research team has been investigating a method for detecting and controlling ...

Tsukuba, Japan—For realizing carbon neutrality, the demand for the development of direct methanol/formic acid-fuel cell technology has been increasing. In this technology, methanol or formic acid is used as an e-fuel for generating electricity. The fuel cells generate electricity via proton transfer; however, conventional proton-exchange membranes suffer from the "crossover phenomenon," where the fuel molecules are also transferred between anodes and cathodes. Thereafter, the fuel molecules are unnecessarily oxidized and the electrodes are deactivated. In this study, the researchers developed a new proton-exchange ...

Tsukuba, Japan—The search for functional natural compounds that can improve age-related cognitive decline has recently emerged as an important research focus to promote healthy aging. Trigonelline (TG), a plant alkaloid found in coffee, as well as in fenugreek seed and radish, was anticipated to possess cognitive enhancement properties. In this study, researchers led by the University of Tsukuba investigated the effects of TG on memory and spatial learning (acquiring, retaining, structuring, and applying information related to the surrounding physical environment) from both a cognitive and molecular biology perspective ...

Tsukuba, Japan—In eukaryotes, genomic DNA, which is a very long double helix containing all the genetic information, wraps around a globular protein called a histone and folds it many times before being contained within the nucleus. Various post-translational modifications (for example, addition of chemical groups) occur on histones. Among them, the methylation of residues of lysine, which is one of the amino acids that make up histones, regulates the folding of genomic DNA and acts as a switch to turn gene transcription on and off. The research group has discovered the methylation of histidine residues as a new post-translational ...

This study is led by Dr Cheng-Guo Duan (Center of Excellence in Molecular Plant Sciences, Chinese Academy of Science). As a conserved epigenetic mark, DNA cytosine methylation at 5’ position (5-mC) plays important roles in multiple biological processes including plant immunity. While, it remains still elusive about the involvement of DNA methylation in the determinants of virulence of phytopathogenic fungi. Verticillium dahliae, one of the major causal pathogens of Verticillium wilt disease that causes great losses in many crops, has a wide host range. Due to the lack of natural disease-resistant ...

This study combined expertise in barley genetics and genomics from the research group led by Dr. Ping Yang (Institute of Crop Sciences, Chinese Academy of Agricultural Sciences) and that in barley microspore culturing led by Dr. Chenghong Liu (Biotech Research Institute, Shanghai Academy of Agricultural Sciences), in order to address the time- and space-cost issue in developing homozygous induced mutants, which are very important genetic resources in theoretical researches as well as pre-breeding.   The researchers applied chemical mutagenesis (ethyl ...

Artifical intelligence not only affords impressive performance, but also creates significant demand for energy. The more demanding the tasks for which it is trained, the more energy it consumes. Víctor López-Pastor and Florian Marquardt, two scientists at the Max Planck Institute for the Science of Light in Erlangen, Germany, present a method by which artificial intelligence could be trained much more efficiently. Their approach relies on physical processes instead of ...

DURHAM, N.C. – Maintaining a water level between 20 and 30 centimeters below the local water table will boost southern peatlands’ carbon storage and reduce the amount of climate-warming carbon dioxide (CO2) and methane they release back into the atmosphere during dry periods by up to 90%, a new Duke University study finds. “We could immediately reduce U.S. carbon losses by 2% to 3% of our total national goal by applying this guideline on about 100,000 acres of restored or partially restored peatlands currently found across ...

A research team, led by Professor Jong-Beom Baek and his team in the School of Energy and Chemical Engineering at UNIST have achieved a significant breakthrough in battery technology. They have developed an innovative method that enables the safe synthesis of fluorinated carbon materials (FCMs) using polytetrafluoroethylene (PTFE) and graphite. Fluorinated carbon materials have garnered considerable attention due to their exceptional stability, attributed to the strong C-F bonding—the strongest among carbon single bonds. However, traditional methods of fluorination involve highly toxic reagents such as hydrofluoric acid (HF), making them unsuitable for practical ...

As energy demand continues to rise, research into new, efficient renewable and clean energy sources is an urgent priority. Currently, renewable energy sources like solar, wind, tide, and geothermal make up less than 40% of the current energy demand. Increasing this percentage and reducing the amount of fossil fuels used will require other, more efficient renewable and clean energy sources. Hydrogen is a promising alternative, but it is currently produced using steam reforming, which is inefficient and produces CO2 emissions. Electrochemical water splitting, also called ...

BOSTON – There is growing evidence that a relative abundance of certain gut microbes may be related to skeletal health, according to a new study published in Frontiers in Endocrinology. If confirmed by additional research, the findings could provide the opportunity to alter gut microbiomes to achieve better bone health, as scientists learn more about “osteomicrobiology,” a new term recently used to characterize this relationship.   Due to the lack of large-scale human studies of the gut microbiome and skeletal health, researchers led by Paul C. Okoro, Data Scientist II at Hebrew SeniorLife and Hinda and Arthur Marcus Institute for ...

Bottom Line: A dendritic cell vaccine administered before and after autologous stem cell transplant (ASCT) was safe and immunogenic and was associated with durable clinical responses in patients with high-risk multiple myeloma. Journal in Which the Study was Published: Clinical Cancer Research, a journal of the American Association for Cancer Research (AACR) Authors: Frederick L. Locke, MD, chair of the Blood and Marrow Transplant and Cellular Immunotherapy Department at Moffitt Cancer Center, was the senior author of the study. Background: “Multiple ...

In order to explore brain disorders and discover potential treatments, it is crucial to analyze and interpret the signals transmitted by the brain.  Although neural probes attached to the brain can effectively detect subtle bio- signals, they lack the ability to amplify and process these signals, necessitating the use of a separate amplifier. The research team identified a solution in common household “inkjet printers” that have been widely available for a long time.   A collaborative research team led by Professor Sungjune Jung (Department of Materials Science and Engineering, Department of Convergence IT Engineering) with PhD candidate ...

University of Queensland researchers have identified a novel drug target with the potential to overcome drug resistance and prevent tumour regrowth in cancer patients. Associate Professor Helmut Schaider from UQ’s Frazer Institute said the newly identified molecule was not currently a target for treatment, opening the potential for drug development. “Drug resistance is the single major cause of death in cancer patients,” Dr Schaider said. “For example, almost half of patients with lung cancer die ...

An international clinical trial exploring a new way to treat rare and aggressive gynaecological cancers has launched in Melbourne.  Based on a WEHI-led discovery, the trial hopes to enhance treatment options for women with two of the most lethal gynaecological cancers – ovarian and uterine carcinosarcomas. The study will offer a novel combination therapy for women with these relapsing cancers and is now open in Australia, with plans to expand to Canada and the United Kingdom in coming months. At a glance New clinical trial launches in Melbourne to test a potential treatment for two aggressive and rare gynaecological ...

New research analysing the effects of two drugs used to treat type 2 diabetes indicates a consistent lack of cardiovascular and renal benefits in Black populations. Cardiovascular disease is the leading cause of severe illness and death associated with type 2 diabetes. Renal disease is also a common complication of type 2 diabetes. The drugs, called sodium-glucose co-transporter 2 inhibitors (SGLT2-Is) and glucogen-like peptide 1 receptor agonists (GLP1-RAs), are some of the newer treatments prescribed to lower blood sugar levels in people with type 2 diabetes. The research findings, published in the Journal of the ...

NEW ORLEANS, LOUISIANA – Ochsner Health is again expanding its Ochsner Scholars program for aspiring nurses and physicians ready to fill critical healthcare shortages in local communities and shape the healthcare workforce of the future. Ochsner is excited to announce tuition assistance for 100 Nurse Scholars pursuing Associate Degree in Nursing (ADN), Licensed Nurse Practitioner (LPN), Bachelor of Science in Nursing (BSN) and Accelerated Bachelor of Science in Nursing (ABSN) degrees this spring to students across Louisiana and Mississippi. Ochsner is also covering tuition for up to 10 Physician Scholars ...