Tokyo, Japan – Scientists from Tokyo Metropolitan University have realized a new polymer that can effectively transport plasmid DNA into T-cells during chimeric antigen receptor (CAR) T-cell therapy, a key treatment for blood cancer. Importantly, it can get genes into floating T-cells, not only ones fixed to surfaces. It is stable, non-toxic, and doesn’t use viruses. It outperforms polyion compounds considered a gold standard in the field, paving the way for new therapies. T-cells, or lymphocytes, are a type of white blood cell that helps our immune system fight germs and protect us from disease. Recently, technology has become available that helps reprogram T-cells to fight cancer. ...

(Santa Barbara, Calif.) — Sometimes simple solutions are better. It all depends on the nature of the problem. For humpback whales, the problem is the rope connecting a crab trap on the seafloor to the buoy on the surface. And for fishermen, it’s fishery closures caused by whale entanglements. Managing this issue is currently a major item on California’s agenda, and it appears less fishing gear may be the optimal solution. So says a team of researchers led by Christopher Free, at UC Santa Barbara, after modeling the benefits and impacts that several management strategies would have on whales and fishermen. ...

A virtual reality (VR) game crashes. A robot rolls dangerously close to the edge of a cliff. An autonomous vehicle speeds toward a pedestrian. Without intelligent control happening every millisecond, accidents can occur. This control can mean applying the brake of an autonomous vehicle to save a life or creating a more user-friendly augmented reality experience. Two professors in the Department of Electrical and Computer Engineering at Texas A&M University are working to enhance and advance the future ...

Wheat is a global staple food and plays a pivotal role in the livelihoods of billions of people. Although long non-coding RNAs (lncRNAs) have been recognized as crucial regulators of numerous biological processes, our knowledge of lncRNAs associated with wheat (Triticum aestivum) grain development remains minimal. Seed Biology published an online paper entitled “A comprehensive atlas of long non-coding RNAs provides insight into grain development in wheat” on 04 September 2023. To ...

Researchers with the ongoing Arizona CoVHORT research study at the University of Arizona Mel and Enid Zuckerman College of Public Health were awarded $3.2 million by the National Institute of Diabetes and Digestive and Kidney Diseases for a five-year study of gastrointestinal symptoms, specifically irritable bowel syndrome, as a condition of long COVID. Led by epidemiologist Kristen Pogreba-Brown, PhD, MPH, the CoVHORT study is a longitudinal research study of COVID-19 and post-COVID conditions. The ...

WASHINGTON, D.C. - The U.S. Department of Energy (DOE) today announced up to $500 million in funding for basic research in support of DOE’s clean energy, economic, and national security goals. The funding will advance the priorities of DOE’s Office of Science and its major programs, including Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, Isotope R&D and Production, and Accelerator R&D and Production. This funding opportunity will help achieve the Biden Administration’s ...

Standing at a crosswalk, the signal changes from “don’t walk,” to “walk.” You might step out into the street straight away, or you might look both ways before you cross. In either scenario, you see the light change, you cross the street. But the context is different; in one case, you didn’t think twice. In the other, you waited; looked to the left and right; saw the coast was clear; then stepped into the street. Researchers have known that certain brain activity when you see the light change and certain brain activity when you step out into the street are the same no matter the context -- there’s a known “pathway” ...

Manufacturers throughout Illinois will have the chance to learn about working with the Materials Manufacturing Innovation Center (MMIC) at the U.S. Department of Energy’s (DOE) Argonne National Laboratory, when the MMIC gets on the bus for the second annual Makers on the Move tour.  The Illinois Manufacturing Association and Illinois Manufacturing Excellence Center (IMEC) sponsor the eight-day, 1,000-mile tour, designed to showcase high-tech, clean, diverse and sustainable modern manufacturing. The branded Makers on the Move bus will stand out on the state’s roadways as it visits facilities, colleges ...

ARLINGTON, Va., September 29, 2023 — People with intermediate risk, localized prostate cancer can be treated as effectively using fewer and higher doses of radiation therapy delivered over five treatment sessions as they can with lower doses delivered over several weeks, a new phase III randomized trial suggests. The findings, which are the latest from a series of studies investigating the benefits of stereotactic body radiation therapy (SBRT) for people diagnosed with prostate cancer, will be presented Monday at the American Society for Radiation Oncology (ASTRO) Annual Meeting. The PACE ...

MIAMI, FLORIDA (STRICTLY EMBARGOED UNTIL SEPT. 29, 2023 AT 5PM ET) – Is it true progression or pseudoprogression in tumor growth? That’s the critical question for radiation and medical oncologists treating patients with glioblastoma, the most common and aggressive form of brain cancer. Distinguishing between these types of progression is vitally important for treatment management. “Knowing if it’s true progression, indicative of a poor response to treatment, or pseudoprogression, a favorable response that may look worse due to swelling or tumor necrosis, is essential for clinicians,” said Eric Mellon, MD, PhD, a radiation oncologist and researcher ...

MIAMI, FLORIDA (EMBARGOED UNTIL SEPT. 29, 2023, AT 5 PM ET, 2023) – Physician burnout was already a trending topic within the medical community before 2020, when the COVID-19 pandemic brought national attention to the issue. Typical stressors such as long hours, poor work-life balance, frustrating insurance denials and cumbersome medical documentation were compounded by new challenges from a novel, deadly virus that killed millions worldwide and necessitated a paradigm shift in care delivery. The side effects were widespread and readily apparent. By late 2021, research by the American Medical Association, Mayo Clinic and Stanford ...

ALL INFORMATION EMBARGOED UNTIL 5 P.M. ET ON SEPT. 29, 2023   Panel Discussion Getting it All Done – Strategies for Coping With Professional Burnout Crystal Seldon Taswell, MD, Sylvester radiation oncologist and researcher, will co-moderate a panel discussion on physician burnout within radiation oncology and medicine. The discussion, titled “Getting It All Done -- Practical Strategies at All Career Stages,” will include background on the extent of the problem, as well as the curriculum gap for residents regarding time management, balancing ...

University of Cincinnati Cancer Center researchers will present abstracts at the American Society for Radiation Oncology (ASTRO) Annual Meeting, held Oct. 1-4 in San Diego.  Lattice therapy shows promise for safer, more effective treatment  In standard radiation treatment, entire tumors receive the same dose of radiation. Cancer Center researchers including Andrew Frankart, MD, are testing the application of a different method called lattice therapy, and he will present three posters detailing research into lattice therapy ...

SAN DIEGO ― The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. This special edition features presentations by MD Anderson researchers at the 2023 American Society for Radiation Oncology (ASTRO) Annual Meeting. Information on all MD Anderson ASTRO Annual Meeting content can be found at MDAnderson.org/ASTRO. Read ...

Using a new recipe for growing blood vessels from living lung tissue in the lab, a University of Virginia School of Engineering and Applied Science research team has developed an analytical tool that could lead to a cure for idiopathic pulmonary fibrosis, or IPF, a lung-destroying disease. Fibrosis is chronic scarring of tissue and it can strike nearly every system in the body. According to the National Institutes of Health, the government estimates that 45% of deaths in the United States can be attributed to fibrotic disorders. In the lungs, fibrosis restricts breathing, so understanding how scarring occurs, and ultimately how to stop it, ...

Center to develop cost-effective method for decarbonized manufacturing for steelmaking without a blast furnace. Steel has a major impact on everyone’s lives and our economy. It is crucial to cars, trucks, airplanes, buildings and more. However, there is a significant issue with its production process. Globally, it accounts for a large percentage of greenhouse gas emissions from the industrial sector. The U.S. Department of Energy (DOE) recently announced $19 million in funding over four years for DOE’s Argonne National Laboratory ...

Study Title: RANO 2.0: Update to the Response Assessment in Neuro-Oncology Criteria for High- and Low-Grade Gliomas in Adults Publication: Journal of Clinical Oncology Dana-Farber Cancer Institute author: Patrick Y. Wen, MD Summary: In order to accurately assess the efficacy of novel therapies for brain tumors it is necessary to have reliable criteria to determine response or progression. Response assessment in brain tumors is difficult because of the irregular shapes of the tumors and the fact that many therapies used to treat these tumors can also produce imaging changes that resemble tumor ...

As an institution renowned for innovation efforts grounded in education and research, the Naval Postgraduate School (NPS) has often been called upon to tackle some of the most difficult technological challenges facing the Navy and the nation. Such a challenge emerged in 2020, when NASA charged NPS and two other research teams with solving a critical barrier facing the development of electric aircraft propulsion (EAP): the creation of a circuit breaker that could support large electric platforms running on direct current (DC) electricity. Thanks to the efforts of a diverse team of faculty and students, as well as several Navy and academic research partners, NPS delivered ...

The Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) will host two new centers dedicated to advancing clean energy technology and combating climate change. The awards are part of DOE’s Energy Earthshots Initiative that launched in 2021 with the goal of speeding up technological breakthroughs and lowering costs.  DOE has so far launched seven Earthshots spanning clean energy and carbon reduction technologies. The Berkeley Lab programs announced today will address two of them: the Hydrogen ...

For the first time, Stanford researchers have found a way to create and stabilize an extremely rare form of gold that has lost two negatively charged electrons, denoted Au2+. The material stabilizing this elusive version of the valued element is a halide perovskite—a class of crystalline materials that holds great promise for various applications including more-efficient solar cells, light sources, and electronics components. Surprisingly, the Au2+ perovskite is also quick and simple to make using off-the-shelf ingredients at room temperature. "It was a real surprise that we were able to synthesize a stable material containing Au2+—I didn't even believe it at ...

Huntsman Cancer Institute shines the spotlight on new discoveries and cutting-edge cancer research. This month, researchers found that increasing access for Black people with prostate cancer may save lives. Also, the first patient in a new small cell lung cancer clinical trial has been enrolled, researchers are using an app to help adolescents and young adults manage cancer symptoms, and investigators are trying to reduce cognitive side-effects after chemotherapy.  Increasing access to Black people with prostate cancer may decrease mortality rate In a study published ...

(Toronto, September 29, 2023) JMIR Publications is pleased to announce it placed No. 348 on the 2023 Report on Business ranking of Canada’s Top Growing Companies, making the ranking over the past three consecutive years. Canada’s Top Growing Companies ranks Canadian companies on three-year revenue growth. JMIR Publications earned its spot with three-year growth of 105%. “Being ranked on this list, year over year, showcases JMIR Publications’ national and global leadership in publishing high-quality open access ...

A transformative initiative aimed at identifying, enhancing and promoting science, technology, engineering and mathematics resources within local communities. The U.S. Department of Energy’s Argonne National Laboratory is proud to announce the official launch of the South Side STEM Opportunity Landscape Project, a transformative initiative aimed at identifying, enhancing and promoting science, technology, engineering and mathematics (STEM) resources within local communities. As part of the Argonne in Chicago initiative that includes offices in Hyde Park, the ...

The notion that some level of microbial exposure might reduce our risk of developing allergies has arisen over the last few decades and has been termed the hygiene hypothesis. Now, an article published in Science Immunology by researchers from Karolinska Institutet challenges this hypothesis by showing that mice with high infectious exposures from birth have the same, if not an even greater ability to develop allergic immune responses than 'clean' laboratory mice. How microbes may prevent allergy has been a topic of great interest in recent times. Studies have suggested that certain infections might reduce the production of inflammatory antibodies to ...

New study makes novel use of plant biomarkers preserved in sediment to reconstruct methane cycling over the past 10,000 years Plant waxes hold an isotopic signature of ancient methane As planet warmed due to slow changes in Earth’s orbit, lakes produced increased amounts of methane, which is a potent greenhouse gas Researcher: ‘Living on a warming planet, we can look to these signs from the past to predict our future’ EVANSTON, Ill. — By studying fossils from ancient aquatic plants, ...