TUCSON, Ariz., August 9, 2023 — Critical Path Institute (C-Path) announced today that Sanofi, a global leader in immunology and diabetes care, has joined its Type 1 Diabetes Consortium (T1DC). Sanofi joins T1DC as part of its commitment to push the boundaries of innovation to improve the lives of those with diabetes. T1DC was established in 2017 with the goal to significantly advance the drug development landscape for T1D prevention and treatment. The consortium achieves this by fostering ...

Researchers are developing a way to incorporate one of the most human of characteristics – uncertainty – into machine learning systems. Human error and uncertainty are concepts that many artificial intelligence systems fail to grasp, particularly in systems where a human provides feedback to a machine learning model. Many of these systems are programmed to assume that humans are always certain and correct, but real-world decision-making includes occasional mistakes and uncertainty. Researchers from the University of Cambridge, along with The Alan Turing Institute, Princeton, and Google DeepMind, have been attempting ...

People with low levels of vitamin K in their blood are more likely to have poor lung function and to say they suffer with asthma, chronic obstructive pulmonary disease (COPD) and wheezing, according to a study published today (Thursday) in ERJ Open Research [1].   Vitamin K is found in leafy green vegetables, vegetable oils and cereal grains. It plays a role in blood clotting, and so helps the body to heal wounds, but researchers know very little about its role in lung health.   Researchers say their new findings do not alter the current advice on vitamin K intake, but they do support further research to ...

Sanford Burnham Prebys’ Cancer Center has received a rare and prestigious Merit Extension Award from the National Cancer Institute (NCI), recognizing and rewarding its earlier accomplishments as well as current research plans. The award extends the center’s current 5-year Cancer Center Support Grant (CCSG) for an additional two years. There are only seven Basic Laboratory Cancer Centers in the NCI’s national network. These centers focus primarily on laboratory research: developing, conducting, translating and advancing fundamental discoveries to clinical testing and, ultimately, ...

In the ongoing search for a cure for Alzheimer’s disease, a burgeoning branch of medicine is bringing new hope. Stem cell therapies are already being used to treat various cancers and disorders of the blood and immune system. In a new proof-of-concept study, scientists at University of California San Diego show stem cell transplants may also be a promising therapeutic against Alzheimer’s.  In the study, publishing this month in Cell Reports, the researchers demonstrate that transplanting hematopoietic ...

PHILADELPHIA—Trying to finish your homework while the big game is on TV? “Visual-movement” neurons in the front of your brain can help you stay focused, according to a new study from neuroscientists in the Perelman School of Medicine at the University of Pennsylvania. In the study, published recently in Neuron, the scientists sought to illuminate the neural mechanism that helps the brain decide whether to focus visual attention on a rewarding task or an alluring distraction. By analyzing neuron activity in animal models as they faced this kind of attentional ...

Scientists at the Cornell Lab of Ornithology have developed a novel way to model whether the populations of more than 500 bird species are increasing or decreasing. The method solves a nagging statistical problem by accounting for year-to-year changes in the behavior of people collecting the data. The result is detailed trend maps for each species down to an eight-mile radius--a major boost for local conservation efforts. Scientists used an approach called Double Machine Learning. Details are published in the journal Methods in Ecology and Evolution. “Changing human behavior presents a problem for statistical analysis ...

“[...] CDK9 inhibitors could play a role in future treatments of hematological diseases and could be a great ally when combined with other therapeutic approaches.”  BUFFALO, NY- August 9, 2023 – A new research perspective was published in Oncotarget's Volume 14 on August 7, 2023, entitled, “CDK9 INHIBITORS: a promising combination partner in the treatment of hematological malignancies.” In their new perspective, researchers Daniel Morillo, Gala Vega and Victor Moreno from Hospital Fundación Jiménez Díaz discuss Cyclin-dependent ...

“We argue that in multicellular organisms, neighbouring cells are in constant competition.” BUFFALO, NY- August 9, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, “A novel theory of ageing independent of damage accumulation.” The underlying cause or causes of aging are an enduring mystery, but in 1977 Kirkwood postulated that organisms might gain a fitness advantage by reducing investment in somatic maintenance if this allowed them to invest more resources in more crucial ...

MINNEAPOLIS – People who take acid reflux medications called proton pump inhibitors for four-and-a-half years or more may have a higher risk of dementia compared to people who do not take these medications, according to new research published in the August 9, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. This study does not prove that acid reflux drugs cause dementia; it only shows an association. Acid reflux is when stomach acid flows into the esophagus, usually after a meal or when lying down. People with acid reflux may experience heartburn and ulcers. People ...

Research from experts at Michigan Medicine, the Children’s Hospital of Philadelphia and Penn Medicine is breaking ground on new ways of treating blood disorders, such as sickle cell anemia, through gene therapy.  To cure blood disorders, patients must undergo high dose chemotherapy and bone marrow transplantation. This requires a match between the recipient and donor immune system, but ~30% of patients do not have a match. Even when they do the donor immune system can attack the patient, graft versus host disease. Gene therapy corrects the mutation in a patient’s own cells ...

ITHACA, N.Y. – Despite broad scientific consensus that climate change has more serious consequences for some groups – particularly those already socially or economically disadvantaged – a large swath of people in the U.S. doesn’t see it that way. A new national survey study found that just over one-third of U.S. adults believe climate change is impacting some groups more than others. Nearly half feel that climate change impacts all groups about equally. And when the question referenced race in climate impacts, even fewer people believed some groups are more adversely affected than others. “Our earlier research showed that ...

New observations of mud cracks made by the Curiosity Rover show that high-frequency, wet-dry cycling occurred in early Martian surface environments, indicating that the red planet may have once seen seasonal weather patterns or even flash floods. The research was published today in Nature. “These exciting observations of mature mud cracks are allowing us to fill in some of the missing history of water on Mars. How did Mars go from a warm, wet planet to the cold, dry place we know today? These mud cracks show us that transitional time, when liquid water was less abundant but still active on the ...

New research suggests that the US municipal bond market systemically misprices risk, as the pricing of municipal debt does not account for local physical climate risk, but does demand larger credit spreads from communities with a larger proportion of Black residents. Erika Smull of Duke University, US, and colleagues present these findings in the open-access journal PLOS ONE on August 9. Across the US, local governments issue municipal bonds to help fund various expenses, such as schools and sewer systems. ...

Two-thirds of turtle injuries and strandings recorded in the Maldives across 12 years arose from entanglement with lost and discarded fishing gear ### Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0289167 Article Title: Evaluation of sea turtle morbidity and mortality within the Indian Ocean from 12 years of data shows high prevalence of ghost net entanglement Author Countries: Republic of the Maldives Funding: The authors received no specific funding for this work. END ...

At one Antarctic research station, contaminant levels exceeding international guidelines across 18 years have resulted from historic practices that have polluted the local ecosystem ### Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0288485 Article Title: Contamination of the marine environment by Antarctic research stations: Monitoring marine pollution at Casey station from 1997 to 2015 Author Countries: Australia, Canada Funding: This research was funded by a Australian Antarctic Science research grants to JSS (AAS 2201, 2948, 4127, 4180, 4633) by the Australian Antarctic Division ...

ChatGPT-authored Japanese writing can be stylistically distinguished with up to 100% accuracy from human-authored text by machine learning algorithms ### Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0288453 Article Title: Distinguishing ChatGPT(-3.5, -4)-generated and human-written papers through Japanese stylometric analysis Author Countries: Japan Funding: This work was partly supported by JSPS KAKENHI Grant Number JP22K12726. The funders did not participate in this study design, data collection, analysis, or decision to publish, except their role in paying the English proofreading and Publication Fee. ...

While engaging in cell division research, Silke Hauf and members of her lab made a surprisingly quiet discovery. When cells express RNA, there is always some fluctuation, or noise, in how much RNA is produced. Hauf’s group found several genes whose noise dips below a previously established threshold, known as the noise floor, during expression. “We have solid data for this phenomenon,” said Hauf, associate professor in the Department of Biological Sciences at Virginia Tech. “There are some genes that are different and can have super low noise.” Often upstaged by the more striking, well-publicized high-noise genes, Hauf and her team were intrigued by these ...

Philadelphia, August 9, 2023 – Since the beginning of the COVID-19 pandemic caused by the SARS-CoV-2 virus, researchers have been trying to determine why this virus creates such negative long-term effects compared with most coronaviruses. Now, a multi-institutional consortium of researchers led by a team at Children’s Hospital of Philadelphia (CHOP) and the COVID-19 International Research Team (COV-IRT) has found that the genes of the mitochondria, the energy producers of our cells, can be negatively impacted by the virus, leading to dysfunction ...

The surface of Mars, unlike the Earth's, is not constantly renewed by plate tectonics. This has resulted in the preservation of huge areas of terrain remarkable for their abundance in fossil rivers and lakes dating back billions of years. Since 2012, NASA's Curiosity, the first rover to ever explore such ancient remains, had already detected the presence of simple organic molecules which can be formed by geological as well as biological processes. However, the emergence of primitive life forms, as hypothesised by scientists, initially requires environmental conditions favourable to the spontaneous organisation ...

– By Christina Nunez In rooms where smoking has taken place regularly, tobacco's imprint lingers on indoor surfaces, even long after regular smoking has stopped. The leftover residues, known as thirdhand smoke, can be a long-term source of indoor pollutants. New research from a team led by the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) zeroes in on carpets as an especially potent – and difficult to clean – reservoir of tobacco contaminants. When thirdhand smoke settles into surfaces, it doesn't ...

A telecommunications fiber optic cable deployed offshore of Oliktok Point, Alaska recorded ambient seismic noise that can be used to finely track the formation and retreat of sea ice in the area, researchers report in The Seismic Record. Andres Felipe Peña Castro of the University of New Mexico and colleagues used distributed acoustic sensing, or DAS, to identify seismic signals related to the motion of waves on open water and the sea ice that suppresses that wave action. The technique offers a way to track sea ice with increasing spatial and temporal resolution—on the scale of hours and kilometers--compared to satellite images that are updated ...

UNIVERSITY PARK, Pa. — Whether it’s work or play that prevents us from getting enough shut-eye during the week, assuming we can make up for it by sleeping in over the weekend is a mistake. New research led by Penn State reveals that cardiovascular health measures, including heart rate and blood pressure, worsen over the course of the week when sleep is restricted to five hours per night, and attempting to catch up on sleep over the weekend is insufficient to return these measures to normal. “Only 65% of adults in the U.S. regularly sleep the recommended seven hours per night, ...

LA JOLLA, CA—New research in the journal Nature Communications gives scientists an important window into how Ebola virus replicates inside host cells. The study, led by scientists at La Jolla Institute for Immunology (LJI), reveals the inner workings of "viral factories," clusters of viral proteins and genomes that form in host cells. The research team, which included experts from Scripps Research and UC San Diego School of Medicine, found that Ebola virus's replication machinery forms fascinating microscopic ...

Simple home workouts using exercise apps can effectively reduce depressive symptoms in healthcare workers and could be a major tool to combat the global mental health crisis in the sector, says new University of British Columbia research. The study, published today in JAMA Psychiatry, divided participants into either a waitlisted control group or an exercise group who were given free access to a suite of home exercise apps called DownDog, that included yoga, cardio and strength training. They were asked to aim for at least 80 minutes of moderate-intensity ...