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Researchers bioengineer an endocrine pancreas for type 1 diabetes

2023-03-01
BOSTON – In people with type 1 diabetes, the body’s immune system attacks and destroys insulin-producing β cells that control blood glucose levels and are part of a group of cells in the pancreas called pancreatic islets. In research published in Cell Reports Medicine, a team led by investigators at Massachusetts General Hospital (MGH), a founding member of Mass General Brigham, recently developed an efficient way to transplant pancreatic islets and demonstrated that the method can effectively reverse type 1 diabetes in nonhuman primates. Pancreatic islet transplantation is a promising treatment approach for type 1 diabetes; however, current methods, ...

New UCF project seeks to advance human understanding of AI reasoning

2023-03-01
ORLANDO, March 1, 2023 — A University of Central Florida researcher has received funding from the U.S. Department of Energy (DOE) to enhance the current understanding of artificial intelligence (AI) reasoning. The project focuses on developing algorithms to create robust multi-modal explanations for foundation, or large, AI models through the exploration of several novel explainable AI methods. The DOE recently awarded $400,000 to fund the project. The project was one of 22 proposals selected for the DOE’s 2022 Exploratory Research for Extreme-Scale Science (EXPRESS) grant, which promotes the study ...

New study reveals parents’ concerns about their sexual and gender minority teens using prep for HIV prevention

2023-03-01
Since its approval in 2012, HIV pre-exposure prophylaxis, or PrEP, has shown promise in reducing HIV infection rates by preventing infection in high-risk HIV-negative people. However, research shows that only around three percent of sexual and gender minority (SGM) adolescents who are eligible for PrEP have used it. In a new study, Christopher Owens, PhD, assistant professor in the Department of Health Behavior at the Texas A&M University School of Public Health, explores factors that may be associated with parents’ acceptance of their SGM adolescent using PrEP. The study, published in the journal AIDS ...

New mathematical model shows promising results for prostate cancer treatment

2023-03-01
A new mathematical model which aims to optimise treatment for prostate cancer has been developed by experts at the University of Portsmouth.  Prostate cancer is the second most common cancer among men worldwide and accounts for 26 percent of all new cancer cases in males in the UK.  Over the past few decades mathematical models of tumour growth have been used to better understand the disease, to make predictions and to guide new experiments and clinical trials. Dr Marianna Cerasuolo, Senior Lecturer from the University’s School of Mathematics and Physics, ...

nTIDE February 2023 Deeper Dive: What’s driving historic highs for employment of people with disabilities?

nTIDE February 2023 Deeper Dive: What’s driving historic highs for employment of people with disabilities?
2023-03-01
East Hanover, NJ – March 1, 2023. In this month’s nTIDE Deeper Dive Lunch & Learn Webinar we explored the factors underlying the unprecedented rise in the employment of people with disabilities during the COVID-19 pandemic while continuing to follow trends in the labor market. This webinar followed two key unemployment indicators–the number unemployed and the proportions of unemployed persons that are on temporary layoffs (i.e., furloughs), comparing trends for people with and without disabilities. “In January, we saw a large increase in the proportion ...

Study forecasts tile drainage and crop rotation changes for nitrogen loss

2023-03-01
URBANA, Ill. – Midwestern agriculture contributes the vast majority of nitrogen in the Gulf of Mexico, causing an oxygen-starved hypoxic zone and challenging coastal economies. State and federal policies have tried for decades to provide solutions and incentives, but the hypoxic zone keeps coming back. A recent study from the University of Illinois offers a new way to understand Midwestern nitrogen dynamics and forecasts future nitrogen loads under various management scenarios across the region.  “Our model explains what's going on across 83 watersheds in the Midwest, providing a quantitative understanding of why certain watersheds ...

Vilcek Foundation announces open call for $150,000 in prizes to immigrant scientists

Vilcek Foundation announces open call for $150,000 in prizes to immigrant scientists
2023-03-01
In 2024, the Vilcek Foundation will award three Vilcek Prizes for Creative Promise in Biomedical Science of $50,000 each. The prizes recognize and celebrate the contributions of rising immigrant scientists in the United States whose work represents a significant contribution to their field. The Vilcek Foundation is hosting an open call for applications for the 2024 prizes; applications will be accepted through June 12, 2023, at 5:00 p.m. ET.  The Vilcek Prizes for Creative Promise are a part of the Vilcek Foundation Prizes program. Awarded ...

Through the eye of the beholder: Researchers find people with autism process illusory shapes differently

2023-03-01
There is this picture – you may have seen it. It is black and white and has two silhouettes facing one another. Or maybe you see the black vase with a white background. But now, you likely see both. It is an example of a visual illusion that reminds us to consider what we did not see at first glance, what we may not be able to see, or what our experience has taught us to know – there is always more to the picture or maybe even a different image to consider altogether. Researchers are finding the process in our brain that allows us to see these visual distinctions may ...

Mulching time of forest meadows influences insect diversity

2023-03-01
Mulching is a possible management method for forest meadows and is important to their upkeep. During the process, the meadow is cut and the cuttings are shredded and left on the meadow. Despite its significance, the effects of this method on insects living in this habitat has rarely been studied up to now. Dr. Maria M. Georgi of the team working with the head of the University of Freiburg’s Chair of Nature Conservation and Landscape Ecology – Prof. Dr. Alexandra-Maria Klein, and her colleagues studied this in-depth. The result: ...

Pseudomonas aeruginosa Bacteria produce a molecule that paralyzes immune system cells

Pseudomonas aeruginosa Bacteria produce a molecule that paralyzes immune system cells
2023-03-01
Bacteria of the species Pseudomonas aeruginosa are antibiotic-resistant hospital germs that can enter blood, lungs and other tissues through wounds and cause life-threatening infections. In a joint project, researchers from the Universities of Freiburg and Strasbourg in France have discovered a mechanism that likely contributes to the severity of P. aeruginosa infections. At the same time, it could be a target for future treatments. The results were recently appeared in the journal EMBO Reports. Many bacterial species use sugar-binding molecules called lectins to attach to and invade host cells. Lectins can also influence the immune response to bacterial infections. However, these ...

Ice Age survivors

Ice Age survivors
2023-03-01
The team analysed the genomes of 356 prehistoric hunter gatherers from different archaeological cultures – including new data sets of 116 individuals from 14 different European and Central Asian countries. Modern humans began to spread across Eurasia around 45,000 years ago but previous research showed that the first modern humans that arrived in Europe did not contribute to later populations. This study focuses on the people who lived between 35,000 and 5,000 years ago and that are, at least partially, the ancestors of the present-day population of Western Eurasia, including – for the first time – the genomes of people who lived during the Last Glacial Maximum (LGM), the ...

Deforestation in the tropics linked to a reduction in rainfall

Deforestation in the tropics linked to a reduction in rainfall
2023-03-01
Projected deforestation in the Congo could result in a 12% reduction in rainfall  Study provides “compelling evidence” to protect forests  Deforestation is resulting in reduced rainfall across large parts of the tropics, according to new research.  People living in tropical forest communities have often complained that the climate gets hotter and drier once trees are cleared but until now, scientists have not been able to identify a clear link between the loss of tree cover and a decline in rainfall.   A research team at the University of Leeds combined satellite data of deforestation and rainfall to show ...

Quantum chemistry: Molecules caught tunneling

Quantum chemistry: Molecules caught tunneling
2023-03-01
Tunneling reactions in chemistry are very difficult to predict. The quantum mechanically exact description of chemical reactions with more than three particles is difficult, with more than four particles it is almost impossible. Theorists simulate these reactions with classical physics and must neglect quantum effects. But where is the limit of this classical description of chemical reactions, which can only provide approximations? Roland Wester from the Department of Ion Physics and Applied Physics at the University of Innsbruck has long wanted to explore this frontier. “It requires an experiment that allows very precise measurements and ...

New study could help pinpoint hidden helium gas fields – and avert a global supply crisis

New study could help pinpoint hidden helium gas fields – and avert a global supply crisis
2023-03-01
Helium – essential for many medical and industrial processes – is in critically short supply worldwide. Production is also associated with significant carbon emissions, contributing to climate change. This study provides a new concept in gas field formation to explain why, in rare places, helium accumulates naturally in high concentrations just beneath the Earth’s surface. The findings could help locate new reservoirs of carbon-free helium – and potentially also hydrogen. Research led by the University of Oxford could help overturn the current supply crisis of helium, ...

Unique alcohol avoidance program is associated with lower death rates

2023-03-01
A statewide alcohol-monitoring program that requires people arrested for drunk driving and other alcohol-involved offenses to be tested frequently for alcohol use can reduce the likelihood that participants die for several years after their involvement with the program, according to a new RAND Corporation study.   Analyzing results from South Dakota’s 24/7 Sobriety Program, researchers found that those arrested for drunk driving who participated in 24/7 Sobriety had on the order of a 50% lower risk of dying during the study period compared to those arrested for drunk driving who did not participate in the program..   The results are published in the latest edition of the ...

Outcomes of women undergoing coronary artery bypass surgery

2023-03-01
About The Study: The results of this study of more than 1.2 million patients indicate that women remain at significantly higher risk for adverse outcomes following coronary artery bypass grafting and no significant improvement has been seen over the course of the last decade. Further investigation into the determinants of operative outcomes in women is urgently needed. Authors: Mario Gaudino, M.D., Ph.D., M.S.C.E., of Weill Cornell Medicine in New York, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamasurg.2022.8156) Editor’s Note: Please see the ...

Reexamining time from breast cancer diagnosis to surgery

2023-03-01
About The Study: This case series study using the data of 373,000 patients from the National Cancer Database found that time from breast cancer diagnosis to surgery of greater than eight weeks was associated with worse overall survival. Time to surgery of greater than eight weeks may partly be associated with disadvantageous social determinants of health. Authors: Heather B. Neuman, M.D., of the University of Wisconsin School of Medicine and Public Health in Madison, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamasurg.2022.8388) Editor’s ...

Oldest human genome from southern Spain

Oldest human genome from southern Spain
2023-03-01
An international team of researchers has analysed ancient human DNA from several archaeological sites in Andalucía in southern Spain. The study reports on the oldest genome to date from Cueva del Malalmuerzo in southern Spain, as well as the 7,000 to 5,000-year-old genomes of early farmers from other well-known sites, such as Cueva de Ardales. The Iberian Peninsula plays an important role in the reconstruction of human population history. As a geographic cul-de-sac in the southwest of Europe, it is on one hand considered a refuge during the last Ice Age with its drastic temperature fluctuations. On the other hand, it may have been one of the starting points for the recolonisation ...

The counting of nine billion trees could help manage climate credits and nature restoration

2023-03-01
Researchers from the University of Copenhagen and NASA have developed a method that has now mapped several billion trees and their carbon uptake in Africa’s Sahel region. In the future, the method could be used to monitor whether climate credit purchases have a positive effect on the number of trees and whether nature restoration is working. The purchase of indulgences for CO2 emissions is gaining steam among global corporations. Carbon offset credits allow companies to emit a given amount of CO2 in exchange for the greenhouse gas being neutralized elsewhere, in the form of trees planted or left unfelled. But with billions upon billions of trees across the planet, keeping track ...

New study unveils epigenetic ‘traffic lights’ controlling stop and go for gene activity

2023-03-01
A major new study in the journal Nature reveals a ‘traffic light’ mechanism controlling genetic activity within cells – a system which could potentially be targeted by cancer drugs already in development. The research describes how ‘epigenetic’ changes to the structure of DNA can act as a stop-go signal in determining whether a gene should be read. Unlike our genetic make-up, which is well understood, the world of epigenetics is still largely unexplored and referred to as the ‘dark matter’ of the genome. But the new findings answer a fundamental and longstanding question – how epigenetic proteins regulate the ...

New NASA DART data prove viability of asteroid deflection as planetary defense strategy

New NASA DART data prove viability of asteroid deflection as planetary defense strategy
2023-03-01
NASA’s Double Asteroid Redirection Test (DART) was Earth’s first attempt at launching a spacecraft to intentionally collide with and deflect an asteroid as a planetary defense technique. On September 26, 2022, the DART spacecraft collided with a small asteroid moon called Dimorphos, which orbits a larger asteroid called Didymos. Neither asteroid posed a threat to Earth, but they represented similar celestial bodies that could one day approach and endanger the planet. In four papers published in the journal Nature on ...

Insilico Medicine’s Generative AI Pioneer Alex Zhavoronkov, PhD at Lab of the Future March 9

Insilico Medicine’s Generative AI Pioneer Alex Zhavoronkov, PhD at Lab of the Future March 9
2023-03-01
Alex Zhavoronkov, PhD, a pioneer of generative artificial intelligence (AI) for biology and chemistry, and founder and CEO of Insilico Medicine (“Insilico”) will present at the Lab of the Future Congress at the Renaissance Boston Waterfront Hotel on March 9, 2pm ET.  In a talk titled “Novel Target Discovery and Molecular Design Using AI,” Dr. Zhavoronkov will share the breakthroughs and discoveries that have made Insilico Medicine a leader in generative AI drug discovery. This includes ...

Review of studies finds disparity in presumptive chlamydia and gonorrhea treatment rates despite CDC guidelines

2023-03-01
INDIANAPOLIS – A Regenstrief Institute-led review of studies on proactive health services for chlamydia and gonorrhea has found that rates of presumptive treatment -- antibiotics prior to laboratory test confirmation -- varies widely. The U.S. Centers for Disease Control and Prevention recommends presumptive treatment of individuals with symptoms of or known contact with these infections to decrease likelihood of secondary infections as well as poor outcomes. The healthcare settings of all 18 of the studies reviewed were within the U.S. and patients were age 14 and older. Presumptive treatment rates were found to ...

Chinese Medical Journal study identifies major risk factors of pulmonary tuberculosis in patients with pneumoconiosis in China

Chinese Medical Journal study identifies major risk factors of pulmonary tuberculosis in patients with pneumoconiosis in China
2023-03-01
Pneumoconiosis comprises a group of heterogeneous lung diseases resulting from the inhalation of mineral dust. It is an occupational hazard with significant economic and social implications. Notably, patients with pneumoconiosis have an elevated risk of contracting pulmonary tuberculosis (PTB). Unfortunately, pneumoconiosis has a strong presence in China. However, extensive population-based studies on the prevalence of PTB in patients with pneumoconiosis have not been conducted in China since almost three decades. To bridge this gap, a team of ...

National Comprehensive Cancer Network updates annual conference with new in-person venue, hybrid format, expert-led sessions, highlighted research perspectives, and small-group conversations

National Comprehensive Cancer Network updates annual conference with new in-person venue, hybrid format, expert-led sessions, highlighted research perspectives, and small-group conversations
2023-03-01
PLYMOUTH MEETING, PA [March 1, 2023] — The National Comprehensive Cancer Network® (NCCN®) today announced the NCCN 2023 Annual Conference will debut a new hybrid format, including in-person events at a new venue. This marks the first time in three years that this premier oncology meeting will be held in-person, and the first-ever time at the Orlando World Center Marriott, starting on March 31. “We’ve heard from many people who learn better by being in the ‘room where it happens,’” said Robert W. ...
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