A study performed by researchers at the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) from the Spanish National Research Council (CSIC) in collaboration with Stony Brook University (USA) proposes a new strategy for the development of new drugs based on the inhibition of tyrosine kinase enzymes, molecules that activate and trigger many cellular processes. The results have been published in the Chemistry - A European Journal. The new approach is based on the regulation of the signaling cascade of tyrosine kinases, and could lead to the development ...

Today as they did 100 years ago, doctors diagnose cancer by taking tissue samples from patients, which they usually fix in formalin for microscopic examination. In the past 20 years, genetic methods have also been established that make it possible to characterize mutations in tumors in greater detail, thus helping clinicians select the best treatment strategy. Even tiny tissue samples can be used to detect proteins Now, a group of researchers from the Berlin-based Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), the Berlin Institute of Health (BIH), Charité - Universitätsmedizin ...

The German National Academy of Sciences Leopoldina and the German Council for Sustainable Development (RNE) have published a joint position paper presenting paths to climate neutrality by 2050. In it, the Leopoldina and the RNE highlight options for action to effect the changes needed within society, at political level and in the business world, in view especially of the urgency and the historic dimensions of the transformation we face. With the paper, the Leopoldina and the RNE are consciously not seeking to engage in a race to set the most ambitious target. They are instead offering an options paper for setting the right course and covering the key implementation steps. ...

Abu Dhabi, UAE: Trans-Neptunian Objects (TNOs), small objects that orbit the sun beyond Neptune, are fossils from the early days of the solar system which can tell us a lot about its formation and evolution. A new study led by Mohamad Ali-Dib, a research scientist at the NYU Abu Dhabi END ...

Chemical engineers at the University of Illinois Chicago and UCLA have answered longstanding questions about the underlying processes that determine the life cycle of liquid foams. The breakthrough could help improve the commercial production and application of foams in a broad range of industries. Findings of the END ...

The glaciers of Nanga Parbat - one of the highest mountains in the world - have been shrinking slightly but continually since the 1930s. This loss in surface area is evidenced by a long-term study conducted by researchers from the South Asia Institute of Heidelberg University. The geographers combined historical photographs, surveys, and topographical maps with current data, which allowed them to show glacial changes for this massif in the north-western Himalaya as far back as the mid-1800s. Detailed long-term glacier studies that extend the observation period ...

DALLAS, June 16, 2021 -- Findings from a small study detailing the treatment of myocarditis-like symptoms in seven people after receiving a COVID-19 vaccine in the U.S. are published today in the American Heart Association's flagship journal Circulation. These cases are among those reported to the Centers for Disease Control and Prevention's Vaccine Adverse Event Reporting System (VAERS) documenting the development of myocarditis-like symptoms in some people who received the COVID-19 vaccine. Myocarditis is a rare but serious condition that causes inflammation of the middle layer of the wall of the heart muscle. It can weaken the heart and affect the heart's electrical system, which keeps the heart pumping regularly. It is most often the result of an infection and/or ...

They're cute, they're furry, and they start diving into frigid Antarctic waters at 2 weeks old. According to a new study from California Polytechnic State University, Weddell seal pups may be one of the only types of seals to learn to swim from their mothers. Weddell seals are the southernmost born mammal and come into the world in the coldest environment of any mammal. These extreme conditions may explain the unusually long time they spend with their mothers. The study, "Early Diving Behavior in Weddell Seal (Leptonychotes Weddellii) Pups," was published earlier this month in the Journal of Mammalogy. According to the Seal Conservation Society, adult Weddell seal females are ...

Once thought to be extinct, lobe-finned coelacanths are enormous fish that live deep in the ocean. Now, researchers reporting in the journal Current Biology on June 17 have evidence that, in addition to their impressive size, coelacanths also can live for an impressively long time--perhaps nearly a century. The researchers found that their oldest specimen was 84 years old. They also report that coelacanths live life extremely slowly in other ways, reaching maturity around the age of 55 and gestating their offspring for five years. "Our most important finding is that the coelacanth's age was underestimated by a factor of five," says Kélig Mahé of IFREMER Channel and North ...

The birth of a human being requires billions of cell divisions to go from a fertilised egg to a baby. At each of these divisions, the genetic material of the mother cell duplicates itself to be equally distributed between the two new cells. In primary microcephaly, a rare but serious genetic disease, the ballet of cell division is dysregulated, preventing proper brain development. Scientists from the University of Geneva (UNIGE), in collaboration with Chinese scientists, have demonstrated how the mutation of a single protein, WDR62, prevents the proper formation of the cable network responsible for separating genetic material into two. As cell division is then slowed down, the brain ...

BOSTON - An antibiotic developed in the 1950s and largely supplanted by newer drugs, effectively targets and kills cancer cells with a common genetic defect, laboratory research by Dana-Farber Cancer Institute scientists shows. The findings have spurred investigators to open a clinical trial of the drug, novobiocin, for patients whose tumors carry the abnormality. In a study in the journal Nature Cancer, the researchers found that in laboratory cell lines and tumor models novobiocin selectively killed tumor cells with abnormal BRCA1 or BRCA2 genes, which help repair damaged DNA. The drug was effective even in tumors resistant to agents known as PARP inhibitors, which have become a prime therapy for cancers with DNA-repair glitches. "PARP inhibitors ...

Ultrathin, flexible computer circuits have been an engineering goal for years, but technical hurdles have prevented the degree of miniaturization necessary to achieve high performance. Now, researchers at Stanford University have invented a manufacturing technique that yields flexible, atomically thin transistors less than 100 nanometers in length - several times smaller than previously possible. The technique is detailed in a paper published June 17 in Nature Electronics. With the advance, said the researchers, so-called "flextronics" move closer to reality. Flexible electronics promise bendable, ...

PHILADELPHIA-- The COVID-19 death rate for Black patients would be 10 percent lower if they had access to the same hospitals as white patients, a new study shows. Researchers from the Perelman School of Medicine at the University of Pennsylvania and OptumLabs, part of UnitedHealth Group, analyzed data from tens of thousands of hospitalized COVID-19 patients and found that Black patients died at higher rates than white patients. But the study, published today in JAMA Network Open, determined that didn't have to be the case if more Black patients were able to get care at different hospitals. "Our study reveals that Black patients have worse outcomes largely because they tend to go to worse-performing hospitals," said the study's first author, David Asch, MD, ...

What The Study Did: The findings of this study suggest that the increased mortality among Black patients hospitalized with COVID-19 is associated with the hospitals at which Black patients disproportionately received care. Authors: David A. Asch, M.D., M.B.A., of the University of Pennsylvania in Philadelphia, is the the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.12842) Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, ...

What The Study Did: Researchers evaluated the association of convalescent plasma treatment with 30-day mortality in hospitalized adults with hematologic (blood) cancers and COVID-19. Authors: Jeremy L.Warner, M.D., M.S., of Vanderbilt University in Nashville, Tennessee, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamaoncol.2021.1799) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please ...

What The Study Did: This study examined whether mandatory daily employee symptom data collection can be used as an early alert surveillance system to estimate COVID-19 hospitalizations in communities where employees live. Authors: Steven Horng, M.D., M.MSc., of Beth Israel Deaconess Medical Center in Boston, is the the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.13782) Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: The full study ...

What The Study Did: In this survey study, COVID-19 was associated with large reductions in economic security among women at high risk of HIV infection in Kenya. However, shifts in sexual behavior may have temporarily decreased their risk of HIV infection. Authors: Harsha Thirumurthy, Ph.D., of the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, is the the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.13787) Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, ...

What The Study Did: Researchers estimated survival and other outcomes of very preterm infants in China discharged against medical advice from neonatal intensive care units before complete care can be provided compared with infants who receive full intensive care treatment. Authors: Yun Cao, M.D., Ph.D., and Weili Yan, Ph.D., of Children's Hospital of Fudan University in Shanghai, China, are the corresponding authors. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.13197) Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest ...

The 'Xpert Ultra' molecular test has a greater capacity than its predecessor ('Xpert MTB/RIF') in detecting tuberculosis cases, either passively (i.e. people who attend the hospital with disease symptoms) or actively (searching for possible cases in the community among contacts of cases). This is the main conclusion of a study performed by ISGlobal, an institution supported by "la Caixa" Foundation, in collaboration with the Manhiça Health Research Centre (CISM), published in the European Respiratory Journal. Tuberculosis (TB) is the leading cause of death by an infectious agent, worldwide. In 2019, 1.4 million people are estimated to have died and 10 million people fell sick from TB, although only 70% of the cases were diagnosed. ...

Scientists have identified a new class of targeted cancer drugs that offer the potential to treat patients whose tumours have faulty copies of the BRCA cancer genes. The drugs, known as POLQ inhibitors, specifically kill cancer cells with mutations in the BRCA genes while leaving healthy cells unharmed. And crucially, they can kill cancer cells that have become resistant to PARP inhibitors - an existing treatment for patients with BRCA mutations. Researchers are already planning to test the new drug class in upcoming clinical trials. If the trials are successful, POLQ inhibitors could enter the clinic as a new approach to treating a range of cancers with BRCA ...

Many diseases caused by a dysregulated immune system, such as allergies, asthma and autoimmunity, can be traced back to events in the first few months after birth. To date, the mechanisms behind the development of the immune system have not been fully understood. Now, researchers at Karolinska Institutet show a connection between breast milk, beneficial gut bacteria and the development of the immune system. The study is published in Cell. "A possible application of our results is a preventative method for reducing the risk of allergies, asthma and autoimmune disease later in life by helping the immune system to establish its regulatory mechanisms," says the paper's last author Petter Brodin, paediatrician and researcher at the Department of Women's and Children's ...

The giant rhino, Paraceratherium, is considered the largest land mammal that ever lived and was mainly found in Asia, especially China, Mongolia, Kazakhstan, and Pakistan. How this genus dispersed across Asia was long a mystery, however. A new discovery has now shed light on this process. Prof. DENG Tao from the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) of the Chinese Academy of Sciences and his collaborators from China and the U.S.A. recently reported a new species Paraceratherium linxiaense sp. nov., which offers important clues to the dispersal of giant rhinos across Asia. The study was published in Communications Biology on June 17. The new species' fossils comprise a completely preserved skull and mandible with their associated atlas, ...

The most accurate distance measurement yet of ultra-diffuse galaxy (UDG) NGC1052-DF2 (DF2) confirms beyond any shadow of a doubt that it is lacking in dark matter. The newly measured distance of 22.1 +/-1.2 megaparsecs was obtained by an international team of researchers led by Zili Shen and Pieter van Dokkum of Yale University and Shany Danieli, a NASA Hubble Fellow at the Institute for Advanced Study. "Determining an accurate distance to DF2 has been key in supporting our earlier results," stated Danieli. "The new measurement reported in this study has crucial implications for estimating the physical properties of the galaxy, thus confirming its lack of dark matter." The ...

One of the main reasons for the hold-ups in the mass vaccination campaigns against COVID-19 are the precautions that must be taken regarding the handling of the vaccines and their administration. They have to be transported under very specific conditions and the syringes used for their administration must be prepared at the same vaccination site. Healthcare workers must ensure they avoid any sudden movements of the vaccines so as not to affect the vector they use, messenger RNA molecules in the case of the Pfizer BioNTech and Moderna vaccines. But research led by the Hospital del Mar Pharmacy Department and Neuropharmacology-Neurophar Research Group at Pompeu Fabra University (UPF), may lead to changes in ...

The ability to insert desirable genes into animal or human cells is the basis of modern life science research and of widespread biomedical applications. The methods used to date for this purpose are mostly non-specific, making it difficult for scientists to control which cell will or will not take up a gene. For this gene transfer, the target genes are often packaged into "viral vectors." These are viruses in which part of the genetic material has been replaced by the target genes. When researchers add these viral vectors to cells, the vectors introduce the genes into the cells. This is the principle behind some of the current SARS-CoV-2 vaccines such as those from AstraZeneca or Johnson&Johnson. However, it is difficult - even impossible - to control into which cells the ...