Researchers at Seattle's Institute for Systems Biology and their collaborators looked at the electronic health records of nearly 630,000 patients who were tested for SARS-CoV-2, and found stark disparities in COVID-19 outcomes -- odds of infection, hospitalization, and in-hospital mortality -- between White and non-White minority racial and ethnic groups. The work was published in the journal Clinical Infectious Diseases. The team looked at sociodemographic and clinical characteristics of patients who were part of the Providence healthcare system in Washington, Oregon and California. These ...

Metformin, a drug used to treat type-2 diabetes, could help reduce chronic inflammation in people living with HIV (PLWH) who are being treated with antiretroviral therapy (ART), according to researchers at the University of Montreal Hospital Research Centre (CRCHUM). Although ART has helped improved the health of PLWH, they are nevertheless at greater risk of developing complications related to chronic inflammation, such as cardiovascular disease. These health problems are mainly due to the persistence of HIV reservoirs in the patients' long-lived memory T cells and to the constant activation of their immune system. In a pilot study published recently in ...

MADISON, Wis. -- Scientists at the University of Wisconsin-Madison have developed a way to use a cell's own recycling machinery to destroy disease-causing proteins, a technology that could produce entirely new kinds of drugs. Some cancers, for instance, are associated with abnormal proteins or an excess of normally harmless proteins. By eliminating them, researchers believe they can treat the underlying cause of disease and restore a healthy balance in cells. The new technique builds on an earlier strategy by researchers and pharmaceutical companies to remove proteins residing inside of a cell, and expands on this system to include proteins ...

For the first time, scientists have documented biofluorescence in an Arctic fish species. The study, led by researchers at the American Museum of Natural History who spent hours in the icy waters off of Greenland where the red-and-green-glowing snailfish was found, is published today in the American Museum Novitates. "Overall, we found marine fluorescence to be quite rare in the Arctic, in both invertebrate and vertebrate lineages," said John Sparks, a curator in the American Museum of Natural History's Department of Ichthyology and one of the authors of the ...

The ongoing COVID-19 pandemic changed the higher education experience for students across the United States, with more than 90 percent of institutions reporting a shift in education delivery with the arrival of COVID-19. The rapid transition to remote study came with its own learning curve for students and faculty alike. But for many students with disabilities, the shift offered new educational modalities as well as challenges - and the hope that some changes will continue after the threat of the virus subsides. "This was a really unique, historical moment," says Nicholas Gelbar '06 (ED), '07 MEd, '13 Ph.D., an associate research professor with the Neag School of Education. "Remote learning, ...

Millions of children weighing less than 15kg are currently denied access to Ivermectin treatment due to insufficient safety data being available to support a change to the current label indication. The WorldWide Antimalarial Resistance Network (WWARN)'s new meta-analysis published today provides evidence that supports removing this barrier and improving treatment equity. ...

DURHAM, N.H.-- Researchers at the University of New Hampshire have found that more than 50% of children in high-risk populations in the United States are not receiving behavioral health services that could improve their developmental outcomes when it comes to mental and physical health problems. In their END ...

HOUSTON - (March 18, 2021) - If you're looking for one technique to maximize photon output from plasmons, stop. It takes two to wrangle. Rice University physicists came across a phenomenon that boosts the light from a nanoscale device more than 1,000 times greater than they anticipated. When looking at light coming from a plasmonic junction, a microscopic gap between two gold nanowires, there are conditions in which applying optical or electrical energy individually prompted only a modest amount of light emission. Applying both together, however, caused a burst of light that far exceeded ...

When it comes to recreational crabbing--one of the most iconic pastimes along Maryland's shores--the current estimate of 8% of "total male commercial harvest" runs just a little too low. Biologists, with local community support, found stronger evidence for the underestimate in the END ...

As one of the founding members of the International Rye Genome Sequencing Group (IRGSG), the University of Maryland (UMD) co-published the first full reference genome sequence for rye in Nature Genetics. UMD and international collaborators saw the need for a reference genome of this robust small grain to allow for the tracking of its useful genes and fulfill its potential for crop improvement across all major varieties of small grains, including wheat, barley, triticale (a cross between wheat and rye that is gaining popularity), and rye. Following the model of international collaboration used ...

Wheat stripe rust is one of the most important wheat diseases and is caused by the plant-pathogenic fungi Puccinia striiformis f. sp. tritici (Pst). Though Pst is known to be highly host-specific, it is interestingly able to infect two unrelated host plants, wheat and barberry, at different spore stages. Pst infects wheat through its urediniospores and infects barberry with its basidiospores. "This complex life cycle poses interesting questions on the co-evolution between the pathogen and the hosts, as well the different mechanisms of pathogenesis underlying the infection of ...

The Journal of Anthropological Research has just published a new article on the development of linguistic documentation among heritage language speakers: "Articulating Lingual Life Histories and Language Ideological Assemblages: Indigenous Activists within the North Fork Mono and Village of Tewa Communities." Specifically, it focuses on the biographical information of individual speakers, and the significance they place on the language in question. Author Paul V. Kroskrity focused his research on two specific communities - the North Fork Rancheria of Mono Indians in California and the Village of Tewa, First Mesa, Hopi Reservation in northeastern Arizona ...

In a study aimed at investigating the mechanism responsible for exacerbating rheumatoid arthritis in smokers, researchers at the Center for Research on Inflammatory Diseases (CRID), linked to the University of São Paulo (USP) in Brazil, discovered a novel path in the inflammatory process associated with the bone damage caused by rheumatoid arthritis. The discovery opens up opportunities for new therapeutic interventions to mitigate the effects of the disease, for which there is no specific treatment at this time. An article on the study is published in Proceedings of the National Academy of Sciences ...

Lung cancer is the leading cause of cancer death in the U.S. for both men and women. While risk for this disease can be influenced by environmental and lifestyle factors like smoking, studies estimate that 18% of lung cancer cases are due to inherited genetic variants. New research led by Baylor College of Medicine investigates how genetic variants contribute to increased risk of lung cancer. The researchers performed whole exome sequencing on germline (inherited) DNA from eight large-scale datasets, including 1,045 patients with a family history of lung cancer or early-onset cancer. Those groups are more likely to harbor genetic risk variants. The analysis ...

Researchers at the University of Ottawa have debunked the decade-old myth of metals being useless in photonics - the science and technology of light - with their findings, recently published in Nature Communications, expected to lead to many applications in the field of nanophotonics. "We broke the record for the resonance quality factor (Q-factor) of a periodic array of metal nanoparticles by one order of magnitude compared to previous reports," said senior author Dr. Ksenia Dolgaleva, Canada Research Chair in Integrated Photonics (Tier 2) and ...

Medical cannabis is a subject of much debate. There is still a lot we do not know about cannabis, but researchers from the Department of Neuroscience at the Faculty of Health and Medical Sciences have made a new discovery that may prove vital to future research into and treatment with medical cannabis. Cannabinoids are compounds found in cannabis and in the central nervous system. Using a mouse model, the researchers have demonstrated that a specific synthetic cannabinoid (cannabinoid WIN55,212-2) reduces essential tremor by activating the support cells of the spinal cord and brain, known as astrocytes. Previous research into medical cannabis has focussed on the ...

LOS ANGELES (March 18, 2021) -- COVID-19 disproportionately affects men compared with women, raising the possibility that a hormone like progesterone may improve clinical outcomes for certain hospitalized men with the disease. New research from Cedars-Sinai published online in the journal Chest supports this hypothesis. The pilot clinical trial, involving 40 men, is believed to be the first published study to use progesterone to treat male COVID-19 patients whose lung functions have been compromised by the coronavirus. While the findings are promising, larger clinical trials are needed to establish the potential of this experimental therapy, the investigators said. The study was prompted ...

In response to the recent freeze-inspired power outages in Texas, some politicians blamed the historic blackouts on wind turbines. The dubious, and largely dismissed, claims nevertheless spotlighted an intriguing fact: Texas, the land made famous by oil derricks and wildcatters, now gets a significant portion of its electricity from clean, renewable sources, most notably wind, but also from water and solar - a troika of sustainability known collectively as WWS. "Texas gets about 20 percent of its electricity from wind alone," says Mark Z. Jacobson, a professor of civil and environmental engineering at Stanford University and senior fellow at the Stanford Woods Institute ...

Technological advances have made it possible for researchers to track the movements of large ocean-dwelling animals in three dimensions with remarkable precision in both time and space. Researchers reporting in the journal iScience on March 18 have now used this biologging technology to find that, for reasons the researchers don't yet understand, green sea turtles, sharks, penguins, and marine mammals all do something rather unusual: swimming in circles. "We've found that a wide variety of marine megafauna showed similar circling behavior, in which animals circled consecutively at a relatively ...

What The Article Says: An oncologist reflects on how advising patients with cancer about travel during a pandemic requires a nuanced consideration of benefit and risk, especially when considering lost opportunities when prognosis is limited. Authors: Christopher E. Jensen, M.D., of the University of North Carolina School of Medicine in Chapel Hill, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaoncol.2021.0125) Editor's Note: The article includes conflicts of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial ...

What The Study Did: Researchers examined whether state medical and recreational cannabis laws were associated with changes in rates of self-harm and assault injuries. Authors: Keith Humphreys, Ph.D., of Stanford University in Stanford, California, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.1955) Editor's Note: Editor's Note: The article includes conflicts of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: The full study and ...

CHAPEL HILL, NC - Males and females, generally speaking, experience and respond to pain differently, but scientists have yet to understand all the brain circuits involved in these differences. Now, new research from the UNC School of Medicine lab of Thomas Kash, PhD, shows how neurons use dopamine to regulate pain differently in male and female mice. The discovery, published in the journal Neuron, could help the scientific community devise better pain management strategies, particularly for women, who are disproportionally affected by pain throughout their lifespans. "We focused on this neural pathway because our previous work and that of others ...

Low plasma levels of protein TGFB1 and polymorphisms in gene TGFB1 act as biomarkers for the prognosis of gastric adenocarcinoma, according to a study led by the University Complutense of Madrid (UCM). In particular, these variants are 12% more frequent in patients with metastatic tumors, "which indicates their importance in the clinical progression of this disease", stated José Manuel Martín Villa, Professor of Immunology and researcher at the Department of Immunology, Ophthalmology and Otolaryngology of the UCM. In addition to identifying patients with poorer progression and high mortality, these markers also identify individuals at ...

SAN ANTONIO -- March 18, 2021 -- Working with a team led by French astronomers, Southwest Research Institute scientists helped identify incredibly powerful winds in Jupiter's middle atmosphere for the first time. The team measured molecules exhumed by the 1994 impact of comet Shoemaker-Levy 9 to trace winds in excess of 900 miles per hour near Jupiter's poles. Jupiter's distinctive red and white bands of swirling clouds allow scientists to track winds in the planet's lower atmosphere, and the SwRI team members have particular expertise in the vivid Jovian aurora, associated with strong winds in the gas giant's upper atmosphere. Until now, wind patterns in the cloudless stratosphere, between the two atmospheric layers, have eluded observation. "The team of ...

Mitochondria are important cellular power plants whose diminished activity has been previously demonstrated to be associated with obesity by a group of researchers at the University of Helsinki. Now, in a new international study coordinated by the University of Helsinki, the researchers have determined that the method of weight loss affects the metabolic pathways of mitochondria in fat tissue, also known as adipose tissue. The study was recently published in the Journal of Clinical Endocrinology and Metabolism. The researchers combined two datasets on calorie restriction diets and two datasets on weight loss surgery, or bariatric surgery, from Europe, monitoring dieters' weight loss as well as metabolism. A biopsy was taken from the study subjects' adipose tissue both at ...