MINNEAPOLIS/ST.PAUL (04/28/2021) -- In a recent discovery by University of Minnesota Medical School, researchers uncovered a new way to potentially target and treat late-stage colorectal cancer - a disease that kills more than 50,000 people each year in the United States. The team identified a novel mechanism by which colorectal cancer cells evade an anti-tumor immune response, which helped them develop an exosome-based therapeutic strategy to potentially treat the disease. "Late-stage colorectal cancer patients face enormous challenges with current treatment options. Most of the time, the patient's immune system cannot efficiently fight against tumors, even with the ...

Seasonally occurring fields of aufeis (icing) constitute an important resource for the water supply of the local population in the Upper Indus Basin. However, little research has been done on them so far. Geographers at the South Asia Institute of Heidelberg University have now examined the spreading of aufeis and, for the first time, created a full inventory of these aufeis fields. The more than 3,700 accumulations of laminated ice are important for these high mountain areas between South and Central Asia, particularly with respect to hydrology and climatology. In the semi-arid Himalaya regions of India and Pakistan, meltwater from snow and glaciers plays an essential role for irrigation in local agriculture and hydropower generation. In ...

LOS ALAMOS, N.M., April 28, 2021--Analysis of data from a lightning mapper and a small, hand-held radiation detector has unexpectedly shed light on what a gamma-ray burst from lightning might look like - by observing neutrons generated from soil by very large cosmic-ray showers. The work took place at the High Altitude Water Cherenkov (HAWC) Cosmic Ray Observatory in Mexico. "This was an accidental discovery," said Greg Bowers, a scientist at Los Alamos National Laboratory and lead author of the study published in Geophysical Research Letters. "We set up this system to study terrestrial gamma-ray flashes - or gamma-ray bursts from lightning - that are ...

New research from the University of Virginia School of Medicine has shed light on the No. 1 cause of epilepsy deaths, suggesting a long-sought answer for why some patients die unexpectedly following an epileptic seizure. The researchers found that a certain type of seizure is associated with sudden death in a mouse model of epilepsy and that death occurred only when the seizure induced failure of the respiratory system. The new understanding will help scientists in their efforts to develop ways to prevent sudden unexpected death in epilepsy (SUDEP). Based on their research, the UVA team has already identified potential approaches to stimulate breathing in the ...

Children and young adults with compromised immune systems, such as those undergoing cancer treatment, may experience a prolonged period of infection with SARS-CoV-2, the virus that causes COVID-19, and the extended duration of infection may increase the incidence of mutations. This case study was conducted by investigators at Children's Hospital Los Angeles and is published in the journal EBioMedicine. Most people are infectious for about 10 days after first showing COVID-19 symptoms. In this study, researchers describe two children and a young adult with acute lymphoblastic leukemia who tested positive for SARS-CoV-2 for months. ...

UPTON, NY--Scientists characterized how the electronic states in a compound containing iron, tellurium, and selenium depend on local chemical concentrations. They discovered that superconductivity (conducting electricity without resistance), along with distinct magnetic correlations, appears when the local concentration of iron is sufficiently low; a coexisting electronic state existing only at the surface (topological surface state) arises when the concentration of tellurium is sufficiently high. Reported in Nature Materials, their findings point to the composition range necessary for topological superconductivity. Topological superconductivity could enable more ...

APRIL 28, 2021, NEW YORK - A Ludwig Cancer Research study has identified a previously unrecognized mechanism by which cancer cells of a relatively benign subtype of pancreatic tumors methodically revert--or "de-differentiate"--to a progenitor, or immature, state of cellular development to spawn highly aggressive tumors that are capable of metastasis to the liver and lymph nodes. The study, led by Ludwig Lausanne's Douglas Hanahan and published in Cancer Discovery, a journal of the American Association for Cancer Research, also shows that engagement of the mechanism is associated with poorer outcomes in patients diagnosed with pancreatic neuroendocrine tumors (PanNETs). Further, its findings provide concrete evidence that such cellular de-differentiation, widely observed ...

April 28, 2021 - Injectable dermal fillers provide a minimally invasive approach to reduce facial lines and wrinkles while restoring volume and fullness in the face. More than 2.7 million dermal filler procedures were performed in 2019, according to the most recent statistics from the American Society of Plastic Surgeons (ASPS). Even as the popularity of dermal fillers continues to skyrocket, plastic surgeons are still working out how to maximize their benefits for patients seeking nonsurgical facial rejuvenation. Most studies have used subjective rating systems, with little objective evidence on the outcomes achieved. One recent study suggested that in addition to their "volumizing" effects, dermal fillers may also have variable "lifting" effects. Sebastian Cotofana, ...

Philadelphia, April 28, 2021 - Researchers from the Center for Autism Research (CAR) at Children's Hospital of Philadelphia (CHOP) found that difficulties in diagnosing toddlers with autism spectrum disorder (ASD) might be due to the dynamic nature of the disorder during child development. Children with clinical characteristics that put them on the diagnostic border of autism have an increased susceptibility to gaining or losing that diagnosis at later ages. The findings were published online by The Journal of Child Psychology and Psychiatry. While most children diagnosed with ASD at early ages retain their diagnosis, a significant number of children have more dynamic presentations of clinical ...

Testicular cancer is the most common type of cancer to affect men between the ages of 15 and 49, and around 95% of these cases are caused by testicular germ cell tumours. Although testicular germ cell tumours typically manifest after puberty, problems in the embryonic development of germ cells can transform them into cancer cells that form tumours later in life. In the embryo, germ cells initially have the potential to form many different cell types, a characteristic called pluripotency. Normally, germ cells lose this ability as embryonic development progresses and they become restricted to only form sex cells - sperm in males and eggs ...

LOS ANGELES - Patients with advanced colorectal cancer may be spared from a toxic side effect caused by a type of targeted therapy used to treat the cancer with the help of another drug normally used to treat melanoma, according to a study led by researchers at the UCLA Jonsson Comprehensive Cancer Center and Memorial Sloan Kettering Cancer Center. For the past decade, epidermal growth factor receptor (EGFR) inhibitors have helped prolong the lives of patients with many advanced cancers, including cancers in the lung, head and neck, colorectal, breast, bladder and pancreas. While these targeted therapy drugs are highly effective at keeping the cancer at bay, they can cause patients to develop ...

OAK BROOK, Ill. - An automated system that uses artificial intelligence (AI) is effective at detecting a common type of wrist fracture on X-rays, according to a study published in the journal Radiology: Artificial Intelligence. Researchers said the AI-derived algorithm could help speed diagnosis and allow earlier treatment. Scaphoid fractures are injuries to one of the small bones of the wrist that typically occur when people try to break a fall with their hands. They comprise up to 7% of all skeletal fractures. Prompt diagnosis is important, as the fracture may fail to heal properly if untreated, leading to a host of problems like arthritis and even loss of function. Conventional X-ray is the imaging technique of choice for diagnosing scaphoid ...

Studying the violent collisions of black holes and neutron stars may soon provide a new measurement of the Universe's expansion rate, helping to resolve a long-standing dispute, suggests a new simulation study led by researchers at UCL (University College London). Our two current best ways of estimating the Universe's rate of expansion - measuring the brightness and speed of pulsating and exploding stars, and looking at fluctuations in radiation from the early Universe - give very different answers, suggesting our theory of the Universe may be wrong. A third type of measurement, looking at the explosions of light and ripples in the fabric of space caused ...

Under the background of global warming, the energy budget of the earth is out of balance with more than 90% of additional heat entering the ocean. The tropical Pacific Ocean has an important influence on the global tropical climate and the climate of China, and the tropical Pacific Western Boundary Currents (WBCs) that flow through it plays an important role in the climate system. Large-scale ocean circulation redistributes ocean heat and mass and is hence one of the basic dynamic processes that shape the earth's Marine environment. The tropical Pacific WBCs system is a key part of the global ocean circulation system. ...

It is challenging to analyze proteins at low concentrations, especially for those in a mixture of various conformations such as intrinsically disordered proteins (IDPs). A research team led by Prof. HUANG Jinqing, Assistant Professor of Department of Chemistry at The Hong Kong University of Science and Technology (HKUST), has developed optical tweezers-coupled Raman spectroscopy that can directly probe the structural features of alpha-synuclein, an IDP closely linked to Parkinson's disease, at the physiological concentration by focusing on individual protein molecules. IDPs play an important role in biological processes and many of them are associated with incurable neurodegenerative ...

Researchers from the Universities of Bristol and Surrey have found that well-fitting, three-layered cloth masks can be as effective at reducing the transmission of COVID-19 as surgical masks. At the height of the COVID-19 pandemic, 139 countries mandated the use of face coverings in public space such as supermarkets and public transports. The World Health Organization also advises the use of face coverings and offers guidance on their effective features. Face coverings suppress the onward transmission of COVID-19 through exhalation and protect the wearer on inhalation. In a paper published by the Physics of Fluids journal, the researchers detail how they looked at how liquid ...

Areas in Sweden with early access to electricity at the start of the 1900s underwent rapid change. Electrification led to more strikes, but it was not those who were threatened by the new technology who protested. Instead, it was the professional groups who had acquired a stronger negotiating position - thanks to technological development, according to new research from Lund University. Labour market conditions are affected by new technology. Currently, the impact of automation on the labour market is often discussed, whether jobs will disappear as computers take over, or whether digitalisation drives development towards a gig economy with uncertain employment conditions. One fear is that the technological development could generate social unrest and a risk of increased ...

Like a chameleon of the night sky, the Moon often changes its appearance. It might look larger, brighter or redder, for example, due to its phases, its position in the solar system or smoke in Earth's atmosphere. (It is not made of green cheese, however.) Another factor in its appearance is the size and shape of moon dust particles, the small rock grains that cover the moon's surface. Researchers at the National Institute of Standards and Technology (NIST) are now measuring tinier moon dust particles than ever before, a step toward more precisely explaining the Moon's apparent color ...

Researchers from the University of Copenhagen, in collaboration with their Swiss colleagues at the University Hospital of Bern, have cracked the code for controlling a group of enzymes that affect our metabolism. The researchers' findings could help us avoid diseases ranging from high cholesterol to infertility to certain types of cancer, which are all due, among other things, to hormonal imbalances. They have found a way to influence a special protein called cytochrome P450 reductase (POR) -- popularly characterized as the 'conductor' of the body's protein orchestra, which helps regulate our hormones and makes it possible to break down medicinal products in the liver. "We have developed a method to ...

Fast growth of the global human population has long been regarded as a major challenge that faces mankind. Presently, this challenge is becoming even more serious than before, in particular because many natural resources are estimated to deplete before the end of this century. The increasing population pressure on agriculture and ecosystems and the environment more generally is predicted to result in worldwide food and water shortages, pollution, lack of housing, poverty and social tension. The situation is exacerbated by global climate change as considerable areas of land are predicted to be flooded and hence taken out of human's use. It is widely believed ...

According to the researchers, three songs from a playlist are enough to identify the person who chose the songs. Hence, companies like YouTube and Spotify can accumulate a great deal of information about their users based only on their musical preferences. The study was led by Dr. Ori Leshman of the Jaime and Joan Constantiner School of Education at Tel Aviv University and Dr. Ron Hirschprung of the Department of Management and Industrial Engineering at Ariel University. The study was published in the journal Telematics and Informatics. The study included ...

PITTSBURGH, April 28, 2021 - Asthma exacerbations rose following a catastrophic Christmas Eve fire two years ago that destroyed pollution controls at the Clairton Coke Works--the largest such facility in the nation, a University of Pittsburgh Graduate School of Public Health analysis concludes. The study, published in the Journal of Allergy and Clinical Immunology, was possible because of a collaboration with the University of Pittsburgh Asthma and Environmental Lung Health Institute at UPMC and the Allegheny County Health Department, with funding from The Heinz Endowments. "In addition to verifying that people living within a 10-mile radius of the coke works had higher rates of asthma exacerbations and use of albuterol rescue medication than those living outside the radius, we learned ...

A comprehensive study from Uppsala University demonstrates that socioeconomic deprivation modifies genetic effects on higher education and abstract reasoning. The paper illustrates how genes play a greater role in educational attainment in more socioeconomically deprived regions of the United Kingdom. The study was recently published in the American Journal of Psychiatry. Education is an important factor in an individual's life and strongly linked to economic outcomes and quality of life. The likelihood of completing higher education is partly determined by genetic factors. Common genetic variants have previously been estimated to contribute 11-13% ...

Breast cancer diagnosis: Around 88 percent of patients survive the dangerous disease in the first five years. Work is important for getting back to normality. Researchers from the University of Bonn and the German Cancer Society investigated how satisfied former patients are with their occupational development over a period of five to six years since diagnosis. About half experienced at least one job change during the study period. Around ten percent of those affected even report involuntary changes. The researchers conclude that there is a need for long-term support measures for patients. The study is now published in the Journal of Cancer Survivorship. Breast cancer is the most commonly occurring cancer in women. ...

Amsterdam, April 28, 2021 - Parkinson's disease (PD) is characterized by slowness of movement and tremors, which often appear asymmetrically in patients. The new model of PD described in this review article published in the Journal of Parkinson's Disease may explain these perplexing asymmetrical motor symptoms and other known variations such as different degrees of constipation and sleep disorders. PD is a heterogenous disorder. Symptoms and the speed with which symptoms progress vary greatly among patients. In three-quarters of patients, motor symptoms initially appear in one side of the body. Some ...