Philadelphia, January 14, 2021--In a large study of pediatric cancer patients, researchers from Children's Hospital of Philadelphia (CHOP) have analyzed the frequency, fusion partners, and clinical outcome of neurotrophic tyrosine receptor kinase (NTRK) fusions, which are clinical biomarkers that identify patients suitable for treatment with FDA-approved TRK inhibitors. The researchers found that NTRK fusions are more common in pediatric tumors and also involve a wider range of tumors than adult cancers, information that could help prioritize screening for NTRK fusions in pediatric cancer patients who might benefit from treatment with TRK inhibitors. The ...

The experiment was performed at the Research Center for Nuclear Physics (RCNP) in Osaka. The research team, lead by scientists from TU Darmstadt and the GSI Helmholtz Center for Heavy-Ion Research, and from the RIKEN Nishina Center for Accelerator-Based Science, discuss the new findings in a contribution to the latest issue of the journal "Science". The strong interaction binds neutrons and protons together to atomic nuclei. The knowledge of properties of nuclei and their theoretical description is basis for our understanding of nuclear matter and the development of the universe. Laboratory-based studies of reactions between atomic nuclei provide means to explore nuclear properties. These experiments ...

Diabetes is characterized by elevated levels of sugar or glucose (hyperglycemia) in the blood. This occurs due to the lack of the hormone insulin in type 1 diabetes, and to reduced insulin levels in combination with insulin resistance in type 2 diabetes. A recent review of data supports stricter control of hemoglobin A1C levels (HbA1C) among pediatric patients with T1D. This review was led by Dr. Maria J. Redondo, pediatric endocrinologist at Texas Children's Hospital and professor at Baylor College of Medicine, in collaboration with Dr. Sarah Lyons, pediatric endocrinologist at Texas Children's and assistant professor at Baylor College of Medicine, ...

A refractive index of zero induces a wave vector with zero amplitude and undefined direction. Therefore, light propagating inside a zero-index medium does not accumulate any spatial phase advance, resulting in perfect spatial coherence. Such coherence brings several potential applications, including arbitrarily shaped waveguides, phase-mismatch-free nonlinear propagation, large-area single-mode lasers, and extended super radiance. A promising platform to achieve these applications is an integrated Dirac-cone material that features an impedance-matched zero index. However, although this platform eliminates ohmic losses via its purely dielectric structure, it still entails out-of-plane radiation loss (about 1 dB/μm), restricting the applications to a small scale. In ...

The development of ultrafast all-optical switches has long been a popular topic in photonics, while the speed of magnetization reversal triggered by means other than magnetic fields has recently attracted intense interest in spintronics. The discovery of all-optical helicity-dependent switching in metallic GdFeCo has promised a merger of the fields of photonics and spintronics, paving the way for faster and more energy-efficient information processing technologies. However, the real potential of all-optical switching is still poorly understood because it is still unclear whether magnetic switching by light can keep up with the GHz frequencies required by photonics technologies. ...

"The lotus roots may break, but the fiber remains joined" is an old Chinese saying that reflects the unique structure and mechanical properties of the lotus fiber. The outstanding mechanical properties of lotus fibers can be attributed to their unique spiral structure, which provides an attractive model for biomimetic design of artificial fibers. In a new study published in Nano Letters, a team led by Prof. YU Shuhong from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) reported a bio-inspired lotus-fiber-mimetic spiral structure bacterial cellulose (BC) hydrogel fiber with high strength, ...

Liwen Sang, independent scientist at International Center for Materials Nanoarchitectonics, National Institute for Materials Science (also JST PRESTO researcher) developed a MEMS resonator that stably operates even under high temperatures by regulating the strain caused by the heat from gallium nitride (GaN). High-precision synchronization is required for the fifth generation mobile communication system (5G) with a high speed and large capacity. To that end, a high-performance frequency reference oscillator which can balance the temporal stability and temporal resolution is necessary as a timing device to generate signals ...

PULLMAN, Wash. - Scientists have identified the presence of a non-tobacco plant in ancient Maya drug containers for the first time. The Washington State University researchers detected Mexican marigold (Tagetes lucida) in residues taken from 14 miniature Maya ceramic vessels. Originally buried more than 1,000 years ago on Mexico's Yucatán peninsula, the vessels also contain chemical traces present in two types of dried and cured tobacco, Nicotiana tabacum and N. rustica. The research team, led by anthropology postdoc Mario Zimmermann, thinks the Mexican marigold was mixed with the tobacco to make smoking more enjoyable. The discovery of the vessels' contents paints a clearer picture of ancient Maya drug use practices. The research, which was published ...

Partially protected areas - marine reserves that allow some forms of fishing - are no more effective socially or ecologically than open marine areas in Australia's Great Southern Reef, a new UNSW study has concluded. The research, published in Conservation Biology today, comes at a time when the High Ambition Coalition of 50 countries of the world (which does not include Australia) have pledged to protect more than 30 per cent of the planet's lands and seas by the end of this decade. But not all protected areas are created equal. The UNSW study discovered partially protected areas in southern Australia had no more fish, invertebrates or algae and no difference in ...

Researchers from Kumamoto University (Japan) have found an Edo period document that clearly indicates the Hosokawa clan, rulers of the Kokura Domain (modern-day Fukuoka Prefecture), completely stopped producing wine in 1632, the year before the shogunate ordered them to move to the Higo Domain (now Kumamoto Prefecture). The researchers believe that the discontinuation of wine production was directly related to this move and because it was considered to be a drink of a religion that was harshly suppressed in Japan at that time, Christianity. Previous analysis of historical documents revealed that the lord of the Hosokawa clan, Tadatoshi Hosokawa, ordered wine production from 1627 to 1630 for medicinal use. His ...

Divergences between scientific and Indigenous and Local Knowledge can provide a better understanding of why local pastoralists may be willing, or not, to participate in conservation initiatives for carnivores, a study from University of Helsinki suggests. Carnivore conservation has historically been based primarily on scientific knowledge using a wide range of sampling methods, such as camera trapping and track surveys. However, the estimates of these common ecological sampling methods can be quite uncertain and can depend on accessibility and geology, which is the case of many remote areas, such as Sibiloi National Park in Northern Kenya. For this reason, the inclusion of local communities that share ...

A research team led by scientists at the RIKEN Nishina Center for Accelerator-Based Science (RNC) has successfully created larger-than-usual strains of zooplankton -- which are used in fish nurseries -- by creating mutations with a heavy ion beam. The new strains of zooplankton could contribute to improving the survival rate and optimizing the growth of juvenile fish in aquaculture. Economically important fish species, such as bluefin tuna, yellowtail, flatfish and groupers, are fed live bait until they are large enough to be fed with artificial foods. ...

Any building project requires the formulation of a series of initial plans prior to starting construction to serve as a basis and guide for the whole process. A similar procedure is followed in software development, with the inclusion of a specific step known as modelling. "The process is equivalent to the production of a set of plans for a building before its construction," explained Universitat Oberta de Catalunya (UOC) Faculty of Computer Science, Multimedia and Telecommunications professor and member of the SOM Research Lab research group -from the Internet Interdisciplinary Institute (IN3)-, Robert Clarisó. Engineers use modelling to describe ...

In the last decades, Artificial Intelligence has shown to be very good at achieving exceptional goals in several fields. Chess is one of them: in 1996, for the first time, the computer Deep Blue beat a human player, chess champion Garry Kasparov. A new piece of research shows now that the brain strategy for storing memories may lead to imperfect memories, but in turn, allows it to store more memories, and with less hassle than AI. The new study, carried out by SISSA scientists in collaboration with Kavli Institute for Systems Neuroscience & Centre for Neural Computation, Trondheim, Norway, has just been published in Physical Review Letters. Neural networks, real or artificial, learn by tweaking the connections ...

An innovative new study is set to examine if changing our mealtimes to earlier or later in the day could reduce the risk of developing Type 2 diabetes. Led by Dr Denise Robertson, Professor Jonathan Johnston and post graduate researcher Shantel Lynch from the University of Surrey, the study, outlined in the journal Nutrition Bulletin, will investigate if changing the time we eat during the day could reduce risk factors such as obesity and cholesterol levels that are typically associated with the development of Type 2 diabetes. The team of researchers will also for the first time investigate, via a series of interviews with participants and their friends and family, the impact of such changes on home life, work/social commitments and whether co-habitants of those who make such ...

Having genitals of a certain shape and size gives male flies a major reproductive advantage, new research shows. University of Exeter scientists examined the reproductive success of male Drosophila simulans flies both alone with a female and in various states of competition with other males. Certain genital shapes were consistently better in terms of number of offspring sired. However - surprisingly, given how fast genital form evolves - the selection documented was rather weak. "Male genitals generally, and in Drosophila specifically, evolve very quickly, so we were really surprised to find this weak selection," said Professor David Hosken, of the University of Exeter. "Selection is the major mechanism of evolution and hence where we see rapid evolution, ...

Mitochondria are vital for the human body as cellular powerhouses: They possess more than 1,000 different proteins, required for many central metabolic pathways. Disfunction of these lead to severe diseases, especially of the nervous system and the heart. In order to transport proteins and metabolites, mitochondria contain a special group of so-called beta-barrel membrane proteins, which form transport pores in the outer mitochondrial membrane. So far, scientists have not been able to explain the operating mode of the sorting and assembly machinery (SAM) for the biogenesis of these beta-barrel proteins. A team led by Prof. Dr. Toshiya Endo from Kyoto University/Japan, Prof. Dr. Nils Wiedemann and ...

Guangzhou, January 15, 2021: New journal BIO Integration (BIOI) publishes its fourth issue, volume 1, issue 4. BIOI is a peer-reviewed, open access, international journal, which is dedicated to spreading multidisciplinary views driving the advancement of modern medicine. Aimed at bridging the gap between the laboratory, clinic, and biotechnology industries, it will offer a cross-disciplinary platform devoted to communicating advances in the biomedical research field and offering insights into different areas of life science, in order to encourage cooperation and exchange among scientists, clinical researchers, and health care providers. The issue contains an original article, three review ...

A clinical trial involving COVID-19 patients hospitalized at UT Health San Antonio and University Health, among roughly 100 sites globally, found that a combination of the drugs baricitinib and remdesivir reduced time to recovery, according to results published Dec. 11 in the New England Journal of Medicine. Six researchers from UT Health San Antonio and University Health are coauthors of the publication because of the San Antonio site's sizable patient enrollment in the trial. The Adaptive COVID-19 Treatment Trial 2 (ACTT-2), which compared the combination therapy versus remdesivir paired with an inactive placebo in hospitalized COVID-19 patients, was supported by the National Institute of Allergy and Infectious Diseases (NIAID), ...

Certain snakes have evolved a unique genetic trick to avoid being eaten by venomous snakes, according to University of Queensland research. Associate Professor Bryan Fry from UQ's Toxin Evolution Lab said the technique worked in a manner similar to the way two sides of a magnet repel each other. "The target of snake venom neurotoxins is a strongly negatively charged nerve receptor," Dr Fry said. "This has caused neurotoxins to evolve with positively charged surfaces, thereby guiding them to the neurological target to produce paralysis. "But some snakes have evolved to replace a negatively charged amino acid on their receptor with a positively charged one, meaning the neurotoxin is repelled. "It's an inventive genetic mutation and it's been completely missed until now. "We've ...

PHILADELPHIA - Our biological or circadian clock synchronizes all our bodily processes to the natural rhythms of light and dark. It's no wonder then that disrupting the clock can wreak havoc on our body. In fact, studies have shown that when circadian rhythms are disturbed through sleep deprivation, jet lag, or shift work, there is an increased incidence of some cancers including prostate cancer, which is the second leading cause of cancer death for men in the U.S. With an urgent need to develop novel therapeutic targets for prostate cancer, researchers at the Sidney Kimmel Cancer - ...

Oxygen levels in the ancient oceans were surprisingly resilient to climate change, new research suggests. Scientists used geological samples to estimate ocean oxygen during a period of global warming 56 million years ago - and found "limited expansion" of seafloor anoxia (absence of oxygen). Global warming - both past and present - depletes ocean oxygen, but the new study suggests warming of 5°C in the Paleocene Eocene Thermal Maximum (PETM) led to anoxia covering no more than 2% of the global seafloor. However, conditions are different today to the PETM - today's rate of carbon emissions is much faster, and we are adding nutrient pollution to the oceans - both of which could drive more rapid and expansive oxygen loss. The study was carried out by an international ...

Champaign, IL, January 15, 2021 - American dairy consumers are often influenced by a variety of factors that can affect their buying habits. These factors include taste, preference, government information, cultural background, social media, and the news. In an article appearing in JDS Communications, researchers found that households that frequently bought food for children are interested in dairy as part of their diet and purchased larger quantities of fluid milk and more fluid milk with a higher fat content. To assess the purchasing habits of households that purchase food for children versus those ...

Families are complicated. For members of the Alligatoridae family, which includes living caimans and alligators - this is especially true. They are closely related, but because of their similarity, their identification can even stump paleontologists. But after the recent discovery of a partial skull, the caimans of years past may provide some clarity into the complex, and incomplete, history of its relatives and their movements across time and space. Michelle Stocker, an assistant professor of vertebrate paleontology in Virginia Tech's Department of Geosciences in the College of Science; Chris Kirk, of the University of Texas at Austin; and Christopher Brochu, of the University of Iowa, have ...

Researchers from University of Stavanger, University of Melbourne, and University of Wisconsin-Madison published a new paper in the Journal of Marketing that examines how major projects undertaken by temporary organizations can be better managed so that cost overruns are minimized. The study forthcoming in the Journal of Marketing is titled "Mobilizing the Temporary Organization: The Governance Roles of Selection and Pricing" and is authored by Elham Ghazimatin, Erik Mooi, and Jan Heide. When consumers return to the skies again, they may do so in Boeing's 787 Dreamliner. But the project, or "temporary organization," created to make this plane ...