As females age, their bodies typically undergo two significant changes that generally occur during adolescence and middle age. The first, known as menarche, is the time during puberty when a girl begins having monthly menstruation cycles, which often tends to range from 8-13 years of age. She enters the second change, known as menopause, 12 months following her last menstruation cycle when her ovarian function ceases, usually sometime in her 40s or 50s. The time after menarche and prior to menopause is known as a woman's reproduction life span and marks the years when she is most able to bear children. For many women, these events occur naturally. However, women can enter menopause earlier than ...

Researchers at King's College London Institute of Psychiatry, Psychology, & Neuroscience, in collaboration with King's College Hospital NHS Foundation Trust, have found small clusters of cells in the brain that identify locations where tumours could become malignant. The study, which has been published in Neuro-Oncology Advances today, analysed pieces of living human brain tissue from 20 people undergoing brain tumour surgery at King's College Hospital, the largest neuro-oncology centre in Europe. The researchers found groups of tumour cells clustered around blood vessels and believe that these sites could be the seedbeds for malignant progression, the process by which a tumour becomes a fast growing and uncontrolled cancer. ...

- Study finds for the first time, in Africa, that mutations are associated with delayed clearance of the parasite among children with malaria treated with common Artemisinin-based combination therapies (ACTs). - While drug efficacy remains high so far, authors call for increased monitoring in the region. New data provide the first clinical evidence that drug-resistant mutations in the malaria parasite Plasmodium falciparum may be gaining a foothold in Africa. The study, conducted in Rwanda, is published in The Lancet Infectious Diseases journal and finds for the first time that the mutations are associated with delayed parasite clearance, as was first shown in South-East Asia when artemisinin-resistance started to emerge. The study ...

Psilocybin, the active compound in magic mushrooms, may be at least as effective as a leading antidepressant medication in a therapeutic setting. This is the finding of a study carried out by researchers at the Centre for Psychedelic Research at Imperial College London. In the most rigorous trial to date assessing the therapeutic potential of a 'psychedelic' compound, researchers compared two sessions of psilocybin therapy with a six-week course of a leading antidepressant (a selective serotonin uptake inhibitor called escitalopram) in 59 people with moderate-to-severe depression. The results, published today in the New England Journal of Medicine, show that while depression ...

New research by University of Texas at Dallas scientists could help solve a major challenge in the deployment of certain COVID-19 vaccines worldwide -- the need for the vaccines to be kept at below-freezing temperatures during transport and storage. In a study published online April 13 in Nature Communications, the researchers demonstrate a new, inexpensive technique that generates crystalline exoskeletons around delicate liposomes and other lipid nanoparticles and stabilizes them at room temperature for an extended period -- up to two months -- in their proof-of-concept experiments. The Moderna and Pfizer/BioNTech COVID-19 vaccines use lipid nanoparticles -- basically spheres of fat molecules -- to protect and deliver the messenger ...

Biomedical engineers at Duke University have developed a self-assembling nanomaterial that can help limit damage caused by inflammatory diseases by activating key cells in the immune system. In mouse models of psoriasis, the nanofiber-based drug has been shown to mitigate damaging inflammation as effectively as a gold-standard therapy. One of the hallmarks of inflammatory diseases, like rheumatoid arthritis, Crohn's disease and psoriasis, is the overproduction of signaling proteins, called cytokines, that cause inflammation. One of the most significant ...

Current research on flexible electronics is paving the way for wireless sensors that can be worn on the body and collect a variety of medical data. But where do the data go? Without a similar flexible transmitting device, these sensors would require wired connections to transmit health data. Huanyu "Larry" Cheng, Dorothy Quiggle Career Development Assistant Professor of Engineering Science and Mechanics in the Penn State College of Engineering, and two international teams of researchers are developing devices to explore the possibilities of wearable, flexible antennae. They published two papers in April in Nano-Micro Letters and Materials & Design. Wearable antenna bends, ...

Biological energy flows, such as in photosynthesis and respiration, depend on the transfer of electrons from one molecule to another. Despite its importance to sustaining life, factors governing the rate of electron transfer, especially over long distances, are not well understood because the systems that mediate such ultrafast processes are very complex. A better understanding of electron transfer rates would help scientists improve chemical transformations, energy conversion, electronic devices, and photonic technologies. Now, an international team of researchers led by UC Riverside has observed picosecond charge transfer mediated by hydrogen bonds in peptides. A picosecond is one trillionth of a second. ...

The coronavirus pandemic has led researchers to switch gears or temporarily abandon projects due to health protocols or not being able to travel. But for Patrick Keys and Elizabeth Barnes, husband and wife scientists at Colorado State University, this past year led to a productive research collaboration. They teamed up with Neil Carter, assistant professor at the University of Michigan, on a paper published in END ...

As older teens and young adults become eligible for COVID-19 vaccination across the country, and younger teens await their turn, new survey data suggest a strong readiness that has grown since fall. But just as with older generations, a shrinking but still sizable minority of people age 14 to 24 say they're not willing to get vaccinated, or that their decision will depend on safety. That makes it crucial for public health authorities, health care providers and others to create vaccination-related materials that reach young people in ways that are relevant to them. The data, from the text-message-based END ...

Our high-speed, high-bandwidth world constantly requires new ways to process and store information. Semiconductors and magnetic materials have made up the bulk of data storage devices for decades. In recent years, however, researchers and engineers have turned to ferroelectric materials, a type of crystal that can be manipulated with electricity. In 2016, the study of ferroelectrics got more interesting with the discovery of polar vortices -- essentially spiral-shaped groupings of atoms -- within the structure of the material. Now a team of researchers led by the U.S. Department of Energy's (DOE) Argonne National Laboratory has uncovered new insights into the behavior of these vortices, insights that may be the first step toward using them for ...

A new study has identified a strong correlation between changes in Taiwan's seismicity rate and its seasonal water cycle fluctuations, suggesting that many faults in this region are so stressed that even minor shifts in strain caused by changes in groundwater storage can trigger earthquakes. Ya-Ju Hsu and colleagues observed that western Taiwan's seismicity rate reaches its highest levels between February and April, when the crust rebounds as stress from the groundwater load decreases, and its seismicity reaches its lowest levels between July and September, at the tail end of monsoon season. However, the researchers ...

COVID-19 and hemorrhagic stroke are a deadly combination, increasing the risk of death up to 2.4 times among patients who have this pairing compared to those who only had hemorrhagic strokes, according to a nationwide study led by University of Utah Health scientists. Patients who survived had longer hospital stays, more medical complications, and less favorable outcomes than those who did not have both conditions. Racial and ethnic minorities and those who were obese or had diabetes were among the most vulnerable. "This is one of the first studies to document that, in patients with hemorrhagic stroke who have comorbid COVID-19, there is a significantly elevated risk of in-hospital death," says Adam de Havenon, M.D., senior author of the study and an assistant professor of neurology ...

When wastewater from villages and cities flows into rivers and lakes, large quantities of fats, proteins, sugars and other carbon-containing, organic substances wind up in nature together with the fecal matter. These organic substances are broken down by bacteria that consume oxygen. The larger the volume of wastewater, the better the bacteria thrive. This, however, means the oxygen content of the water continues to decrease until finally the fish, muscles or worms literally run out of air. This has created low-oxygen death zones in many rivers and lakes around the world. No gold standard for measurements until now In order to measure how heavily the waters are polluted with organic matter from feces, government ...

Grave goods, such as stone tools, have revealed that Neolithic farmers had different work-related activities for men and women. Researchers at the University of York analysed 400 stone objects found in graves at cemetery sites across Europe and noted there were differences in size, weight, and raw material dependent on whether the body was a male or a female. Archaeologists had previously thought that polished stone tools in this period were used for woodworking, but analysis now shows a much wider range of tasks, with different activities for men and women. The tools found in female graves were most likely used for the working of animal skins and hide, and tools for the men were associated with hunting ...

Researchers at HSE University have identified the genes that play a crucial role in breast cancer metastasis. The results of the study were published in the journal PLOS ONE. Every human cell includes a huge number of various molecules: DNA, RNA, proteins, etc. One of the essential classes of molecules that interact with each other are microRNAs, along with their target genes and transcription factors. MicroRNAs are small molecules, which can directly reduce the concentration (expression) of target genes, while transcription factors are able to both increase and reduce the expression of ...

A new state-by-state analysis shows a statistical association between high adherence to mask wearing and reduced rates of COVID-19 in the U.S. Charlie Fischer and colleagues at the Boston University School of Public Health in Massachusetts present these findings in the open-access journal PLOS ONE on April 14. During the COVID-19 pandemic, different states have enacted different policies on mask wearing, with some states having no mask requirements and others requiring masks in all public spaces. Understanding the link between mask wearing and COVID-19 rates could help inform policies to mitigate stress on healthcare systems, economic instability, and death. To help clarify the effects of mask wearing, Fischer and colleagues examined publicly ...

Combining immune-boosting drugs with radiation and surgery increased the survival and anticancer immune response in mouse models of mesothelioma in preclinical research by Princess Margaret Cancer Centre researchers. In a series of exciting experiments using mouse models of mesothelioma cancer, researchers found that combining two immunotherapy drugs can amplify the anti-tumour response first triggered by a short course of radiation, conferring long-lasting control and resistance against cancer. These response rates are improved further by adding surgery to remove the remaining tumour. Better treatments are urgently needed for mesothelioma patients, as ...

INDIANAPOLIS, IN AND BERKELEY, CA (April 14, 2021) - Researchers from Indiana University School of Medicine and OMGYES have conducted the first-ever, large-scale, nationally representative study focused on women's techniques for increasing their own pleasure from vaginal penetration. The findings, published today in the scientific journal, PLOS ONE, identify and name four distinct methods: Angling, Pairing, Rocking and Shallowing. The research was led by Dr. Devon J. Hensel, Associate Professor of Research at Indiana University School of Medicine, and Dr. Christiana von Hippel, an OMGYES Research Scientist. "For the first time, we have ...

Berkeley -- Engineers at the University of California, Berkeley, have created a tiny wireless implant that can provide real-time measurements of tissue oxygen levels deep underneath the skin. The device, which is smaller than the average ladybug and powered by ultrasound waves, could help doctors monitor the health of transplanted organs or tissue and provide an early warning of potential transplant failure. The technology, created in collaboration with physicians at the University of California, San Francisco, also paves the way for the creation of a variety of miniaturized sensors that could track other key biochemical markers in the body, ...

New research published in Science Advances provides a template for how to develop directly-acting antivirals with novel modes of action, that would combat COVID-19 by suppressing the SARS-CoV-2 viral infection. The study focused on the macrodomain part of the Nsp3 gene product that SARS-CoV-2 uses to suppress the host cell's natural antiviral response. This part of the virus's machinery, also known as Mac1, is essential for its reproduction: previous studies have shown that viruses that lack it cannot replicate in human cells, suggesting that blocking ...

"Family clustering is a confirmed phenomenon associated with Covid-19, and harrowing stories of this disease ravaging families continue to be reported," a new article explains in the March-April issue of the Hastings Center Report. In one extreme example, 28 extended family members in California reportedly tested positive for Covid-19. Two of the family members who quarantined together required hospitalization, and one of them died from the infection. In family clustering cases, multiple loved ones may suffer from the symptoms of Covid-19 and be hospitalized, in quarantine, or recovering; and family ...

The slurred speech, poor coordination, and sedative effects of drinking too much alcohol may actually be caused by the breakdown of alcohol products produced in the brain, not in the liver as scientists currently think. That is the finding of a new study led by researchers from the University of Maryland School of Medicine (UMSOM) and the National Institute on Alcohol Abuse and Alcoholism. It was published recently in the journal Nature Metabolism and provides new insights into how alcohol may affect the brain and the potential for new treatments to treat alcohol misuse. It is well known that the liver is the major organ ...

One of the technical challenges the current data revolution faces is finding an efficient way to route the data. This task is usually performed by electronic switches, while the data itself is transferred using light confined in optical waveguides. For this reason, conversion from an optical to an electronic signal and back-conversion are required, which costs energy and limits the amount of transferable information. These drawbacks are avoidable with a full optical switch operation. One of the most promising approaches is based on microelectromechanical systems (MEMS), thanks ...

Most people by now have memorized the public health guidelines meant to help minimize transmission of COVID-19: wash your hands, wear a mask, keep six feet apart from others. That part is easy. What some may not realize is that upholding these guidelines in certain urban areas can present new challenges. For example, how are you supposed to stay six feet apart from other people when the standard width of a sidewalk is only four feet? What do you do when you want to cross an intersection that requires pressing a button to activate the pedestrian signal, but you are avoiding touching any surfaces? The COVID-19 pandemic has drastically altered the way individuals interact with other people and their environment, but some public health guidelines meant to protect ...