LA JOLLA--(April 15, 2021) One of the characteristic hallmarks of Alzheimer's disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but they've largely failed in clinical trials. New research by Salk scientists upends conventional views of the origin of one prevalent type of plaque, indicating a reason why treatments have been unsuccessful. The traditional view holds that the brain's trash-clearing immune cells, called microglia, inhibit the growth of plaques by "eating" them. The Salk scientists show instead that microglia promote the formation of dense-core plaques, and that this action sweeps wispy plaque ...

What The Study Did: How prescribing of opioid analgesics and buprenorphine for opioid use disorder changed throughout the COVID-19 pandemic was examined in this study. Authors: Janet M. Currie, Ph.D., of Princeton University in Princeton, New Jersey, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.6147) Editor's Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author ...

BOSTON - Researchers from Massachusetts General Hospital (MGH) have used a couples-based framework to describe the experiences of individuals diagnosed with young-onset dementia (YOD) and their partners. In a study published in JAMA Network Open, the team conducted in-depth interviews to understand how couples navigate challenges related to YOD. This framework has been used to successfully develop patient-caregiver treatments for other severe medical conditions, including stroke, breast cancer and neurological injury. Using this approach to understand couples' coping patterns within YOD can help increase much-needed resources for affected couples. Young-onset dementias ...

PHILADELPHIA-- A new study from researchers at the Perelman School of Medicine at the University of Pennsylvania found significant disparities in the use of sodium-glucose cotransporter 2 (SGLT2) inhibitors, a class of drugs proven to treat type 2 diabetes, with usage remaining low with Black, Asian, and lower-income groups despite an increase in overall usage for patients with type 2 diabetes. The END ...

Technology and commercial advancements are expected to continue to drive down the cost of wind energy, according to a survey led by Lawrence Berkeley National Laboratory (Berkeley Lab) of the world's foremost wind power experts. Experts anticipate cost reductions of 17%-35% by 2035 and 37%-49% by 2050, driven by bigger and more efficient turbines, lower capital and operating costs, and other advancements. The findings are described in an article in the journal Nature Energy. The study summarizes a global survey of 140 wind experts on three wind applications - onshore (land-based) wind, fixed-bottom offshore wind, and ...

The causes of the serious muscle disease ALS still remain unknown. Now, researchers at Karolinska Institutet and KTH Royal Institute of Technology, among others, have examined a type of cell in the brain blood vessels that could explain the unpredictable disease origins and dynamics. The results indicate a hitherto unknown connection between the nervous and vascular systems. The study, which is published in Nature Medicine, has potential implications for earlier diagnoses and future treatments. ALS (amyotrophic lateral sclerosis) is a neurodegenerative disease of the motor neurons that eventually ...

PHILADELPHIA--Real-word evidence is suggesting, for the first time, the most beneficial treatment courses that could help extend the lives of patients with metastatic non-small cell lung cancer, according to research from the Abramson Cancer Center at the University of Pennsylvania. In a new study published online today in JAMA Oncology, researchers show that patients harboring a KRAS gene mutation with high levels of PDL-1 lived longer when treated with immunotherapy alone, compared to patients without this mutation. This survival difference by KRAS status was not seen, however, in patients treated with both chemotherapy and immunotherapy, suggesting combination therapy for patients without the mutation may be preferred. The new findings, based off an analysis of the Flatiron ...

Inspired by the workings of a bat's ear, Rolf Mueller, a professor of mechanical engineering at Virginia Tech, has created bio-inspired technology that determines the location of a sound's origin. Video: https://www.youtube.com/watch?v=buFM5KkAnEo Mueller's development works from a simpler and more accurate model of sound location than previous approaches, which have traditionally been modeled after the human ear. His work marks the first new insight for determining sound location in 50 years. The findings were published in Nature Machine Intelligence ...

There is no cheaper way to generate electricity today than with the sun. Power plants are currently being built in sunny locations that will supply solar electricity for less than two cents per kilowatt hour. Solar cells available on the market based on crystalline silicon make this possible with efficiencies of up to 23 percent. Therefore they hold a global market share of around 95 percent. With even higher efficiencies of more than 26 percent, costs could fall further. An international working group led by photovoltaics researchers from Forschungszentrum Jülich ...

More than 20 years after the launch of a landmark clinical trial, follow-up examinations and analyses found that not all patients with elevated eye pressure need pressure-lowering treatment to prevent vision loss from glaucoma. When the study was launched, it was universally accepted that all patients with elevated eye pressure should be given medication to lower that pressure. The Ocular Hypertension Treatment Study -- funded by the National Eye Institute of the National Institutes of Health (NIH) and led by researchers at Washington University School of Medicine ...

Prime editing (PE), a "search-and-replace" CRISPR-based genome editing technique, has great potential for gene therapy and agriculture. It can introduce desired base conversions, deletions, insertions, and combination edits into target genomic sites. Prime editors have been successfully applied in animals and plants, but their off-target effects, which can be a major hindrance to real-life application, have not been thoroughly evaluated until now. Prof. GAO Caixia from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences (CAS) and her research team recently performed a comprehensive and genome-wide analysis of the off-target effects of PEs in rice plants. Off-target ...

It is an old-standing theory in evolutionary ecology: animal species on islands have the tendency to become either giants or dwarfs in comparison to mainland relatives. Since its formulation in the 1960s, however, the 'island rule' has been severely debated by scientists. In a new publication in Nature Ecology and Evolution on April 15, researchers solved this debate by analysing thousands of vertebrate species. They show that the island rule effects are widespread in mammals, birds and reptiles, but less evident in amphibians. Dwarf hippos and elephants in the Mediterranean islands are examples of large ...

Using a new single-cell technique, WEHI researchers have uncovered a way to understand the programming behind how stem cells make particular cell types. The research uncovered 30 new genes that program stem cells to make the dendritic cells that kick-start the immune response. By uncovering this process, the researchers hope they will be able to find new immunotherapy treatments for cancer, and plan to expand this technique in other areas such as discovering new drug targets in tumour initiation. At a glance WEHI researchers have developed a new single cell method to understand the programming behind what causes stem cells to make ...

El Niño-Southern Oscillation (ENSO) is an irregular periodic variation in winds and sea surface temperatures (SSTs) over the tropical eastern Pacific Ocean. It may lead to extreme weather events across the globe due to its ability to change global atmospheric circulation. Thus, determining how ENSO responds to greenhouse warming is crucial in climate science. However, quantifying and understanding ENSO-related changes in a warmer climate remains challenging due to the complexity of air-sea feedbacks in the tropical Pacific Ocean and to model bias. An international team of scientists ...

Antibodies are not only produced by our immune cells to fight viruses and other pathogens in the body. For a few decades now, medicine has also been using antibodies produced by biotechnology as drugs. This is because antibodies are extremely good at binding specifically to molecular structures according to the lock-and-key principle. Their use ranges from oncology to the treatment of autoimmune diseases and neurodegenerative conditions. However, developing such antibody drugs is anything but simple. The basic requirement is for an antibody to bind to its target molecule in an optimal way. At the same time, an antibody drug must fulfil a host of additional criteria. For example, it should not trigger ...

COVID-19 has been associated with increases in opioid overdose deaths, which may be in part because the pandemic limited access to buprenorphine, a treatment used for opioid dependency, according to a new study led by Princeton University researchers. The researchers found that Americans who were already taking opioids did not experience disruptions in their supply. Patients who were not previously taking opioids for pain management were less likely to receive a new prescription in the first months of the pandemic, but prescriptions for new patients soon bounced back to previous levels. At the same time, fewer ...

A number of SARS-CoV-2 variants have emerged from immunocompromised hosts, research has identified. It is thought that variants of concern - including B.1.1.7, a variant first identified in Kent - were a result of long-term infection in people with a weakened immune system. Persistent infections in immunocompromised people could cause the virus to mutate more frequently because the person's immune system cannot clear the virus as quickly as the immune system of a healthy person. Authors Professor Wendy Barclay, Dr Thomas Peacock, Professor Julian Hiscox and Rebekah Penrice-Randal explain the importance of monitoring genetic changes in SARS-CoV-2 for future control of the virus: ...

Besides enabling more potent smartphones and higher download speeds while riding the subway, cutting-edge technologies like artificial intelligence, robotics, and wireless communications are on the verge of revolutionizing well-established industrial fields. A remarkable example is "smart agriculture," which has seen a tremendous increase in the use of drones for various tasks, especially in Japan. Drones, or "unmanned aerial vehicles" (UAVs), have been the focus of extensive research for agricultural applications. For example, they can take aerial images of a field and, through subsequent image processing, identify problems in specific areas of the crop fields. Another notable use case for UAVs that has been quickly gaining traction is the spraying of pesticides. In ...

The extreme summer drought of 2018 was a special situation for both nature and scientists. It was very hard on the forest. At the same time, it offered researchers from the Universities of Basel (Switzerland) and Würzburg (Germany) the opportunity to study the reaction of trees to this climatic phenomenon. Research in the treetops "The summer of 2018 was hotter and drier than in any other year since weather records began," says ecophysiologist Professor Bernhard Schuldt from the University of Wuerzburg. Together with Dr Matthias Arend and Professor Ansgar Kahmen from the University of Basel, he was significantly involved in the study, which is published in the scientific journal PNAS. "A unique opportunity arose for us to study the influence of ...

A new paper in the Review of Economic Studies indicates that disease can alter the social networks and economic growth of countries for generations, even after the disease itself is eradicated. Social networks are an important determinant of a country's growth as they affect the diffusion of ideas and the rate of technological progress. But social networks also diffuse diseases that can rapidly spread and dampen growth. As ideas and germs diffuse through the same human interactions, the network structure of a country ultimately depends on its epidemiological environment. In countries with low prevalence of infectious diseases, high diffusion networks ...

An estimated 334,000 COVID-19 cases are attributable to meatpacking plants, resulting in $11.2 billion in economic damage, according to a new study led by a researcher at the University of California, Davis. The study was published in the journal Food Policy. It found that beef- and pork-processing plants more than doubled per capita infection rates in counties that had them. Chicken-processing plants increased transmission rates by 20 percent. The study looked specifically at large meatpacking plants generating more than 10 million pounds per month. Conservative estimate Researchers said both the economic impact ...

LAWRENCE -- How did the first humans migrate to populate North America? It's one of the great scientific puzzles of our day, especially because forbidding glaciers covered most of Canada, Alaska and Pacific Northwest during the Last Glacial Maximum (LGM). These glaciers limited human movements between northern ice-free areas, like the Beringia Land Bridge, and southern ice-free areas, like the continental United States. Now, research from the University of Kansas into the whole genomes of the American pine marten and Pacific pine marten -- weasel-like mammals that range today from Alaska to the American Southwest -- could shed light ...

Philadelphia, April 15, 2021 - A new study shows that markers of fear recall differ between men and women, but in a hormone-dependent manner. Aberrant fear-memory processing in the brain is thought to underlie anxiety disorders, which affect hundreds of millions of people worldwide. The neurobiological mechanisms underlying these disorders remain poorly understood, but recent studies suggest that neural oscillations in the prefrontal cortex can reflect the strength of fear recall activity, providing a physiological measure. Women suffer from anxiety disorders at twice the rate of men and indeed ...

Researchers in Sweden have developed a more eco-friendly way to remove heavy metals, dyes and other pollutants from water. The answer lies in filtering wastewater with a gel material taken from plant cellulose and spiked with small carbon dots produced in a microwave oven. Reporting in the journal Sustainable Marials and Technologies, researchers from KTH Royal Institute of Technology, in collaboration with Politecnico di Torino, engineered a more sustainable technique for producing hydrogel composites, a type of material that is wteidely studied for wastewater decontamination. Minna Hakkarainen, who leads ...

PITTSBURGH, April 15, 2021 - Oncologists faced with treating older women with breast cancer often must decide if the treatment may be more detrimental than the cancer. A study published today in JAMA Network Open by researchers at UPMC Hillman Cancer Center and the University of Pittsburgh School of Medicine sheds new light on this choice and suggests the rate of cancer recurrence or survival may be no different in treated vs. untreated elderly patients diagnosed in the early stages of the cancer diagnosed most commonly in women. "As a breast surgeon, I want to give my patients the best chance of survival with the best quality ...