Certain plasma microRNAs could serve as diagnostic biomarkers in mild traumatic brain injury, a new study from the University of Eastern Finland shows. The biomarkers were discovered in an animal model and they were successfully used also to diagnose mild traumatic brain injury in a subgroup of patients. The study was published in the International Journal of Molecular Sciences. Mild traumatic brain injury is difficult to detect by contemporary conventional imaging methods. In fact, most patients do not exhibit visible structural damage to the brain, which could ...

The tiniest microchips yet can be made from graphene and other 2D-materials, using a form of 'nano-origami', physicists at the University of Sussex have found. This is the first time any researchers have done this, and it is covered in a paper published in the ACS Nano journal. By creating kinks in the structure of graphene, researchers at the University of Sussex have made the nanomaterial behave like a transistor, and have shown that when a strip of graphene is crinkled in this way, it can behave like a microchip, which is around 100 times smaller than conventional microchips. Prof ...

A cloud simulation that captures the development and evolution of clouds based on atmospheric physical processes is more accurate than other models. "Our model describes atmospheric conditions and thermodynamic processes as well as the fluid dynamics that govern the motion of air in the atmosphere," says Torsten Hädrich, a KAUST Ph.D. student in the international research team. "This allows us to simulate cloud phenomena more realistically than previous methods." The model can take known atmospheric information at any time, such as temperature, humidity and wind, and simulate cloud formation, which is used for "nowcasting" of imminent cloud phenomena. "For example, our model is able to simulate the formation of cumulonimbus clouds by considering ...

Scientists at Cardiff University have discovered a unique way to target a common virus that affects one in 200 newborn babies in the UK but for which there is only limited treatments available. Human cytomegalovirus (HCMV) is a master at "hiding" from the body's immune system so antibodies and T-cells cannot attack it as they do in other viruses, like the current coronavirus. The researchers have now discovered a new type of antibody in the lab which - instead of killing the virus directly - marks infected cells so the immune system can "see" them. Once the immune system can see the infected cells it is able to kill the virus. The team have submitted a patent for the unique immunotherapeutic and hope it can help to treat HCMV, which can leave newborn babies severely disabled or ...

It does not happen often. But on rare occasions, physicians make mistakes and may make a wrong diagnosis. Patients may have many diseases all at once, where it can be difficult to distinguish the symptoms of one illness from the other, or there may be a lack of symptoms. Errors in diagnosis may lead to incorrect treatment or a lack of treatment. Therefore, everyone in the healthcare system tries to minimise errors as much as possible. Now, researchers at the University of Copenhagen have developed an algorithm that can help with just that. 'Our new algorithm can find the patients who have such an unusual disease trajectory that they may indeed not suffer from the disease ...

Scientists have discovered that pollution concentration varies between seasons. A new study, conducted in the North China Plain, determined where volatile organic compounds (VOCs) are distributed within the vertical layers of the atmosphere, and found notable changes from winter to summer. "The concentration of VOCs in the vertical direction was much higher in winter than that in summer and their emission sources showed different contributions in both seasons," said Guiqian Tang, associate professor in the Institute of Atmospheric Physics, Chinese Academy of Sciences, and the corresponding author of a study just published in Advances in Atmospheric Sciences . The researchers conducted a field campaign from June 8 to July 3, 2019. They focused ...

Researchers have used the zebrafish (Danio rerio) to identify the role of a gene involved in cardiac rhythm, which could help explain the fundamentals of what it takes to make a human heartbeat. The University of Melbourne study also found that mutation of the gene, Tmem161b, causes potentially fatal cardiac arrhythmia. 2.5 per cent of Australians are living with cardiac arrhythmia ( END ...

Almost half of people testing positive for coronavirus have reported symptoms of depression, according to a new study published in the International Journal of Environmental Research and Public Health. Researchers from Bangladesh, the United States and Anglia Ruskin University (ARU) in the UK carried out a cross-sectional survey of more than 1,000 Bangladeshi adult coronavirus patients over the course of one month. A total of 48% of respondents were categorised as having moderate to severe depression, with a higher prevalence in those with persistent symptoms, low family income ...

Brain tumours are the most common solid tumours in childhood and the largest cause of death from cancer in this age group Being able to classify a brain tumour's type, without the use of biopsy, is hard to do; however diffusion weighted imaging, an advanced imaging technique, when combined with machine learning, can help a UK-based multi-centre study, including WMG, University of Warwick has found. Being able to characterise the tumour(s) faster and more accurately means they can be treated more efficiently Diffusion weighted imaging and machine learning can successfully classify the diagnosis and characteristics of common types of paediatric brain tumours a UK-based multi-centre study, including WMG at the University of Warwick ...

Researchers from North Carolina State University, Boston University and Kraton Corporation have demonstrated a family of self-sterilizing polymers that are effective at inactivating coronaviruses, including SARS-CoV-2 - the virus that causes COVID-19. The work opens the door to a suite of applications that could help to reduce the transmission of COVID-19 and other diseases. "Our work here provides conclusive evidence that these materials, anionic polymers, can inactivate human coronaviruses quickly and efficiently," says Richard Spontak, co-author of a paper on the work accepted for publication in Advanced Science. Spontak is a Distinguished Professor of Chemical and Biomolecular Engineering and ...

A team of soil scientists developed a new approach to the automatic generation and updating of soil maps. Having applied machine learning technologies to a set of rules traditionally used by experts in manual mapping, the team obtained a highly accurate model that provides easy-to-interpret results. The study was published in ISPRS International Journal of Geo-Information. Many software solutions for digital soil mapping are based on statistical models. The accuracy of such programs is limited because statistical models depend on the quality and quantity of field data and can ignore local irregularities in soil properties. It is difficult to obtain accurate and useful information from ...

TAMPA, Fla. - One of the most challenging issues in cancer therapy is the development of drug resistance and subsequent disease progression. In a new article featured on this month's cover of Cancer Research, Moffitt Cancer Center researchers, in collaboration with Oxford University, report results from their study using mathematical modeling to show that cell turnover impacts drug resistance and is an important factor that governs the success of adaptive therapy. Cancer treatment options have increased substantially over the past few decades; however, many patients eventually develop drug resistance. Physicians strive to overcome resistance by either trying to target cancer cells through an alternative approach or targeting the resistance mechanism itself, but success with ...

Oncotarget recently published "Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors" by Mortensen, et al. which reported that there is a growing interest in the antibody-based delivery of cytokines to the tumor environment as a means to boost the anti-cancer activity of tumor-resident T cells and NK cells. Here, the authors described the expression and characterization of fusion proteins, featuring the L19 antibody and an engineered cytokine with interleukin-2 and interleukin-15 ...

Oncotarget recently published "AKT isoforms have discrete expression in triple negative breast cancers and roles in cisplatin sensitivity" which reported that the authors investigated the expression and net effect of the individual isoforms in triple negative breast cancers and response to cisplatin treatment using cellular, mice models and clinical samples. Interestingly, analysis of the expressions of AKT isoforms in clinical samples showed relatively higher expression of AKT1 in primary tissues; whereas lung and liver metastatic samples showed elevated ...

Coffee, cola or an energy drink: caffeine is the world's most widely consumed psychoactive substance. Researchers from the University of Basel have now shown in a study that regular caffeine intake can change the gray matter of the brain. However, the effect appears to be temporary. No question - caffeine helps most of us to feel more alert. However, it can disrupt our sleep if consumed in the evening. Sleep deprivation can in turn affect the gray matter of the brain, as previous studies have shown. So can regular caffeine consumption affect brain structure due to poor sleep? A research team led by Dr. Carolin Reichert and Professor Christian Cajochen of the University of Basel ...

Here is a link to watch a video interview with Dr. Beatrice Aramini about this topic on the Oncotarget YouTube Channel Oncotarget published "Cancer stem cells and macrophages: molecular connections and future perspectives against cancer" which reported that Cancer stem cells have been considered the key drivers of cancer initiation and progression due to their unlimited self-renewal capacity and their ability to induce tumor formation. Macrophages, particularly tumor-associated macrophages, establish a tumor microenvironment to protect and induce CSCs development and dissemination. Many studies in the past decade have been performed to understand the molecular ...

For the first time, physicists from the University of Basel have produced a graphene compound consisting of carbon atoms and a small number of nitrogen atoms in a regular grid of hexagons and triangles. This honeycomb-structured "kagome lattice" behaves as a semiconductor and may also have unusual electrical properties. In the future, it could potentially be used in electronic sensors or quantum computers. Researchers around the world are searching for new synthetic materials with special properties such as superconductivity -- that is, the conduction of electric current without resistance. These new substances are an important step in the development ...

Climate change is rapid in the Arctic. As the climate warms, shrubs expand towards higher latitudes and altitudes. Researcher Julia Kemppinen together with her colleagues investigated the impacts of dwarf shrubs on tundra soils in the sub-Arctic Fennoscandia. The study revealed that the dominance of dwarf shrubs impacts soil microclimate and carbon stocks. Microclimate describes the moisture and temperature conditions close to ground surface. Shrubs are the largest plant life form in the Arctic, and in comparison, to other arctic plants, shrubs use more water and cast more shade. "The results indicate ...

WASHINGTON -- When people pause before replying to a question, even for just a few seconds, their answers are perceived to be less sincere and credible than if they had replied immediately, according to research published by the American Psychological Association. And the longer the hesitation, the less sincere the response appears. "Evaluating other people's sincerity is a ubiquitous and important part of social interactions," said lead author Ignazio Ziano, PhD, of Grenoble Ecole de Management. "Our research shows that response speed is an important cue on which people base their sincerity inferences." The research was published in the Journal of Personality and Social Psychology. Researchers ...

Cancer is one of the most thought-provoking healthcare problems throughout the world. The development of therapeutic agents with highly selective anti-cancer activities is increasingly attractive due to the lack of tumor selectivity of conventional treatments. Scientists at Japan Advanced Institute of Science and Technology (JAIST) have created a photosynthetic bacteria-based cancer optotheranostics (Figure 1). Discovered by Associate Professor Eijiro Miyako and his team from JAIST, natural purple photosynthetic bacteria (PPSB) can play a key role as a highly active cancer immunotheranostics agent that uses the bio-optical-window I and II near-infrared (NIR) light thanks to the light harvesting nanocomplexes in microbial ...

There is no coat colour that distinguishes dingoes from dingo-dog hybrids, a study involving UNSW Sydney has found. The Centre for Ecosystem Science research suggests that animals assumed to be dingo-dog hybrids based on their coat colour and culled may have been pure dingoes. "We actually found pure dingoes that had a brindle, black and tan, patchy or sable coat colour," Dr Kylie Cairns, a conservation biologist from UNSW Sydney and co-author of the study said. "So that's showing that really dingoes are much more variable than we think and seeing an animal with an odd coat colour doesn't immediately mean that it's a hybrid. "Using coat colour to decide what animals should be culled is not a very good idea." The study follows 2019 research by UNSW and collaborators which found ...

San Antonio, Texas (February 15, 2020) - Researchers at the Southwest National Primate Research Center (SNPRC) at Texas Biomedical Research Institute (Texas Biomed) may have found a new pathway to treat and control tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb). Using single-cell RNA sequencing (scRNAseq), a next-generation sequencing technology, scientists were able to further define the mechanisms that lead to TB infection and latency. Co-led by Deepak Kaushal, Ph.D., Director of the SNPRC, this is the first study that used scRNAseq to study TB in macaques in depth. Results from the study were published ...

Scientists of Kemerovo State University, within the framework of the Russian Scientific Foundation grant "Cultivation of isolated cells and organs of rare and endemic medicinal plants of Siberia and the Far East in vitro as a biotechnological method for obtaining biologically active substances", are investigating the fundamental principles of in vitro cultivation of isolated cells and organs of rare medicinal plants - producers of biologically active substances with cytotoxic, antioxidant and antimicrobial properties. One of the urgent problems of medicine and biology is the search and use of plant objects as medicines. The unfavorable environmental situation and the increasing need for medicinal raw materials create its shortage. A new solution ...

In our ongoing struggle to reduce the usage of fossil fuel, technology to directly convert the world's waste heat into electricity stands out as very promising. Thermoelectric materials, which carry out this energy conversion process, have, thus, recently become the focus of intense research worldwide. Of the various potential candidates applicable at a broad range of temperatures, between 30 and 630 °C, lead telluride (PbTe) offers the best thermoelectric performance. Unfortunately, the outstanding qualities of PbTe are eclipsed by the toxic nature of lead, driving researchers to look into safer thermoelectric semiconductors. Tin telluride (SnTe) could be an ...

Ben-Gurion University Researchers Uncover a Catch-22 When It Comes to Social Media Online Support Groups and Privacy Concerns BEER-SHEVA, Israel...February 16, 2021- People who seek support online social media groups may end up not getting the help they need due to privacy concerns, according to a new study by Ben-Gurion University of the Negev (BGU) and Gutenberg University in Sweden. The new research, published in END ...