The processes in living beings follow a finely orchestrated choreography down to the molecular level. Rhythmic processes are found everywhere in biology, for example, the 24-hour circadian cycle, a kind of "internal clock", plays an important role in regulating many processes in living cells, including metabolism and cell division mechanisms. Scientists from Saarbrücken and Kaiserslautern have now taken a closer look at a similar cycle, the somewhat shorter ultradian cycle of baker's yeast. Under the leadership of Bruce Morgan, Professor of Biochemistry at ...

Combining healthy lifestyle interventions reduces heart disease through beneficial effects on different lipoproteins and associated cholesterols, according to a study published February 9 in eLife. Having a healthy lifestyle has long been associated with a lower risk of developing heart disease. The new study provides more detailed information on how healthy lifestyles improve cholesterol, and suggests that combining cholesterol-lowering medications and lifestyle interventions may yield the greatest benefits to heart health. Cholesterol-lowering ...

The fact that cells are motile and come into contact with each other is one of biology's fundamental principles. During embryonic development, cells must communicate with their neighbors in order to find their proper place in the differentiating organism. Wound healing is another process in which direct intercellular interactions are essential. In this context, motility enables cells to migrate to the location of the lesion and regenerate lost structures. Cancer cells also make use of this property to leave their site of origin in the primary tumor, which allows them to initiate the formation of metastatic tumors in other tissues. "In recent years, biologists ...

An international study has shown, for the first time, that the capacity of the human brain to recover and rewire itself peaks around two weeks after a stroke and diminishes over time. The finding, published today in the Neurorehabilitation and Neural Repair journal, is the result of a study in London and Adelaide that followed the recovery of 60 stroke patients up to one year after their stroke. Lead author Dr Brenton Hordacre, from the University of South Australia, says the multi-site study showed conclusive evidence that the brain only has a small window of opportunity to more easily repair itself after stroke. "Earlier animal studies suggested ...

Icebergs are melting faster than current models describe, according to a new study by mathematicians at the University of Sydney. The researchers have proposed a new model to more accurately represent the melt speed of icebergs into oceans. Their results, published in Physical Review Fluids, have implications for oceanographers and climate scientists. Lead author and PhD student Eric Hester said: "While icebergs are only one part of the global climate system, our improved model provides us with a dial that we can tune to better capture the reality of Earth's changing climate." Current models, which are incorporated into the methodology used by the Intergovernmental Panel on Climate Change, ...

Over the past years, global data traffic has experienced a boom, with over 12.5 billion connected devices all over the world. The current world-wide deployment of the 5G telecommunications standard is triggering the need for smaller devices with enhanced performances, such as higher speed, lower power consumption and reduced cost as well as easier manufacturability. In search for the appropriate technology, photonic devices emerged as the leading technology for the evolution of such information and communication technologies, already surpassing ...

ADELPHI, Md. -- The Army of the future will involve humans and autonomous machines working together to accomplish the mission. According to Army researchers, this vision will only succeed if artificial intelligence is perceived to be ethical. Researchers, based at the U.S. Army Combat Capabilities Development Command, now known as DEVCOM, Army Research Laboratory, Northeastern University and the University of Southern California, expanded existing research to cover moral dilemmas and decision making that has not been pursued elsewhere. This research, featured in Frontiers in Robotics and AI, tackles the fundamental challenge of developing ethical artificial intelligence, ...

The human condition is riddled with extreme events, which bring chaos into our lives. Natural disasters leave a trail of destruction, causing direct and horrible pain and suffering - costing lives, creating injuries, destroying houses, livelihoods, crops and broken infrastructures. While extensive research has been conducted on the economic and public healthcare costs of these types of disasters around the world, their effect does not end there. A team of researchers from the Hebrew University of Jerusalem sought to better understand the behavioral and social implications ...

Psychotherapy for panic disorder produces good results, and the effects are lasting. That is the result from a large long-term study from Lund University in Sweden. Two years after treatment were 70 per cent of the patients clearly improved and 45 per cent were remitted. Panic disorder is one of the most common causes of mental illness in Sweden and worldwide. Approximately 2 per cent have panic disorder. When untreated, the condition is associated with emotional distress and social isolation. Panic attacks often debut in adolescence or early adulthood and many of those affected ...

We live in modern times, that is full of electronics. Smartphones, laptops, tablets, and many other devices need electrical energy to operate. Portable devices made our lives easier, so novel solutions in clean energy and its storage are desirable. Lithium-ion (Li-ion) batteries are the most common solutions that dominate the global market and are a huge problem due to their insufficient recovery. Because of their limited power, short cycle life, and non-environment-friendly nature, scientists recently focused on novel solutions like supercapacitors that offer much more than batteries. Why? Let's take a look closer at these devices. Supercapacitors bring together the properties of a standard capacitor and the Li-ion battery. In practice, ...

Following the civil war outbreak in Syria nearly ten years ago, Israel began admitting wounded Syrians into the country for humanitarian medical treatment. In accordance with the Israeli government's decision, the Israel Defense Forces, medical corps, health care system and hospitals in the north of the country joined together to provide medical treatment to thousands of wounded Syrians. The logistics of evacuating the injured from the battlefield and transferring them to Israeli territory was often prolonged due to the fact that Israel and Syria are defined as enemy countries. Most of the wounded were brought to the Galilee ...

Biophysicists at Ludwig-Maximilians-Universitaet (LMU) in Munch have developed a new theory, which accounts for the observation that cells can perceive their own shapes, and use this information to direct the distribution of proteins inside the cell. Many cellular processes are critically dependent on the precise distribution and patterning of proteins on the cell membrane. Diverse studies have shown that, in addition to protein-protein interactions and transport processes, cell shape can also have a considerable impact on intracellular pattern formation. Conversely, there are patterning processes in which any dependence on cell form would be deleterious. Using starfish oocytes as a model system, LMU physicists led by Professor Erwin ...

In shallow water, less than 30 metres, the survival of hard corals depends on photosynthetic unicellular algae (zooxanthellae) living in their tissues. But how does the coral adapt at depth when the light disappears? French researchers from the CNRS, EPHE-PSL and their international collaborators, associated with Under the Pole (Expedition III), have studied for the first time the distribution of these so-called mesophotic corals in the French Polynesian archipelago, from the surface to 120 metres deep (with a record descent of 172 metres). As the amount of light decreases, the coral associates ...

DARIEN, IL - A new study found that treating obstructive sleep apnea with CPAP therapy increased self-reported physical activity in adults with a history of heart disease. During a mean follow-up period of 3.7 years, the group treated with CPAP therapy reported approximately 20% higher levels of moderate physical activity compared with the control group. The study also found the CPAP group was more likely to report activity levels consistent with expert recommendations. "We were pleased to find that our CPAP users reported that they were better able to maintain their levels of activity over the four years of the study, and that they reported fewer limitations in moderate and vigorous activities including those that are important for independent aging, like walking up the stairs," ...

The researchers used a biophysical method called thermal proteome profiling (TPP) to gain a comprehensive overview of which human proteins are functionally altered during SARS-CoV-2 infection. TPP monitors protein amounts and denaturation temperatures - the points at which proteins heat up so much that they lose their 3D structure. A shift in denaturation temperature indicates that a particular protein has undergone a functional change upon infection, possibly due to the virus hijacking the protein for use in its own replication. The scientists observed that infection with SARS-CoV-2 changed the abundance and thermal stability of hundreds of cellular proteins. This included ...

Psycholinguists from the HSE Centre for Language and Brain found that when reading, people are not only able to predict specific words, but also words' grammatical properties, which helps them to read faster. Researchers have also discovered that predictability of words and grammatical features can be successfully modelled with the use of neural networks. The study was published in the journal PLOS ONE. The ability to predict the next word in another person's speech or in reading has been described by many psycho- and neurolinguistic studies over the last 40 years. It is assumed that this ability allows us to process the information faster. Some recent publications on the English language have demonstrated evidence that while reading, people can ...

Canadian researchers are the first to study how different patterns in the way older adults walk could more accurately diagnose different types of dementia and identify Alzheimer's disease. A new study by a Canadian research team, led by London researchers from Lawson Health Research Institute and Western University, evaluated the walking patterns and brain function of 500 participants currently enrolled in clinical trials. Their findings are published today in Alzheimer's & Dementia: The Journal of the Alzheimer's Association. "We have longstanding evidence showing that cognitive problems, such as poor memory and executive dysfunction, can ...

Nature has its way of maintaining balance. This statement rightly holds true for plants that are eaten by herbivores--insects or even mammals. Interestingly, these plants do not just silently allow themselves to be consumed and destroyed; in fact, they have evolved a defense system to warn them of predator attacks and potentially even ward them off. The defense systems arise as a result of inner and outer cellular signaling in the plants, as well as ecological cues. Plants have developed several ways of sensing damage; a lot of these involve the sensing of various "elicitor" molecules produced by either the predator ...

It is almost ten years since the scientific journal Science called optogenetics the "breakthrough of the decade". Put simply, the technique makes it possible to control the electrical activity of cells with pulses of light. With its help, scientists can gain new insights into the functioning of nerve cells, for example, and thus better understand neurological and psychiatric diseases such as depression and schizophrenia. Established procedure on animal cells In research on animal cells, optogenetics is now an established technique used in many fields. The picture is different in plant research: transferring the principle to plant cells and applying it widely has not been possible until now. However, this has now changed: Scientists ...

Individual variation in the shape and structure of the Achilles tendon may influence our susceptibility to injury later in life, says a study published today in eLife. The findings suggest that studying individual Achilles tendon shape (or 'morphology') could help with identifying patients at risk of injury and designing new, potentially personalised approaches for treating and preventing Achilles tendinopathy and similar conditions. The Achilles tendon is the tissue that links the calf muscles to the heel bone. It is fundamental to our movement and athletic ability. Its unique structure, which combines three smaller sub-tendons, increases the efficiency of our movement by allowing individual control from connected muscles. For this control to occur, the ...

A drug that helps us to eat less could help the more than 650 million people around the world who live with obesity. One of the emerging drug candidates that interest researchers is the hormone GDF15 that, when given to rodents, lowers their appetite and body weight. New research from the University of Copenhagen finds that the body produces large amounts GDF15 during extended bouts of vigorous exercise, presumably as a physiological stress signal. This finding highlights central differences between GDF15 given as a drug (pharmacology), and GDF15 released naturally in response to vigorous exercise (physiology). This is an important distinction ...

From 2015 to 2019, public school districts in the United States invested nearly $5 billion to upgrade their Wi-Fi networks, according to EducationSuperHighway. However, in the age of COVID-19-mandated virtual learning, millions of K-12 students still lack the minimal connectivity at home for digital learning. In a new study from the University of Notre Dame, researchers quantify how school district connectivity increases test scores, but underscore the dark side of technology -- increased behavior problems. A $600,000 increase in annual internet access spending produces a financial gain of approximately $820,000 to $1.8 million, alongside losses from disciplinary problems totaling $25,800 to $53,440, according to new research from Yixing Chen, an ...

Researchers at the University of Chicago, the University of Birmingham, and Bournemouth University have uncovered evidence that physical embodiment can occur without the sense of touch, thanks to a study involving two participants who lack the ability to feel touch. The research was published on Feb. 12 in END ...

Coral reefs have thrived for millions of years in their shallow ocean water environments due to their unique partnerships with the algae that live in their tissues. Corals provide a safe haven and carbon dioxide while their algal symbionts provide them with food and oxygen produced from photosynthesis. Using the corals Orbicella annularis and Orbicella faveolate in the southern Caribbean, researchers at the Carl R. Woese Institute for Genomic Biology (IGB) have improved our ability to visualize and track these symbiotic interactions in the face of globally warming sea surface temperatures and ...

In coming decades as coastal communities around the world are expected to encounter sea-level rise, the general expectation has been that people's migration toward the coast will slow or reverse in many places. However, new research co-authored by Princeton University shows that migration to the coast could actually accelerate in some places despite sea-level change, contradicting current assumptions. The research, published in Environmental Research Letters, uses a more complex behavioral decision-making model to look at Bangladesh, whose coastal zone is at high risk. They found job opportunities are most abundant in coastal cities across Bangladesh, attracting more ...