Our bodies often dispatch stem cells to mend or replace biological damage, but how these repair agents make their way through dense tissue to arrive at the scene had been a mystery. "How stem cells squeeze through tissue openings a hundred to a thousand times smaller than themselves had been a perplexing question," says Ovijit Chaudhuri, professor of mechanical engineering. In an article published in the Jan. 8 edition of Science Advances, Chaudhuri and colleagues reveal that stem cells use their nucleus - a large, stiff organelle within the cell - as a means of propulsion. Their discovery was surprising because scientists had thought cells would have particular ...

(St. Louis) - A new study by investigators at the Shriners Hospital for Children -- St. Louis suggests the damaging effects of obesity are not due to body weight but rather come from something much smaller - biochemical signals released by fat cells. The study focuses on the link between overweight or obesity and the development of osteoarthritis, a painful disease of the joints. The investigation was led by Dr. Farshid Guilak, director of the St. Louis Shriners Hospital Research Center. "We've shown here that it's not overloading of the joints that is responsible for osteoarthritis, but, more likely, a factor given off by fat cells that makes cartilage susceptible to degeneration," ...

ATLANTA AND TAMPA, FLA. - JANUARY 11, 2021 - A new study suggests a link between toxoplasma gondii (T. gondii) infection and the risk of glioma, a type of brain cancer, in adults. The report, appearing in the International Journal of Cancer, finds that people who have glioma are more likely to have antibodies to T. gondii (indicating that they have had a previous infection) than a similar group that was cancer free. For the study, investigators led by James Hodge, JD, MPH and Anna Coghill, PhD examined the association between T. gondii antibodies measured several years before the cancer ...

Scientists at Dana-Farber Cancer Institute and the Centers for Disease Control and Prevention have uncovered new evidence of the potential health risks of chemicals in tobacco and marijuana smoke. In a study published online today by END ...

Around 1085 AD, along the southern rim of Northern Arizona's elevated Colorado Plateau, a volcano erupted, forever changing ancient Puebloan fortunes and all nearby life. Among the 600 or so volcanoes that dot the landscape of the San Francisco volcanic fields, this one blew. It was the very first (and last) eruption for what came to be known as Sunset Crater, aptly named for its multi-hued, 1,000-foot-tall cinder cone. Today, ASU School of Earth and Space Exploration scientist Amanda Clarke and her team have been working to solve the mysterious root cause of the Sunset Crater eruption and any lessons learned to better understand the threats similar ...

Fieldwork led by Dr Eleanor Scerri, head of the Pan-African Evolution Research Group at the Max Planck Institute for the Science of Human History in Germany and Dr Khady Niang of the University of Cheikh Anta Diop in Senegal, has documented the youngest known occurrence of the Middle Stone Age. This repertoire of stone flaking methods and the resulting tools includes distinctive ways of producing sharp flakes by carefully preparing nodules of rock, some of which were sometimes further shaped into tool forms known as 'scrapers' and 'points.' Middle Stone Age finds most commonly occur in the African record between around 300 thousand and 30 thousand years ago, after which point ...

Researchers have taken an important step forward in developing a controlled human infection model to test leishmaniasis vaccines. The University of York-led study identified and characterised a new strain of Leishmania parasite that will form the basis of a new controlled human infection model for the disease which is transmitted by the bite of sand flies. The team then produced the parasite to the standards required for use in human clinical studies. The use of controlled human infection models has already proved invaluable in accelerating vaccine development for cholera, malaria, typhoid, ...

Conditions are ripe for transforming the U.S. mental health care system, with scientific advances, the growth of Medicaid and political consensus on the importance of improving mental health creating the possibility that goals once thought out of reach may be possible, according to a new RAND Corporation study. Broad changes will be needed to improve how Americans receive mental health care, such as integrating behavioral health care into general health care settings, providing supportive housing to the homeless and promoting comprehensive mental health education. Federal mental health parity legislation is one recent promising development that aims to put ...

Human papillomavirus (HPV) can infect the mouth and throat to cause cancers of the oropharynx. A new study published early online in END ...

Canada must dismantle anti-Black racism in health care to address its harmful effects on people's health, argue authors of a commentary in CMAJ (Canadian Medical Association Journal) http://www.cmaj.ca/lookup/doi/10.1503/cmaj.201579 Racism has significant negative effects on the physical and mental health of Black people and people of nondominant racial groups. For example, there have been significantly higher death rates from COVID-19 among Black people in North America and the United Kingdom. Anti-Black racism also exists in the medical system, with stereotyping and bias by health care providers and an underrepresentation of Black physicians. "First, we who work in health care must acknowledge the existence of anti-Black racism in ...

An analysis of a large nationally representative longitudinal study by University of California San Diego Herbert Wertheim School of Public Health and Human Longevity Science report that starting tobacco products, including e-cigarettes, before the age of 18 is a major risk factor for people becoming daily cigarette smokers. Reporting in the January 11, 2021 online edition of Pediatrics, researchers found that in 2014 people age 12 to 24 who used e-cigarettes were three times as likely to become daily cigarette smokers in the future. Among those who reported using a tobacco product, daily use increased with age through age 28. Daily cigarette smoking nearly doubled between 18 to 21 year olds (12 percent) and 25 to 28 year ...

Marijuana use increases throughout the calendar year, with use up 13 percent on average at the end of each year (2015-2019) compared to the beginning, according to a new study published in the journal Drug and Alcohol Dependence. "We found that marijuana use is consistently higher among those surveyed later in the year, peaking during late fall or early winter before dropping at the beginning of the following year. We think this may be due, in part, to a 'Dry January' in which some people stop drinking alcohol or even stop using marijuana as part of a New Year's ...

The gut plays a central role in the regulation of the body's metabolism and its dysfunction is associated with a variety of diseases, such as obesity, diabetes, colitis and colorectal cancer that affect millions of people worldwide. Targeting endocrine dysfunction at an early stage by stimulating the formation of specific enteroendocrine cells from intestinal stem cells could be a promising regenerative approach for diabetes therapy. For this, however, a detailed understanding of the intestinal stem cell lineage hierarchy and the signals regulating the recruitment of the different intestinal cell types is critical. Heiko Lickert ...

How the larvae of colorful clownfish that live among coral reefs in the Philippines are dispersed varies widely, depending on the year and seasons - a Rutgers-led finding that could help scientists improve conservation of species. Right after most coral reef fish hatch, they join a swirling sea of plankton as tiny, transparent larvae. Then currents, winds and waves disperse them, frequently to different reefs. During seven years of surveys of coral reef-dwelling clownfish, scientists measured how the dispersal of larvae varied over the years and seasonally, including during monsoons, according Rutgers-led research in the journal Molecular Ecology. They found that larvae dispersal varied a lot on both timescales. Their research suggests that when scientists ...

A new study shows that the gigantic Megalodon or megatooth shark, which lived nearly worldwide roughly 15-3.6 million years ago and reached at least 50 feet (15 meters) in length, gave birth to babies larger than most adult humans. This latest research shedding light on the reproductive biology, growth and life expectancy of Megalodon (formally called Otodus megalodon) appears in the international journal Historical Biology. Although Otodus megalodon is typically portrayed as a super-sized, monstrous shark in novels and films such as the 2018 sci-fi film "The Meg," scientific data support a more modest but still impressive estimate of about 50 feet (15 meters) for the presently known largest individuals. The ...

Positive "tipping points" could spark cascading changes that accelerate action on climate change, experts say. A tipping point is a moment when a small change triggers a large, often irreversible, response. Professor Tim Lenton, Director of the Global Systems Institute (GSI) at the University of Exeter, has previously warned the world is "dangerously close" to several tipping points that could accelerate climate change. But in a new paper in the journal Climate Policy, Professor Lenton and Simon Sharpe, a Deputy Director in the UK Cabinet Office COP 26 unit, identify tipping points in human societies that could rapidly ...

Tokyo, Japan - Researchers from Tokyo Metropolitan University mixed and designed a new, high entropy alloy (HEA) superconductor, using extensive data on simple superconducting substances with a specific crystal structure. HEAs are known to preserve superconducting characteristics up to extremely high pressures. The new superconductor, Co0.2Ni0.1Cu0.1Rh0.3Ir0.3Zr2, has a superconducting transition at 8K, a relatively high temperature for an HEA. The team's approach may be applied to discovering new superconducting materials with specific desirable properties. It's been over a hundred years since the discovery of superconductivity, where certain materials were found to suddenly show minimal resistance to electrical currents below a transition temperature. As we explore ...

A new risk-stratification tool which can accurately predict the likelihood of deterioration in adults hospitalised with COVID-19 has been developed by researchers from the UK Coronavirus Clinical Characterisation Consortium (known as ISARIC4C). Researchers say the online tool, made freely available to NHS doctors from today (Friday 8 January 2021), could support clinicians' decision making - helping to improve patient outcomes and ultimately save lives. The tool assesses 11 measurements* routinely collected from patients, including age, gender, and physical measurements (such as oxygen levels) along with some standard laboratory tests and calculates a percentage risk ...

Study of 1,733 patients first diagnosed in Wuhan (China) between January and May followed to June and September. 76% of COVID-19 patients have at least one symptom six months after symptom onset. Fatigue or muscle weakness is the most common symptom, with sleep difficulties and anxiety or depression also frequently reported. Lower antibodies against COVID-19 in patients six months after becoming ill compared with during acute infection raises concerns about the possibility of re-infection. More than three quarters of COVID-19 patients have at least one ongoing symptom six months after initially becoming unwell, according to research published in The Lancet. The cohort study, looking at long-term effects of COVID-19 infection on people hospitalised ...

COVID-19 patients admitted to intensive care in the early months of the pandemic were subject to a significantly higher burden of delirium and coma than is typically found in patients with acute respiratory failure. Choice of sedative medications and curbs on family visitation played a role in increasing acute brain dysfunction for these patients. That's according to an international study published Jan. 8 in The Lancet Respiratory Medicine, led by researchers at Vanderbilt University Medical Center in coordination with researchers in Spain. The study, which is far the largest of its kind to date, tracks the incidence of delirium and coma in 2,088 COVID-19 patients admitted before April 28, 2020, to 69 adult intensive care units across 14 countries. ICU delirium is ...

Hundreds of cancer patients have benefitted from using computer algorithms to manage their symptoms and improve their wellbeing in a unique UK trial. The early stage colorectal, breast or gynecological cancer patients took part in the trial of the eRAPID system, developed by the University of Leeds, which allowed them to report online symptoms from home and receive instant advice on whether to self-manage or seek medical attention. Patients reported better symptom control and physical wellbeing in the early weeks of treatment, with the system preventing symptom deterioration in about 9% of patients after 12 weeks. Patients reported more confidence in managing ...

A year ago, trying to find patients who would agree to see their University of Michigan mental health provider through a video screen felt like pulling teeth. Only 26 video visits with a few early-adopters had happened in nearly six months, compared with more than 30,000 in-person visits. But Jennifer Severe, M.D., one of the three psychiatrists who helped launch a test of telehealth initiatives in the U-M's outpatient psychiatry clinic, wasn't about to give up. She prepared to give a talk at the beginning of April of 2020, hoping to convince more of her colleagues to give telepsychiatry a try, now that a major insurance ...

Eating a healthy diet, such as the Mediterranean diet, has a positive impact on health, but little is known about the effects of including unhealthy foods in an otherwise healthy diet. Now researchers at Rush University Medical Center have reported diminished benefits of a Mediterranean diet among those with high frequency of eating unhealthy foods. The results of their study were published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association on Jan. 7. "Eating a diet that emphasizes vegetables, fruit, fish and whole grains may positively affects a person's health," said Puja Agarwal, PhD, a nutritional epidemiologist and assistant professor in the Department of Internal Medicine at Rush Medical College. "But when it is combined with fried food, ...

In a technique known as DNA origami, researchers fold long strands of DNA over and over again to construct a variety of tiny 3D structures, including miniature biosensors and drug-delivery containers. Pioneered at the California Institute of Technology in 2006, DNA origami has attracted hundreds of new researchers over the past decade, eager to build receptacles and sensors that could detect and treat disease in the human body, assess the environmental impact of pollutants, and assist in a host of other biological applications. Although the principles of DNA origami are straightforward, the technique's tools and methods for designing new structures are not always easy to grasp and have not been well documented. In addition, scientists new to the method have had no single reference they ...

Canada is at the forefront of global efforts to end child marriage abroad. Yet this practice remains legal and persists across the country. In Canada, more than 3,600 marriage certificates were issued to children, usually girls, under the age of 18 between 2000 and 2018, according to a new study from researchers at McGill University. In recent years, an increasing number of child marriages have been common-law unions. Child marriage, defined as formal or informal (common-law) marriage before the age of 18, is a globally-recognized indicator of gender inequality because the negative consequences for ...