The rapid spread of SARS-CoV2 (COVID-19) has not only left societies with a high number of excess deaths and a wide range of health consequences, but also taken a heavy toll on wider global economies - impacting other sectors outside health. Future analysis must take into account societal impacts of a wide range of responses to COVID-19, if policymakers are to take better decisions about resource allocation, intervention implementation and boosting economic and social recovery. In practice, many health economic evaluations tend to adopt a narrow study perspective predominantly estimating the economic impact around healthcare costs. They fail ...

Digital COVID-19 'symptom checkers' may stop some patients from getting prompt treatment for serious illness, suggests an international case simulation study, published in the online journal BMJ Health & Care Informatics. Both the US and UK symptom checkers consistently failed to identify the symptoms of severe COVID-19, bacterial pneumonia, and sepsis, frequently advising these cases to stay home, the findings indicate. The availability and use of symptom checkers is on the rise, and they are currently being used at a national level to pick up COVID-19 infection. Identifying which patients with COVID-19 require treatment is difficult, because the infection can mimic common conditions ...

PHILADELPHIA--Even before the COVID-19 pandemic, mental health issues have been on the rise across the nation, but many struggle to access the care they need. Collaborative care--a proven approach for improving psychiatric care--combats this issue by integrating mental health professionals into the primary care setting. Penn Medicine's collaborative care program, Penn Integrated Care (PIC), utilizes a centralized resource center to facilitate intake, triage, and referral management for all patients with mental health needs. A new study, published today in the Annals of Family Medicine, suggests ...

Juvenile white-tailed deer that strike out to find new home ranges -- despite facing more risks -- survive at about the same rate as those that stay home, according to a team of researchers who conducted the first mortality study of male and female dispersal where deer were exposed to threats such as hunting throughout their entire range. Dispersal occurs when a juvenile leaves the area where it was born and moves to a new location where the young animal establishes its adult home range, explained Duane Diefenbach, Penn State adjunct professor of wildlife ecology. The instinctual dispersal of young deer from the area where they were born to a new home range protects the species' gene pool from inbreeding with close relatives. Diefenbach's ...

Researchers have identified a critical mechanism that allows deadly bacteria to gain resistance to antibiotics. The findings offer a potential new drug target in the search for effective new antibiotics as we face the growing threat of antimicrobial resistance (AMR) and infections caused by bacterial pathogens. The study investigated quinolone antibiotics which are used to treat a range of bacterial infections, including TB (tuberculosis). Quinolones work by inhibiting bacterial enzymes, gyrase and topoisomerase IV, thereby preventing DNA replication and RNA synthesis essential to growth. They are ...

Spectacular fossil plants preserved within a volcanic ash fall in China have shed light on an evolutionary race 300 million years ago, which was eventually won by the seed-bearing plants that dominate so much of the Earth today. New research into fossils found at the 'Pompeii of prehistoric plants', in Wuda, Inner Mongolia, reveals that the plants, called Noeggerathiales, were highly-evolved members of the lineage from which came seed plants. Noeggerathiales were important peat-forming plants that lived around 325 to 251 million years ago. Understanding their relationships to other plant groups ...

TROY, N.Y. -- Using a nanopore, researchers have demonstrated the potential to reduce the time required for sequencing a glycosaminoglycan -- a class of long chain-linked sugar molecules as important to our biology as DNA -- from years to minutes. As published this week in the Proceedings of the National Academies of Sciences, a team from Rensselaer Polytechnic Institute showed that machine-learning and image recognition software could be used to quickly and accurately identify sugar chains -- specifically, four synthetic heparan sulfates -- based on the electrical signals generated as they passed through a tiny hole in a crystal wafer. "Glycosaminoglycans are a complex repertoire of sequences, ...

An international team of scientists have explained how legume trees are key in liberating minerals locked in iron minerals and the benefits are passed on to nearby trees The research shows that the trees are able to alter their soils microbiome in a way that increases access to nutrients and supports growth The findings provide new insight into the role of these trees in safeguarding the function of tropical forests and sustainable reforestation Researchers have found that nitrogen-fixing legume trees can support themselves and surrounding trees not only with increased access to nitrogen, but with other key nutrients through enhanced mineral weathering. The team, led by the University ...

In the United States, one in 10 babies are born too soon, resulting in complications that can affect their locomotor development and influence such simple tasks as balance, walking and standing later in life. A new peer-reviewed study by Children's National Hospital, published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS), explores exactly what neural circuitry of the cerebellum is affected due to complications that occur around the time of birth causing these learning deficits, and finds a specific type of neurons -- Purkinje cells -- to play a central role. Up until now, there has been a sparsity of techniques available to measure neuronal ...

American adults without a college degree have experienced greater reductions in life expectancy when compared to their more-educated counterparts, USC and Princeton researchers have found. The study reveals that after nearly a century of declining mortality up to the late 1990s, the progress continued into the 21st century for more-educated Americans but stalled for the population as a whole and reversed for the two-thirds of Americans who do not have a college degree. The study appeared Monday in the Proceedings of the National Academy of Sciences. The ...

Malaria is the deadliest pathogen in human history. Nearly half the people on Earth are at risk of contracting the disease from the parasites that cause it. But humans aren't the only ones who can get these parasites--different forms are found in other animals, including birds. By studying the DNA of those strains, scientists can get a better picture of how malarial parasites live, which may give clues on how to stop the disease. In a new paper in PNAS, researchers analyzed blood samples of more than 1,000 species of birds from the Andes looking for malaria; they found that the strains of malaria present in a local area don't always neatly align with the types of birds living there. "Traditionally, we thought that there's ...

(Boston)--Despite the positive advances that anti-human immunodeficiency virus (HIV) therapy, commonly called anti-retroviral therapy (ART) or highly active antiretroviral therapy (HAART), has had on the life expectancy of HIV-positive people, finding a cure for HIV or acquired immunodeficiency syndrome (AIDS) has remained elusive. "One of the major challenges in curing HIV is that there is a persistent latent reservoir of virus that is not targeted by current antiretroviral treatments and is hidden from immune cells. When treatment is interrupted, this reservoir of the virus allows the HIV ...

Here is a link to a free Altmetric Report on this Research Output Aging-US published "Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial" which reported that the aim of the current study was to evaluate whether hyperbaric oxygen therapy (HBOT) affects telomere length (TL) and senescent cell concentrations in a normal, non-pathological, aging adult population. Thirty-five healthy independently living adults, aged 64 and older, were enrolled to receive 60 daily HBOT exposures. Whole blood samples were collected at baseline, at the 30th and 60th session, and 1-2 weeks following the last HBOT session. Telomeres length of T helper, T cytotoxic, natural killer and ...

CHAMPAIGN, Ill. -- Tiny fluorescent semiconductor dots, called quantum dots, are useful in a variety of health and electronic technologies but are made of toxic, expensive metals. Nontoxic and economic carbon-based dots are easy to produce, but they emit less light. A new study that uses ultrafast nanometric imaging found good and bad emitters among populations of carbon dots. This observation suggests that by selecting only super-emitters, carbon nanodots can be purified to replace toxic metal quantum dots in many applications, the researchers said. The findings, published in the Proceedings of the National Academy of Sciences, ...

About one billion people worldwide are at risk for schistosomiasis -- a debilitating disease caused by parasitic worms that live in fresh water and in intermediate snail hosts. A new study finds that the transmission risk for schistosomiasis peaks when water warms to 21.7 degrees centigrade, and that the most effective interventions should include snail removal measures implemented when the temperature is below that risk threshold. The Proceedings of the National Academy of Sciences published the results, led by Emory University, the University of South Florida and the ...

When it comes to microelectronics, there is one chemical element like no other: silicon, the workhorse of the transistor technology that drives our information society. The countless electronic devices we use in everyday life are a testament to how today very high volumes of silicon-based components can be produced at very low cost. It seems natural, then, to use silicon also in other areas where the properties of semiconductors -- as silicon is one -- are exploited technologically, and to explore ways to integrate different functionalities. Of particular interest in this ...

Determining how rapidly the universe is expanding is key to understanding our cosmic fate, but with more precise data has come a conundrum: Estimates based on measurements within our local universe don't agree with extrapolations from the era shortly after the Big Bang 13.8 billion years ago. A new estimate of the local expansion rate -- the Hubble constant, or H0 (H-naught) -- reinforces that discrepancy. Using a relatively new and potentially more precise technique for measuring cosmic distances, which employs the average stellar brightness within giant elliptical galaxies as a rung on the distance ladder, astronomers calculate a rate -- 73.3 kilometers per second per megaparsec, give or take 2.5 km/sec/Mpc -- that lies in the middle of three ...

Inflammation in the body has been linked to the intensity of tobacco smoking among people with HIV, according to a team of University of Massachusetts Amherst researchers. Krishna Poudel, associate professor of community health education in the School of Public Health and Health Sciences, and colleagues reported positive linear relationships between intensity, duration and pack-years of smoking and inflammation in HIV-positive people. They believe it to be the first, more thorough examination of specific smoking-related variables with the levels of inflammation in this group, while also taking into account highly active antiretroviral therapy (HAART) and other important factors. The study's findings ...

WASHINGTON--Without efforts to mitigate climate change, summers spanning nearly six months may become the new normal by 2100 in the Northern Hemisphere, according to a new study. The change would likely have far-reaching impacts on agriculture, human health and the environment, according to the study authors. In the 1950s in the Northern Hemisphere, the four seasons arrived in a predictable and fairly even pattern. But climate change is now driving dramatic and irregular changes to the length and start dates of the seasons, which may become more extreme in the future under a business-as-usual climate scenario. "Summers are getting longer and hotter while winters shorter and warmer ...

Nursing homes with the largest proportions of non-White residents experience 3.3 times more COVID-19 deaths than do nursing homes with the largest proportions of White residents, according to a new study from the University of Chicago. The paper, published in JAMA Network Open, suggests that these differences are likely due to nursing home size and the level of coronavirus spread in the local community, reinforcing the inseparability of long-term care facilities from society at large when it comes to bringing the COVID-19 pandemic to heel. Since the start of the ...

Traumatic brain injury (TBI) is a major cause of disability and a risk factor for early-onset dementia. The injury is characterized by a physical insult followed acutely by complement driven neuroinflammation. Complement, a part of the innate immune system that functions both in the brain and throughout the body, enhances the body's ability to fight pathogens, promote inflammation and clear damaged cells. Complement plays a role in the brain, regardless of infection or injury, as it influences brain development and synapse formation. In TBI, complement- induced inflammation partially determines the outcome in the weeks immediately following injury. However, more research is needed to define a role for the complement system in neurodegeneration ...

For cancer cells to metastasize, they must first break free of a tumor's own defenses. Most tumors are sheathed in a protective "basement" membrane -- a thin, pliable film that holds cancer cells in place as they grow and divide. Before spreading to other parts of the body, the cells must breach the basement membrane, a material that itself has been tricky for scientists to characterize. Now MIT engineers have probed the basement membrane of breast cancer tumors and found that the seemingly delicate coating is as tough as plastic wrap, yet surprisingly elastic like a party balloon, able to inflate to twice its original size. But while a balloon becomes much easier to blow up after some initial effort, the team found that a basement membrane becomes stiffer as it expands. ...

Found around the world, powdery mildew is a fungal disease especially harmful to plants within the sunflower family. Like most invasive pathogens, powdery mildew is understudied and learning how it affects hosts can help growers make more informed decisions and protect their crops. Scientists at the University of Washington and the University of Central Florida inoculated 126 species of plants in the sunflower family with powdery mildew, growing 500 plants from seeds that were collected from the wild and provided from the USDA germplasm network. Through this ...

BOSTON - The higher rates of obesity in Black, Indigenous and People of Color (BIPOC) compared with other groups in the United States can be attributed in large part to systemic racism, according to a new perspective article published in the Journal of Internal Medicine. The authors offer a 10-point strategy to study and solve the public health issues responsible for this disparity. "First, it is important to recognize that the interplay of obesity and racism is real. Once persons recognize this, they can begin to appropriately address and treat obesity in BIPOC communities," says co-author Fatima Cody ...

Women who experienced hypertensive disorders of pregnancy (HDPs) but did not develop chronic hypertension have a greater risk of premature mortality, specifically cardiovascular disease (CVD)-related deaths, according to a study published in the Journal of the American College of Cardiology (JACC). A separate JACC study examined the cardiovascular health risks associated with pregnancy in obese women with heart disease. HDPs, which occur in approximately 10% of all pregnancies worldwide, are among the most common health issues during pregnancy. There are four types of HDPs: chronic hypertension, gestational hypertension (GHTN), preeclampsia and ...