What The Study Did: Findings of this study suggest that patients recovering from COVID-19-associated acute kidney injury require monitoring of kidney function following hospital discharge. Authors: F. Perry Wilson, M.D. M.S.C.E., of the Yale University School of Medicine in New Haven, Connecticut, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.1095) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author ...

In the first study of the genomic architecture of the human placenta, scientists at the Wellcome Sanger Institute, the University of Cambridge and their collaborators have confirmed that the normal structure of the placenta is different to any other human organ and resembles that of a tumour, harbouring many of the same genetic mutations found in childhood cancers. The study, published today (10 March 2021) in Nature, found evidence to support the theory of the placenta as a 'dumping ground' for genetic defects, whereas the fetus corrects or avoids these errors. The findings provide a clear rationale for studying the association between genetic aberrations and birth outcomes, in order to better understand problems such as premature birth and stillbirth. In the earliest ...

What The Study Did: Researchers analyzed individual-level inpatient data from multiple U.S. hospital to further describe patients with diabetic ketoacidosis (a life-threatening complication of diabetes) with and without COVID-19. Authors:  Francisco J. Pasquel, M.D., M.P.H., of the Emory University School of Medicine in Atlanta, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.1091) Editor's Note: The article ...

What The Study Did: Researchers in this survey study assessed the level of stigma toward people with varying degrees of hair loss. Authors: Arash Mostaghimi, M.D., M.P.A., M.P.H., of Brigham and Women's Hospital in Boston, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamadermatol.2020.5732) Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding ...

A massive effort to map the precise binding locations of over 400 different kinds of proteins on the yeast genome has produced the most thorough and high-resolution map of chromosome architecture and gene regulation to date. The study reveals two distinct gene regulatory architectures, expanding the traditional model of gene regulation. So-called constitutive genes, those that perform basic 'housekeeping' functions and are nearly always active at low levels require only a basic set of regulatory controls; whereas those that that are activated by environmental signals, known as inducible genes, have a more specialized architecture. This finding in yeast could open the ...

The unprecedented discovery of an ancient lamprey growth series, published in the prestigious scientific journal, Nature, is overturning long-held ideas as to what modern lampreys may tell us about the origin of vertebrates (all animals with a backbone such as goldfish, lizards, crows and people). "Lampreys and modern hagfish are the only jawless fish alive that branched off from the family tree of vertebrates before they got jaws," says Dr Rob Gess from the Albany Museum in Makhanda, who discovered the ancient fossils. "This makes them very interesting for researchers attempting to understand the earliest stages of vertebrate history." Until now, it was commonly believed that modern lampreys were swimming ...

The unpredictable nature of life during the coronavirus pandemic is particularly challenging for many people. Not everyone can cope equally well with the uncertainty and loss of control. Research has shown that while a large segment of the population turns out to be resilient in times of stress and potentially traumatic events, others are less robust and develop stress-related illnesses. Events that some people experience as draining seem to be a source of motivation and creativity for others. These differing degrees of resilience demonstrate that people recover from stressful events ...

In a study recently published in Nature Communications, scientists from The Novo Nordisk Foundation Center for Biosustainability (DTU) and Yale University have investigated how bacteria that are commonly found in sugarcane ethanol fermentation affect the industrial process. By closely studying the interactions between yeast and bacteria, it is suggested that the industry could improve both its total yield and the cost of the fermentation processes by paying more attention to the diversity of the microbial communities and choosing between good and bad bacteria. The scientists dissected yeast-bacteria interactions in sugarcane ethanol fermentation by reconstituting every possible combination ...

Fuel cells, which are attracting attention as an eco-friendly energy source, obtain electricity and heat simultaneously through the reverse reaction of water electrolysis. Therefore, the catalyst that enhances the reaction efficiency is directly connected to the performance of the fuel cell. To this, a POSTECH-UNIST joint research team has taken a step closer to developing high-performance catalysts by uncovering the ex-solution and phase transition phenomena at the atomic level for the first time. A joint research team of Professor Jeong Woo Han and Ph.D. candidate Kyeounghak Kim of POSTECH's Department of Chemical Engineering, and Professor Guntae Kim of UNIST have uncovered the mechanism by which PBMO - a catalyst used ...

Italian and Russian researchers confirmed the hypothesis that the self-maintaining order in eukaryotic cells (cells with nuclei) is a result of two spontaneous mechanisms' collaboration. Similar molecules gather into 'drops' on the membrane and then leave it as tiny vesicles enriched by the collected molecules. The paper with the research results was published in the journal Physical Review Letters. The research was carried out by an international interdisciplinary team of biologists (from Polytechnic University of Turin, Italian Institute for Genomic Medicine of the University of Turin and Candiolo Cancer Institute) and ...

Variant B.1.1.7 of COVID-19 associated with a significantly higher mortality rate, research shows The highly infectious variant of COVID-19 discovered in Kent, which swept across the UK last year before spreading worldwide, is between 30 and 100 per cent more deadly than previous strains, new analysis has shown. A pivotal study, by epidemiologists from the Universities of Exeter and Bristol, has shown that the SARS-CoV-2 variant, B.1.1.7, is associated with a significantly higher mortality rate amongst adults diagnosed in the community compared to previously circulating strains. The study compared death rates among people infected ...

Newly published research has revealed a close link between proteins associated with Alzheimer's disease and age-related sight loss. The findings could open the way to new treatments for patients with deteriorating vision and through this study, the scientists believe they could reduce the need for using animals in future research into blinding conditions. Amyloid beta (AB) proteins are the primary driver of Alzheimer's disease but also begin to collect in the retina as people get older. Donor eyes from patients who suffered from age-related macular degeneration (AMD), the most common cause of blindness amongst adults in the UK, have been shown to contain high levels of AB in their retinas. This new study, published in the journal Cells, builds on previous ...

The Telomeres and Telomerase Group led by Maria A. Blasco at the Spanish National Cancer Research Centre (CNIO) continues to make progress in unravelling the role that telomeres -the ends of chromosomes that are responsible for cellular ageing as they shorten- play in cancer. The CNIO team was among the first to propose that shelterins, proteins that wrap around telomeres and act as a protective shield, might be therapeutic targets for cancer treatment. Subsequently, they found that eliminating one of these shelterins, TRF1, blocks the initiation and progression of lung cancer and glioblastoma in mouse models and prevents glioblastoma stem cells from forming secondary tumours. Now, in a study published in PLOS Genetics, ...

People with aphantasia - that is, the inability to visualise mental images - are harder to spook with scary stories, a new UNSW Sydney study shows. The study, published today in Proceedings of the Royal Society B, tested how aphantasic people reacted to reading distressing scenarios, like being chased by a shark, falling off a cliff, or being in a plane that's about to crash. The researchers were able to physically measure each participant's fear response by monitoring changing skin conductivity levels - in other words, how much the story made a person sweat. This type of test is commonly ...

WESTMINSTER, Colorado - March 10, 2021 - The paperbark tree (Melaleuca quinquenervia) was introduced to the U.S. from Australia in the 1900s. Unfortunately, it went on to become a weedy invader that has dominated natural landscapes across southern Florida, including the fragile wetlands of the Everglades. According to an article in the journal END ...

ften, humans display biases, i.e., unconscious tendencies towards a type of decision. Despite decades of study, we are yet to discover why biases are so persistent in all types of decisions. "Biases can help us make better decisions when we use them correctly in an action that has previously given us great reward. However, in other cases, biases can play against us, such as when we repeat actions in situations when it would be better not to", says Rubén Moreno Bote, coordinator of the UPF Theoretical and Cognitive Neuroscience Laboratory. In these cases, decisions are guided by tendencies, or inclinations, that do not benefit our wellbeing. For example, playing the lottery more regularly after winning ...

Recent studies estimate that we use an astounding 129 billion face masks globally every month - that is 3 million a minute. Most of them are disposable face masks made from plastic microfibers. - With increasing reports on inappropriate disposal of masks, it is urgent to recognize this potential environmental threat and prevent it from becoming the next plastic problem, researchers warn in a comment in the scientific journal Frontiers of Environmental Science & Engineering. The researchers are Environmental Toxicologist Elvis Genbo Xu from University of Southern Denmark and Professor of Civil and Environmental Engineering ...

Global targets to improve the welfare of people across the planet will have mixed impacts on the world's forests, according to new research. The United Nations' 17 key areas for global development - known as the Sustainable Development Goals (SDGs) - range from tackling poverty, hunger and sanitation to promoting clean energy, economic growth and reducing inequality. Many of these goals, such as improved peace and justice, good health and wellbeing, and quality education, will have a positive impact on the Earth's natural forests. But others, including creating new roads, industry and infrastructure, ...

Nearly 100 percent of the red snapper sampled in the Gulf of Mexico over a six-year period by University of South Florida (USF) marine scientists showed evidence of liver damage, according to a study reported in Aquatic Toxicology. The study is the first to correlate the concentration of crude oil found in the workhorses of the digestive system -- the liver, gall bladder, and bile - with microscopic indicators of disease, such as inflammation, degenerative lesions, and the presence of parasites. The team sampled nearly 570 fish from 72 Gulf locations between 2011 to 2017 in the wake of the historic 2010 Deepwater Horizon oil spill. "The results add to the list of other species we've analyzed indicating early warning ...

In a breakthrough for quantum computing, University of Chicago researchers have sent entangled qubit states through a communication cable linking one quantum network node to a second node. The researchers, based in the Pritzker School of Molecular Engineering (PME) at the University of Chicago, also amplified an entangled state via the same cable first by using the cable to entangle two qubits in each of two nodes, then entangling these qubits further with other qubits in the nodes. The results, published February 24, 2021 in Nature, could help make quantum computing more feasible and could lay the groundwork for future quantum communication networks. "Developing methods that ...

"Phase transitions" are a central phenomenon in physical sciences. Despite being technical-sounding, they are actually something we all experience in everyday life: ice melting into liquid water, or hot water evaporating as steam. Solid, liquid, and gas are three well known "phases" and, when one turns into another, that is a phase transition. Rare-earth nickelate oxides, also called nickelates, have attracted a lot of interest from researchers because they display an electronic phase transition, which may be exploited in future electronic devices. This particular phase transition consists of turning from a metallic ...

Game theory is known to be a useful tool in the study of Machine Learning (ML) and Artificial Intelligence (AI) Multi-Agent interactions. One basic component of these ML and AI systems is the exploration-exploitation trade-off, a fundamental dilemma between taking a risk with new actions in the quest for more information about the environment (exploration) and repeatedly selecting actions that result in the current maximum reward or (exploitation). However, the outcome of the exploration-exploitation process is often unpredictable in practice and ...

The balance of human intestinal microbiota, consisting of hundreds of bacterial species and phages (bacteria viruses), is crucial to good health. A research team, including scientists from the CNRS* and the Institut Pasteur, has characterised the phage-bacterial interaction networks of the microbiota in ten healthy individuals, with unprecedented precision. Scientists detected several hundred bacterial and phage genomes and identified the thousands of interactions that bind them by quantifying the contacts between the DNA molecules of viruses and their hosts. This method has the advantage ...

Researchers have published a study revealing their successful approach to designing much quieter propellers. The Australian research team used machine learning to design their propellers, then 3D printed several of the most promising prototypes for experimental acoustic testing at the Commonwealth Scientific and Industrial Research Organisation's specialised 'echo-free' chamber. Results now published in Aerospace Research Central show the prototypes made around 15dB less noise than commercially available propellers, validating the team's design methodology. RMIT University aerospace engineer and lead researcher Dr Abdulghani Mohamed said the impressive results were enabled by two key innovations - the numerical algorithms ...

Researchers at the University of Alabama at Birmingham have identified a new molecular target that could potentially treat the deadly, aging-related lung disease idiopathic pulmonary fibrosis (IPF). The study, which will be published March 10 in the Journal of Experimental Medicine (JEM), suggests that targeting a protein called MDM4 could prevent respiratory failure by initiating a genetic program that removes scar tissue from the lungs. IPF is characterized by the accumulation of scar tissue that stiffens the lungs and makes it difficult for patients to breathe and get sufficient oxygen into their blood. Though the causes of IPF remain unclear, age is a significant risk factor: the disease is ...