What The Study Did: The results of this study suggest that cumulative exposure to cigarette smoke is an independent risk factor for hospital admission and death from COVID-19. Authors: Katherine E. Lowe, M.Sc., of the Cleveland Clinic Lerner College of Medicine of Case Western Reserve in Cleveland, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2020.8360) Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for ...

What The Study Did: The association of a shelter-in-place order with lower rates of seasonal respiratory viral activity was examined in this study. Authors: Elizabeth Partridge, M.D., of the University of California at Davis School of Medicine in Sacramento, is the corresponding author. To access the embargoed study:  Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2020.35281) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media ...

A study designed to study how the immune system impacts gut bacteria - has led to the extraordinary discovery of two molecules that can not only provide profound protection in experimental models of asthma but can also substantially reduce the severity of an attack. Neither of these molecules, one of which is already commercially available as a dietary supplement, were previously known to have an effect on asthma - and they also appear, from animal studies, to have a role in treating the respiratory illness that is prevalent, and often fatal, in people with serious COVID-19. The researchers aim to test one of the molecules in a clinical trial in 2021 in asthmatics. As further evidence that these two molecules ...

As the planet's burden of rubber and plastic trash rises unabated, scientists increasingly look to the promise of closed-loop recycling to reduce waste. A team of researchers at Princeton's Department of Chemistry announces the discovery of a new polybutadiene molecule - from a material known for over a century and used to make common products like tires and shoes - that could one day advance this goal through depolymerization. The Chirik lab reports in Nature Chemistry that during polymerization the molecule, named (1,n'-divinyl)oligocyclobutane, enchains in a repeating sequence of squares, a previously ...

Human females rely on aids like charting, test strips or wearable tech to identify periods of fertility. Some animals, like baboons, undergo obvious physical changes during ovulation. How did fertility become so hard to detect in humans? For nearly half a century, the evolution of concealed ovulation in human females has been explained as useful for securing male partners to help raise and support children. A END ...

It was previously thought that collisions between galaxies would necessarily add to the activity of the massive black holes at their centers. However, researchers have performed the most accurate simulations of a range of collision scenarios and have found that some collisions can reduce the activity of their central black holes. The reason is that certain head-on collisions may in fact clear the galactic nuclei of the matter which would otherwise fuel the black holes contained within. When you think about gargantuan phenomena such as the collision of galaxies, it might be tempting to imagine it as some sort of cosmic cataclysm, with stars crashing and exploding, and destruction on an epic scale. ...

New genetic faults discovered in people with a heart condition that is sometimes inherited in families could transform the diagnosis and treatment of the hidden disease, according to research funded by the British Heart Foundation (BHF) and published in Nature Genetics. Researchers have found a new type of genetic change in the DNA of people with hypertrophic cardiomyopathy (HCM) - a silent killer amongst families that can cause sudden death in young people due to the thickening of the heart muscle. This ground-breaking discovery, which may be the biggest advance in our knowledge of the genetic basis of the ...

1. Key points of the work - An emerging semiconductor for future power devices, beta-gallium oxide (β-Ga2O3), was investigated using a technique called transmission terahertz time-domain spectroscopy (THz-TDS) for the first time - The findings on the fundamental properties of β-Ga2O3 at THz frequencies are significant to the development of this semiconductor's power electronic applications - THz-TDS can be used as a noninvasive tool for the evaluation of electrical properties instead of conventional electrical measurements that degrade the semiconductor quality 2. Overview of the work The β-Ga2O3 ultra-wide bandgap (UWBG) ...

Cisplatin has been used to treat cancer since the 1970s. Since then, many other platinum-containing cytostatic drugs have been developed, such as triplatinNC, a highly charged complex that contains three ligand-bridged platinum atoms. Unlike cisplatin, this drug also directly inhibits metastasis. The reason for this seems to be modulation of the geometry of a sugar component of heparan sulfate, an important component of the extracellular matrix, reports a research team in the journal Angewandte Chemie. Heparan sulfate, a glycosaminoglycan, is a chain of ring-shaped sugar molecules. It is involved in many regulatory processes, as well as in the growth and metastasis of tumors. In order for ...

The absence of monsoon rains at the source of the Nile was the cause of migrations and the demise of entire settlements in the late Roman province of Egypt. This demographic development has been compared with environmental data for the first time by professor of ancient history, Sabine Huebner of the University of Basel - leading to a discovery of climate change and its consequences. The oasis-like Faiyum region, roughly 130 km south-west of Cairo, was the breadbasket of the Roman Empire. Yet at the end of the third century CE, numerous formerly thriving settlements there declined and were ultimately abandoned by their inhabitants. Previous excavations and contemporary papyri have shown that problems with field irrigation were the cause. Attempts by ...

Researchers perform experiments that can add or subtract a single quantum of sound--with surprising results when applied to noisy sound fields. Quantum mechanics tells us that physical objects can have both wave and particle properties. For instance, a single particle--or quantum--of light is known as a photon, and, in a similar fashion, a single quantum of sound is known as a phonon, which can be thought of as the smallest unit of sound energy. A team of researchers spanning Imperial College London, University of Oxford, the Niels Bohr Institute, University ...

G3BP proteins inhibit the metabolic driver MTOR - a signaling protein that plays a central role in tumor diseases and developmental disorders of the brain. This is reported in this week´s issue of the renowned journal Cell. The study was led by scientists from the University of Innsbruck and the German Cancer Research Center (DKFZ) in collaboration with the Medical University of Innsbruck and a Europe-wide research network. The signaling protein MTOR (Mechanistic Target of Rapamycin) is a sensor for nutrients such as amino acids and sugars. When sufficient nutrients are available, MTOR boosts metabolism and ensures that sufficient energy and building blocks are available for the growth ...

It is clear that COVID-19 has drastically changed our world, but how can we use the lessons learnt to build a more resilient and sustainable future? The International Institute for Applied Systems Analysis (IIASA) and the International Science Council (ISC) have drawn on the combined strengths and expertise of the two organizations to help find a way forward. The COVID-19 pandemic, which has impacted almost every aspect of our lives over the past year, is a warning: We need to step back from business-as-usual onto new transformative pathways to reach the Sustainable Development Goals and the commitments of the Paris Agreement. Systems science is ideally positioned to address global impacts ...

For those who are diagnosed and have begun treatment for HIV, it is standard practice to regularly monitor viral load in the blood to assess response to treatment. A study of people living with HIV in Ethiopia shows that poverty and labour mobility are linked to high viral load despite treatment, indicating treatment failure. The researchers behind the study recommend that socioeconomic conditions should be taken into account to a greater extent in low-income countries to ensure that HIV treatment can achieve the best possible results. Treatment using antiretroviral therapy (ART) is the same across the globe. For people living with HIV in low-income countries, however, ...

Study conducted by researchers from the GIGA CRC In vivo Imaging laboratory at ULiège demonstrates, for the first time in humans, how the first deposits of tau proteins in the brainstem are associated with neurophysiological processes specific to the early stages of Alzheimer's disease development. During the pre-clinical stages of Alzheimer's disease, i.e. when subtle changes are taking place in the brain but no cognitive symptoms can be observed, the cortex presents a state of transient hyperexcitability. To date, several studies conducted in animals have shown that tau and beta-amyloid proteins - central to the development of Alzheimer's disease - were associated with increased cortical excitability and dysfunction ...

Olive trees are some of the most important woody crops in the world and Verticillium wilt, caused by the Verticillium dahliae fungus, is the most concerning disease for farmers in the olive sector. In Spain, the leader in olive oil and table olive production, the increase in Verticillium wilt is primarily due to taking over infested soils formerly used for cotton (one of the main hosts for this pathogen) and the spread of a defoliating variant of the pathogen, which is more ferocious and ends up killing the olive tree. This is why agronomy research efforts are focused on the search for the most resistant crops and the implementation of practices that reduce disease rates. In this vein, UCOLIVO Group researcher Juan Moral at the María de Maeztu Excellence Unit, Agronomy Department, ...

ISIS, Al Qaeda, and the Taliban use their English-language magazines to encourage women to support jihad in different ways, according to new research. Experts hope highlighting these varying recruitment strategies will be of use for those trying to stop radicalisation and terrorism. The Taliban-produced magazines encourage women to carry out a traditional role in the home and support men rather than to be violent and commit jihad themselves. Tahrik-e Taliban Pakistan (TTP) and ISIS encourage women to be violent - to pick up arms and fight. The magazines encourage women to leave their husbands if they don't support jihad, even without permission. Researchers from the University of Exeter analysed ...

Scientists have identified that the evolutionary development of human and primate brains may have been similar for communication and memory. Although speech and language are unique to humans, experts have found that the brain's pathway is similarly wired in monkeys which could signify an evolutionary process dating back at least 25 million years. In a study, published in the journal Neuron, teams led by Newcastle University and the University of Iowa, compared auditory cortex information from humans and primates and found strong links. Professor Chris Petkov, from Newcastle University's Faculty of Medical Sciences, UK, said: "Our language abilities help us to crystallise memories and make them vivid, such as 'the singer sounded ...

Certain anchor proteins inhibit a key metabolic driver that plays an important role in cancer and developmental brain disorders. Scientists from the German Cancer Research Center (DKFZ) and the University of Innsbruck, together with a Europe-wide research network, discovered this molecular mechanism, which could open up new opportunities for personalized therapies for cancer and neuronal diseases. They published their results in the journal Cell. The signaling protein MTOR (Mechanistic Target of Rapamycin) is a sensor for nutrients such as amino acids and sugars. When sufficient nutrients are available, MTOR boosts metabolism and ensures that sufficient energy and cellular building blocks are available. Since MTOR is a central switch for metabolism, ...

All the cells in the human body share the same genes. But how our genes are expressed determines whether a cell becomes a brain cell or a liver cell. In addition, changes in gene expression often play a significant role in development of diseases. One mechanism that contributes to the changes in gene expression is the interaction between the proteins called histones and enzymes known as HDACs. These enzymes help the cell divide and develop, which is the reason why they serve as targets for anti-cancer medicine: When you inhibit the enzymes, the cancer cells will stop dividing and growing further. Despite being targets for clinically approved medicines, researchers do not know all the details of how they ...

Special immune cells found in the brain, microglia, play a key role in the processes that make you feel uneasy and depressed in correlation with inflammation. This is the conclusion of a study using mice carried out by researchers at Linköping University, Sweden. The results have been published in the scientific journal Immunity, and suggest that microglial cells contribute to the negative mood experienced during several neurological diseases, and maybe also depression. David Engblom's research group at Linköping University has spent many years looking at why inflammation in the body, such as a common cold or influenza, causes us to feel poorly ...

Artificial intelligence and automation are changing the world, one industry at a time! Whatever humans can do, machines are learning to also do effectively, with lower costs and fewer errors. The maritime shipping industry is no different. Ships are now increasingly automated (called maritime autonomous surface ships or MASSs), reducing the need for human input. While this bodes well for labor and fuel costs, the question naturally raised is, what happens to the jobs of seafarers, the chief workforce of the shipping industry, once MASSs take over. To find out, researchers from Korea used complex mathematical models and simulations ...

RESEARCH TRIANGLE PARK, N.C. -- Design of Army aerial vehicles and weapon systems relies on the ability to predict aerodynamic behavior, often aided by advanced computer simulations of the flow of air over the body. High-fidelity simulations assist engineers in maximizing how much load a rotorcraft can lift or how far a missile can fly, but these simulations aren't cheap. The simulations that designers currently use require extensive data processing on supercomputers and capture only a portion of vortex collision events - which can cause significant performance degradation, from loss of lift on a rotor to complete loss of control of a munition. A new turbulence model could change that. The Army Research Office, an ...

Teenagers with happy childhood memories are likely to drink less, take fewer drugs and enjoy learning, according to research published in the peer-reviewed journal END ...

New Orleans, LA - An analysis by Nicholas Gilpin, PhD, Professor of Physiology and Associate Director of the Alcohol and Drug Abuse Center of Excellence at LSU Health New Orleans School of Medicine, and Michael Taffe, PhD, Professor of Psychiatry at the University of California San Diego, summarizes long-standing racial inequities in federal funding for biosciences research from the National Institutes of Health (NIH). Their report describes prior failures to correct these racial inequities and offers strategies that may be effective in eliminating these disparities. Their paper, published online in the open-access ...