Individually rare but collectively common intermediate-size copy number variations may be negatively associated with educational attainment, according to a study in the May 26 issue of JAMA. Copy number variations (CNVs) are regions of the genome that differ in the number of segments of DNA. The Database of Genomic Variants catalogs approximately 2.4 million DNA CNVs. Some of them have been previously implicated as causal of a wide variety of traits and conditions. According to background information in the article large (defined as larger than 500 kb), recurrent CNVs ...

In a small study in Chile that included patients with gallbladder cancer, exposure to aflatoxin (a toxin produced by mold) was associated with an increased risk of gallbladder cancer, according to a study in the May 26 issue of JAMA. In Chile, gallbladder cancer is a leading cause of cancer death in women. Exposure to aflatoxin, a liver carcinogen, is associated with gallbladder cancer in primates. Aflatoxin contamination has been identified in Chile, including in aji rojo (red chili peppers). Aji rojo is associated with gallbladder cancer; however, the association of ...

(NEW YORK -- May 26, 2015) Spouses of patients receiving hospice for three or more days more frequently reported reduced depression symptoms, compared to surviving spouses of patients who did not receive hospice, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai published online today in JAMA Internal Medicine. This is the first national study to examine depressive symptoms as an outcome for spouses of people with all types of serious illnesses that used hospice care, which is designed to improve quality of life as opposed to offering ...

A typical characteristic of the brain of an Alzheimer sufferer is the presence of insoluble Tau protein aggregates. Scientists at VIB, KU Leuven and Janssen Pharmaceutica have demonstrated that the distribution of these aggregates through the brain is facilitated by synaptic connections between brain cells. This news is highly significant because the focus is increasingly on repairing synaptic connections as a therapeutic strategy in neurodegenerative diseases such as Alzheimer's. In fact, it is generally accepted that a loss of synaptic connections leads to a loss in cognitive ...

Biologists from the University of Leicester have discovered that one of nature's most important pollinators - the buff-tailed bumblebee - either ascends to the status of queen or remains a lowly worker bee based on which genes are 'turned on' during its lifespan. The paper, entitled 'Reproductive workers show queen-like gene expression in an intermediately eusocial insect, the buff-tailed bumble bee Bombus terrestris', which is published in the journal Molecular Ecology, suggests that the development of an individual bumblebee into its designated caste of male, worker ...

Sperm in the first fraction of ejaculate are more numerous, move more and present better quality DNA than those lagging behind. This is the conclusion of a study led by the Ginemed fertility clinic, which confirms that while the objective of the first fraction is to fertilise the egg, the second phase is so that no sperm from any other male has a chance to fertilise it. A study led by the Ginemed Assisted Human Reproduction Clinic analyses the advantages of using fractions of ejaculate separately in in-vitro fertilisation as a way to improve the sample of the semen. The ...

Strapped into a motion-enabled simulator and wearing 3D glasses, 36 adolescent volunteers recently experienced what it was like to "travel" through a field of virtual stars. The experiments provided new and convention-busting data about how sensory stimuli are processed by the brains of individuals with Autism Spectrum Disorder. The study, entitled "Self-motion perception in autism is compromised by visual noise but integrated optimally across multiple senses," was published online in the Proceedings of the National Academy of Sciences on May 4th, 2015. The authors of ...

The team has completed two genomics studies on the tropical disease, a condition that is estimated to cause up to 30 million illnesses and over a quarter of a million deaths globally each year. The first study, published in the journal Nature Genetics, suggests that the H58-strain, which is likely to have emerged in Asia approximately thirty years ago, is now rapidly spreading across Africa, where it has been introduced on several separate occasions. A key feature of this strain appears to be its ability to acquire resistance to commonly available antibiotics. Dr Melita ...

TORONTO, May 27, 2015--A good working relationship with police is essential for the smooth operation of a busy Emergency Department. Police are in and out of EDs regularly, supporting EMS, transporting patients and helping to provide a safe environment for hospital staff. Not surprisingly, differences of opinion arise from time to time over a health care worker's duty to protect patient privacy and the police need to conduct a criminal investigation. That's why it's essential to develop strategies to optimize communications between police and ED workers, according to ...

ATHENS, GA - Over the past century, many forests have shifted from open to closed canopies. The change in forest structure could be contributing to declines in pollinator species, especially native bees, according to a new study by U.S. Forest Service scientists. The study shows how common present-day forest conditions affect pollinators, especially bees. "Bees prefer open forests," says Jim Hanula, a research entomologist at the Southern Research Station (SRS) Insects, Diseases, and Invasive Plants research unit. "We found that total tree basal area was the best predictor ...

WASHINGTON, May 26, 2015 -- You might have heard that microwaving your food is dangerous. Maybe your health nut friend told you that eating frozen veggies is less healthful than eating fresh ones. Is a glass of red wine really good for your heart? This week, Reactions is here to sort out the "old wives' tales" from the facts, taking on a swath of food myths. Check out the videos here: http://bit.ly/ACSFoodMyths. Subscribe to the series at http://bit.ly/ACSReactions, and follow us on Twitter @ACSreactions to be the first to see our latest videos. INFORMATION: The ...

CLEMSON, S.C. -- If you've been to the doctor, you probably know what to do when you're handed a plastic cup and shown to the bathroom. Most patients hand over the sample and give little thought to what happens when it's shipped to the lab for analysis. Ken Marcus and his students are the exceptions. They have developed a new testing method that they believe will reduce costs, get faster results and lower the volume of urine needed for a sample. Marissa Pierson, a master's student, closes the lid on a centrifuge while working in a Clemson University lab with Ken Marcus. It's ...

This news release is available in German. Quantum physics is full of fascinating phenomena. Take, for instance, the cat from the famous thought experiment by the physicist Erwin Schrodinger. The cat can be dead and alive at once, since its life depends on the quantum mechanically determined state of a radioactively decaying atom which, in turn, releases toxic gas into the cat's cage. As long as one hasn't measured the state of the atom, one knows nothing about the poor cat's health either - atom and kitty are intimately "entangled" with each other. Equally striking, ...

This news release is available in German. Leipzig / Helsinki. A first global scale study has estimated how forest emitted compounds affecting cloud seeds via formation of low-volatility vapours. According to the latest projections, terrestrial vegetation emits several million tons of extremely low-volatility organic compounds (ELVOCs) per year to the atmosphere. These oxidation products of compounds such as monoterpenes results in an increase of condensing vapours that can further form cloud condensation nuclei over the continents and thus has an influence ...

Montréal, May 25, 2015 - A team of researchers at the IRCM led by François Robert, PhD, uncovered a critical role for two proteins in chromatin structure. Their breakthrough, recently published in the scientific journal Molecular Cell, helps explain how DNA is organized in our cells. This discovery could lead to a better understanding of what causes certain types of cancer, such as lymphoma. Dr. Robert and his team study chromatin, the structure composed of DNA and proteins that makes up chromosomes. Its main role is to package DNA molecules containing all the ...

LOS ANGELES (May 26, 2015) - Biomedical researchers at Cedars-Sinai have invented a tiny drug-delivery system that can identify cancer cell types in the brain through "virtual biopsies" and then attack the molecular structure of the disease. If laboratory research with mice is borne out in human studies, the results could be used to deliver nano-scale drugs that can distinguish and fight tumor cells in the brain without resorting to surgery. "Our nanodrug can be engineered to carry a variety of drugs, proteins and genetic materials to attack tumors on several fronts ...

Queen's University PhD student Matt Shultz is researching magnetic, massive stars, and his research has uncovered questions concerning the behaviour of plasma within their magnetospheres. Drawing upon the extensive dataset assembled by the international Magnetism in Massive Stars (MiMeS) collaboration, led by Mr. Shultz's supervisor, Queen's professor Gregg Wade, along with some of his own observations collected with both the Canada-France-Hawaii Telescope and the European Southern Observatory's Very Large Telescope, Mr. Shultz is conducting the first systematic population ...

Washington, D.C. -- May 26, 2015 -- A new study has demonstrated that a protein called Niemann-Pick C1 (NPC1) is critical for the Ebola virus to infect a host. The study, published in the May/June issue of mBio, the online open-access journal of the American Society for Microbiology, suggests that drugs that block NPC1 could be used to treat this deadly disease. "The science behind the concept of blocking the interaction between NPC1 and the virus is solid. Now, it is just a matter of powering through and identifying drugs that can inhibit NPC1 and moving them forward," ...

An international team including scientists from Albert Einstein College of Medicine of Yeshiva University and the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) has identified the molecular "lock" that the deadly Ebola virus must pick to gain entry to cells. The findings, made in mice, suggest that drugs blocking entry to this lock could protect against Ebola infection. The study was published in today's edition of the online journal mBio. The researchers found that the Ebola virus can't infect cells unless it first attaches to a host protein called ...

By unlocking the secrets of a bizarre virus that survives in nearly boiling acid, scientists at the University of Virginia School of Medicine have found a blueprint for battling human disease using DNA clad in near-indestructible armor. "What's interesting and unusual is being able to see how proteins and DNA can be put together in a way that's absolutely stable under the harshest conditions imaginable," said Edward H. Egelman, PhD, of the UVA Department of Biochemistry and Molecular Genetics. "We've discovered what appears to be a basic mechanism of resistance - to ...

Mitsuyoshi Nakao, Director of the Institute of Molecular Embryology and Genetics in Kumamoto University and Associate Professor Noriko Saitoh revealed that a cluster of defined, non-coding RNAs are mechanistically involved in endocrine therapy resistance in human breast cancer cells. Furthermore, resveratrol, a kind of polyphenol, was found to repress these RNAs and inhibit the proliferative activity of breast cancer cells which had acquired resistance. The work was published in Nature Communications on April 29th, 2015. Breast cancer is one of the most common types ...

This news release is available in French. Commuting length, distance, and means are stress factors that can lead to burnout, says Annie Barreck of the University of Montreal's School of Industrial Relations. "A correlation exists between commuting stress factors and the likelihood of suffering from burnout. But their importance varies according to the individual, the conditions in which their trips take place, and the place where the individual works," she explained. Barreck will present her research today at the 83rd congress of the Association francophone pour ...

In a new national survey of rheumatoid arthritis (RA) patients, Health Union found a severe impact on quality of life, employment, and ability to afford treatment. The autoimmune condition attacks the body, resulting in joint inflammation, pain, stiffness, and swelling, but may also harm other organs. About 1.3 million Americans or about one percent of the global population have RA. Ninety-four percent of respondents with RA said they cannot do as much as they were able before acquiring the disease. Additionally, 67% said others do not understand the severity of their ...

Protected areas are the cornerstone to prevent species extinctions. The Convention on Biological Diversity have set a target to protect 17% of all terrestrial land by 2020. Many of the international recommendations concerning protection goals are provided for single countries to take action individually. Researchers in the University of Helsinki, Finland, stress the importance of international collaborations in the protected area expansion process. "It has been shown that working at the country level is less efficient than promoting transnational collaborations. As ...

New UK research has challenged the assumption that people with rheumatoid arthritis always take their medication as prescribed. Researchers from the Arthritis Research UK Centre for Epidemiology at The University of Manchester found that 40% of patients scored low on an adherence questionnaire at least once during their time in a recent study, indicating that they might not be taking their expensive biological therapies as regularly as prescribed. Their research is published online in the journal Rheumatology. The findings have prompted Arthritis Research UK's head ...