The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association, Acta Pharmaceutica Sinica B (APSB) is a monthly journal, in English, which publishes significant original research articles, rapid communications and high quality reviews of recent advances in all areas of pharmaceutical sciences -- including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics. Featured papers in this issue are: Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5 by authors Yang Liu, Xiaojia Liu, Na Zhang, Mingxiao Yin, Jingwen Dong, Qingxuan ...

"The findings provide an increased understanding of how the virus gets through the stomach and intestinal system. Continued research can provide answers to whether this property can also be used to create vaccines that ride 'free rides' and thus be given in edible form instead of as syringes," says Lars-Anders Carlson, researcher at Umeå University. The virus that the researchers have studied is a so-called enteric adenovirus. It has recently been clarified that enteric adenoviruses are one of the most important factors behind diarrhea among infants, and they are estimated to kill more than 50,000 children under the age of five each year, ...

Researchers from Trinity College Dublin have discovered a key mechanism underlying bacterial skin colonisation in atopic dermatitis, which affects millions around the globe. Atopic dermatitis (AD, also called commonly eczema) is the most common chronic inflammatory skin disorder in children, affecting 15-20% of people in childhood. During disease flares, patients experience painful inflamed skin lesions accompanied by intense itch and recurrent skin infection. The bacterium Staphylococcus aureus (S. aureus) thrives on skin affected by AD, increasing inflammation and worsening AD symptoms. Although a small number of therapies are available at present for patients with moderate ...

Leading research at Newcastle University has been used to shape how dentistry can be carried out safely during the Covid-19 pandemic by mitigating the risks of dental aerosols. It is well known that coronavirus can spread in airborne particles, moving around rooms to infect people, and this has been a major consideration when looking into patient and clinician safety. Research, published in the Journal of Dentistry, has led the way in helping shape national clinical guidance for the profession to work effectively under extremely challenging circumstances. The findings have been used by the Dental Schools' Council, Association of Dental Hospitals and the Scottish Dental Clinical Effectiveness ...

Micro-CT scanning and digital reconstructions have been used to compare the skulls of the Tasmanian tiger (thylacine) and wolf across their early development and into adulthood, establishing that not only did the thylacine resemble the wolf as adults, but also as newborns and juveniles. "Remarkably, the Tasmanian tiger pups were more similar to wolf pups than to other closely related marsupials," Professor Andrew Pask from the University of Melbourne said. The collaborative study with Flinders University and Museums Victoria complement earlier findings that thylacine and wolf have evolved ...

Artificial intelligence and machine learning are already an integral part of our everyday lives online. For example, search engines such as Google use intelligent ranking algorithms and video streaming services such as Netflix use machine learning to personalize movie recommendations. As the demands for AI online continue to grow, so does the need to speed up AI performance and find ways to reduce its energy consumption. Now a University of Washington-led team has come up with a system that could help: an optical computing core prototype that uses phase-change material. This system is fast, energy efficient and capable of accelerating ...

Topological materials are characterised by unique electronic and physical properties that are determined by the underlying topology of their electronic systems. Scientists from the Max Planck Institutes for Microstructure Physics (Halle) and for Chemical Physics of Solids (Dresden) have now discovered that (TaSe4)2I is the first material in which a charge density wave induces a phase transition between the semimetal to insulator state. An international team of scientists at the Max Planck Institute for Microstructure Physics, Halle (Saale), the Max Planck Institute for Chemical Physics of Solids ...

Delivery of genetic molecules such as mRNA into cells is vital with important applications such as vaccine development. Various agents have been developed for mRNA delivery. However, conventional mRNA nanocarriers mainly focus on their physical interaction with mRNA molecules, or protection / delivery of mRNA, such as adjusting physical properties of nanocarriers to control binding with mRNA or cellular uptake. Moreover, effective mRNA delivery in hard-to-transfect APCs remains a challenge. The hard-to-transfect nature in APCs is partly attributed to the suppressed mRNA translation associated with the intrinsic high intracellular glutathione (GSH) level. Thus, ...

Photorespiration is a highly energy consuming process in plants that leads to the release of previously fixed CO2. Thus, engineering this metabolic process is a key approach for improvement of crop yield and for meeting the challenge of ever-rising CO2 levels in the atmosphere. Researchers led by Tobias Erb from the Max Planck Institute for Terrestrial Microbiology in Marburg, Germany, have now succeeded in engineering the TaCo pathway, a synthetic photorespiratory bypass. This new-to-nature metabolic connection opens up new possibilities of CO2 fixation ...

With the rapid development of smart portable electronics and electric vehicles, the consumption of lithium resource will increase dramatically and the cost of lithium-ion batteries (LIBs) may increase significantly in the future. In addition, the shortage (0.0017 wt% in the earth's crust) and uneven crustal distribution of lithium also limit its further development and application. As potassium (2.7 wt% in the earth's crust) have properties similar to lithium and abundant reserves. Therefore, as an alternative to LIBs, potassium ion batteries (PIBs) have become the focus of research. Potassium (2.92 V vs. ...

Scientists from the Max Planck Institute of Psychiatry, led by Nikolaos Koutsouleris, combined psychiatric assessments with machine-learning models that analyse clinical and biological data. Although psychiatrists make very accurate predictions about positive disease outcomes, they might underestimate the frequency of adverse cases that lead to relapses. The algorithmic pattern recognition helps physicians to better predict the course of disease. The results of the study show that it is the combination of artificial and human intelligence that optimizes the prediction ...

The spiky structure that erupts from the smooth surface of a ferrofluid when a magnet is brought close can be predicted more accurately than previously thought. KAUST researchers have shown that computational algorithms can calculate the ferrofluid's bristling response to a magnet by simulating only the liquid's surface layer. Ferrofluids are liquid suspensions of iron-based particles that behave like a regular fluid, but once a magnet is present, the ferrofluid rapidly shape-shifts to form spikes that align with the magnetic field. Originally developed by NASA, ferrofluids have numerous uses ranging from advanced electronics to nanomedicine and have the potential for even broader use, if their magnetic responses could be predicted more accurately. Dominik Michels and ...

Co-culture: stimulate the metabolic potential and explore the molecular diversity of natural products from microorganisms Announcing a new publication for Marine Life Science & Technology journal. In this review article the authors Xiao-Yue Peng, Jin-Tao Wu, Chang?Lun Shao, Zhi-Yong Li, Min Chen and Chang-Yun Wang from the Ocean University of China, Qingdao, China, Yangzhou University, Yangzhou, China, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China and Shanghai Jiao Tong University, Shanghai, China consider the metabolic potential and molecular diversity of natural products from microorganisms. Microbial secondary metabolites have long ...

Announcing a new publication for Marine Life Science & Technology journal. In this review article the authors Caiwen Li, Meng Li and Qian Huang from Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China consider the impact of the parasitic dinoflagellate Hematodinium on aquaculture of marine crustaceans in China. Hematodinium is a type of parasitic dinoflagellate that infects marine crustaceans globally. The parasite lives mainly in the hemolymph or hemocoels of affected hosts, and results in mortalities due to malfunction or loss of functions of major organs. In recent years, the parasite has developed into an emerging epidemic pathogen not only affecting wild populations of economically valuable marine crustaceans ...

Good news for those who need a cuppa to start the day. Researchers from the National University of Singapore (NUS) have created new probiotic coffee and tea drinks that are packed with gut-friendly live probiotics. Supervised by Associate Professor Liu Shao Quan from the Department of Food Science and Technology at the NUS Faculty of Science, the two doctoral students who worked on these two new beverages assert that their drinks have a great taste, and can be stored chilled or at room temperature for more than 14 weeks without compromising on their probiotic viability. Traditional probiotic carriers like yoghurts and cultured milks are dairy-based products. The rise in veganism, along with common health issues like lactose intolerance, high ...

Today's electronic devices strive for new form factors - to make them foldable, stretchable, and deformable. To produce such devices that are highly stretchable or deformable, it is necessary to develop electrodes and circuit lines whose electrical properties can withstand harsh deformation or mechanical damage. To this, POSTECH-Yonsei University joint research team has recently developed liquid metal ink to accelerate printed electronic devices that can be changed into any shape. Professor Unyong Jeong and Dr. Selvaraj Veerapandian of POSTECH's Department of Materials Science and Engineering, with Professor Aloysius Soon and Dr. Woosun Jang of Yonsei University's Department of Materials Science and Engineering, have developed liquid metal microparticles ...

NIH-supported pilot study found team-based approach may improve buprenorphine care. WHAT: A collaborative approach to treating opioid use disorder that relies heavily on community pharmacists is feasible and may increase adherence and participant satisfaction, according to a pilot study published today in Addiction. The study was supported by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, through the NIDA Center for the Clinical Trials Network. Most people with opioid use disorder who would benefit from medication do not receive it. Buprenorphine is a safe and effective ...

DALLAS - Jan. 11, 2021 - A set of biomarkers not traditionally associated with cell fate can accurately predict how genetically identical cells behave differently under stress, according to a UT Southwestern study. The findings, published by Cell Reports as a Dec. 1 cover story, could eventually lead to more predictable responses to pharmaceutical treatments. Groups of the same types of cells exposed to the same stimuli often display different responses. Some of these responses have been linked to slight differences in genetics between individual cells. However, even genetically identical cells can diverge in ...

As the planet continues to warm, the twin challenges of diminishing water supply and growing energy demand are intensifying. But because water and energy are inextricably linked, as we try to adapt to one challenge - say, by getting more water via desalination or water recycling - we may be worsening the other challenge by choosing energy-intensive processes. So, in adapting to the consequences of climate change, how can we be sure that we aren't making problems worse? Now, researchers at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab), UC Berkeley, and UC Santa Barbara have developed a science-based analytic framework to evaluate such complex connections between water and energy, and options for adaptations in response to an evolving ...

CORVALLIS, Ore. - Researchers in the Oregon State University College of Engineering have developed a battery anode based on a new nanostructured alloy that could revolutionize the way energy storage devices are designed and manufactured. The zinc- and manganese-based alloy further opens the door to replacing solvents commonly used in battery electrolytes with something much safer and inexpensive, as well as abundant: seawater. Findings were published today in Nature Communications. "The world's energy needs are increasing, but the development of next-generation electrochemical energy storage systems with high energy density and long cycling life ...

PULLMAN, Wash. - Biomarkers in human sperm have been identified that can indicate a propensity to father children with autism spectrum disorder. These biomarkers are epigenetic, meaning they involve changes to molecular factors that regulate genome activity such as gene expression independent of DNA sequence, and can be passed down to future generations. In a study published in the journal Clinical Epigenetics on Jan. 7, researchers identified a set of genomic features, called DNA methylation regions, in sperm samples from men who were known to have autistic children. Then in a set of blind tests, the researchers were able to use the presence of these features to determine whether other men had fathered autistic children with 90% ...

New research shows people who pursue meaningful activities - things they enjoy doing - during lockdown feel more satisfied than those who simply keep themselves busy. The study, published in PLOS ONE, shows you're better off doing what you love and adapting it to suit social distancing, like swapping your regular morning walk with friends for a zoom exercise session. Simply increasing your level of activity by doing mindless busywork will leave you unsettled and unsatisfied. Co-lead researcher Dr Lauren Saling from RMIT University in Melbourne, Australia said while novelty lockdown activities - like baking or painting - have their place, trying to continue what you enjoyed before lockdown can be more rewarding. "Busyness might be distracting but it won't necessarily be fulfilling," ...

COVID-19 infections are once again rising at an alarming rate in San Francisco's Latinx community, predominantly among low-income essential workers, according to results of a massive community-based testing blitz conducted before and after the Thanksgiving holiday by Unidos En Salud -- a volunteer-led partnership between the Latino Task Force for COVID-19 (LTF), UC San Francisco , the Chan Zuckerberg Biohub (CZ Biohub), and the San Francisco Department of Public Health (SFDPH). Unidos En Salud launched their "Healthy Holidays" initiative the weekend before Thanksgiving (Nov. 22-24) in San Francisco's Mission District, where they have been perfecting their community-based surveillance testing ...

The genetic material of plants, animals and humans is well protected in the nucleus of each cell and stores all the information that forms an organism. For example, information about the size or color of flowers, hair or fur is predefined here. In addition, cells contain small organelles that contain their own genetic material. These include chloroplasts in plants, which play a key role in photosynthesis, and mitochondria, which are found in all living organisms and represent the power plants of every cell. But is the genetic material actually permanently stored within one cell? No! As so far known, the genetic material can migrate from cell to cell and thus even be exchanged between different organisms. Researchers at the Max Planck Institute of Molecular Plant Physiology (MPI-MP) ...

We are fascinated by machines that can control cars, compose symphonies, or defeat people at chess, Go, or Jeopardy! While more progress is being made all the time in Artificial Intelligence (AI), some scientists and philosophers warn of the dangers of an uncontrollable superintelligent AI. Using theoretical calculations, an international team of researchers, including scientists from the Center for Humans and Machines at the Max Planck Institute for Human Development, shows that it would not be possible to control a superintelligent AI. The study was published in the Journal of Artificial Intelligence Research. Suppose someone ...