Researchers from Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, USA, report a modification wherein replacing the RNA strand of a heteroduplex oligonucleotide with DNA may enhance the efficacy of antisense oligonucleotide-based drugs Tokyo, Japan - Antisense oligonucleotides (ASO) hold great promise for pharmacotherapy. Now, researchers at Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, advancing their earlier work on a heteroduplex oligonucleotide (HDO) model, have demonstrated augmentation of ASO-based ...

For the first time, researchers have used a novel catalyst process to recycle a type of plastic found in everything from grocery bags and food packaging to toys and electronics into liquid fuels and wax. The team published their results on Dec. 10 in Applied Catalysis B: Environmental. "Plastics are essential materials for our life because they bring safety and hygiene to our society," said paper co-authors Masazumi Tamura, associate professor in the Research Center for Artificial Photosynthesis in the Advanced Research Institute for Natural Science and Technology in Osaka City University, and Keiichi Tomishige, professor in the Graduate School of Engineering in Tohoku University. "However, the growth of the global ...

An imbalance of the body's oxygen producing free radicals and its antioxidant cells could be the reason why gum disease and chronic kidney disease affect each other, a new study led by the University of Birmingham has found. Periodontitis - or gum disease - is a common, inflammatory disease which causes bleeding gums, wobbly or drifting teeth and can eventually result in tooth loss. Previous studies have shown a link between the severe oral inflammation caused by gum disease and chronic kidney disease (CKD) which demonstrated that those with worse inflammation of the gums have worse kidney function. Previous research also showed that patients with CKD and periodontitis experience ...

Practicing gratitude and looking to the future will help safeguard our mental wellbeing during Covid-19 lockdowns, a new study in the Journal of Positive Psychology reports. In the first study of its kind, researchers from the University of Surrey investigated the effectiveness of three psychological interventions -- nostalgia, a sentimentality for the past; gratitude, recognising the good things currently in our life; and best possible self, thinking about positive elements of the future -- and how they each affect wellbeing during lockdowns. Personal characteristics such as emotion regulation (the ability to respond ...

In a joint collaboration, Danish and German researchers have characterized a cellular activity that protects our cells from potentially toxic by-products of gene expression. This activity is central for the ability of multicellular organisms to uphold a robust evolutionary 'reservoir' of gene products. Manufacturing processes need quality control systems in order to ensure proper assembly of functional products. Moreover, space-consuming, and perhaps even toxic, by-products of such processes need to be properly discarded or recycled by efficient waste handling systems. By analogy, transcription of our genome is an imperfect process that produces large quantities of non-functional and potentially harmful transcripts both from within and ...

Researchers at the Francis Crick Institute and the University of Western Australia have developed a new imaging method to see where antibiotics have reached bacteria within tissues. The method could be used to help develop more effective antibiotic treatments, reducing the risk of antibiotic resistance. During bacterial infections like tuberculosis, bacteria enter human cells, which poses a challenge for treatment, as antibiotics must reach and enter all infected cells in order to be effective. If researchers could select for or develop more effective antibiotics based on where they reach, this may reduce the length of treatment ...

A joint research team from KAIST and UCSD has developed a deep neural network named DeepTFactor that predicts transcription factors from protein sequences. DeepTFactor will serve as a useful tool for understanding the regulatory systems of organisms, accelerating the use of deep learning for solving biological problems. A transcription factor is a protein that specifically binds to DNA sequences to control the transcription initiation. Analyzing transcriptional regulation enables the understanding of how organisms control gene expression in response to genetic or environmental changes. In this regard, finding the transcription factor of an organism is the first step in the analysis ...

While glass is a truly ubiquitous material that we use on a daily basis, it also represents a major scientific conundrum. Contrary to what one might expect, the true nature of glass remains something of a mystery, with scientific inquiry into its chemical and physical properties still underway. In chemistry and physics, the term glass itself is a mutable concept: It includes the substance we know as window glass, but it may also refer to a range of other materials with properties that can be explained by reference to glass-like behaviour, including, for instance, ...

Sunlight offers a potential solution in the search for an energy source that does not harm the planet, but this depends on finding a way to efficiently turn electromagnetic energy into electricity. Researchers from KAUST have shown how a known herbicide can improve this conversion in organic devices. While solar cells have traditionally been made from inorganic materials such as silicon, organic materials are starting to break through as an alternative because they are light, flexible and relatively inexpensive to make, even offering the possibility for ...

MTO process, which was first commercialized in 2010, is a catalytic process converting methanol, which is typically made from coal, natural gas, biomass, and CO2, over SAPO-34 zeolite catalyst. It's becoming one of the main streams for producing light olefins, including ethylene and propylene, from non-oil resources. One of the major challenges in MTO is the rapid deactivation of zeolite catalyst due to the coke deposition. In industrial practices, a fluidized bed reactor-regenerator configuration is normally used in order to maintain the continuous operation, in ...

Dr. Camilo Ricordi, director of the Diabetes Research Institute (DRI) and Cell Transplant Center at the University of Miami Miller School of Medicine, and his team of international collaborators are reporting the results of a groundbreaking randomized controlled trial showing umbilical cord-derived mesenchymal stem cell (UC-MSC) infusions safely reduce risk of death and quicken time to recovery for the most severe COVID-19 patients. Dr. Ricordi's peer-reviewed paper has just been published in STEM CELLS Translational Medicine (SCTM) January 2021. The clinical trial, authorized by the FDA last ...

Dr. Camilo Ricordi, director of the Diabetes Research Institute (DRI) and Cell Transplant Center at the University of Miami Miller School of Medicine, and his team of international collaborators are reporting the results of a groundbreaking randomized controlled trial showing umbilical cord-derived mesenchymal stem cell (UC-MSC) infusions safely reduce risk of death and quicken time to recovery for the most severe COVID-19 patients. Dr. Ricordi's peer-reviewed paper has just been published in STEM CELLS Translational Medicine (SCTM) January 2021. The clinical trial, authorized by the FDA last April, was initiated by The Cure Alliance, a 501(c)(3) non-profit organization of research scientists founded ten years ago by Dr. Ricordi for scientists ...

Like any other plant, Arabidopsis thaliana or mouse-ear cress, needs nitrogen to survive and thrive. But, like maize, beans and sugar beet, it prefers nitrogen in the form of nitrate, growing better on nitrate rich soil. Whereas, pine and rice for example preferentially grow on ammonium nutrition, another form of the key macronutrient nitrogen. If the concentration or the availability of the different forms of nitrogen fluctuate, plants have to adapt quickly. "One of the most important questions is, what is the role of plant hormones in adaptation to the nitrogen availability? How do the machineries within a plant cope with their changing environment?" asks Eva Benková, developmental biologist and Professor at the Institute of Science and Technology (IST) Austria. Finding the balance In ...

University of Miami Miller School of Medicine researchers led a unique and groundbreaking randomized controlled trial showing umbilical cord derived mesenchymal stem cell infusions safely reduce risk of death and quicken time to recovery for the severest COVID-19 patients, according to results published in STEM CELLS Translational Medicine in January 2021. The study's senior author, Camillo Ricordi, M.D., director of the Diabetes Research Institute (DRI) and Cell Transplant Center at the University of Miami Miller School of Medicine, said treating COVID-19 with mesenchymal stem cells makes sense. Results: treatment group vs. ...

Inspired by the color-changing skin of cuttlefish, octopuses and squids, Rutgers engineers have created a 3D-printed smart gel that changes shape when exposed to light, becomes "artificial muscle" and may lead to new military camouflage, soft robotics and flexible displays. The engineers also developed a 3D-printed stretchy material that can reveal colors when light changes, according to their study in the journal ACS Applied Materials & Interfaces. Their invention is modeled after the amazing ability of cephalopods such as cuttlefish, octopuses and squids to change the color and texture of their soft skin for camouflage and communication. This is achieved by the ...

In modern times, manufacturers produce highly specialized materials for a wide array of uses, called polymers. Polymers have a variety of purposes owing to their versatile properties, ranging from being used in construction due to their high tensile strength and resistance to manufacturing plastic bags that require more lightweight, flexible materials, such as nylon or polyethene. These differences between the properties of different polymers stems from their internal structure. Polymers are made up of long chains of smaller sub-units, called "monomers." Crystallization occurs when crystalline polymers are melted, then cooled down slowly, which enables the chains to organize themselves into neatly arranged ...

Grasslands are managed worldwide to support livestock production, while remaining natural or semi-natural ones provide critical services that contribute to the wellbeing of both people and the planet. Human activities are however causing grasslands to become a source of greenhouse gas emissions rather than a carbon sink. A new study uncovered how grasslands used by humans have changed our climate over the last centuries. Grasslands are the most extensive terrestrial biome on Earth and are critically important for animal forage, biodiversity, and ecosystem services. They absorb and release carbon dioxide (CO2), and emit methane (CH4) from grazing livestock and nitrous oxide (N2O) from soils, especially when manure or ...

A new study out of the University of Chicago Medicine following young adult drinkers for 10 years has found that individuals who reported the highest sensitivity to alcohol's pleasurable and rewarding effects at the start of the trial were more likely to develop an alcohol use disorder (AUD) over the course of the study. Moreover, when retested on their responses 10 years later, those who became alcoholics had the highest levels of alcohol stimulation, liking and wanting - and these were heightened compared to their baseline with no signs of tolerance to these pleasurable effects. The research, published on Jan. 5 in the American Journal of Psychiatry, followed a ...

Bird diets provide a real treasure for research into the distribution and conservation of their prey, such as overlooked and rare bush-cricket species, point out scientists after studying the diet of the Eurasian Eagle Owl (Bubo bubo) in southeastern Bulgaria. In their END ...

Chemotherapy for breast cancer costs the UK economy more than £248 million annually, including 'out-of-pocket' personal costs of more than £1,000 per patient - according to new research from the University of East Anglia. A new study published today is the first to investigate the total non-healthcare cost of chemotherapy to the UK. It includes the cost of lost productivity, work absence, and personal costs such as paying for transport and parking for treatment, the cost of wigs and new bras, and over the counter medications. The UEA research team say that better targeting of treatment could help avoid placing unnecessary costs upon patients, their caregivers and wider society. Prof Richard Fordham, from UEA's ...

Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent. 1. State laws promoting flu vaccination for hospital workers may help prevent deaths from flu and pneumonia Abstract: https://www.acpjournals.org/doi/10.7326/M20-0413 URL goes live when the embargo lifts Research ...

New Rochelle, NY, January 4, 2021--Crop plants and animals can be infected by bacterial pathogens that reduce yield, cause food wastage, and carry human pathogens that spread disease on consumption. Bacteriophage can play an important role in microbial control, according to a new Special Issue on Agriculture and Aquaculture published in the peer-reviewed journal PHAGE: Therapy, Applications, and Research. Click here to read the issue. "Although the number of problems associated with bacterial diseases in agriculture and aquiculture has increased, food producers ...

When Yellowstone National Park's Steamboat Geyser -- which shoots water higher than any active geyser in the world -- reawakened in 2018 after three and a half years of dormancy, some speculated that it was a harbinger of possible explosive volcanic eruptions within the surrounding geyser basin. These so-called hydrothermal explosions can hurl mud, sand and rocks into the air and release hot steam, endangering lives; such an explosion on White Island in New Zealand in December 2019 killed 22 people. A new study by geoscientists who study geysers throws cold water on that idea, finding few indications of underground magma movement that would be a prerequisite to an eruption. The geysers sit just outside the nation's largest ...

UNIVERSITY PARK, Pa. -- American politicians have long been expected to uphold a certain veneer: powerful, influential and never vulnerable. New Penn State research has found that these idealized forms of masculinity may also help explain support for Donald Trump in the 2016 presidential election and in the days leading up to the 2020 election. Across several studies, the researchers found that when men and women endorsed "hegemonic masculinity" -- a culturally idealized form of masculinity that says men should be strong, tough, and dominant -- they were more likely to vote for and have positive feelings about Trump. The researchers found this was true ...

A geosciences team led by the University of South Florida (USF) has developed a new way to reconstruct the sizes of volcanic eruptions that occurred thousands of years ago, creating a first-of-its kind tool that can aid scientists in understanding past explosive eruptions that shaped the earth and improve the way of estimating hazards of future eruptions. The advanced numerical model the USF team developed allows scientists to reconstruct eruption rates through time by estimating the dimensions of the umbrella clouds that contribute to the accumulation ...