HOUSTON ― Researchers from The University of Texas MD Anderson Cancer Center demonstrated that anti-PD-L1 immunotherapy in combination with mutation-directed targeted therapy extended overall survival (OS) in patients with anaplastic thyroid carcinoma (ATC). Findings from the Phase II single center study published today in JAMA Oncology.  The trial enrolled 42 patients across three cohorts to evaluate mutation-matched targeted therapy and the immune checkpoint inhibitor atezolizumab. The median OS across all cohorts was 19 months, which compares favorably to historical OS of five months for patients with ATC. ...

Producing materials such as steel, plastics and cement in the United States alone inflicts $79 billion a year in climate-related damage around the world, according to a new study by engineers and economists at the University of California, Davis. Accounting for these costs in market prices could encourage progress toward climate-friendly alternatives.  “We wanted to look at the cost to society to produce these materials,” said Elisabeth Van Roijen, a recent Ph.D. graduate from the UC Davis Department of Civil and Environmental Engineering ...

On-demand ride services or ride-sourcing services have been experiencing fast development and steadily reshaping the way people travel in the past decade. Various optimization algorithms, including reinforcement learning approaches, have been developed to help ride-sourcing platforms design better operational strategies to achieve higher efficiency. However, due to cost and reliability issues, it is commonly infeasible to validate these models and train/test these optimization algorithms within real-world ride-sourcing platforms. Acting as a proper test bed, a simulation platform for ride-sourcing systems will thus be essential for both ...

A team of researchers has undertaken a study of the future of carbon anodes for lithium-ion batteries. Their review provides a comprehensive overview of the progression in carbon anode development and the current status of their industrialization. This study underscores the critical role of interphase regulation engineering in advancing lithium-ion battery technology.   Their research is published in the journal Carbon Future on September 24, 2024.   Today, graphite is the most commonly used material for anodes in lithium-ion batteries. Graphite can operate at a low voltage, is readily available, and cost effective. While graphite materials ...

WASHINGTON — Researchers have developed a faster and more accurate method for acquiring and reconstructing high-quality 3D surface measurements. The approach could greatly improve the speed and accuracy of surface measurements used for industrial inspection, medical applications, robotic vision and more. “Traditional 3D imaging works by comparing two viewpoints, similar to how our eyes work together to judge depth,” said research team leader Ce Zhu from the University of Electronic Science and Technology of China. “In contrast, our new approach ‘feels’ the surface by projecting light ...

Background and Aims Glutathione peroxidase 4 (GPX4) is a key factor in ferroptosis, which is involved in ischemia-reperfusion injury. However, little is known about its role in hepatic ischemia-reperfusion injury (HIRI). This study aimed to investigate the role of GPX4 methylation in ferroptosis during HIRI.   Methods For the in vivo experiments, an ischemia-reperfusion model was created by subjecting mice to simulated HIRI. Ferroptosis occurrence, GPX4 promoter methylation, and global methylation levels were then assessed.   Results Ferroptosis ...

A review paper by scientists at Institute of Chemistry, Chinese Academy of Sciences summarized the progress of biointegrated flexible and stretchable optoelectronics for wearable and implantable cardiac healthcare. The new review paper, published on Oct. 18 in the journal Cyborg and Bionic Systems, focuses on the advances in biointegrated flexible and stretchable optoelectronics for wearable and implantable cardiac healthcare systems. With the prevalence of cardiovascular disease, it is imperative that medical monitoring and treatment become more instantaneous and comfortable for ...

The Science and Science Careers’ 2024 Top Employers Survey polled employees in biotechnology, biopharmaceutical, pharmaceutical, and related industries to determine the 20 best employers as well as their driving characteristics. Respondents to the web-based survey were asked to rate companies based on 24 characteristics, including innovative leadership, respect for employees, and social responsibility. Insmed, Bridgewater, New Jersey, receives the top honor this year in a ranking of the world’s most respected employers. The rankings, determined from a study conducted by an independent research firm commissioned by the Science/AAAS Office of Publishing, ...

It takes a lot to succeed with ambitious goals. Among other things, we need passion and belief that we will succeed, and we usually need support from others. However, we also need to have the right attitude – the right mindset, one that makes us willing to do what it takes to change and improve. Experts refer to it as a growth mindset. So, how do we know if we actually have the right mindset? How can a coach know if a talented athlete has the mindset needed to become one of the best? An individual’s mindset is influenced by external factors that can change, and it may also vary from day to ...

WASHINGTON—A vigorous workout does more to suppress hunger levels in healthy adults than does moderate exercise, and females may be especially susceptible to this response, according to a small study published in the Journal of the Endocrine Society. The study examines the effects of exercise intensity on ghrelin levels and appetite between men and women. Ghrelin is known as the “hunger hormone” and is associated with perceptions of hunger. “We found that high intensity exercise suppressed ghrelin levels more than moderate intensity exercise,” said lead author Kara Anderson, Ph.D., of the University ...

PLYMOUTH MEETING, PA [October 24, 2024] — New research published online-ahead-of-print in JNCCN—Journal of the National Comprehensive Cancer Network found that people with newly-diagnosed hormone receptor (HR)-negative, human epidermal growth factor receptor 2 (HER2)-positive breast cancer were more likely to receive timely, guideline-concordant treatment and have longer survival in states that participate in Medicaid expansion under the Affordable Care Act (ACA). A team of researchers—led by the American Cancer Society (ACS), and including Kathryn J. Ruddy, MD, MPH, of the Mayo Clinic ...

Decades after it was first found in Japan, a species of crustacean with unique black-and-white coloring that resembles a panda has been confirmed to be new to science. Melitid amphipods are shrimp-like crustaceans found worldwide. The newly classified Melita panda — named after the charismatic mammal — was first found in the 1990s. Details of the discovery and morphological analysis were published in a ZooKeys article on 21 September. The discovery of the Melita panda highlights the importance of studying species taxonomy, which is the naming and classification of organisms, for conservation efforts. It is impossible to know if a species is in ...

BOSTON (Oct. 24, 2024) – With the rise in incidence of food allergies in children in the past decade, there has been a corresponding increase in the need for professional psychology services due to increased anxiety. A new study being presented at this year’s American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting in Boston showed a more than 50% increase in psychology referrals at one center in 2023 compared to yearly referrals from 2018-2022. “Our center has devoted significant resources to address the psychosocial support needed by many families who have children with food allergies,” ...

BOSTON (Oct. 24, 2024) – Anaphylaxis can come on suddenly and without warning, and because its symptoms can be fatal, it is scary for those who encounter it. Two new studies being presented at this year’s American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting in Boston show it is not only patients and caregivers who misunderstand how best to treat anaphylaxis: emergency medical professionals often follow incorrect protocols for treating severe allergic reactions. “We know early recognition of anaphylaxis and treatment with epinephrine improves outcomes,” says Sasha Alvarado, DO, Co-Director of Quality ...

BOSTON (Oct. 24, 2024) – About 10% of Americans believe they are allergic to penicillin, and approximately 90% of those patients are not actually allergic. As a result, those with the penicillin allergy label are often prescribed more toxic, dangerous and expensive antibiotics that might not be necessary or effective. A new study being presented at this year’s American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting in Boston showed that syphilis patients labeled as penicillin allergic who are low risk should be delabeled to avoid treatment failure and other negative ...

BOSTON (Oct. 24, 2024) – In many cultures, it is common to burn incense for religious and cultural practices, including meditations, celebrations and spiritual and ancestral worship. A new medically challenging case being presented at this year’s American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting in Boston warns that, for those with allergies and asthma, health problems from burning incense can be a significant risk to adults and children. “Our patient was an 87-year-old woman with history of asthma and COPD, ...

BOSTON (Oct. 24, 2024) – Parents of children with atopic dermatitis (AD, also called eczema) know that the allergic condition can mean a heightened risk of developing food allergies. The desire to prevent food allergies causes some parents to consider elimination diets, cutting out certain foods from their child’s diet. A new study being presented at this year’s American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting in Boston showed that elimination diets in the case ...

BOSTON (Oct. 24, 2024) – Throughout the Covid pandemic, media widely reported that Black patients were more likely than White patients to refuse vaccines, including the influenza and Covid vaccines. A new study being presented at this year’s American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting in Boston showed that self-identified non-White patients were less likely to demonstrate vaccine-hesitancy than the self-identified White patient group. “We found ...

  BOSTON (Oct. 24, 2024) – Eosinophilic Esophagitis (EoE), a disorder of the esophagus, is increasingly recognized as a major cause of swallowing difficulties in children and adults. It affects about one in 2,000 people and is part of a spectrum of allergic conditions. A new study being presented at this year’s American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting in Boston investigated the probability of patients with certain atopic (allergic) conditions developing EoE. “We did a separate analysis of four common allergic conditions – asthma, allergic rhinitis, atopic dermatitis and food allergy – to determine ...

BOSTON (Oct. 24, 2024) – People have heard for years that climate change is having a significant impact on plant vegetation patterns and influencing how pollen and mold produce. A new study being presented at this year’s American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting in Boston showed that, in Chicago, there has been a significant increase in sensitization to pollens and molds in patients with nasal allergies. “Our goal was to analyze changes in pollen sensitization patterns ...

A single treatment with, a CRISPR-Cas9 based gene editing therapy, is enough to replace the daily medication of patients with hereditary angioedema (HAE), a condition characterized by severe, painful and sudden onset of swelling, sometimes resulting in death. Confirming the findings published earlier this year from researchers from Amsterdam UMC, the University of Auckland and Cambridge University Hospitals NHS Foundation Trust. This phase two study is published today in the New England Journal of Medicine and presented at American College of Allergy, Asthma & Immunology's annual congress on the ...

A collaborative research group, including researchers from Exploratory Research Center on Life and Living Systems and Institute for Molecular Science of National Institutes of Natural Sciences, as well as Nagoya City University, Nagoya University, and University of Tsukuba, has uncovered a new mechanism in the growth of amyloid β (Aβ) fibrils, which are closely associated with Alzheimer’s disease. Using advanced high-speed atomic force microscopy (HS-AFM), the team was able to observe Aβ fibril growth at the molecular ...

A new study1 from researchers at the Friedman School of Nutrition Science and Policy at Tufts University has found that consuming pistachios daily may significantly improve eye health by increasing macular pigment optical density (MPOD), due to the plant pigment lutein, a key factor in protecting the eyes from blue (visible) light and age-related damage. The randomized controlled trial showed that compared to eating a usual diet alone, eating 2 ounces (57 grams) of pistachios per day for 12 weeks as part of a usual diet resulted in a significant increase in MPOD in otherwise healthy middle-aged to older adults. MPOD is an important indicator of eye health, ...

Background and Aims Metabolic dysfunction-associated steatotic liver disease (MASLD) and its more advanced form, metabolic dysfunction-associated steatohepatitis, have emerged as the most prevalent liver diseases worldwide. Currently, lifestyle modification is the foremost guideline-recommended management strategy for MASLD. However, it remains unclear which detrimental signals persist in MASLD even after disease remission. Thus, we aimed to examine the persistent changes in liver transcriptomic profiles following ...

ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) and Caris Life Sciences®(Caris) announced today a multi-year research collaboration wherein Caris is pairing its highly sophisticated and comprehensive genomic, transcriptomic and proteomic profiling, advanced artificial intelligence (AI) and machine learning algorithms with ECOG-ACRIN’s immense research capabilities. The first project is underway and leverages the tumor tissue samples from the Trial Assigning Individualized Options for Treatment (Rx) or TAILORx, breast cancer clinical trial. TAILORx is one of the world's largest breast cancer research resources. The TAILORx trial and its associated biospecimen ...