Editorial  To Improve Screenings With Technology, Focus on People First Background: This issue of Annals of Family Medicine includes four original studies that illustrate valuable concepts to consider when incorporating technology in screening to improve early detection and management of disease.   Editorial Stance: These studies highlight the importance of centering any digital health intervention on the patient’s specific clinical needs. The authors emphasize that digital tools work best when they work with, rather than replace, clinicians. Additionally, the authors stress that we must ...

Background and Goal: This study examined long‑term shifts toward focused practice among family physicians in Ontario, Canada, as well as changes in the number of comprehensive family physicians relative to population growth. Study Approach: Researchers linked multiple Ontario health‑administrative data sets to track practice patterns for every general practitioner or family physician from fiscal years 1993/94 through 2021/22. Analyses were stratified by physician sex and years in practice.  Main Results: The proportion of family physicians working in focused roles rose to 19.2% ...

Mental‑health disorders and suicide rates have risen steadily over the past 20 years, with rural areas seeing the sharpest increases. To broaden access to mental‑health resources for adults, physicians placed a little free library containing 10–15 books on anxiety, depression, post‑traumatic stress disorder, and related conditions near the entrance of a rural primary care clinic in Minnesota. A flyer with a QR code directs visitors to a community‑run webpage with additional resources. Patients who take a book are asked to complete a short survey capturing demographics, referral ...

UNIVERSITY PARK, Pa. — Fragrances and lotions don't just change the way people smell, they actively alter the indoor air chemistry around the wearer, disrupting a critical natural process the body uses to protect itself from pollution, according to an international research team that includes scientists from Penn State. The new study, published in the journal Science Advances, revealed that personal care products like perfumes and even unscented lotions alter the chemical composition of the “human oxidation field,” a natural protective air shield around a person’s breathing zone ...

CAMBRIDGE, MA -- The human brain contains about 86 billion neurons. These cells fire electrical signals that help the brain store memories and send information and commands throughout the brain and the nervous system. The brain also contains billions of astrocytes — star-shaped cells with many long extensions that allow them to interact with millions of neurons. Although they have long been thought to be mainly supportive cells, recent studies have suggested that astrocytes may play a role in memory storage ...

Employees’ early work experiences in an organization can significantly affect their socialization. Much of the research on this topic has documented how certain organization-wide practices succeed or fail in making newcomers so-called good citizens, but little is known about how different early experiences lead to varied socialization outcomes. In a new study, researchers examined the impact of early project team assignments on newcomers’ career kickoffs. They found that those assigned to more complex projects during this phase had better outcomes later in their careers. The study, ...

NIJMEGEN, The Netherlands, 27 May 2025 – In a comprehensive Genomic Press interview published today, Professor Barbara Franke unveils her remarkable scientific journey from an inquisitive child fascinated by nature to becoming one of the world's most influential researchers in biological psychiatry. The molecular psychiatrist at Radboud University has fundamentally transformed our understanding of how genetic variations lead to altered behavior in neurodevelopmental conditions, particularly ...

Tsukuba, Japan—The human genome is broadly classified into the genome residing in the cell nucleus (nuclear DNA) and the genome residing in the mitochondria (mitochondrial DNA: mtDNA). Mitochondria are cell organelles that produce energy essential for life activities through oxidative phosphorylation (mitochondrial respiration), and mtDNA encodes a set of genes required for mitochondrial respiration. Previous research has led to the widely accepted hypothesis that the accumulation of multiple mutations in mtDNA with aging induces a decline in mitochondrial respiratory function, resulting in the "mitochondrial theory of aging." Nevertheless, whether the decrease in mitochondrial ...

Chinese researchers recently uncovered molecular evidence supporting Lamarckism—a long-debated theory from the early 19th century that acquired characteristics can be inherited.  The evidence was revealed in a new study by scientists from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, which deciphered the evolutionary patterns of cold adaptation during rice's northward expansion. The study was published on May 22 in Cell.  Led by Prof. CAO Xiaofeng, the researchers demonstrated that DNA methylation—a form of epigenetic variation ...

Learning to play music by ear is challenging for most musicians, but research from a team at the University of Waterloo may help musicians-in-training find the right notes. The Waterloo team analyzed a range of YouTube videos that focused on learning music by ear and identified four simple ways music learning technology can better aid prospective musicians – helping people improve recall while listening, limiting playback to small chunks, identifying musical subsequences to memorize, and replaying notes indefinitely. “There ...

(WASHINGTON—May 27, 2025) The American Society of Hematology (ASH) and the International Society on Thrombosis and Haemostasis (ISTH) released new and updated clinical practice guidelines for the treatment of pediatric venous thromboembolism (VTE). The guidelines, published in ASH’s peer-reviewed journal Blood Advances, were developed by an expert panel following a rigorous review process. They aim to improve health outcomes by providing evidence-based recommendations for managing VTE in children.    The ...

In recent years, the space industry has experienced unprecedented explosive growth, with the number of satellite launches increasing exponentially. By the end of 2023, the number of global operational spacecraft exceeded 9,850, and the annual revenue of the space economy reached a staggering $400 billion. As space technology becomes increasingly integrated into our daily lives, enhancing the stealth of high-value space objects like spacecraft to reduce the risk of detection has become a critical challenge.   Currently, space objects face ground-based detection threats primarily ...

Complex modulation of optical fields (i.e., the control of light’s amplitude and phase) is vital to the application of lasers in diverse fields, such as optical communication, three-dimensional display, biomedical imaging, and astronomy. Yet, despite dazzling progress seen by applications of complex field modulation (CFM), improvements to technical capabilities such as accuracy, speed, and versatility remain highly in demand.   Key to the overall performance of CFM technologies are spatial light modulators (SLMs): advanced devices that provide two-dimensional arrays of electronically addressable pixels whose optical properties can be independently controlled to ...

Burden of Memory Disorders and the Role of Traditional Medicine The growing global population of elderly individuals has led to a dramatic rise in chronic diseases, including neurocognitive disorders such as Alzheimer’s disease. These conditions, which are expected to affect over 150 million people worldwide by 2050, are marked by memory loss, impaired judgment, and cognitive decline. While pharmacological interventions exist, their limitations in accessibility, affordability, and side effect profiles have prompted the exploration of holistic approaches. This review emphasizes traditional ...

A new study published in JAMA Internal Medicine reveals a concerning decline in self-reported mental health among mothers in the United States between 2016 and 2023. Conducted by researchers at the Columbia University Mailman School of Public Health, the study also found modest but measurable declines in self-reported physical health during the same period. This large-scale analysis examined data from 198,417 mothers who participated in the National Survey of Children’s Health (NSCH), a nationally representative annual survey of households with children aged 0–17. Most participating mothers were over age 30, and over half had a privately ...

About The Study: This cohort study identified symptom patterns and derived research indices that were distinct between the 2 age groups (infants/toddlers [0-2 years] vs preschool-aged children [3-5 years]) and differed from those previously identified in older ages, demonstrating the need to characterize long COVID separately across age ranges.  Corresponding Author: To contact the corresponding author, Rachel S. Gross, MD, MS, email rachel.gross@nyulangone.org. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamapediatrics.2025.1066) Editor’s ...

About The Study: In this study, conducted when surgical and pharmacological weight-loss interventions were nearly nonexistent, sustained midlife weight loss compared with persistent overweight was associated with a decreased risk of chronic diseases beyond type 2 diabetes and decreased all-cause mortality. Corresponding Author: To contact the corresponding author, Timo E. Strandberg, MD, PhD, email timo.strandberg@helsinki.fi. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.11825) Editor’s Note: Please see the article for additional information, ...

About The Study: In this trial, patient-delivered lifestyle intervention (mentor interventionists plus peer support) yielded significantly better weight loss maintenance and cardiovascular risk outcomes compared with standard-of-care treatment delivered by professionals. Future research may examine the effectiveness of this novel treatment approach in community and clinical settings.  Corresponding Author: To contact the corresponding author, Tricia M. Leahey, PhD, email tricia.leahey@uconn.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2025.1345) Editor’s ...

An inexpensive, long-approved HIV drug can improve vision in patients with a blinding complication of diabetes more effectively and a much lower cost than many existing treatments, an initial clinical trial suggests. Further, the drug is taken orally, potentially offering patients an alternative to monthly injections directly into their eyes. The drug, lamivudine, could represent an important new option for millions of patients with diabetic macular edema (DME), a condition which causes fluid to build up in the retina of the eye. ...

Batteries are nearing their limits in terms of how much power they can store for a given weight. That’s a serious obstacle for energy innovation and the search for new ways to power airplanes, trains, and ships. Now, researchers at MIT and elsewhere have come up with a solution that could help electrify these transportation systems. Instead of a battery, the new concept is a kind of fuel cell — which is similar to a battery but can be quickly refueled rather than recharged. In this case, the fuel is liquid sodium metal, an inexpensive and widely available commodity. The other side of the cell is just ordinary air, which serves as ...

ALEXANDRIA, VA —The American Academy of Otolaryngology–Head and Neck Surgery Foundation (AAO-HNSF) published the new Clinical Practice Guideline (CPG): Surgical Management of Chronic Rhinosinusitis today in Otolaryngology–Head and Neck Surgery. Chronic rhinosinusitis (CRS) affects 11.6% of adults and prompts 4.1 million annual ambulatory visits. "Chronic rhinosinusitis doesn't just affect the nose—it can influence a person's general life. Patients can struggle with poor sleep, ...

Scientists have unearthed surprising details about how our bodies handle insulin – the hormone that plays a crucial role in regulating blood sugar and developing diabetes. The discovery could lead to better treatment of type 2 diabetes and earlier diagnosis, potentially even before the disease develops. In a new paper in the scientific journal Cell, researchers from the University of Copenhagen found that all individuals have unique and varying degrees of insulin resistance at the molecular level. The discovery of this ‘molecular fingerprint’ for insulin sensitivity challenges the traditional binary classification ...

Spinal cord injury (SCI) significantly impacts the central nervous system, with limited effective treatments available. Brain-derived neurotrophic factor (BDNF) plays a crucial role in neuronal growth, survival, and regeneration after SCI. MicroRNAs, particularly miR-124-3p, have been implicated in SCI pathophysiology. However, the relationship between miR-124-3p and BDNF in the context of SCI remains unclear. This study aimed to investigate the correlation between miR-124-3p expression and BDNF levels in a rat model of spinal cord injury and to assess how the timing of injury affects this relationship. Methods This study included 72 male Wistar rats divided ...

Humans were making tools from whale bones as far back as 20,000 years ago, according to a study conducted by scientists from the Institute of Environmental Science and Technology of the Universitat Autònoma de Barcelona (ICTA-UAB), the French National Centre for Scientific Research (CNRS), and the University of British Columbia. This discovery broadens our understanding of early human use of whale remains and offers valuable insight into the marine ecology of the time.  Whales, the largest animals on Earth, were an important ...

A recent study explores the potential of germinated flours as functional ingredients in breadmaking, highlighting both their nutritional benefits and their technological challenges. The growing demand for healthier foods has inspired the scientific community to reexamine traditional ingredients through a modern lens. One such example is germinated flours, which are emerging as a promising alternative for enhancing the nutritional profile of bread, one of the most widely consumed foods worldwide. At the Food Science and Technology Laboratory at ESPOL, researchers comprehensively reviewed the latest findings on the use of germinated ...