A new study indicates that a commonly used mood stabilizing drug may help prevent head and neck cancer. The study is published early online in Cancer, a peer-reviewed journal of the American Cancer Society. Valproic acid (VPA) is currently prescribed as an anti-seizure medication and mood stabilizer, but it is also being studied as an anticancer agent because it inhibits histone acetyl transferases, which help control gene expression by changing DNA structure. Johann Christoph Brandes MD, PhD, of the Atlanta Veterans Affairs Medical Center and Emory University in Atlanta, ...

New consensus statements have been developed to help tackle the growing threat of multidrug-resistant tuberculosis (TB) and extensively drug-resistant tuberculosis (TB). Published online today (24 March 2014) in the European Respiratory Journal¸ the statements mark the first time that physicians who treat patients with multidrug- and extensively drug-resistant TB have reached a consensus on important areas of patient management where scientific evidence is inconclusive. The World Health Organization (WHO) estimates that currently 450,000 new cases with MDR-TB occur ...

To mark the Stop TB Partnerships' World TB Day on Monday 24 March 2014, The Lancet journals will publish a special new collection of Reviews, Comment, and Articles to cast light, and the world's attention, on tuberculosis, in the hope of raising this disease higher up the agendas of international communities. The new publications discuss topics ranging from extremely drug-resistant tuberculosis, to the role of advocacy in tuberculosis, and new anti-tuberculosis drugs, highlighting the key areas and challenges to be met if inroads are to be made into winning the battle ...

Researchers from Brigham and Women's Hospital (BWH) and Harvard Medical School (HMS) in Boston have estimated that around one million children suffer from tuberculosis (TB) annually— twice the number previously thought to have tuberculosis and three times the number that are diagnosed every year. The researchers also estimated that around 32,000 children suffer from multidrug-resistant tuberculosis (MDR-TB) annually. These findings are published in The Lancet on March 23, 2014. "Despite children comprising approximately one quarter of the world's population, there ...

Massachusetts General Hospital (MGH) investigators may have found a way to solve a problem that has plagued a group of drugs called ligand-mimicking integrin inhibitors, which have the potential to treat conditions ranging from heart attacks to cancer metastasis. In a Nature Structural & Molecular Biology paper receiving advance online publication, the researchers provide a structural basis for the design of new and safer integrin inhibitors. Integrins are receptor proteins found on the surface of cells that determine whether or not cells adhere to adjacent cells and ...

Researchers the world round are working to develop optical chips, where light can be controlled with nanostructures. These could be used for future circuits based on light (photons) instead of electron - that is photonics instead of electronics. But it has proved to be impossible to achieve perfect photonic nanostructures: they are inevitably a little bit imperfect. Now researchers at the Niels Bohr Institute in collaboration with DTU have discovered that imperfect nanostructures can offer entirely new functionalities. They have shown that imperfect optical chips can be ...

COLUMBUS, Ohio—For the first time, physicists have demonstrated that information can flow through a diamond wire. In the experiment, electrons did not flow through diamond as they do in traditional electronics; rather, they stayed in place and passed along a magnetic effect called "spin" to each other down the wire—like a row of sports spectators doing "the wave." Spin could one day be used to transmit data in computer circuits—and this new experiment, done at The Ohio State University, revealed that diamond transmits spin better than most metals in which researchers ...

Researchers have found that people born with a rare abnormality of their chromosomes have a 2,700-fold increased risk of a rare childhood leukaemia. In this abnormality, two specific chromosomes are fused together but become prone to catastrophic shattering. Acute lymphoblastic leukaemia, or ALL, is the most common childhood cancer. Scientists previously found that a small subset of ALL patients have repeated sections of chromosome 21 in the genomes of their leukaemia cells. This form of ALL – iAMP21 ALL – requires more intensive treatment than many other types of ALL. ...

Scientists at Johns Hopkins report that compounds they hoped would "wake up" dormant reservoirs of HIV inside immune system T cells — a strategy designed to reverse latency and make the cells vulnerable to destruction — have failed to do so in laboratory tests of such white blood cells taken directly from patients infected with HIV. "Despite our high hopes, none of the compounds we tested in HIV-infected cells taken directly from patients activated the latent virus," says Robert F. Siliciano, M.D., Ph.D., a professor of medicine at the Johns Hopkins University School ...

CAMBRIDGE, MA -- Inspired by natural materials such as bone — a matrix of minerals and other substances, including living cells — MIT engineers have coaxed bacterial cells to produce biofilms that can incorporate nonliving materials, such as gold nanoparticles and quantum dots. These "living materials" combine the advantages of live cells, which respond to their environment, produce complex biological molecules, and span multiple length scales, with the benefits of nonliving materials, which add functions such as conducting electricity or emitting light. The new materials ...

Potsdam: Rift valleys are large depressions formed by tectonic stretching forces. Volcanoes often occur in rift valleys, within the rift itself or on the rift flanks as e.g. in East Africa. The magma responsible for this volcanism is formed in the upper mantle and ponds at the boundary between crust and mantle. For many years, the question of why volcanoes develop outside the rift zone in an apparently unexpected location offset by tens of kilometers from the source of molten magma directly beneath the rift has remained unanswered. A team of scientists from the GFZ German ...

Warmer summers brought on by climate change will cause more deaths in London and southeast England than the rest of the country, scientists predict. Researchers at Imperial College London looked at temperature records and mortality figures for 2001 to 2010 to find out which districts in England and Wales experience the biggest effects from warm temperatures. In the most vulnerable districts, in London and the southeast, the odds of dying from cardiovascular or respiratory causes increased by over 10 per cent for every 1C rise in temperature. Districts in the far north ...

PHOENIX, Ariz. — March 23, 2014 — The cause of a rare type of ovarian cancer that most often strikes girls and young women has been uncovered by an international research team led by the Translational Genomics Research Institute (TGen), according to a study published online today by the renowned scientific journal, Nature Genetics. By applying its groundbreaking work in genomics, TGen led a study that included Mayo Clinic, Johns Hopkins University, St. Joseph's Hospital and Medical Center; Evergreen Hematology and Oncology, Children's Hospital of Alabama, the Autonomous ...

This alternative approach to creating artificial organic molecules, called bioretrosynthesis, was first proposed four years ago by Brian Bachmann, associate professor of chemistry at Vanderbilt University. Now Bachmann and a team of collaborators report that they have succeeded in using the method to produce the HIV drug didanosine. The proof of concept experiment is described in a paper published online March 23 by the journal Nature Chemical Biology. "These days synthetic chemists can make almost any molecule imaginable in an academic laboratory setting," said Bachmann. ...

(March 23, 2014, Beaverton, OR) Treating cervical cancer cells with AHCC led to the eradication of HPV, human papillomavirus, as well as a decrease in the rate of tumor growth in-vitro and in-vivo, in research presented at the Society of Gynecological Oncology 45th Annual Meeting on Women's Cancer in Tampa, Florida. The study was led by Dr. Judith A. Smith, Pharm.D., at the University of Texas Health Science Center (UTHealth) Medical School at Houston. In the study cervical cancer cells were treated with AHCC and incubated for 72 hours with sampling every 24 hours. The ...

JDRF is the leading global organization funding type 1 diabetes (T1D) research. Their annual Boston walk, planned for Saturday, September 27 is expected to raise more than $1.3M for T1D research. Whalen became involved with JDRF three years ago after his then three-year-old son, Jesse, was diagnosed with type 1 diabetes. Seeing the daily challenges Jesse faces, Whalen formed the "Jesse James Gang" team to participate in the JDRF Walk to Cure Diabetes. Over the past three years, the Jesse James Gang has raised more than $20,000. "The JDRF Boston Walk ...

Kimco Insurance, Inc. - Kim Williams Allstate Insurance Agency in Longwood, Florida announces their new relationship with the Seminole County Regional Chamber of Commerce in Central Florida. Kimco Insurance, Inc. is a licensed Allstate insurance agency in Wekiva Springs located at 237 N. Hunt Club Boulevard, Suite 101, Longwood, Florida 32779. Kimco Insurance, Inc. recently joined the Seminole County Regional Chamber of Commerce to partner with area businesses and network within the community. "Seminole County Florida is a great area for business growth. Our ...

Dr. Anand Lalaji, the founder and creator of Inside Injuries, is eagerly anticipating the launch of a newly redesigned website from an Atlanta area marketing and PR firm, Local Marketing, Inc. The brainchild of Dr. Lalaji, Inside Injuries provides avid sports fans and casual enthusiasts alike with an "inside" look at some of the most common injuries sustained in football, baseball, soccer, hockey, UFC, and other popular sports in the United States and around the world. "When I first created Inside Injuries, I didn't expect it to catch on the way that ...

Memphis rap artist and songwriter Teflon Don has released his new single, "Nobody But You," featuring R&B singers Chris J and Porcelan Chalet. Just only a few weeks ago Teflon Don, Chris J and Porcelan Chalet joined producer, arranger and engineer Johnathan "J'Dav" Davenport in the studio to collaborate on the powerful new Ray Nelson (RayNel Music) produced music single. The release of the single has been receiving high praise from people such as Michael J. Sykes a.k.a. "M.I.A.M.I. Mike," President of Palm Tree Entertainment and Soulja ...

Recently eSight Energy, a global energy management software company, has become ISO-9001 certified. This standard, set forth by International Standards Organization (ISO), is based on a number of quality management principles including a strong customer focus, the motivation of top management, the process approach and continual improvement. ISO-9001 not only benefits the company, but its customers as well. To earn this accreditation, eSight Energy implemented a quality management system in all areas of business, including: facilities, people, training, services, and ...

Just in time for wedding season, Attitude Couture's new collection of stunning wedding dresses includes a variety of inspired looks for brides seeking the perfect dress for their perfect day. Based in New Orleans, Attitude Couture is an exclusive label collection of special occasion women's wear. "There's a reason so many people enjoy watching shows like 'Say Yes to the Dress.' Wedding dresses are part of the dream of a beautiful day, a beautiful event and a beautiful life," said Robin Spindt, owner of Attitude Couture. "We are proud to offer gorgeous ...

Every year, Leadership Excellence identifies and recognizes the top 500 leadership development programs. For the second year in a row, Kubica LaForest Consulting has been named to this list. In 2012 they were among the top 40 in their category. This year, they will be honored next month at the Global Leadership Forum in Vail, Colorado, as one of the Top 10 Small Consulting firms in the U.S. in leadership development. Leadership Excellence has been recognizing the Top 500 leadership development programs for the past 30 years. Organizations are grouped into eight categories, ...

Claudia Y. Burgoa recently released her latest highly anticipated novel Getting By (A Knight's Tale). Getting By is a new-adult contemporary romance novel, published February 18, 2014. This is the first book in the Knight's series. When Emma Anderson arrived at San Francisco International Airport, she regretted accepting the distinction of being the maid of honor to Gaby's--her childhood friend--wedding. It had been years since the last time she set foot in Menlo Park, where her parents had been killed. The rug where she had been shoving her feelings since that day ...

Exclusive women's handcrafted accessories collection, Harkiss Designs (http://harkissdesigns.com), will hold a Spring Trunk Show event to introduce the public to the unique handmade designs by East African artisans, as well as promote the message of empowering East African women one item at a time. The event will take place on Thursday, March 27, 2014 from 5 PM to 9 PM at 205 East 85th Street, New York, NY. Harriet Zaffoni, founder of Harkiss Designs, has personally made it her mission to create an atmosphere where East African men and women can easily support themselves ...

"Thank You America - It was really great to receive my Award for 'Best Blues Artist' in The Artists In Music Awards on Feb 8th. Thank you Mikey Jayy for providing such a great platform for Independent Artists. Also loved jamming with Ron Tanski and Rob Heft in Old Hollywood and not only playing my first American Show but recording the live album and DVD - see you all in November - can't wait!" Influenced by some of the great rock and blues players such as Jimi Hendrix, Eric Clapton and Freddie King. Sewell worked as a session player in most of the major London ...