Michael Clarke, Consultant Ophthalmologist at Newcastle Eye Centre, says that apart from trauma and orthopaedics, ophthalmology receives more NHS outpatient referrals than any other speciality. He says that opticians are constrained by legislation to refer patients to a medical practitioner if abnormalities are found at an NHS sight test. However, the testing done at NHS sight tests has become more complex and many patients are now referred with clinically insignificant abnormalities, leading to wastage of appointments in Hospital Eye Services. So called 'Eye Health ...

Boston, MA —People with a genetic predisposition to obesity are at a higher risk of obesity and related chronic diseases from eating fried foods than those with a lower genetic risk, according to a new study from researchers from Harvard School of Public Health, Brigham and Women's Hospital, and Harvard Medical School. It is the first study to show that the adverse effects of fried foods may vary depending on the genetic makeup of the individual. "Our study shows that a higher genetic risk of obesity may amplify the adverse effects of fried food consumption on body weight, ...

Results of a phase 2 study published in The Lancet suggest that simvastatin, a cheap cholesterol lowering drug, might be a potential treatment option for the secondary progressive, or chronic, stage of multiple sclerosis (MS), which is currently untreatable. Findings from the MS-STAT trial showed that a high, daily dose of simvastatin was safe, well tolerated, and slowed brain atrophy (shrinkage) by 43% over two years compared with placebo. Longitudinal studies suggest that atrophy progression is linked with disability. In its early stages, MS is characterised by intermittent ...

Adults hospitalised with H1N1 influenza during the 2009-2010 pandemic were 25% less likely to die from the disease if they were given antiviral drugs called neuraminidase inhibitors (NAIs) such as Tamiflu®, according to a large meta-analysis involving more than 29 000 patients from 38 countries, published in The Lancet Respiratory Medicine journal. The findings also indicate that treatment within 2 days of flu symptoms developing halved the risk of death compared with later treatment or no treatment. "Many governments have stockpiles of Tamiflu that are close to expiry. ...

Increased adiposity is likely to cause reduced physical activity in children, according to research published in this week's PLOS Medicine. The results of the study, conducted by Rebecca Richmond and colleagues from the MRC Integrative Epidemiology Unit at the University of Bristol, UK, suggest that promoting weight loss in overweight and obese children might also increase childhood activity levels. Previous studies have shown an association between low physical activity and higher body mass index (BMI) in children but were not able to determine whether childhood adiposity ...

DURHAM, N.C. -- Growing drug resistance, a high prevalence of S. aureus bacteria and ineffective antibiotics prescribed to one in three patients are among the challenges facing community hospitals in treating patients with serious bloodstream infections, according to researchers at Duke Medicine. The findings, published March 18, 2014, in the journal PLOS ONE, provide the most comprehensive look at bloodstream infections in community hospitals to date. While the majority of people in need of medical care go to community hospitals, much of the existing research on bloodstream ...

PHILADELPHIA - Most people appreciate that not getting enough sleep impairs cognitive performance. For the chronically sleep-deprived such as shift workers, students, or truckers, a common strategy is simply to catch up on missed slumber on the weekends. According to common wisdom, catch up sleep repays one's "sleep debt," with no lasting effects. But a new Penn Medicine study shows disturbing evidence that chronic sleep loss may be more serious than previously thought and may even lead to irreversible physical damage to and loss of brain cells. The research is published ...

PITTSBURGH, March 18, 2014 – Stem cells derived from human muscle tissue were able to repair nerve damage and restore function in an animal model of sciatic nerve injury, according to researchers at the University of Pittsburgh School of Medicine. The findings, published online today in the Journal of Clinical Investigation, suggest that cell therapy of certain nerve diseases, such as multiple sclerosis, might one day be feasible. To date, treatments for damage to peripheral nerves, which are the nerves outside the brain and spinal cord, have not been very successful, ...

A new study, published today in the journal in PLOS ONE, shows which plant food supplements are most popular across Europe, with consumers using them to complement their diets or to maintain health. The team of researchers from the Fundación para la Investigación Nutricional and the University of Surrey found that these products are taken in many different forms, including in tea, juice or by tablet. They analysed data from six European countries, collecting information from 2359 adult consumers of plant food supplements in Finland, Germany, Italy, Romania, Spain and ...

Critically ill patients receiving mechanical ventilation had a higher prevalence of prior psychiatric diagnoses and an increased risk of a new psychiatric diagnosis and medication use after hospital discharge, according to a study in the March 19 issue of JAMA. With recent advances in medical care, more patients are surviving critical illness. Critically ill patients are exposed to stress, including pain, respiratory distress, and delirium, all of which may impact subsequent mental health. The extent of psychiatric illness prior to critical illness, as well as the magnitude ...

In a surveillance study of infection with the bacterium Haemophilus influenzae among women of reproductive age in England and Wales from 2009-2012, pregnancy was associated with a greater risk of this infection, which was associated with poor pregnancy outcomes such as premature birth and stillbirth, according to a study in the March 19 issue of JAMA. Haemophilus influenzae can cause illnesses that include respiratory infections. Some studies have suggested an increased risk of invasive H influenzae disease during pregnancy, although these were based on a small number ...

Using a patient's age to raise the threshold for an abnormal result of a blood test used to assess patients with a suspected pulmonary embolism (blood clot in lungs) appeared to be safe and led to fewer healthy patients with the diagnosis, according to a study in the March 19 issue of JAMA. D-dimer is a breakdown product of a blood clot, and measuring D-dimer levels is one way doctors exclude a diagnosis of pulmonary embolism (PE). Several studies have shown that D-dimer levels increase with age. As a result, the proportion of healthy patients with abnormal test results ...

Men who as children had glomerular disease, a disorder of the portion of the kidney that filters blood and one that usually resolves with time, were more likely than men without childhood glomerular disease to have high blood pressure as an adult, according to a study in the March 19 issue of JAMA. Glomerular disease was defined for this study as glomerulonephritis or nephrotic syndrome (both are kidney disorders). Most children who develop glomerular disease have a favorable prognosis with complete resolution of all signs and symptoms. Yet the long-term complications ...

NEW YORK, NY (March 18, 2014) — Vitamin D deficiency has been implicated in numerous health conditions in recent years, including depressed mood and major depressive disorder. Recent observational studies provide some support for an association of vitamin D levels with depression, but the data do not indicate whether vitamin D deficiency causes depression or vice versa. These studies also do not examine whether vitamin D supplementation improves depression. A systematic review of clinical trials that have examined the effect of vitamin D supplementation on depression ...

Cardiac conduction altered by intragenic enhancer Genome-wide association studies (GWAS) have determined a surprising link between dysfunctional cardiac conduction and variants within SCN10A, which encodes nociceptor-associated sodium-gated ion channel subunit NaV1.8. Follow-up functional studies targeting NaV1.8 revealed only a minor contribution to cardiac physiology; therefore, it was unclear how SCN10A mutations promoted the development of cardiac conduction disease. In this issue of the Journal of Clinical Investigation, the research groups of Vincent Christoffels, ...

Boulder, Colo., USA – Geology papers published 17 Mar. 2014 cover (1) modeling of seabed turbidity currents; (2) a large earthquake at Lake Vättern, Switzerland, about 11,500 years ago; (3) genesis of high-grade gold at the Porgera gold deposit, Papua New Guinea; (4) discovery of the Ediacaran guide fossil Cloudina sp. and the depositional age of the Bambuí Group; (5) earthquakes along the fossil Moho in Alpine Corsica; and (6) using LiDAR to better understand New Zealand's Alpine Fault. Highlights are provided below. Geology articles published ahead of print can be accessed ...

Scientists, using cameras aboard NASA's Lunar Reconnaissance Orbiter (LRO), have created the largest high resolution mosaic of our moon's north polar region. The six-and-a-half feet (two-meters)-per-pixel images cover an area equal to more than one-quarter of the United States. Web viewers can zoom in and out, and pan around an area. Constructed from 10,581 pictures, the mosaic provides enough detail to see textures and subtle shading of the lunar terrain. Consistent lighting throughout the images makes it easy to compare different regions. "This unique image is a tremendous ...

Earth dodged a huge magnetic bullet from the sun on July 23, 2012. According to University of California, Berkeley, and Chinese researchers, a rapid succession of coronal mass ejections – the most intense eruptions on the sun – sent a pulse of magnetized plasma barreling into space and through Earth's orbit. Had the eruption come nine days earlier, it would have hit Earth, potentially wreaking havoc with the electrical grid, disabling satellites and GPS, and disrupting our increasingly electronic lives. The solar bursts would have enveloped Earth in magnetic fireworks ...

COLUMBIA, Mo. – The world's oceans cover more than 72 percent of the earth's surface, impact a major part of the carbon cycle, and contribute to variability in global climate and weather patterns. However, accurately predicting the condition of the ocean is limited by current methods. Now, researchers at the University of Missouri have applied complex statistical models to increase the accuracy of ocean forecasting that can influence the ways in which forecasters predict long-range events such as El Nińo and the lower levels of the ocean food chain—one of the world's ...

For the most common form of childhood eye cancer, unilateral retinoblastoma, shortening the time from the first appearance of symptoms to diagnosis of disease has no bearing on survival or stage of the disease, according to a study by researchers at Columbia University Mailman School of Public Health in partnership with the Hospital Infantil de Mexico. The results appear online in the journal Cancer Epidemiology, Biomarkers & Prevention. Because retinoblastoma is easily detectable by shining a light into a child's eye—often as a "cat's eye" reflection revealed through ...

DALLAS, March 19, 2014 — The health benefits of eating dark chocolate have been extolled for centuries, but the exact reason has remained a mystery –– until now. Researchers reported here today that certain bacteria in the stomach gobble the chocolate and ferment it into anti-inflammatory compounds that are good for the heart. Their findings were unveiled at the 247th National Meeting & Exposition of the American Chemical Society (ACS), the world's largest scientific society. The meeting, attended by thousands of scientists, features more than 10,000 reports on new advances ...

DALLAS, March 18, 2014 — When a heart gets damaged, such as during a major heart attack, there's no easy fix. But scientists working on a way to repair the vital organ have now engineered tissue that closely mimics natural heart muscle that beats, not only in a lab dish but also when implanted into animals. They presented their latest results at the 247th National Meeting & Exposition of the American Chemical Society (ACS), the world's largest scientific society. The talk was one of more than 10,000 being presented at the meeting, which continues here through Thursday. "Repairing ...

They may have tiny brains, but bumblebees are capable of some remarkable learning feats, especially when they might get a tasty reward, according to two studies by University of Guelph researchers. PhD student Hamida Mirwan and Prof. Peter Kevan, School of Environmental Sciences, are studying bees' ability to learn by themselves and from each other. In the first study, published in February in Animal Cognition, the researchers found bees capable of learning to solve increasingly complex problems. The researchers presented bees with a series of artificial flowers that ...

A new UBC study reveals that corporate leaders are victims of herd mentality when adopting new innovations, sometimes with deadly consequences. The paper, by Sauder School of Business Associate Professor Marc-David L. Seidel and INSEAD Professor Henrich R. Greve, shows leaders tend to pursue innovations, even as complex as airplanes, based on early adoption by competitors not close scrutiny of the technical merits. "Business leaders tend to panic when new innovations are about to hit the market. They scramble to buy an apparent early leader," says Seidel. "Sometimes ...

Neuroscientists and bioengineers at Stanford are working together to solve a mystery: how does nature construct the different types of synapses that connect neurons -- the brain cells that monitor nerve impulses, control muscles and form thoughts. In a paper published in the Proceedings of the National Academy of Sciences, Thomas C. Südhof, M.D., a professor of molecular and cellular physiology, and Stephen R. Quake, a professor of bioengineering, describe the diversity of the neurexin family of proteins. Neurexins help to create the synapses that connect neurons. Think ...