In a new report published in the Journal of Leukocyte Biology, scientists lay the groundwork for the development of novel tumor therapies that may help rid the body of cancer by inhibiting the recruitment of a specific suppressive immune cell type called "regulatory T-cells." The approach described in the report shows that an immune molecule, called interleukin-27, promotes the recruitment of regulatory T-cells. This suggests that by stopping IL-27's immunosuppressive function, cancer therapies can more effectively activate other T-cells to attack and destroy cancer tumors. "Our ...

SAN FRANCISCO, CALIF. -- Alaska's seismic network records thousands of quakes produced by glaciers, capturing valuable data that scientists could use to better understand their behavior, but instead their seismic signals are set aside as oddities. The current earthquake monitoring system could be "tweaked" to target the dynamic movement of the state's glaciers, suggests State Seismologist Michael West, who will present his research today at the annual meeting of the Seismological Society of America (SSA). "In Alaska, these glacial events have been largely treated as ...

ANN ARBOR—In the classic marriage vow, couples promise to stay together in sickness and in health. But a new study finds that the risk of divorce among older married couples rises when the wife—but not the husband—becomes seriously ill. "Married women diagnosed with a serious health condition may find themselves struggling with the impact of their disease while also experiencing the stress of divorce," said Amelia Karraker, a researcher at the University of Michigan Institute for Social Research, who presents her findings May 1 at the annual meeting of the Population ...

PHILADELPHIA — A new computational model that simulates bone metastasis of prostate cancer has the potential to rapidly assess experimental therapy outcomes and help develop personalized medicine for patients with this disease, according to data published in Cancer Research, a journal of the American Association for Cancer Research. "Bone remodeling is a balanced and extremely well regulated process that controls the health of our bones and the levels of circulating calcium," said Leah M. Cook, Ph.D., postdoctoral fellow in the Department of Tumor Biology at the Moffitt ...

PHILADELPHIA — Vitamin D deficiency was an indicator of aggressive prostate cancer and spread of the disease in European-American and African-American men who underwent their first prostate biopsy because of abnormal prostate-specific antigen (PSA) and/or digital rectal examination (DRE) test results, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research. "Vitamin D is a steroid hormone that is known to affect the growth and differentiation of benign and malignant prostate cells in prostate cell lines and ...

Johns Hopkins researchers say they have successfully used stem cells derived from human body fat to deliver biological treatments directly to the brains of mice with the most common and aggressive form of brain tumor, significantly extending their lives. The experiments advance the possibility, the researchers say, that the technique could work in people after surgical removal of brain cancers called glioblastomas to find and destroy any remaining cancer cells in difficult-to-reach areas of the brain. Glioblastoma cells are particularly nimble; they are able to migrate ...

The butterfly (Dryas iulia) and the bee (Centris sp.) were most likely seeking scarce minerals and an extra boost of protein. On a beautiful December day in 2013, they found the precious nutrients in the tears of a spectacled caiman (Caiman crocodilus), relaxing on the banks of the Río Puerto Viejo in northeastern Costa Rica. A boat carrying students, photographers, and aquatic ecologist Carlos de la Rosa was passing slowing and quietly by, and caught the moment on film. They watched [and photographed] in barely suppressed excitement for a quarter of an hour while the ...

The present study illustrates, for the hypersonic flows, through the local and marching analysis, the crossover of the mode W and the mode T at O(1) wavenumber and large Görtler number regime. In fact, it is at this wavenumber regime that the instability is most likely to occur. The two approaches are expected to deliver similar results and the marching analysis helps to express the details of the crossover and confirm the result of the local analysis. In fact the study of Görtler instability goes back to the date of the 1940s. Since Görtler's pioneering investigation ...

CHICAGO --- African-American and European-American men at high risk of prostate cancer have greater odds of being diagnosed with an aggressive form of the disease if they have a vitamin D deficiency, according to a new study from Northwestern Medicine® and the University of Illinois at Chicago (UIC). Results of the study will be published May 1 in Clinical Cancer Research, a journal of the American Association for Cancer Research. "Vitamin D deficiency could be a biomarker of advanced prostate tumor progression in large segments of the general population," said Adam ...

BOSTON, MA – A new research study led by Brigham and Women's Hospital (BWH) published in The Journal of the American Geriatrics Society in May, shows an association between midlife and later life sleeping habits with memory; and links extreme sleep durations to worse memory in later life. The study suggests that extreme changes in sleep duration from middle age to older age may also worsen memory function. "Sleep Duration In Midlife and Later Life In Relation to Cognition: The Nurses' Health Study," led by Elizabeth Devore, ScD, instructor in medicine in the Channing ...

A UT Arlington chemistry professor, renowned for his work in the area of chemical separations, is leading an effort to find a more accurate way to measure water content in pharmaceuticals – a major quality issue for drug manufacturers. Daniel W. Armstrong, UT Arlington's Robert A. Welch Chair in Chemistry, says the new technique could be 100 times more sensitive than one of the most popular current methods. "The analysis for water in many consumer products, including drugs, is one of the most required tests done in the world," said Armstrong. "Current methods have many ...

A University of Arizona-led team of physicists has discovered how to change the crystal structure of graphene, more commonly known as pencil lead, with an electric field, an important step toward the possible use of graphene in microprocessors that would be smaller and faster than current, silicon-based technology. Graphene consists of extremely thin sheets of graphite: when writing with a pencil, graphene sheets slough off the pencil's graphite core and stick to the page. If placed under a high-powered electron microscope, graphene reveals its sheet-like structure ...

Tracing where your DNA was formed over 1,000 years ago is now possible due to a revolutionary technique developed by a team of international scientists led by experts from the University of Sheffield. The ground breaking Geographic Population Structure (GPS) tool, created by Dr Eran Elhaik from the University of Sheffield's Department of Animal and Plant Sciences and Dr Tatiana Tatarinova from the University of Southern California, works similarly to a satellite navigation system as it helps you to find your way home, but not the one you currently live in – but rather ...

A variety of cancers are treated with the anti-tumor agent bleomycin, though its disease-fighting properties remain poorly understood. In a new study, lead author Basab Roy—a researcher at Arizona State University's Biodesign Institute—describes bleomycin's ability to cut through double-stranded DNA in cancerous cells, like a pair of scissors. Such DNA cleavage often leads to cell death in particular types of cancer cells. The paper is co-authored by professor Sidney Hecht, director of Biodesign's Center for BioEnergetics. The study presents, for the first time, alternative ...

VIDEO: University of Iowa Communication Studies researchers Keli Steuber and Andrew High talk about infertility. Click here for more information. Many women coping with infertility count on relatives or close friends for encouragement and assistance. But according to research at the University of Iowa, when it comes to support, women may not be receiving enough—or even the right kind. "Infertility is a more prevalent issue than people realize. It affects one in six couples, ...

University of Adelaide researchers have discovered that stem cells taken from teeth can grow to resemble brain cells, suggesting they could one day be used in the brain as a therapy for stroke. In the University's Centre for Stem Cell Research, laboratory studies have shown that stem cells from teeth can develop and form complex networks of brain-like cells. Although these cells haven't developed into fully fledged neurons, researchers believe it's just a matter of time and the right conditions for it to happen. "Stem cells from teeth have great potential to grow into ...

LA JOLLA—Scientists at the Salk Institute for Biological Studies have identified a key genetic switch linked to the development, progression and outcome of cancer, a finding that may lead to new targets for cancer therapies. The switch, a string of nucleotides dubbed a long non-coding RNA (lncRNA), does not code for proteins like regular RNA. Instead, the scientists found, this particular lncRNA acts as an on/off switch for a key gene whose excessive activity is tied to inflammation and cancer, COX-2. The COX-2 gene mediates inflammation, which in most cases helps our ...

RIVERSIDE, Calif. — Imagine an automobile crash test that uses test dummies painted all over with a substance that can change color according to the levels of stress that various parts of the dummies' bodies will endure. Such a "color map" could provide vital information to engineers designing safer automobiles. Or imagine baseball gloves that when worn show the batters if they are using the appropriate amount of pressure to grip their bats, resulting in better performance. New technology developed at the University of California, Riverside may now make the above and ...

Alexandria, Va., - Global Positioning System (GPS) technology was conceived in the 1960s to provide precise time and location data to the U.S. military, but it was soon embraced by geodesists and earth scientists. The first major test of GPS as a seismic tool occurred on Oct. 17, 1989, when the Loma Prieta earthquake struck San Francisco just as the third game of the World Series was about to begin at Candlestick Park. The quake killed 63 people, injured several thousand and caused an estimated $6 billion in damage. Prior to the quake, geoscientists had placed GPS markers ...

Simple sequence repeats, abbreviated SSRs and frequently referred to as microsatellites, are highly variable sections of the genome. 'Sequence repeat' refers to the fact that a nucleotide motif is repeated. 'Simple,' because the repeated sequence often consists of only a couple of nucleotides—for example, ATAT. Because these markers typically have high rates of molecular evolution, the number of repeats present in the genome often differs between individuals. By isolating SSRs and comparing length differences between taxa, evolutionary relationships can be inferred. Their ...

PITTSBURGH, April 30, 2014 – Damaged leg muscles grew stronger and showed signs of regeneration in three out of five men whose old injuries were surgically implanted with extracellular matrix (ECM) derived from pig bladder, according to a new study conducted by researchers at the University of Pittsburgh School of Medicine and the McGowan Institute for Regenerative Medicine. Early findings from a human trial of the process and from animal studies were published today in Science Translational Medicine. When a large volume of muscle is lost, typically due to trauma, the ...

SAN DIEGO (April 30, 2014) – New analysis of data from the 2003-2010 What We Eat In America (WWEIA) National Health and Nutrition Examination Survey (NHANES), a program of the Centers for Disease Control and Prevention (CDC), indicates that consumers of frozen meals (1) compared to consumers of quick service restaurant (QSR) meals (2) had lower calorie intakes and better Healthy Eating Index (HEI) score. In fact, the analysis revealed that those who consumed frozen meals consumed 253 fewer calories than those who consumed a quick service restaurant meal. These results ...

The rate at which new species evolve is limited by competition for ecological niches, report scientists from the University of Chicago in Nature on April 30. The study, which analyzes the evolutionary and genetic relationships between all 461 songbird species that live in the Himalayan mountains, suggests that as ecological niches within an environment are filled, the formation of new species slows or even stops. To study what controls the process of speciation, Trevor Price, PhD, professor of ecology and evolution at the University of Chicago, Dhananjai Mohan of the ...

SAN DIEGO, CA – April 30, 2014 – Three new mango-related studies were presented this week at the 2014 Federation of American Societies for Experimental Biology (FASEB) in San Diego, revealing initial findings on the effects of mango consumption on ulcerative colitis and bone parameters in animal models. "The mango industry's nutrition research program is committed to advancing our understanding of the role mangos can play as part of a healthy diet," said Megan McKenna, Director of Marketing for the National Mango Board. "These studies provide important insights that ...

WEST LAFAYETTE, Ind. - Significant tornado outbreaks and especially strong tornadoes are more likely occur within periods of activity lasting three or more days, according to a Purdue University tornado expert. Jeff Trapp, a professor of earth, atmospheric and planetary sciences, examined 30 years of U.S. weather records and found that an outbreak of 20 or more reported tornadoes had a 74 percent probability of occurring during a period of tornado activity lasting three or more days. During those same periods, a tornado rated 3 or higher on the Enhanced Fujita scale had ...