A newly discovered molecule provides a new drug target for controlling both asthma-induced muscle thickening and cancerous tumor growth. This molecule, called "microRNA-10a," normally helps genes produce proteins or make copies of themselves, also play an important role in the growth or overgrowth of human airway smooth muscle cells and some forms of cancer. This newly discovered role, which was published in the May 2014 issue of The FASEB Journal, suggests that manipulating microRNA-10a could lead to new asthma and cancer drugs. "We hope this study will serve as the ...

A protein believed to be limited to the hematopoietic system, called Kindlin-3, has been identified as a major player in both the formation and spread of breast cancer to other organs. This discovery, published in the May 2014 issue of The FASEB Journal, could open the door to an entirely new class of breast cancer drugs that targets this protein's newly found activity. "Kill Kindlin-3 to cure cancer," said Elzbieta Pluskota, Ph.D., a researcher involved in the work from the Department of Molecular Cardiology at the Cleveland Clinic Lerner Research Institute in Cleveland, ...

Ottawa (May 1st, 2014) – A new expert panel report, Environmental Impacts of Shale Gas Extraction in Canada, concludes that shale gas development must be supported by well-targeted science and management strategies to understand and mitigate potential impacts. The report, released today by the Council of Canadian Academies, addresses environmental and associated health impacts and offers insights regarding public engagement and trust. Shale gas is leading an energy boom which is having profound economic, environmental, and social impacts across much of North America. ...

New Orleans, LA – Kristopher Kaliebe, MD, Clinical Assistant Professor of Psychiatry at the LSU Health Sciences Center New Orleans School of Medicine, offers parents and caregivers three simple family-oriented goals to overcome the complex problem of childhood obesity and related mental disorders. They involve limit setting to address the brain's "get more" drive strengthened through habitual over-consumption of temptations including highly caloric processed food, hyper-reality media and electronics, as well as excessive sitting. His 3 "rules" of living promote physical ...

Activity in areas of the brain related to reward and self-control may offer neural markers that predict whether people are likely to resist or give in to temptations, like food, in daily life, according to research in Psychological Science, a journal of the Association for Psychological Science. "Most people have difficulty resisting temptation at least occasionally, even if what tempts them differs," say psychological scientists Rich Lopez and Todd Heatherton of Dartmouth College, authors on the study. "The overarching motivation of our work is to understand why some ...

Antimicrobial agents incorporated into edible films applied to foods to seal in flavor, freshness and color can improve the microbiological safety of meats, according to researchers in Penn State's College of Agricultural Sciences. Using films made of pullulan -- an edible, mostly tasteless, transparent polymer produced by the fungus Aureobasidium pulluns -- researchers evaluated the effectiveness of films containing essential oils derived from rosemary, oregano and nanoparticles against foodborne pathogens associated with meat and poultry. The results demonstrate that ...

How hard can it be to make a wheel rotate in a machine? Very hard actually, when the wheel sits in one of those nano-small molecular machines that are predicted to be running our future machines. But before the molecular machines become part of our daily lives, researchers must be able to control them. A Danish/American research team have now solved part of this problem. There are large machines and there are small machines - and then there are molecular machines. They are nano-tiny collections of molecular building blocks that together make up a machine and operate various ...

In the 1950s and 1960s, pregnant women with morning sickness were often prescribed the new drug thalidomide. Shortly after the medicine was released on the market, a reported 10,000 infants were born with an extreme form of the rare congenital phocomelia syndrome, which caused death in 50 percent of cases and severe physical and mental disabilities in others. Although various factors are now known to cause phocomelia, the prominent roots of the disease can be found in the use of the drug thalidomide. Now, half a century later, new research by Dr. Noam Shomron, Prof ...

Boston, MA-- New findings from an in vitro study, led by researchers at Brigham and Women's Hospital (BWH), show that the combination of statins and eicosapentaenoic acid (EPA), an omega-3 fatty acid, may potentially reduce cardiovascular risk. This research is being presented May 1 at a peer-reviewed poster session at the National Lipid Association Scientific Sessions in Orlando, Florida. "We know that endothelial cell dysfunction is emerging as an early and important predictor of cardiovascular disease and plays an essential role in plaque development. Treatments that ...

Smokers may avoid treatment to quit smoking if they previously gained weight while trying to quit, according to researchers at Penn State College of Medicine. Weight gain is a predictable occurrence for smokers who have recently quit. Within the first year after quitting, they gain an average of eight to14 pounds, and some smokers report that they keep smoking simply because they do not want to gain weight from quitting. Susan Veldheer, project manager in the Department of Public Health Sciences, predicted that smokers would avoid treatment to quit if they are highly ...

CHICAGO --- Northwestern Medicine® scientists have newly identified a protein's key role in cell and physiological aging and have developed – in collaboration with Tohoku University in Japan -- an experimental drug that inhibits the protein's effect and prolonged the lifespan in a mouse model of accelerated aging. The rapidly aging mice fed the experimental drug lived more than four times longer than a control group, and their lungs and vascular system were protected from accelerated aging, the new study reports. The experimental drug could potentially be used to treat ...

A team of researchers from SUNY Downstate Medical Center (SUNY Downstate) and Sanford-Burnham Medical Research Institute (Sanford-Burnham) has found that deficiencies in hyaluronan, also known as hyaluronic acid or HA, can lead to spontaneous epileptic seizures. HA is a polysaccharide molecule widely distributed throughout connective, epithelial, and neural tissues, including the brain's extracellular space (ECS). Their findings, published on April 30 in The Journal of Neuroscience, equip scientists with key information that may lead to new therapeutic approaches to epilepsy. ...

VIDEO: Land plants detect light with pigments called phytochromes, which are sensitive to red light. But red light is absorbed by water, so aquatic algae have evolved phytochromes with a much... Click here for more information. Aquatic algae can sense an unexpectedly wide range of color, allowing them to sense and adapt to changing light conditions in lakes and oceans. The study by researchers at UC Davis was published earlier this year in the journal Proceedings of the National ...

Weather systems that bring rainstorms to many drought-prone areas of northern Africa, carry Saharan dust across the ocean and seed Atlantic hurricanes could grow stronger as a result of human-caused climate change, a new analysis by Stanford scientists suggests. Known as African easterly waves, or AEWs, these weather systems form above northern Africa during the summer season and travel east to west, toward the Atlantic Ocean. "Not only are AEWs important for rainfall in West Africa, they also play a role in climate across the Atlantic, including here in the United ...

Small classes, especially in the first four years of school, can have an important and lasting impact on student achievement, a new report shows. In a review of over 100 papers from 1979-2014, education expert Dr David Zyngier from Monash University's Faculty of Education looked at whether the conclusions reached on the effect of smaller class sizes still hold true today. "The question of class size continues to attract the attention of educational policymakers and researchers alike," Dr Zyngier said. "Many argue that much of Australia's increased expenditure on education ...

Real freedom, gender-based violence, terrorism laws, and asylum seekers' rights are all considered in a report released today on vital human rights issues in Australia and around the world. The 2014 Castan Human Rights Report, by Monash University's Castan Centre for Human Rights Law, highlights the Centre's research and its relevance to some of the most important human rights issues facing society. A key finding of the report is that freedom in Australia is being undermined. Director of the Castan Centre Professor Sarah Joseph said the recent narrow debate on the ...

ARLINGTON HEIGHTS, Ill. (May 1, 2014) – Some of the 26 million Americans with asthma may also be prone to bone loss. According to a study published today in the May issue of Annals of Allergy, Asthma & Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology, there seems to be association between asthma and a decrease in bone mineral density. "We know prolonged use of corticosteroids in the treatment of asthma is a risk factor of osteoporosis, but we haven't had definite data showing the relationship between asthma itself and bone loss," ...

PORTLAND, Ore. — People with multiple sclerosis who for one year followed a plant-based diet very low in saturated fat had much less MS-related fatigue at the end of that year — and significantly less fatigue than a control group of people with MS who didn't follow the diet, according to an Oregon Health & Science University study being presented today at the American Academy of Neurology's annual meeting in Philadelphia, Pa. The study was the first randomized-controlled trial to examine the potential benefits of the low fat diet on the management of MS. The study found ...

If you think the 1930s drought that caused The Dust Bowl was rough, new research looking at tree rings in the Rocky Mountains has news for you: Things can get much worse in the West. In fact the worst drought of this century barely makes the top 10 of a study that extended Utah's climate record back to the year 1429. With sandpaper and microscopes, Brigham Young University professor Matthew Bekker analyzed rings from drought-sensitive tree species. He found several types of scenarios that could make life uncomfortable in what is now the nation's third-fastest-growing ...

Researchers at University of California, Santa Barbara, in collaboration with Rice University, have recently demonstrated a rapid synthesis technique for large-area Bernal (or AB) stacked bilayer graphene films that can open up new pathways for digital electronics and transparent conductor applications. The invention also includes the first demonstration of a bilayer graphene double-gate field-effect transistor (FET), showing record ON/OFF transistor switching ratio and carrier mobility that could drive future ultra-low power and low-cost electronics. Graphene is ...

Australia's coastline has been struck by up to 145 possible tsunamis since prehistoric times, causing deaths previously unreported in the scientific literature, a UNSW Australia study has revealed. The largest recorded inundation event in Australia was caused by an earthquake off Java in Indonesia on 17 July 2006, which led to a tsunami that reached up to 7.9 metres above sea level on land at Steep Point in Western Australia. The continent was also the site of the oldest known tsunami in the world - an asteroid impact that occurred 3.47 billion years ago in what is now ...

CAMBRIDGE, Mass. -- Out on the edge of the universe, 75,000 light years from us, a galaxy known as Segue 1 has some unusual properties: It is the faintest galaxy ever detected. It is very small, containing only about 1,000 stars. And it has a rare chemical composition, with vanishingly small amounts of metallic elements present. Now a team of scientists, including an MIT astronomer, has analyzed that chemical composition and come away with new insights into the evolution of galaxies in the early stages of our universe — or, in this case, into a striking lack of evolution ...

LIVERPOOL, UK – 30 April 2014: Scientists at the University of Liverpool have shown how the travel and socialisation patterns of people in Southern China can give greater insight into how new diseases such as bird flu may spread between populations. Southern China is one of the most important regions of the planet for the development and spread of new diseases in humans. In recent years a combination of high population density, frequent contact between humans and animals and the developed transport links in the region have given rise to diseases such as SARS and avian ...

Children who spend significant time outdoors could have a stronger sense of self-fulfillment and purpose than those who don't, according to new Michigan State University research linking children's experiences in nature with how they define spirituality. In the study, published recently in the Journal of the Study of Religion, Nature and Culture, children who played outside five to 10 hours per week said they felt a spiritual connection with the earth, and felt their role is to protect it. "These values are incredibly important to human development and well-being," ...

CHICAGO (May 1, 2014)—When it comes to buying a mouthguard, parents who want to reduce their child's risk of a sports-related concussion should visit a dentist instead of a sporting goods store. High school football players wearing store-bought, over-the-counter (OTC) mouthguards were more than twice as likely to suffer mild traumatic brain injures (MTBI)/concussions than those wearing custom-made, properly fitted mouthguards, reports a new study in the May/June 2014 issue of General Dentistry, the peer-reviewed clinical journal of the Academy of General Dentistry (AGD). "Researchers ...