LOS ANGELES (June 24, 2014) – Although deep brain stimulation can be an effective therapy for dystonia – a potentially crippling movement disorder – the treatment isn't always effective, or benefits may not be immediate. Precise placement of DBS electrodes is one of several factors that can affect results, but few studies have attempted to identify the "sweet spot," where electrode placement yields the best results. Researchers led by investigators at Cedars-Sinai, using a complex set of data from records and imaging scans of patients who have undergone successful DBS ...

Ottawa/Toronto, CANADA – June 25, 2014 – Pediatric emergency medicine researchers at the Children's Hospital of Eastern Ontario (CHEO) together with the Ontario Neurotrauma Foundation (ONF) today launch the first comprehensive pediatric concussion guidelines. "There have been recommendations and policies on concussion available in the past, but they tend to have focused on sports-related injury and not on children and youth," said Dr. Roger Zemek, project leader, scientist at CHEO, and Assistant Professor of Pediatrics and Emergency Medicine at the University of Ottawa. ...

The incarceration rate has nearly quadrupled since the U.S. declared a war on drugs, researchers say. Along with that, racial disparities abound. Incarceration rates for black Americans are more than six times higher than those for white Americans, according to the U.S. Bureau of Justice Statistics. To explain these growing racial disparities, researchers at Virginia Tech are using the same modeling techniques used for infectious disease outbreaks to take on the mass incarceration problem. By treating incarceration as an infectious disease, the scientists demonstrated ...

Optimality principles have been used, in a holistic approach, to describe flow processes in several important geosystems. Optimality principles refer to the state of a physical system that is controlled by an optimal condition subject to physical and/or resource constraints. While significant successes have been achieved in applying them, some principles appear to contradict each other. For example, scientists have found that the formation of channel networks in a river basin follows the minimization of energy expenditure (MEE) rate, while the Earth-atmosphere system ...

Policymakers should conduct "net energy analyses" when evaluating the long-term sustainability of energy technologies, according to new Stanford University research. Net energy analysis provides a quantitative way to compare the amount of energy a technology produces over its lifetime with the energy required to build and maintain it. The technique can complement conventional energy planning, which often focuses on minimizing the financial cost of energy production, say Stanford researchers. "The clearest answer to 'why is net energy important?' is that net energy, ...

AMHERST, Mass. – Challenging risk assessment methods used for decades by toxicologists, a new review of the literature led by environmental health scientist Laura Vandenberg at the University of Massachusetts Amherst suggests that oral gavage, the most widely accepted method of dosing lab animals to test chemical toxicity, does not accurately mimic how humans are exposed to chemicals in everyday life. Oral gavage refers to the way researchers give chemicals to animals by putting a tube down their throats to deliver substances directly to the stomach. It has been used ...

TORONTO, June 25, 2014–There's good news for the 30 per cent or more of adults who suffer from insomnia--difficulty falling asleep, waking up for prolonged periods during the night or unwanted early morning awakenings. New research from St. Michael's Hospital has found that insomnia does not put them at increased risk of developing high blood pressure. Dr. Nicholas Vozoris, a respirologist at St. Michael's, said there is growing concern among patients and health care providers about the potential medical consequences of insomnia, especially on the cardiovascular system. If ...

The rate of deforestation in the Brazilian Amazon has declined. An international team of scientists, including one from Virginia Tech, reviewed published research about policy interventions and commodity market effects, and determined that positive incentives for farmers, counties, and states can do as much to preserve forests as public policies that call for penalties. "The challenge now is to build upon this progress," the team reports in an article in the June 6 issue of Science. "Some immediate and simple positive incentives for responsible, low-deforestation farmers ...

University freshers struggle to remember basic concepts from their A-level studies according to new research from the University of East Anglia. A new report published today shows that even grade-A students could only remember 40 per cent of their A-Level syllabus by the first week of term at university. Researchers tested nearly 600 students in their first week of term at five universities – three of which were in the prestigious Russell Group. It is hoped that the findings will assist the re-design of A-Levels to make them more relevant to higher education. The ...

Daily headlines on internet pages and blogs claim: "New ingredient X is harmful to your health." Such warnings can scare people into avoiding these ingredients without actually knowing the facts, leading some people to have food fears about ingredients such as sugar, fat, sodium, high-fructose corn syrup (HFCS), mono sodium glutamate (MSG), and others. While some of these food fears are merited, others can be misleading. A new Cornell University study published in Food Quality and Preference, investigated who might be most prone to food fears, why, and what can they do ...

Four years after falling in love with the disco clam – a cute little mollusk known for its underwater light show – Lindsey Dougherty has discovered the secret of its mirrored lips. A dive instructor and University of California, Berkeley, graduate student, Dougherty first encountered the two-inch clam in 2010 while diving with her mother and sister in Wakatobi, Indonesia. She and her sister even did a bit of underwater disco dancing to the clam's flashing beat. "I've dived with humpback whales and great white sharks," said Dougherty, who first learned to dive at age ...

Boston, MA – In a groundbreaking study, researchers from Brigham and Women's Hospital (BWH) have identified a related family of molecules believed to be a major root cause of pulmonary hypertension, a deadly vascular disease with undefined origins. This is one of the first studies to leverage advanced computational network modeling to decipher the molecular secrets of this complex human disease. The study is published online June 24, 2014 in The Journal of Clinical Investigation. Despite the rising number of people diagnosed with the disease worldwide, pulmonary hypertension ...

Habitat loss is a primary driver of biodiversity loss – so it isn't surprising that optimising the amount of protected land is high on policy-makers' priorities. However, according to research to be published in the Open Access journal PLOS Biology on June 24 by Oscar Venter and colleagues, many protected areas are established in locations of low economic value, failing to protect the imperilled biodiversity found on more valuable land. More of the earth's land surface is set to be protected in the next decade, but the trend of using poor quality land seems set to continue. ...

Obesity levels are rising throughout the world. As obesity rates increase, so do the incidences of diabetes, heart disease, and other serious health conditions. The bacteria within an individual's gut can influence their susceptibility to these disorders. Therefore, altering the microbe population in the gut could prevent or reverse disease. A June 24th study in the Journal of Clinical Investigation demonstrates that modified bacteria can prevent weight gain in mice. Sean Davies and colleagues at Vanderbilt University made bacteria that produce a compound called NAPE, ...

Millions of women will develop breast cancer at some point in their lives. While many women will completely recover from this cancer, others will not respond to treatment, and predicting which women will not respond to treatment is currently difficult. Breast cancer cells divide rapidly, and treatments that can restrict their growth are of great interest. In a June 24th study in the Journal of Clinical Investigation, Rong Li and colleagues at the University of Texas determined that activation of the estrogen receptor β (ERβ) limits tumor cell growth. Cancer cells ...

Irvine, Calif. — A newly discovered biomarker – visible in brain scans for hours after febrile seizures – predicts which individuals will subsequently develop epilepsy, according to UC Irvine researchers. This diagnostic ability could lead to improved use of preventive therapies for the disorder. A team led by Dr. Tallie Z. Baram found that rats exhibiting this novel signal in magnetic resonance imaging scans of their brains manifested symptoms of epilepsy months after experiencing very long febrile seizures. Those that did not possess this biomarker remained free of ...

Cold Spring Harbor, NY – There are new clues about malfunctions in brain cells that contribute to intellectual disability and possibly other developmental brain disorders. Professor Linda Van Aelst of Cold Spring Harbor Laboratory (CSHL) has been scrutinizing how the normal version of a protein called OPHN1 helps enable excitatory nerve transmission in the brain, particularly at nerve-cell docking ports containing AMPA receptors (AMPARs). Her team's new work, published June 24 in the Journal of Neuroscience, provides new mechanistic insight into how OPHN1 defects can ...

Washington, DC — Within hours of a fever-induced seizure, magnetic resonance imaging (MRI) may be able to detect brain changes that occur in those most likely to develop epilepsy later in life, according to an animal study published in the June 25 issue of The Journal of Neuroscience. The findings may one day help improve methods to detect children at a heightened risk for developing epilepsy and guide efforts to prevent epilepsy development in those at greatest risk. Febrile seizures — convulsions brought on by fever — typically last only a few minutes and are relatively ...

COLUMBUS, Ohio – In the complex environment of a spinal cord injury, researchers have found that immune cells in the central nervous system of elderly mice fail to activate an important signaling pathway, dramatically lowering chances for repair after injury. These studies were the first to show that spinal cord injuries are more severe in elderly mice than in young adults, corroborating previous anecdotal findings from clinical settings. They also revealed a previously unknown player in the repair of spinal cord injuries in young adults. A key messenger in that pathway ...

Scientists from James Cook University, the Wildlife Conservation Society, the University of Queensland, Stanford University, BirdLife International, the International Union for Nature Conservation, and other organizations have warned that the world's protected areas are not safeguarding most of the world's imperilled biodiversity, and clear changes need to be made on how nations undertake future land protection if wildlife is going to be saved. These findings come at a time when countries are working toward what could become the biggest expansion of protected areas in history. The ...

Scientists from James Cook University, the Wildlife Conservation Society, the University of Queensland, Stanford University, BirdLife International, the International Union for Nature Conservation, and other organizations have warned that the world's protected areas are not safeguarding most of the world's imperilled biodiversity, and clear changes need to be made on how nations undertake future land protection if wildlife is going to be saved. These findings come at a time when countries are working toward what could become the biggest expansion of protected areas in history. The ...

(PHILADELPHIA) – Patients who received regional anesthesia during hip fracture surgery had moderately lower mortality and a significantly lower length of stay than those who received general anesthesia, according to new research from the Perelman School of Medicine at the University of Pennsylvania. The study, published this week in JAMA, employed a new, more reliable Penn-developed technique for comparative-effectiveness research to pinpoint best practices. In a related study published in JAMA Internal Medicine this week, the team also reported high rates of mortality ...

The addition of tomosynthesis, a 3-dimensional breast imaging technique, to digital mammography in more than 170,000 examinations was associated with a decrease in the proportion of patients called back for additional imaging and an increase in the cancer detection rate, according to a study in the June 25 issue of JAMA. Screening mammography has played a key role in reducing breast cancer mortality, although it has drawn criticism for excessive false-positive results, limited sensitivity, and the potential of overdiagnosis of clinically insignificant lesions. In 2011, ...

Among more than 56,000 adults undergoing hip repair between 2004 and 2011, the use of regional anesthesia compared with general anesthesia was not associated with a lower risk of death at 30 days, but was associated with a modestly shorter length of hospital stay, according to a study in the June 25 issue of JAMA. Each year, more than 300,000 hip fractures occur in the United States, which can lead to functional disability and death. Regional anesthesia for hip fracture surgery may reduce postoperative complications, and practice guidelines have called for broader use ...

Among patients with a severe, life-threatening type of sclerosis, treatment with hematopoietic stem cell transplantation (HSCT), compared to intravenous infusion of the chemotherapeutic drug cyclophosphamide, was associated with an increased treatment-related risk of death in the first year, but better long-term survival, according to a study in the June 25 issue of JAMA. Systemic sclerosis is an autoimmune connective tissue disease characterized by vasculopathy (a disorder of the blood vessels), low-grade inflammation, and fibrosis (development of excess fibrous connective ...